WO2002055098A2 - Latency associated peptide for providing latency to pharmaceutically active proteins - Google Patents

Latency associated peptide for providing latency to pharmaceutically active proteins Download PDF

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Publication number
WO2002055098A2
WO2002055098A2 PCT/GB2002/000068 GB0200068W WO02055098A2 WO 2002055098 A2 WO2002055098 A2 WO 2002055098A2 GB 0200068 W GB0200068 W GB 0200068W WO 02055098 A2 WO02055098 A2 WO 02055098A2
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
lap
fusion protein
active agent
acid construct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2002/000068
Other languages
English (en)
French (fr)
Other versions
WO2002055098A3 (en
Inventor
Yuti Chernajovsky
Hanna Stina Dreja
Gillian Adams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Queen Mary University of London
Original Assignee
Queen Mary and Westfiled College University of London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queen Mary and Westfiled College University of London filed Critical Queen Mary and Westfiled College University of London
Priority to DE60203692T priority Critical patent/DE60203692T2/de
Priority to AU2002219345A priority patent/AU2002219345B2/en
Priority to EP02729440A priority patent/EP1349944B1/en
Priority to DK02729440T priority patent/DK1349944T3/da
Priority to JP2002555832A priority patent/JP4201253B2/ja
Priority to AT02729440T priority patent/ATE293169T1/de
Publication of WO2002055098A2 publication Critical patent/WO2002055098A2/en
Publication of WO2002055098A3 publication Critical patent/WO2002055098A3/en
Priority to ZA2003/05237A priority patent/ZA200305237B/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PCT/GB2002/000068 2001-01-09 2002-01-09 Latency associated peptide for providing latency to pharmaceutically active proteins Ceased WO2002055098A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE60203692T DE60203692T2 (de) 2001-01-09 2002-01-09 Latency associated peptide von tgf-beta um pharmazeutisch aktive proteine latent zu machen
AU2002219345A AU2002219345B2 (en) 2001-01-09 2002-01-09 Latency associated peptide for providing latency to pharmaceutically active proteins
EP02729440A EP1349944B1 (en) 2001-01-09 2002-01-09 Latency associated peptide of tgf-beta for providing latency to pharmaceutically active proteins
DK02729440T DK1349944T3 (da) 2001-01-09 2002-01-09 Latensassocieret peptid af TGF-beta til at bibringe farmaceutisk aktive proteiner latens
JP2002555832A JP4201253B2 (ja) 2001-01-09 2002-01-09 薬学的活性物質に潜在性を提供する方法
AT02729440T ATE293169T1 (de) 2001-01-09 2002-01-09 Latency associated peptide von tgf-beta um pharmazeutisch aktive proteine latent zu machen
ZA2003/05237A ZA200305237B (en) 2001-01-09 2003-07-07 Latency associated peptide for providing latency to pharmaceutically active proteins

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/756,283 US6942853B2 (en) 2001-01-09 2001-01-09 Latent fusion protein
GB0100551.1 2001-01-09
GBGB0100551.1A GB0100551D0 (en) 2001-01-09 2001-01-09 Protein

Publications (2)

Publication Number Publication Date
WO2002055098A2 true WO2002055098A2 (en) 2002-07-18
WO2002055098A3 WO2002055098A3 (en) 2002-11-21

Family

ID=26245544

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/000068 Ceased WO2002055098A2 (en) 2001-01-09 2002-01-09 Latency associated peptide for providing latency to pharmaceutically active proteins

Country Status (10)

Country Link
US (1) US6942853B2 (enExample)
EP (1) EP1349944B1 (enExample)
JP (1) JP4201253B2 (enExample)
AT (1) ATE293169T1 (enExample)
AU (1) AU2002219345B2 (enExample)
DE (1) DE60203692T2 (enExample)
DK (1) DK1349944T3 (enExample)
ES (1) ES2240740T3 (enExample)
GB (1) GB0100551D0 (enExample)
WO (1) WO2002055098A2 (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009077755A3 (en) * 2007-12-17 2009-10-15 Queen Mary & Westfield College Latency associated protein construct with aggrecanase sensitive cleavage site
WO2010000591A3 (fr) * 2008-06-10 2010-05-27 Commissariat A L'energie Atomique Et Aux Energies Alternatives Peptides cycliques fluorescents, procedes de preparation de ceux-ci et utilisation de ces peptides pour mesurer l'activite enzymatique d'une enzyme protease
EP2878308A1 (en) * 2013-12-02 2015-06-03 Otto-von-Guericke-Universität Magdeburg Agents and methods for the suppression of T cell activation
US9198842B2 (en) 2009-06-30 2015-12-01 Repregen Limited Multicomponent glasses for use in personal care products
WO2015198072A1 (en) 2014-06-27 2015-12-30 Stealthyx Therapeutics Limited Modified latency associated protein construct
WO2020165457A1 (en) 2019-02-15 2020-08-20 Consejo Superior De Investigaciones Cientificas (Csic) Cortistatin or an analogue thereof as a pharmaceutically active agent in latent form
WO2021097376A1 (en) * 2019-11-14 2021-05-20 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
WO2021198324A1 (en) 2020-03-31 2021-10-07 Stealthyx Therapeutics Limited Modified latency associated protein construct
WO2021207669A1 (en) * 2020-04-10 2021-10-14 Cytomx Therapeutics, Inc. Activatable cytokine constructs and related compositions and methods
US11667687B2 (en) 2021-03-16 2023-06-06 Cytomx Therapeutics, Inc. Masked activatable interferon constructs

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141392B2 (en) * 2001-01-09 2006-11-28 Queen Mary And Westfield College Latent fusion protein
AU2003217415B2 (en) * 2002-02-14 2009-01-08 William J Rutter Chimeric molecules for cleavage in a treated host
AU2006302587A1 (en) * 2005-10-04 2007-04-19 Greenville Hospital System Latent procytotoxins and uses thereof
DE102006009324A1 (de) 2006-03-01 2007-09-06 Dr.Ing.H.C. F. Porsche Ag Verfahren und Steuergerät zur Steuerung eines variablen Turbolader-Turbinenströmungsquerschnitts
EP2572734B1 (en) 2006-10-31 2016-04-06 East Carolina University Cytokine-based fusion proteins for treatment of immune disorders
EP3348275A3 (en) 2009-03-31 2018-10-24 East Carolina University Cytokines and neuroantigens for treatment of immune disorders
US8734774B2 (en) 2010-04-02 2014-05-27 University Of Rochester Protease activated cytokines
JP6516235B2 (ja) * 2014-10-31 2019-05-22 国立大学法人富山大学 キメラタンパク質及びそれを用いたミクログリア活性阻害剤
CN113840832A (zh) 2018-05-14 2021-12-24 狼人治疗公司 可活化白介素-2多肽及其使用方法
MX2020012252A (es) 2018-05-14 2021-04-28 Werewolf Therapeutics Inc Polipeptidos de interleucina 12 activables y metodos de uso de los mismos.
US12459980B2 (en) 2018-07-25 2025-11-04 AskGene Pharma, Inc. IL-21 prodrugs and methods of use thereof
KR20250154552A (ko) * 2018-09-27 2025-10-28 실리오 디벨럽먼트, 인크. 마스킹된 사이토카인 폴리펩타이드
EP3969035A4 (en) 2019-05-14 2023-06-21 Werewolf Therapeutics, Inc. SEPARATION UNITS AND METHODS AND THEIR USE
WO2020252264A1 (en) 2019-06-12 2020-12-17 AskGene Pharma, Inc. Novel il-15 prodrugs and methods of use thereof
EP4251187A4 (en) 2020-11-25 2025-09-10 Xilio Dev Inc TUMOR-SPECIFIC CLASSIBLE LINKERS

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US5284763A (en) 1985-03-22 1994-02-08 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
CA2003886A1 (en) 1988-12-16 1990-06-16 Anthony F. Purchio Cloning and expression of simian transforming growth factor-beta 1
CA2068204C (en) 1989-11-22 2002-02-12 Arthur Levinson Latency associated peptides and uses therefor
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
PT698094E (pt) 1993-05-12 2004-05-31 Inst Genetics Llc Composicoes de bmp-11
CA2151547C (en) 1994-06-10 2010-10-12 Elliott A. Gruskin Recombinant chimeric proteins and methods of use thereof
US5800811A (en) * 1995-06-06 1998-09-01 Hall; Frederick L. Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site
WO1997012048A1 (en) * 1995-09-27 1997-04-03 Medical Research Council Recombinant viruses incorporating a protease cleavable protein
DE19701141C1 (de) 1997-01-16 1998-04-09 Hoechst Ag Genkonstrukte für durch Proteasen aktivierbare Wirksubstanzen
JP4566290B2 (ja) * 1997-04-30 2010-10-20 ツインストランド・ホールディングス・インコーポレイテッド 癌、ウイルスまたは寄生虫感染を治療するためのリシン様毒素変異体
GB2324960A (en) 1997-05-09 1998-11-11 Univ Manchester Delivery of naked DNA for wound healing
AU1103900A (en) 1998-10-07 2000-04-26 Stryker Corporation Modified tgf-beta superfamily proteins
AU8911101A (en) * 2000-09-11 2002-03-26 Univ Columbia Combinatorial fluorescence energy transfer tags and uses thereof

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009077755A3 (en) * 2007-12-17 2009-10-15 Queen Mary & Westfield College Latency associated protein construct with aggrecanase sensitive cleavage site
JP2011507498A (ja) * 2007-12-17 2011-03-10 クイーン メアリー アンド ウェストフィールド カレッジ アグリカナーゼ感受性切断部位を有する潜在関連タンパク質構築物
US8357515B2 (en) 2007-12-17 2013-01-22 Queen Mary & Westfield College Latency associated protein construct with aggrecanase sensitive cleavage site
WO2010000591A3 (fr) * 2008-06-10 2010-05-27 Commissariat A L'energie Atomique Et Aux Energies Alternatives Peptides cycliques fluorescents, procedes de preparation de ceux-ci et utilisation de ces peptides pour mesurer l'activite enzymatique d'une enzyme protease
US9139862B2 (en) 2008-06-10 2015-09-22 Commissariat A L'energie Atomique Et Aux Energies Alternatives Fluorescent cyclic peptides, preparation method thereof and use of these peptides for measuring the enzymatic activity of a protease enzyme
US9198842B2 (en) 2009-06-30 2015-12-01 Repregen Limited Multicomponent glasses for use in personal care products
EP2878308A1 (en) * 2013-12-02 2015-06-03 Otto-von-Guericke-Universität Magdeburg Agents and methods for the suppression of T cell activation
WO2015198072A1 (en) 2014-06-27 2015-12-30 Stealthyx Therapeutics Limited Modified latency associated protein construct
US10435451B2 (en) 2014-06-27 2019-10-08 Stealthyx Therapeutics Limited Modified latency associated protein construct
ES2780274A1 (es) * 2019-02-15 2020-08-24 Consejo Superior De Investig Científicas (Csic) Cortistatina o un análogo de la misma como agente farmacéuticamente activo en forma latente
WO2020165457A1 (en) 2019-02-15 2020-08-20 Consejo Superior De Investigaciones Cientificas (Csic) Cortistatin or an analogue thereof as a pharmaceutically active agent in latent form
US20220135640A1 (en) * 2019-02-15 2022-05-05 Consejo Superior De Investigaciones Cientificas (Csic) Cortistatin or an analogue thereof as a pharmaceutically active agent in latent form
WO2021097376A1 (en) * 2019-11-14 2021-05-20 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
US12036266B2 (en) 2019-11-14 2024-07-16 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
US12076371B2 (en) 2019-11-14 2024-09-03 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
WO2021198324A1 (en) 2020-03-31 2021-10-07 Stealthyx Therapeutics Limited Modified latency associated protein construct
WO2021207669A1 (en) * 2020-04-10 2021-10-14 Cytomx Therapeutics, Inc. Activatable cytokine constructs and related compositions and methods
US11365233B2 (en) 2020-04-10 2022-06-21 Cytomx Therapeutics, Inc. Activatable cytokine constructs and related compositions and methods
CN115667523A (zh) * 2020-04-10 2023-01-31 西托姆克斯治疗公司 可活化细胞因子构建体和相关组合物以及方法
US12091442B2 (en) 2020-04-10 2024-09-17 Cytomx Therapeutics, Inc. Activatable cytokine constructs and related compositions and methods
US11667687B2 (en) 2021-03-16 2023-06-06 Cytomx Therapeutics, Inc. Masked activatable interferon constructs

Also Published As

Publication number Publication date
JP4201253B2 (ja) 2008-12-24
EP1349944A2 (en) 2003-10-08
AU2002219345B2 (en) 2006-03-16
US6942853B2 (en) 2005-09-13
ES2240740T3 (es) 2005-10-16
JP2004520031A (ja) 2004-07-08
DK1349944T3 (da) 2005-07-25
WO2002055098A3 (en) 2002-11-21
DE60203692T2 (de) 2006-03-02
DE60203692D1 (de) 2005-05-19
GB0100551D0 (en) 2001-02-21
EP1349944B1 (en) 2005-04-13
US20020151478A1 (en) 2002-10-17
ATE293169T1 (de) 2005-04-15

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