WO2002057015A3 - Vorrichtung und verfahren zum dosieren kleiner flüssigkeitsmengen - Google Patents

Vorrichtung und verfahren zum dosieren kleiner flüssigkeitsmengen Download PDF

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Publication number
WO2002057015A3
WO2002057015A3 PCT/EP2002/000186 EP0200186W WO02057015A3 WO 2002057015 A3 WO2002057015 A3 WO 2002057015A3 EP 0200186 W EP0200186 W EP 0200186W WO 02057015 A3 WO02057015 A3 WO 02057015A3
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
nozzle
connecting channel
medium reservoir
dosed
Prior art date
Application number
PCT/EP2002/000186
Other languages
English (en)
French (fr)
Other versions
WO2002057015A2 (de
Inventor
Roland Zengerle
Peter Koltay
Original Assignee
Roland Zengerle
Peter Koltay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roland Zengerle, Peter Koltay filed Critical Roland Zengerle
Priority to AU2002235830A priority Critical patent/AU2002235830A1/en
Priority to US10/250,607 priority patent/US7396510B2/en
Priority to EP02702254A priority patent/EP1351766B1/de
Priority to AT02702254T priority patent/ATE303867T1/de
Priority to DE50204175T priority patent/DE50204175D1/de
Publication of WO2002057015A2 publication Critical patent/WO2002057015A2/de
Publication of WO2002057015A3 publication Critical patent/WO2002057015A3/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Nozzles (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Eine Mikrodosiervorrichtung umfaßt ein Medienreservoir (4) zum Enthalten einer zu dosierenden Flüssigkeit (8), eine Düse (6), die über einen Verbindungskanal (10) mit dem Medienreservoir (4) verbunden ist und über den Verbindungskanal (10) mit der zu dosierenden Flüssigkeit (8) befüllbar ist, und eine Antriebseinrichtung zum Beaufschlagen einer in dem Medienreservoir (4) und der Düse (6) befindlichen Flüssigkeit (8) mit einer solchen Kraft bei einer Betätigung der Antriebseinrichtung, daß ein im wesentlichen identischer Druck auf die im Medienreservoir (4) und in der Düse (6) befindliche Flüssigkeit ausgeübt wird. Strömungswiderstände des Verbindungskanals (10) und der Düse (6) sind derart ausgeführt, daß bei einer Betätigung der Antriebseinrichtung ein Volumenstrom in dem Verbindungskanal (10) klein im Vergleich zu einem Volumenstrom in der Düse (6), der einen Ausstoß der zu dosierenden Flüssigkeit aus einer Ausstoßöffnung (22) der Düse (6) bewirkt, ist.
PCT/EP2002/000186 2001-01-18 2002-01-10 Vorrichtung und verfahren zum dosieren kleiner flüssigkeitsmengen WO2002057015A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2002235830A AU2002235830A1 (en) 2001-01-18 2002-01-10 Device and method for dosing small amounts of liquid
US10/250,607 US7396510B2 (en) 2001-01-18 2002-01-10 Device and method for dosing small amounts of liquid
EP02702254A EP1351766B1 (de) 2001-01-18 2002-01-10 Vorrichtung und verfahren zum dosieren kleiner flüssigkeitsmengen
AT02702254T ATE303867T1 (de) 2001-01-18 2002-01-10 Vorrichtung und verfahren zum dosieren kleiner flüssigkeitsmengen
DE50204175T DE50204175D1 (de) 2001-01-18 2002-01-10 Vorrichtung und verfahren zum dosieren kleiner flüssigkeitsmengen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10102152.6 2001-01-18
DE10102152A DE10102152C1 (de) 2001-01-18 2001-01-18 Vorrichtung und Verfahren zum Dosieren kleiner Flüssigkeitsmengen

Publications (2)

Publication Number Publication Date
WO2002057015A2 WO2002057015A2 (de) 2002-07-25
WO2002057015A3 true WO2002057015A3 (de) 2002-12-05

Family

ID=7670982

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/000186 WO2002057015A2 (de) 2001-01-18 2002-01-10 Vorrichtung und verfahren zum dosieren kleiner flüssigkeitsmengen

Country Status (6)

Country Link
US (1) US7396510B2 (de)
EP (1) EP1351766B1 (de)
AT (1) ATE303867T1 (de)
AU (1) AU2002235830A1 (de)
DE (2) DE10102152C1 (de)
WO (1) WO2002057015A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10257004A1 (de) * 2002-12-06 2004-06-17 Steag Microparts Gmbh Vorrichtung zur parallelen Dosierung von Flüssigkeiten
US20050233472A1 (en) * 2003-09-19 2005-10-20 Kao H P Spotting high density plate using a banded format
US20050226771A1 (en) * 2003-09-19 2005-10-13 Lehto Dennis A High speed microplate transfer
DE102004006453B4 (de) * 2004-02-05 2007-03-29 Ing. Erich Pfeiffer Gmbh Dosiervorrichtung
DE102004006452B4 (de) 2004-02-05 2006-04-20 Ing. Erich Pfeiffer Gmbh Mikrodosiervorrichtung
EP2392402A3 (de) 2004-02-18 2012-03-21 Life Technologies Corporation Mehrstufige Biotests auf modularen Mikrofluidanwendungsplattformen
DE102006047658B4 (de) 2006-09-29 2009-03-19 Ing. Erich Pfeiffer Gmbh Mikrodosiervorrichtung für ein flüssiges Medium
DE102007023014A1 (de) * 2007-05-15 2008-11-27 Kba-Metronic Ag Verfahren und System zur Dosierung und zum Aufbringen einer Reagenzflüssigkeit
CN109991035B (zh) * 2017-12-29 2021-12-24 台达电子工业股份有限公司 微量取样装置
CN111617812B (zh) * 2019-10-17 2021-12-03 北京京东方健康科技有限公司 微流控基板及其流体驱动方法、微流控装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE9011816U1 (de) * 1990-08-14 1990-10-18 Siemens Ag, 8000 Muenchen, De
EP0465071A2 (de) * 1990-06-24 1992-01-08 Lexmark International, Inc. Tintenstrahldruckkopf
US5943079A (en) * 1995-11-20 1999-08-24 Brother Kogyo Kabushiki Kaisha Ink jet head
WO1999052625A2 (de) * 1998-04-09 1999-10-21 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Verfahren und vorrichtung zur anfertigung von synthese- oder analysereihen
DE19917029A1 (de) * 1999-04-15 2000-11-09 Inst Mikrotechnik Mainz Gmbh Verfahren und Vorrichtung zur dosierten Ausgabe von Flüssigkeitsmengen im Bereich von 0,1 nl bis 100 mul

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537231A (en) * 1983-08-29 1985-08-27 Becton, Dickinson And Company Dispenser apparatus for simultaneously dispensing predetermined equal volumes of liquid including a disposable dispenser module
US5593290A (en) * 1994-12-22 1997-01-14 Eastman Kodak Company Micro dispensing positive displacement pump
DE19648694C1 (de) * 1996-11-25 1998-04-30 Vermes Mikrotechnik Gmbh Bidirektionale dynamische Mikropumpe
DE19706513C2 (de) * 1997-02-19 1999-06-17 Hahn Schickard Ges Mikrodosiervorrichtung und Verfahren zum Betreiben derselben
US5957167A (en) * 1997-12-18 1999-09-28 Pharmacopeia, Inc. Article for dispensing small volumes of liquid
DE19802368C1 (de) * 1998-01-22 1999-08-05 Hahn Schickard Ges Mikrodosiervorrichtung
DE19913076A1 (de) * 1999-03-23 2000-10-19 Hahn Schickard Ges Vorrichtung und Verfahren zum Aufbringen von Mikrotröpfchen auf ein Substrat
JP4399072B2 (ja) * 1999-12-03 2010-01-13 ノードソン株式会社 液状物の吐出装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0465071A2 (de) * 1990-06-24 1992-01-08 Lexmark International, Inc. Tintenstrahldruckkopf
DE9011816U1 (de) * 1990-08-14 1990-10-18 Siemens Ag, 8000 Muenchen, De
US5943079A (en) * 1995-11-20 1999-08-24 Brother Kogyo Kabushiki Kaisha Ink jet head
WO1999052625A2 (de) * 1998-04-09 1999-10-21 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Verfahren und vorrichtung zur anfertigung von synthese- oder analysereihen
DE19917029A1 (de) * 1999-04-15 2000-11-09 Inst Mikrotechnik Mainz Gmbh Verfahren und Vorrichtung zur dosierten Ausgabe von Flüssigkeitsmengen im Bereich von 0,1 nl bis 100 mul

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DUCREE J ET AL: "TOPSPOT- A NEW METHOD FOR THE FABRICATION OF MICROARRAYS", PROCEEDINGS OF THE ANNUAL INTERNATIONAL WORKSHOP ON MICRO ELECTROMECHANICAL SYSTEMS, IEEE, 2000, pages 317 - 322, XP001005903 *

Also Published As

Publication number Publication date
US20040074557A1 (en) 2004-04-22
WO2002057015A2 (de) 2002-07-25
EP1351766A2 (de) 2003-10-15
AU2002235830A1 (en) 2002-07-30
DE10102152C1 (de) 2002-06-20
US7396510B2 (en) 2008-07-08
ATE303867T1 (de) 2005-09-15
EP1351766B1 (de) 2005-09-07
DE50204175D1 (de) 2005-10-13

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