WO2002038744A3 - Proteases - Google Patents

Proteases Download PDF

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Publication number
WO2002038744A3
WO2002038744A3 PCT/US2001/051034 US0151034W WO0238744A3 WO 2002038744 A3 WO2002038744 A3 WO 2002038744A3 US 0151034 W US0151034 W US 0151034W WO 0238744 A3 WO0238744 A3 WO 0238744A3
Authority
WO
WIPO (PCT)
Prior art keywords
prts
provides
proteases
polynucleotides
agonists
Prior art date
Application number
PCT/US2001/051034
Other languages
French (fr)
Other versions
WO2002038744A2 (en
Inventor
Ernestine A Lee
April J A Hafalia
Henry Yue
Preeti G Lal
Monique G Yao
Yan Lu
Narinder K Chawla
Original Assignee
Incyte Genomics Inc
Ernestine A Lee
April J A Hafalia
Henry Yue
Preeti G Lal
Monique G Yao
Yan Lu
Narinder K Chawla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Ernestine A Lee, April J A Hafalia, Henry Yue, Preeti G Lal, Monique G Yao, Yan Lu, Narinder K Chawla filed Critical Incyte Genomics Inc
Priority to JP2002542060A priority Critical patent/JP2004535153A/en
Priority to US10/399,645 priority patent/US20040029249A1/en
Priority to EP01987550A priority patent/EP1387886A2/en
Priority to CA002425829A priority patent/CA2425829A1/en
Priority to AU2002239753A priority patent/AU2002239753A1/en
Publication of WO2002038744A2 publication Critical patent/WO2002038744A2/en
Publication of WO2002038744A3 publication Critical patent/WO2002038744A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

The invention provides human proteases (PRTS) and polynucleotides which identify and encode PRTS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PRTS.
PCT/US2001/051034 2000-10-18 2001-10-18 Proteases WO2002038744A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2002542060A JP2004535153A (en) 2000-10-18 2001-10-18 Protease
US10/399,645 US20040029249A1 (en) 2001-10-18 2001-10-18 Proteases
EP01987550A EP1387886A2 (en) 2000-10-18 2001-10-18 Proteases
CA002425829A CA2425829A1 (en) 2000-10-18 2001-10-18 Proteases
AU2002239753A AU2002239753A1 (en) 2000-10-18 2001-10-18 Proteases

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US24157300P 2000-10-18 2000-10-18
US60/241,573 2000-10-18
US24364300P 2000-10-25 2000-10-25
US60/243,643 2000-10-25
US24525600P 2000-11-02 2000-11-02
US60/245,256 2000-11-02
US24839500P 2000-11-13 2000-11-13
US60/248,395 2000-11-13
US24982600P 2000-11-16 2000-11-16
US60/249,826 2000-11-16
US25230300P 2000-11-20 2000-11-20
US60/252,303 2000-11-20
US25098100P 2000-12-01 2000-12-01
US60/250,981 2000-12-01

Publications (2)

Publication Number Publication Date
WO2002038744A2 WO2002038744A2 (en) 2002-05-16
WO2002038744A3 true WO2002038744A3 (en) 2003-11-20

Family

ID=27569436

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/051034 WO2002038744A2 (en) 2000-10-18 2001-10-18 Proteases

Country Status (5)

Country Link
EP (1) EP1387886A2 (en)
JP (1) JP2004535153A (en)
AU (1) AU2002239753A1 (en)
CA (1) CA2425829A1 (en)
WO (1) WO2002038744A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138925A1 (en) * 2000-04-13 2003-07-24 Tim Keith Novel human gene relating to respiratory diseases, obesity, and inflammatory bowel disease
US6683165B1 (en) 1999-04-13 2004-01-27 Genome Therapeutics Corporation Human gene relating to respiratory diseases and obesity
WO2002066643A2 (en) * 2000-11-13 2002-08-29 Curagen Corporation Proteins, polynucleotides encoding them and methods of using the same
ES2280306T3 (en) * 2000-12-25 2007-09-16 Astellas Pharma Inc. PROTEASA NOVEDOSA.
AU2002243679A1 (en) * 2001-01-24 2002-08-06 Zymogenetics, Inc. Cub domain protein zcub3 and materials and methods for making it
WO2002088303A2 (en) * 2001-04-03 2002-11-07 Bristol-Myers Squibb Company Polynucleotide encoding a novel cysteine protease of the calpain superfamily, can-12, and variants thereof
WO2003104394A2 (en) * 2002-05-21 2003-12-18 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembrane serine protease 12, the encoded polypeptides and methods based thereon
EP1544304A4 (en) * 2002-07-31 2006-05-10 Astellas Pharma Inc Novel serine protease
BRPI0922344A2 (en) * 2008-12-19 2017-10-24 3B Pharmaceuticals Gmbh tfpi inhibitors and methods of use
WO2020260309A1 (en) 2019-06-24 2020-12-30 Urteste Sp. Z O.O. Novel diagnostic marker for pancreatic cancer
EP3845664A1 (en) * 2020-01-02 2021-07-07 Urteste Sp. z o.o. Novel diagnostic marker for prostate cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017820A1 (en) * 1993-02-05 1994-08-18 Daratech Pty. Ltd. Polypeptides obtainable from species of fasciola, and vaccines, methods of treatment and dna sequences of the same
WO1996013523A1 (en) * 1994-10-27 1996-05-09 Khepri Pharmaceuticals, Inc. Cathepsin o2 protease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017820A1 (en) * 1993-02-05 1994-08-18 Daratech Pty. Ltd. Polypeptides obtainable from species of fasciola, and vaccines, methods of treatment and dna sequences of the same
WO1996013523A1 (en) * 1994-10-27 1996-05-09 Khepri Pharmaceuticals, Inc. Cathepsin o2 protease

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 12 December 1992 (1992-12-12), XP002245648, Database accession no. L07772 *
DATABASE EMBL [online] 20 February 1989 (1989-02-20), XP002245647, Database accession no. M20496 *
DATABASE EMBL [online] 24 February 1989 (1989-02-24), XP002245646, Database accession no. X12451 *
DATABASE SWISSPROT [online] 1 April 1988 (1988-04-01), XP002245645, Database accession no. P07711; Q96QJ0 *
DATABASE WPI Section Ch Week 200158, Derwent World Patents Index; Class B04, AN 2001-524255, XP002245650 *

Also Published As

Publication number Publication date
AU2002239753A1 (en) 2002-05-21
JP2004535153A (en) 2004-11-25
EP1387886A2 (en) 2004-02-11
WO2002038744A2 (en) 2002-05-16
CA2425829A1 (en) 2002-05-16

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