WO2002026950A3 - Transferases - Google Patents

Transferases Download PDF

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Publication number
WO2002026950A3
WO2002026950A3 PCT/US2001/030424 US0130424W WO0226950A3 WO 2002026950 A3 WO2002026950 A3 WO 2002026950A3 US 0130424 W US0130424 W US 0130424W WO 0226950 A3 WO0226950 A3 WO 0226950A3
Authority
WO
WIPO (PCT)
Prior art keywords
trnfr
provides
transferases
polynucleotides
agonists
Prior art date
Application number
PCT/US2001/030424
Other languages
French (fr)
Other versions
WO2002026950A2 (en
Inventor
Preeti G Lal
Y Tom Tang
Henry Yue
Neil Burford
Ameena R Gandhi
Bridget A Warren
Monique G Yao
Catherine M Tribouley
Mariah R Baughn
Ernestine A Lee
April J A Hafalia
Yan Lu
Jennifer A Griffin
Madhu S Sanjanwala
Li Ding
Original Assignee
Incyte Genomics Inc
Preeti G Lal
Y Tom Tang
Henry Yue
Neil Burford
Ameena R Gandhi
Bridget A Warren
Monique G Yao
Catherine M Tribouley
Mariah R Baughn
Ernestine A Lee
April J A Hafalia
Yan Lu
Jennifer A Griffin
Madhu S Sanjanwala
Li Ding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Preeti G Lal, Y Tom Tang, Henry Yue, Neil Burford, Ameena R Gandhi, Bridget A Warren, Monique G Yao, Catherine M Tribouley, Mariah R Baughn, Ernestine A Lee, April J A Hafalia, Yan Lu, Jennifer A Griffin, Madhu S Sanjanwala, Li Ding filed Critical Incyte Genomics Inc
Priority to EP01975548A priority Critical patent/EP1320584A2/en
Priority to AU2001294866A priority patent/AU2001294866A1/en
Priority to CA002423694A priority patent/CA2423694A1/en
Priority to US10/398,038 priority patent/US20040167065A1/en
Priority to JP2002530714A priority patent/JP2004532605A/en
Publication of WO2002026950A2 publication Critical patent/WO2002026950A2/en
Priority to US10/288,252 priority patent/US20030143686A1/en
Publication of WO2002026950A3 publication Critical patent/WO2002026950A3/en
Priority to US10/976,440 priority patent/US20050112745A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Abstract

The invention provides human transferases (TRNFR) and polynucleotides which identify and encode TRNFR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRNFR.
PCT/US2001/030424 2000-09-29 2001-09-28 Transferases WO2002026950A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP01975548A EP1320584A2 (en) 2000-09-29 2001-09-28 Transferases
AU2001294866A AU2001294866A1 (en) 2000-09-29 2001-09-28 Transferases
CA002423694A CA2423694A1 (en) 2000-09-29 2001-09-28 Transferases
US10/398,038 US20040167065A1 (en) 2000-09-29 2001-09-28 Transferases
JP2002530714A JP2004532605A (en) 2000-09-29 2001-09-28 Transferase
US10/288,252 US20030143686A1 (en) 2000-09-29 2002-11-04 Transferases
US10/976,440 US20050112745A1 (en) 2000-09-29 2004-10-29 Transferases

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US23652300P 2000-09-29 2000-09-29
US60/236,523 2000-09-29
US23848100P 2000-10-06 2000-10-06
US60/238,481 2000-10-06
US24402500P 2000-10-27 2000-10-27
US60/244,025 2000-10-27
US24600100P 2000-11-03 2000-11-03
US60/246,001 2000-11-03
US24793100P 2000-11-09 2000-11-09
US60/247,931 2000-11-09
US24963900P 2000-11-16 2000-11-16
US60/249,639 2000-11-16
US25281900P 2000-11-21 2000-11-21
US60/252,819 2000-11-21
US10/398,038 US20040167065A1 (en) 2000-09-29 2001-09-28 Transferases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/288,252 Continuation US20030143686A1 (en) 2000-09-29 2002-11-04 Transferases

Publications (2)

Publication Number Publication Date
WO2002026950A2 WO2002026950A2 (en) 2002-04-04
WO2002026950A3 true WO2002026950A3 (en) 2003-02-20

Family

ID=37772654

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/030424 WO2002026950A2 (en) 2000-09-29 2001-09-28 Transferases

Country Status (6)

Country Link
US (1) US20040167065A1 (en)
EP (1) EP1320584A2 (en)
JP (1) JP2004532605A (en)
AU (1) AU2001294866A1 (en)
CA (1) CA2423694A1 (en)
WO (1) WO2002026950A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1326985A1 (en) * 2000-08-18 2003-07-16 MERCK PATENT GmbH Identification of a human n-terminal acetyltransferase gene
ATE416253T1 (en) 2000-08-21 2008-12-15 Millennium Pharm Inc ATCR-1, A HUMAN ACYL TRANSFERASE AND USES THEREOF
US6887695B2 (en) * 2001-03-28 2005-05-03 Zymogenetics, Inc. Transglutaminase ztg2
US20050112568A1 (en) * 2001-06-05 2005-05-26 Lori Friedman Dgks as modifiers of the p53 pathwha and methods of use
WO2003008590A1 (en) * 2001-07-16 2003-01-30 Kissei Pharmaceutical Co., Ltd. Human mitochondrial gpat
WO2003016515A2 (en) * 2001-08-16 2003-02-27 Bayer Healthcare Ag Regulation of human glycerol-3-phosphate acyltransferase-like protein
JP4378175B2 (en) * 2002-03-14 2009-12-02 独立行政法人産業技術総合研究所 Novel N-acetylglucosamine transferase, nucleic acid encoding the same, and their cancer and / or tumor diagnostic uses
WO2003093826A2 (en) * 2002-04-29 2003-11-13 Clinigenetics Assays for identifying cholesterol - lowering molecules
WO2004043397A2 (en) * 2002-11-12 2004-05-27 Genentech, Inc. Compositions and methods for the treatment of rheumatoid arthritis
US20080038278A1 (en) * 2006-02-24 2008-02-14 Jingsong Cao GPAT3 encodes a mammalian, microsomal acyl-coa:glycerol 3- phosphate acyltransferase

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463395A1 (en) * 1990-06-22 1992-01-02 F. Hoffmann-La Roche Ag Detection of poor metabolizers of drugs
WO1997044466A1 (en) * 1996-05-17 1997-11-27 Endorecherche, Inc. Characterization and use of an isolated uridine diphospho-glucuronosyltransferase
WO1998054302A2 (en) * 1997-05-27 1998-12-03 Icos Corporation Human lysophosphatidic acid acyltransferase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463395A1 (en) * 1990-06-22 1992-01-02 F. Hoffmann-La Roche Ag Detection of poor metabolizers of drugs
WO1997044466A1 (en) * 1996-05-17 1997-11-27 Endorecherche, Inc. Characterization and use of an isolated uridine diphospho-glucuronosyltransferase
WO1998054302A2 (en) * 1997-05-27 1998-12-03 Icos Corporation Human lysophosphatidic acid acyltransferase

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_EST [online] EMBL; 14 October 1998 (1998-10-14), NCI-CGAP: "qd53g08.x1 Soares_fetal_heart_NbHH19W Homo sapiens cDNA clone IMAGE:1733246 3' similar to SW:NAR4_HUMAN Q93070 ECTO-ADP-RIBOSYLTRANSFERASE 4 ;, mRNA sequence", XP002204540, retrieved from EBI Database accession no. AI190442 *
DATABASE EM_EST [online] EMBL; 16 October 1998 (1998-10-16), NCI-CGAP: "qd45c07.x1 Soares_fetal_heart_NbHH19W Homo sapiens cDNA clone IMAGE:1732428 3' similar to SW:NAR4_HUMAN Q93070 ECTO-ADP-RIBOSYLTRANSFERASE 4 ;, mRNA sequence", XP002204539, retrieved from EBI Database accession no. AI203531 *
DATABASE EM_HUM [online] EMBL; 17 August 1996 (1996-08-17), KOCH-NOLTE ET AL.: "H. sapiens ART4 gene", XP002204538, retrieved from EBI accession no. HSART4 Database accession no. X95826 *
DATABASE EM_HUM [online] EMBL; 2 October 2000 (2000-10-02), GUBIN ET AL.: "Homo sapiens blood group carrier molecule DOK1 mRNA, complet cds.", XP002204542, retrieved from EBI Database accession no. AF290204 *
DATABASE SWALL [online] 1 March 2001 (2001-03-01), GUBIN ET AL.: "Blood group carrier molecule DOK1", XP002204541, retrieved from EBI Database accession no. Q9HB06 *
DATABASE SWALL [online] 1 November 1997 (1997-11-01), KOCH-NOLTE ET AL.: "Ecto-ADP-ribosyltransferase 4 (EC 2.4.2.31) ....", XP002204537, retrieved from EBI accession no. NAR4_HUMAN Database accession no. Q93070 *
GUBIN ET AL.: "Identification of the Dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family", BLOOD, vol. 96, no. 7, 1 October 2000 (2000-10-01), pages 2621 - 2627, XP002204536 *
KOCH-NOLTE ET AL.: "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins", GENOMICS, vol. 39, no. 3, 1 February 1997 (1997-02-01), pages 370 - 376, XP002204535 *
VESSEY D A ET AL: "DETERMINATION OF THE SEQUENCE OF THE ARYLACETYL ACYL- COA:AMINO ACID N-ACYLTRANSFERASE FROM BOVINE LIVER MITOCHONDRIA AND ITS HOMOLOGY TO THE ARALKYL ACYL- COA:AMINO ACID N-ACYLTRANSFERASE", JOURNAL OF BIOCHEMICAL TOXICOLOGY, VCH PUBLISHERS, DEERFIELD, FL, US, vol. 12, no. 5, 1998, pages 275 - 279, XP002931296, ISSN: 0887-2082 *

Also Published As

Publication number Publication date
AU2001294866A1 (en) 2002-04-08
US20040167065A1 (en) 2004-08-26
EP1320584A2 (en) 2003-06-25
CA2423694A1 (en) 2002-04-04
WO2002026950A2 (en) 2002-04-04
JP2004532605A (en) 2004-10-28

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