WO2002050866A2 - Procede et appareil destines a ejecter des ions a partir d'un piege a ions quadrupolaire - Google Patents

Procede et appareil destines a ejecter des ions a partir d'un piege a ions quadrupolaire Download PDF

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Publication number
WO2002050866A2
WO2002050866A2 PCT/GB2001/005264 GB0105264W WO0250866A2 WO 2002050866 A2 WO2002050866 A2 WO 2002050866A2 GB 0105264 W GB0105264 W GB 0105264W WO 0250866 A2 WO0250866 A2 WO 0250866A2
Authority
WO
WIPO (PCT)
Prior art keywords
ion trap
rectangular wave
wave voltage
varying
mass
Prior art date
Application number
PCT/GB2001/005264
Other languages
English (en)
Other versions
WO2002050866A3 (fr
Inventor
Li Ding
Original Assignee
Shimadzu Research Laboratory (Europe) Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Research Laboratory (Europe) Ltd. filed Critical Shimadzu Research Laboratory (Europe) Ltd.
Priority to US10/451,579 priority Critical patent/US6900433B2/en
Publication of WO2002050866A2 publication Critical patent/WO2002050866A2/fr
Publication of WO2002050866A3 publication Critical patent/WO2002050866A3/fr

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/424—Three-dimensional ion traps, i.e. comprising end-cap and ring electrodes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods

Definitions

  • This invention relates to quadrupole mass spectrometry.
  • the invention relates to quadrupole mass spectrometry.
  • the invention relates to quadrupole mass spectrometry.
  • hyperboloid mass spectrometer E.P. Sheretov employed a pulse generator to feed the
  • the z-axis of the ion trap is not the only way to achieve axial resonance excitation.
  • ejecting ions from a quadrupole ion trap including means for creating a digital control
  • switching means for generating a time-varying rectangular wave voltage in
  • Figure 1 shows a 3-dimensional quadrupole ion trap driven by a rectangular wave
  • Figure 2 shows an "a-q" stability diagram for ion motion in the z-direction of a
  • Figure 3 shows how the amplitude of ion oscillation increases with time as excitation
  • the excitation voltage has a pulsed waveform and is
  • Figure 4 illustrates the equivalence between the superimposition of two waveforms
  • Figure 5 shows a simulation result in which ions are ejected in sequence according to
  • a mass analyser normally works in co-operation with an ion source.
  • the ion source normally works in co-operation with an ion source.
  • ion trap e.g. a El source
  • a high frequency digital control signal 1 is generated by a digital control
  • the digital control unit 2 comprises a digital signal
  • DDS Direct Digital Synthesiser
  • the digital signal processor converts clock pulses into an
  • the timing accuracy of the digital control signal is much better than the period
  • control signal 1 is then supplied to a high voltage switch circuit
  • the high voltage switch circuit 3 includes
  • switches 31 and 32 which are typically bipolar or FET transistors. The two switches
  • 31,32 are connected together in series between a source 33 of a high DC voltage level
  • V H a source 34 of a low DC voltage level
  • V L a low DC voltage level
  • the output 35 of the switch circuit 3 is
  • V is just the pulse height from low level
  • Figure 2 shows a stability diagram in which the stable region for motion
  • the intrinsic or secular frequency is the main frequency
  • the intrinsic oscillation can also be resonantly excited by application of an additional
  • an additional AC voltage can either be applied to the
  • waveform (a) represents ion oscillation in the z-axis direction
  • waveform (c) shows
  • each excitation pulse gives rise to a defocusing force (shown by arrows in the drawing) causing oscillatory motion of ions in the z-axis direction to grow.
  • Figure 4 each excitation pulse gives rise to a defocusing force (shown by arrows in the drawing) causing oscillatory motion of ions in the z-axis direction to grow.
  • composite waveform (d) is slightly wider than the others, so increasing the duty cycle
  • the frequency of the rectangular wave needs to be adjusted to
  • the ion trap can be built to generate, as precisely as possible, the pure quadrupole
  • It may be constructed using hyperboloid-shaped electrodes or a combination of flat
  • the two end cap electrodes may be shaped and positioned asymmetrically, and differentially coupled to respective parts of the
  • ions can be preferentially ejected from one
  • the main purpose of this invention is to carry out a mass scan in mass analysis, but
  • the quadrupole ion trap is a rotationally symmetric ion trap
  • the ejection method can also be used with
  • Another pair of diagonally opposed electrodes is connected to a fixed potential

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

L'invention concerne un procédé destiné à éjecter des ions à partir d'un piège à ions quadrupolaire. Ce procédé consiste à créer un signal de commande numérique, à utiliser ce signal de commande numérique pour commander la synchronisation d'une unité de commutation de manière à produire une tension rectangulaire à variation temporelle, à diriger cette tension rectangulaire vers le piège à ions en vue de piéger les ions dans une plage prédéterminée de rapports masse/charge, puis à faire varier le rapport cyclique de chaque nième onde de la tension rectangulaire (n représentant un nombre entier supérieur à 1) de façon à provoquer l'éjection des ions présentant un rapport masse/charge prédéterminé. Ledit procédé permet d'analyser le rapport masse/charge par réglage de la fréquence de la tension rectangulaire, d'où la sélection d'un point de départ pour l'analyse du rapport masse/charge, puis par variation de cette fréquence pendant la variation du rapport cyclique, d'où l'éjection des ions piégés, en séquence, selon ce rapport masse/charge.
PCT/GB2001/005264 2000-12-21 2001-11-29 Procede et appareil destines a ejecter des ions a partir d'un piege a ions quadrupolaire WO2002050866A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US10/451,579 US6900433B2 (en) 2000-12-21 2001-11-29 Method and apparatus for ejecting ions from a quadrupole ion trap

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0031342.9A GB0031342D0 (en) 2000-12-21 2000-12-21 Method and apparatus for ejecting ions from a quadrupole ion trap
GB0031342.9 2000-12-21

Publications (2)

Publication Number Publication Date
WO2002050866A2 true WO2002050866A2 (fr) 2002-06-27
WO2002050866A3 WO2002050866A3 (fr) 2003-07-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/005264 WO2002050866A2 (fr) 2000-12-21 2001-11-29 Procede et appareil destines a ejecter des ions a partir d'un piege a ions quadrupolaire

Country Status (3)

Country Link
US (1) US6900433B2 (fr)
GB (1) GB0031342D0 (fr)
WO (1) WO2002050866A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009144469A1 (fr) * 2008-05-30 2009-12-03 Thermo Fisher Scientific (Bremen) Gmbh Spectromètre de masse
CN102751162A (zh) * 2010-12-31 2012-10-24 聚光科技(杭州)股份有限公司 一种提高离子阱碰撞诱导解离性能的方法及装置
US8610054B2 (en) 2009-05-01 2013-12-17 Shimadzu Corporation Ion analysis apparatus and method of use

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9924722D0 (en) * 1999-10-19 1999-12-22 Shimadzu Res Lab Europe Ltd Methods and apparatus for driving a quadrupole device
GB0121172D0 (en) * 2001-08-31 2001-10-24 Shimadzu Res Lab Europe Ltd A method for dissociating ions using a quadrupole ion trap device
JPWO2003041116A1 (ja) * 2001-11-07 2005-03-03 株式会社日立ハイテクノロジーズ 質量分析方法及びイオントラップ質量分析計
GB0404285D0 (en) * 2004-02-26 2004-03-31 Shimadzu Res Lab Europe Ltd A tandem ion-trap time-of flight mass spectrometer
GB0524042D0 (en) * 2005-11-25 2006-01-04 Micromass Ltd Mass spectrometer
GB0526245D0 (en) 2005-12-22 2006-02-01 Shimadzu Res Lab Europe Ltd A mass spectrometer using a dynamic pressure ion source
US8173961B2 (en) * 2007-04-09 2012-05-08 Shimadzu Corporation Ion trap mass spectrometer
JP4894918B2 (ja) * 2007-04-12 2012-03-14 株式会社島津製作所 イオントラップ質量分析装置
US8334506B2 (en) 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
US7973277B2 (en) 2008-05-27 2011-07-05 1St Detect Corporation Driving a mass spectrometer ion trap or mass filter
US8754368B2 (en) * 2008-06-20 2014-06-17 Shimadzu Corporation Mass spectrometer
US20110139972A1 (en) * 2009-12-11 2011-06-16 Mark Hardman Methods and Apparatus for Providing FAIMS Waveforms Using Solid-State Switching Devices
US9536721B2 (en) 2011-05-05 2017-01-03 Shimadzu Research Laboratory (Europe) Ltd. Device for manipulating charged particles via field with pseudopotential having one or more local maxima along length of channel
KR20150023635A (ko) * 2012-06-04 2015-03-05 지멘스 악티엔게젤샤프트 전기적으로 하전된 입자들을 콜렉팅하기 위한 디바이스 및 방법
WO2014038672A1 (fr) * 2012-09-10 2014-03-13 株式会社島津製作所 Procédé de sélection ionique dans un piège ionique et dispositif de piège ionique
US9536719B2 (en) * 2014-04-28 2017-01-03 Thermo Finnigan Llc Methods for broad-stability mass analysis using a quadrupole mass filter
US10186412B2 (en) 2014-06-12 2019-01-22 Washington State University Digital waveform manipulations to produce MSn collision induced dissociation
GB201507474D0 (en) * 2015-04-30 2015-06-17 Shimadzu Corp A circuit for generating a voltage waveform at an output node
US10312066B1 (en) * 2018-04-19 2019-06-04 Washington State University Generation of digital waveforms with high resolution duty cycle
CN109065437B (zh) * 2018-08-03 2020-04-24 北京理工大学 一种四极电场联合偶极电场的离子共振激发操作方法和装置
CN112509904B (zh) * 2020-11-30 2024-05-03 上海裕达实业有限公司 可切换的数字离子阱质谱射频电源系统及其控制方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920985A (en) 1972-03-27 1975-11-18 Unisearch Ltd Means for effecting improvements to mass spectrometers and mass filters
SU1088090A1 (ru) 1979-03-11 1984-04-23 Рязанский Радиотехнический Институт Способ питани датчиков квадрупольных масс-спектрометров
SU1660075A1 (ru) 1988-12-22 1991-06-30 Ryazanskij Radiotekhnicheskij Способ развертки спектра масс в гиперболоидном масс-спектрометре
US5248882A (en) * 1992-05-28 1993-09-28 Extrel Ftms, Inc. Method and apparatus for providing tailored excitation as in Fourier transform mass spectrometry
GB9924722D0 (en) 1999-10-19 1999-12-22 Shimadzu Res Lab Europe Ltd Methods and apparatus for driving a quadrupole device

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BONNER R. F. ET AL.: "Ion-Molecule reaction studies with a quadrupole ion storage trap." INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PHYSICS., vol. 2, 1972, pages 197-203, XP002218371 ELSEVIER SCIENTIFIC PUBLISHING CO. AMSTERDAM., NL *
SHERETOV E P ET AL: "Modulation parametric resonances and their influence on stability diagram structure" INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 184, no. 2-3, 5 April 1999 (1999-04-05), pages 207-216, XP004162238 ISSN: 1387-3806 cited in the application *
WALDREN R. M. ET AL.: "The quadrupole ion store (quistor). PArt III. Studies on phase-synchronized ion ejection: The effects of ejection pulse width and detection pulse delay." INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PHYSICS., vol. 29, no. 4, 1979, XP002218370 ELSEVIER SCIENTIFIC PUBLISHING CO. AMSTERDAM., NL *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009144469A1 (fr) * 2008-05-30 2009-12-03 Thermo Fisher Scientific (Bremen) Gmbh Spectromètre de masse
GB2472560A (en) * 2008-05-30 2011-02-09 Thermo Fisher Scient Mass spectrometer
GB2472560B (en) * 2008-05-30 2013-03-06 Thermo Fisher Scient Bremen Mass spectrometer
US9058964B2 (en) 2008-05-30 2015-06-16 Thermo Fisher Scientific (Bremen) Gmbh Mass spectrometer power sources with polarity switching
US9911586B2 (en) 2008-05-30 2018-03-06 Thermo Fisher Scientific (Bremen) Gmbh Mass spectrometer with power supply switching and dummy load
US8610054B2 (en) 2009-05-01 2013-12-17 Shimadzu Corporation Ion analysis apparatus and method of use
CN102751162A (zh) * 2010-12-31 2012-10-24 聚光科技(杭州)股份有限公司 一种提高离子阱碰撞诱导解离性能的方法及装置

Also Published As

Publication number Publication date
WO2002050866A3 (fr) 2003-07-24
GB0031342D0 (en) 2001-02-07
US6900433B2 (en) 2005-05-31
US20040079875A1 (en) 2004-04-29

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