WO2001079468A3 - Drug metabolizing enzymes - Google Patents

Drug metabolizing enzymes Download PDF

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Publication number
WO2001079468A3
WO2001079468A3 PCT/US2001/011869 US0111869W WO0179468A3 WO 2001079468 A3 WO2001079468 A3 WO 2001079468A3 US 0111869 W US0111869 W US 0111869W WO 0179468 A3 WO0179468 A3 WO 0179468A3
Authority
WO
WIPO (PCT)
Prior art keywords
metabolizing enzymes
drug metabolizing
dme
provides
polynucleotides
Prior art date
Application number
PCT/US2001/011869
Other languages
French (fr)
Other versions
WO2001079468A2 (en
Inventor
Jennifer L Policky
April Hafalia
Neil Burford
Huijun Z Ring
Preeti Lal
Catherine M Tribouley
Monique G Yao
Henry Yue
Y Tom Tang
Chandra Patterson
Debopriya Das
Madhu S Sanjanwala
Ameena R Gandhi
Roopa Reddy
Farrah A Khan
Mariah R Baughn
Jaya Ramkumar
Jennifer A Griffin
Janice Au-Young
Original Assignee
Incyte Genomics Inc
Jennifer L Policky
April Hafalia
Neil Burford
Huijun Z Ring
Preeti Lal
Catherine M Tribouley
Monique G Yao
Henry Yue
Y Tom Tang
Chandra Patterson
Debopriya Das
Madhu S Sanjanwala
Ameena R Gandhi
Roopa Reddy
Farrah A Khan
Mariah R Baughn
Jaya Ramkumar
Jennifer A Griffin
Janice Au-Young
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN00819428.9A priority Critical patent/CN1202393C/en
Application filed by Incyte Genomics Inc, Jennifer L Policky, April Hafalia, Neil Burford, Huijun Z Ring, Preeti Lal, Catherine M Tribouley, Monique G Yao, Henry Yue, Y Tom Tang, Chandra Patterson, Debopriya Das, Madhu S Sanjanwala, Ameena R Gandhi, Roopa Reddy, Farrah A Khan, Mariah R Baughn, Jaya Ramkumar, Jennifer A Griffin, Janice Au-Young filed Critical Incyte Genomics Inc
Priority to AU2001255324A priority patent/AU2001255324A1/en
Priority to CA002403644A priority patent/CA2403644A1/en
Priority to JP2001577452A priority patent/JP2004512818A/en
Priority to EP01928472A priority patent/EP1272638A2/en
Priority to US10/258,080 priority patent/US20040029125A1/en
Publication of WO2001079468A2 publication Critical patent/WO2001079468A2/en
Publication of WO2001079468A3 publication Critical patent/WO2001079468A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01021—Aldehyde reductase (1.1.1.21), i.e. aldose-reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01045—2-Hydroxyacylsphingosine 1-beta-galactosyltransferase (2.4.1.45)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention provides human drug metabolizing enzymes (DME) and polynucleotides which identify and encode DME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of DME.
PCT/US2001/011869 2000-04-13 2001-04-12 Drug metabolizing enzymes WO2001079468A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN00819428.9A CN1202393C (en) 2001-04-12 2000-04-18 Gaseous wave refrigeration device with flow regulator function
AU2001255324A AU2001255324A1 (en) 2000-04-13 2001-04-12 Drug metabolizing enzymes
CA002403644A CA2403644A1 (en) 2000-04-13 2001-04-12 Drug metabolizing enzymes
JP2001577452A JP2004512818A (en) 2000-04-13 2001-04-12 Drug metabolizing enzymes
EP01928472A EP1272638A2 (en) 2000-04-13 2001-04-12 Drug metabolizing enzymes
US10/258,080 US20040029125A1 (en) 2001-04-12 2001-04-12 Drug metabolizing enzymes

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US19759000P 2000-04-13 2000-04-13
US60/197,590 2000-04-13
US19840300P 2000-04-19 2000-04-19
US60/198,403 2000-04-19
US20018500P 2000-04-28 2000-04-28
US60/200,185 2000-04-28
US20223400P 2000-05-05 2000-05-05
US60/202,234 2000-05-05
US20350900P 2000-05-11 2000-05-11
US60/203,509 2000-05-11

Publications (2)

Publication Number Publication Date
WO2001079468A2 WO2001079468A2 (en) 2001-10-25
WO2001079468A3 true WO2001079468A3 (en) 2002-07-18

Family

ID=27539372

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/011869 WO2001079468A2 (en) 2000-04-13 2001-04-12 Drug metabolizing enzymes

Country Status (5)

Country Link
EP (1) EP1272638A2 (en)
JP (1) JP2004512818A (en)
AU (1) AU2001255324A1 (en)
CA (1) CA2403644A1 (en)
WO (1) WO2001079468A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852518B1 (en) 1999-07-20 2005-02-08 The Regents Of The University Of California Glycosyl sulfotransferases GST-4α, GST-4β, and GST-6
WO2002026834A2 (en) * 2000-09-25 2002-04-04 Millennium Pharmaceuticals Inc. 32624 a novel human udp-glucuronosyl and glycosyl transferase family member and uses thereof
US20020123475A1 (en) * 2000-06-30 2002-09-05 Leiby Kevin R. 32626, a novel human UDP-glycosyltransferase and uses thereof
US6987014B2 (en) * 2000-08-30 2006-01-17 Applera Corporation Isolated nucleic acid molecules encoding human drug metabolizing proteins
EP1404841B1 (en) 2000-10-31 2011-08-17 Eisai Inc. Cyp1b1 nucleic acids and methods of use
GB0307914D0 (en) * 2003-04-07 2003-05-14 Univ Dundee Cytochrome p450
WO2023081000A1 (en) * 2021-11-03 2023-05-11 Simbiosys, Inc. Metabolic modeling for disease prognosis and treatment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463395A1 (en) * 1990-06-22 1992-01-02 F. Hoffmann-La Roche Ag Detection of poor metabolizers of drugs
WO1997044466A1 (en) * 1996-05-17 1997-11-27 Endorecherche, Inc. Characterization and use of an isolated uridine diphospho-glucuronosyltransferase
EP0905232A1 (en) * 1996-12-12 1999-03-31 Kirin Beer Kabushiki Kaisha NOVEL Beta 1-4 N-ACETYLGLUCOSAMINYLTRANSFERASE AND GENE ENCODING THE SAME

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463395A1 (en) * 1990-06-22 1992-01-02 F. Hoffmann-La Roche Ag Detection of poor metabolizers of drugs
WO1997044466A1 (en) * 1996-05-17 1997-11-27 Endorecherche, Inc. Characterization and use of an isolated uridine diphospho-glucuronosyltransferase
EP0905232A1 (en) * 1996-12-12 1999-03-31 Kirin Beer Kabushiki Kaisha NOVEL Beta 1-4 N-ACETYLGLUCOSAMINYLTRANSFERASE AND GENE ENCODING THE SAME

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_HUM [online] EMBL; 16 January 2000 (2000-01-16), WATERSTON R.H.: "Homo sapiens chromosome 4 clone RP11-468N14, complete sequence", XP002186102, retrieved from EBI accession no. AC021146 Database accession no. AC021146 *
DATABASE EM_HUM [online] EMBL; 29 September 2000 (2000-09-29), SUGANO ET AL.: "Homo sapiens cDNA: FLJ21934 fis, clone HEP04364", XP002186103, retrieved from EBI accession no. AK025587 Database accession no. AK025587 *
DATABASE SWALL [online] 1 March 2001 (2001-03-01), KAWABATA ET AL.: "cDNA: FLJ21934 fis, clone HEP04364", XP002186764, retrieved from EBI accession no. Q9H6S4 Database accession no. Q9H6S4 *
KIMURA S ET AL: "THE HUMAN DEBRISOQUINE 4-HYDROXYLASE (CYP2D) LOCUS: SEQUENCE AND IDENTIFICATION OF THE POLYMORPHIC CYP2D6 GENE, A RELATED GENE, AND A PSEUDOGENE", AMERICAN JOURNAL OF HUMAN GENETICS, UNIVERSITY OF CHICAGO PRESS, CHICAGO,, US, vol. 45, no. 6, 1 December 1989 (1989-12-01), pages 889 - 904, XP000570035, ISSN: 0002-9297 *

Also Published As

Publication number Publication date
WO2001079468A2 (en) 2001-10-25
CA2403644A1 (en) 2001-10-25
AU2001255324A1 (en) 2001-10-30
JP2004512818A (en) 2004-04-30
EP1272638A2 (en) 2003-01-08

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