WO2001059127A3 - Drug metabolizing enzymes - Google Patents

Drug metabolizing enzymes Download PDF

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Publication number
WO2001059127A3
WO2001059127A3 PCT/US2001/004423 US0104423W WO0159127A3 WO 2001059127 A3 WO2001059127 A3 WO 2001059127A3 US 0104423 W US0104423 W US 0104423W WO 0159127 A3 WO0159127 A3 WO 0159127A3
Authority
WO
WIPO (PCT)
Prior art keywords
metabolizing enzymes
drug metabolizing
dme
provides
polynucleotides
Prior art date
Application number
PCT/US2001/004423
Other languages
French (fr)
Other versions
WO2001059127A2 (en
Inventor
Y Tom Tang
Henry Yue
Mariah R Baughn
Monique G Yao
Olga Bandman
Yalda Azimzai
Preeti Lal
Ameena R Gandhi
Huijun Z Ring
Leo L Shih
Junming Yang
Jennifer L Policky
Original Assignee
Incyte Genomics Inc
Y Tom Tang
Henry Yue
Mariah R Baughn
Monique G Yao
Olga Bandman
Yalda Azimzai
Preeti Lal
Ameena R Gandhi
Huijun Z Ring
Leo L Shih
Junming Yang
Jennifer L Policky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Y Tom Tang, Henry Yue, Mariah R Baughn, Monique G Yao, Olga Bandman, Yalda Azimzai, Preeti Lal, Ameena R Gandhi, Huijun Z Ring, Leo L Shih, Junming Yang, Jennifer L Policky filed Critical Incyte Genomics Inc
Priority to JP2001558463A priority Critical patent/JP2003522528A/en
Priority to CA002399873A priority patent/CA2399873A1/en
Priority to EP01907197A priority patent/EP1254236A2/en
Priority to AU2001235000A priority patent/AU2001235000A1/en
Publication of WO2001059127A2 publication Critical patent/WO2001059127A2/en
Publication of WO2001059127A3 publication Critical patent/WO2001059127A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Abstract

The invention provides human drug metabolizing enzymes (DME) and polynucleotides which identify and encode DME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of DME.
PCT/US2001/004423 2000-02-11 2001-02-08 Drug metabolizing enzymes WO2001059127A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001558463A JP2003522528A (en) 2000-02-11 2001-02-08 Drug metabolizing enzymes
CA002399873A CA2399873A1 (en) 2000-02-11 2001-02-08 Drug metabolizing enzymes
EP01907197A EP1254236A2 (en) 2000-02-11 2001-02-08 Drug metabolizing enzymes
AU2001235000A AU2001235000A1 (en) 2000-02-11 2001-02-08 Drug metabolizing enzymes

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US18185600P 2000-02-11 2000-02-11
US60/181,856 2000-02-11
US18368400P 2000-02-17 2000-02-17
US60/183,684 2000-02-17
US18514100P 2000-02-25 2000-02-25
US60/185,141 2000-02-25
US18681800P 2000-03-03 2000-03-03
US60/186,818 2000-03-03
US18834500P 2000-03-09 2000-03-09
US60/188,345 2000-03-09
US18999700P 2000-03-17 2000-03-17
US60/189,997 2000-03-17

Publications (2)

Publication Number Publication Date
WO2001059127A2 WO2001059127A2 (en) 2001-08-16
WO2001059127A3 true WO2001059127A3 (en) 2002-02-07

Family

ID=27558717

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/004423 WO2001059127A2 (en) 2000-02-11 2001-02-08 Drug metabolizing enzymes

Country Status (5)

Country Link
EP (1) EP1254236A2 (en)
JP (1) JP2003522528A (en)
AU (1) AU2001235000A1 (en)
CA (1) CA2399873A1 (en)
WO (1) WO2001059127A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020137890A1 (en) 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6835812B1 (en) 1999-04-29 2004-12-28 University Of Tennessee Research Corporation Human p-Hyde proteins
JP2003529321A (en) * 1999-04-29 2003-10-07 ザ・ユニバーシティ・オブ・テネシー・リサーチ・コーポレイション Isolated nucleic acids of the P-HYDE family, P-HYDE proteins, and methods of inducing susceptibility to inducing cell death in cancer
US20020022254A1 (en) * 2000-07-28 2002-02-21 Karl Guegler Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
US20030148920A1 (en) * 2000-12-27 2003-08-07 Steven Rosen Sulfatases and methods of use thereof
US20060063230A1 (en) 2000-12-27 2006-03-23 Roman Naworth Sulfatases and methods of use thereof
GB0202748D0 (en) * 2002-02-06 2002-03-27 Impharmatica Ltd Protein

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463395A1 (en) * 1990-06-22 1992-01-02 F. Hoffmann-La Roche Ag Detection of poor metabolizers of drugs
US5843739A (en) * 1992-12-10 1998-12-01 Nickerson Biocem Limited DNA encoding 2-acyltransferases
WO1998054302A2 (en) * 1997-05-27 1998-12-03 Icos Corporation Human lysophosphatidic acid acyltransferase
US5888793A (en) * 1998-02-25 1999-03-30 Incyte Pharmaceuticals, Inc. Human lysophosphatidic acid acyltransferase
WO2000037655A1 (en) * 1996-03-19 2000-06-29 Cell Therapeutics, Inc. Mammalian lysophosphatidic acid acyltransferase

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463395A1 (en) * 1990-06-22 1992-01-02 F. Hoffmann-La Roche Ag Detection of poor metabolizers of drugs
US5843739A (en) * 1992-12-10 1998-12-01 Nickerson Biocem Limited DNA encoding 2-acyltransferases
WO2000037655A1 (en) * 1996-03-19 2000-06-29 Cell Therapeutics, Inc. Mammalian lysophosphatidic acid acyltransferase
WO1998054302A2 (en) * 1997-05-27 1998-12-03 Icos Corporation Human lysophosphatidic acid acyltransferase
US5888793A (en) * 1998-02-25 1999-03-30 Incyte Pharmaceuticals, Inc. Human lysophosphatidic acid acyltransferase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CARIM ET AL.: "Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 180147", EMBL SEQUENCE DATABASE, 9 August 1999 (1999-08-09), HEIDELBERG DE, XP002172011 *
KIMURA S ET AL: "THE HUMAN DEBRISOQUINE 4-HYDROXYLASE (CYP2D) LOCUS: SEQUENCE AND IDENTIFICATION OF THE POLYMORPHIC CYP2D6 GENE, A RELATED GENE, AND A PSEUDOGENE", AMERICAN JOURNAL OF HUMAN GENETICS,US,UNIVERSITY OF CHICAGO PRESS, CHICAGO,, vol. 45, no. 6, 1 December 1989 (1989-12-01), pages 889 - 904, XP000570035, ISSN: 0002-9297 *
LEUNG, D.W.: "Homo sapiens lysophosphatidic acid acyltransferase-gamma2 (LPAAT-gamma2) mRNA, complete cds.", EMBL SEQUENCE DATABASE, 6 July 2000 (2000-07-06), HEIDELBERG DE, XP002172013 *
MYERS ET AL.: "Homo sapiens clone P1 C124G1", EMBL SEQUENCE DATABASE, 4 December 1997 (1997-12-04), HEIDELBERG DE, XP002172010 *
OTTENWAELDER ET AL.: "Homo sapiens mRNA; EST DKFZp761N142_s1", EMBL SEQUENCE DATABASE, 25 September 1999 (1999-09-25), HEIDELBERG DE, XP002172012 *

Also Published As

Publication number Publication date
WO2001059127A2 (en) 2001-08-16
EP1254236A2 (en) 2002-11-06
CA2399873A1 (en) 2001-08-16
AU2001235000A1 (en) 2001-08-20
JP2003522528A (en) 2003-07-29

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