WO2002055501A2 - N-pyridyl carboxamide derivatives and pharmaceutical compositions containing them - Google Patents

N-pyridyl carboxamide derivatives and pharmaceutical compositions containing them Download PDF

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Publication number
WO2002055501A2
WO2002055501A2 PCT/US2002/000742 US0200742W WO02055501A2 WO 2002055501 A2 WO2002055501 A2 WO 2002055501A2 US 0200742 W US0200742 W US 0200742W WO 02055501 A2 WO02055501 A2 WO 02055501A2
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WO
WIPO (PCT)
Prior art keywords
optionally substituted
phenyl
methyl
amino
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/000742
Other languages
English (en)
French (fr)
Other versions
WO2002055501A3 (en
Inventor
Guoqing Chen
Shon Booker
Guolin Cai
Michael Croghan
Lucian Dipietro
Celia Dominguez
Daniel Elbaum
Julie Germain
Qi Huang
Joseph L Kim
Tae-Seong Kim
Vinod F Patel
Leon M Smith
Andrew Tasker
Ning Xi
Shimin Xu
Chester Chenguang Yuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Priority to CA002434274A priority Critical patent/CA2434274A1/en
Priority to MXPA03006010A priority patent/MXPA03006010A/es
Priority to AU2002248339A priority patent/AU2002248339B2/en
Priority to EP02717324A priority patent/EP1358161A2/en
Priority to JP2002556173A priority patent/JP2004531473A/ja
Publication of WO2002055501A2 publication Critical patent/WO2002055501A2/en
Publication of WO2002055501A3 publication Critical patent/WO2002055501A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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PCT/US2002/000742 2001-01-12 2002-01-11 N-pyridyl carboxamide derivatives and pharmaceutical compositions containing them Ceased WO2002055501A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002434274A CA2434274A1 (en) 2001-01-12 2002-01-11 N-pyridyl carboxamide derivatives and pharmaceutical compositions containing them
MXPA03006010A MXPA03006010A (es) 2001-01-12 2002-01-11 Derivados de arilamina sustituida y metodos de uso.
AU2002248339A AU2002248339B2 (en) 2001-01-12 2002-01-11 Substituted Arylamine Derivatives and Methods of Use
EP02717324A EP1358161A2 (en) 2001-01-12 2002-01-11 N-pyridyl carboxamide derivatives and pharmaceutical compositions containing them
JP2002556173A JP2004531473A (ja) 2001-01-12 2002-01-11 Ｎ−ピリジルカルボキサミド誘導体及びそれらを含有する医薬組成物

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US26136001P 2001-01-12 2001-01-12
US60/261,360 2001-01-12
US32368601P 2001-09-19 2001-09-19
US60/323,686 2001-09-19
US10/046,526 US20020147198A1 (en) 2001-01-12 2002-01-10 Substituted arylamine derivatives and methods of use
US10/046,526 2002-01-10

Publications (2)

Publication Number Publication Date
WO2002055501A2 true WO2002055501A2 (en) 2002-07-18
WO2002055501A3 WO2002055501A3 (en) 2002-12-19

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PCT/US2002/000742 Ceased WO2002055501A2 (en) 2001-01-12 2002-01-11 N-pyridyl carboxamide derivatives and pharmaceutical compositions containing them

Country Status (7)

Country Link
US (1) US20020147198A1 (OSRAM)
EP (1) EP1358161A2 (OSRAM)
JP (1) JP2004531473A (OSRAM)
AU (1) AU2002248339B2 (OSRAM)
CA (1) CA2434274A1 (OSRAM)
MX (1) MXPA03006010A (OSRAM)
WO (1) WO2002055501A2 (OSRAM)

Cited By (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000678A1 (de) * 2001-05-08 2003-01-03 Schering Aktiengesellschaft Cyanoanthranylamid-derivate und deren verwendung als arzneimittel
GB2381750A (en) * 2001-10-10 2003-05-14 Inspire Pharmaceuticals Inc Treatment for enhancing joint lubrication
WO2004007458A1 (en) * 2002-07-17 2004-01-22 Amgen Inc. Substituted 2-alkylamine nicotinic amide derivatives and use there of
WO2004013102A1 (de) * 2002-07-31 2004-02-12 Schering Aktiengesellschaft Vegfr-2 und vegfr-3 inhibitorische anthranylamidpyrimidene
WO2004007481A3 (en) * 2002-07-17 2004-02-19 Amgen Inc Substituted amine derivatives and methods of use in the treatment of angiogenesis relates disorders
WO2004050623A1 (en) * 2002-12-02 2004-06-17 Ortho-Mcneil Pharmaceutical, Inc. Methods for preparing phenylalkyne derivatives
WO2004063330A2 (en) 2003-01-06 2004-07-29 Osi Pharmaceuticals, Inc. (2-carboxamido) (3-amino) thiophene compounds
WO2005054179A2 (en) 2003-12-03 2005-06-16 Leo Pharma A/S Hydroxamic acid esters and pharmaceutical use thereof
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