WO2002031491A2 - Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite - Google Patents

Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite Download PDF

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Publication number
WO2002031491A2
WO2002031491A2 PCT/US2000/028163 US0028163W WO0231491A2 WO 2002031491 A2 WO2002031491 A2 WO 2002031491A2 US 0028163 W US0028163 W US 0028163W WO 0231491 A2 WO0231491 A2 WO 0231491A2
Authority
WO
WIPO (PCT)
Prior art keywords
probe
analytical instrument
laser
protein
affinity capture
Prior art date
Application number
PCT/US2000/028163
Other languages
English (en)
Other versions
WO2002031491A3 (fr
Inventor
Scot Weinberger
Werner Ens
Alexander Laboda
Victor Spicer
Raymond G. Bryan
Ken Standing
Pete Tornatore
James R. MCNABB
Original Assignee
Ciphergen Biosystems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciphergen Biosystems, Inc. filed Critical Ciphergen Biosystems, Inc.
Priority to CA002425456A priority Critical patent/CA2425456A1/fr
Priority to IL15493200A priority patent/IL154932A0/xx
Priority to EP00972093A priority patent/EP1327256A2/fr
Priority to JP2002534826A priority patent/JP2004524511A/ja
Priority to AU2001210807A priority patent/AU2001210807A1/en
Priority to PCT/US2000/028163 priority patent/WO2002031491A2/fr
Priority to KR10-2003-7005172A priority patent/KR20040010541A/ko
Priority to CNA008199590A priority patent/CN1502116A/zh
Priority to US10/095,259 priority patent/US20020195555A1/en
Publication of WO2002031491A2 publication Critical patent/WO2002031491A2/fr
Publication of WO2002031491A3 publication Critical patent/WO2002031491A3/fr

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

Abstract

L'invention concerne un instrument d'analyse comportant une interface à sonde de détection d'affinité, une source d'ionisation à désorption laser, et un spectromètre de masse en tandem. L'invention concerne également des procédés faisant appel à cet instrument pour la découverte et l'identification de protéines ainsi que pour la caractérisation d'interactions moléculaires.
PCT/US2000/028163 2000-10-11 2000-10-11 Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite WO2002031491A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA002425456A CA2425456A1 (fr) 2000-10-11 2000-10-11 Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite
IL15493200A IL154932A0 (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry
EP00972093A EP1327256A2 (fr) 2000-10-11 2000-10-11 Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite
JP2002534826A JP2004524511A (ja) 2000-10-11 2000-10-11 アフィニティ捕捉タンデム質量分析のための装置および方法
AU2001210807A AU2001210807A1 (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry
PCT/US2000/028163 WO2002031491A2 (fr) 2000-10-11 2000-10-11 Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite
KR10-2003-7005172A KR20040010541A (ko) 2000-10-11 2000-10-11 친화성 포착 탠덤 질량 분광계를 위한 장치 및 방법
CNA008199590A CN1502116A (zh) 2000-10-11 2000-10-11 亲和捕获串联质谱分析设备和方法
US10/095,259 US20020195555A1 (en) 2000-10-11 2002-03-08 Apparatus and methods for affinity capture tandem mass spectrometry

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/028163 WO2002031491A2 (fr) 2000-10-11 2000-10-11 Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/095,259 Continuation US20020195555A1 (en) 2000-10-11 2002-03-08 Apparatus and methods for affinity capture tandem mass spectrometry

Publications (2)

Publication Number Publication Date
WO2002031491A2 true WO2002031491A2 (fr) 2002-04-18
WO2002031491A3 WO2002031491A3 (fr) 2003-01-09

Family

ID=21741880

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028163 WO2002031491A2 (fr) 2000-10-11 2000-10-11 Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite

Country Status (8)

Country Link
EP (1) EP1327256A2 (fr)
JP (1) JP2004524511A (fr)
KR (1) KR20040010541A (fr)
CN (1) CN1502116A (fr)
AU (1) AU2001210807A1 (fr)
CA (1) CA2425456A1 (fr)
IL (1) IL154932A0 (fr)
WO (1) WO2002031491A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2384778A (en) * 2001-12-21 2003-08-06 Sense Proteomic Ltd Probe for mass spectrometry
US7074334B2 (en) 2001-05-23 2006-07-11 Klaus Wanner Method for determining the binding behavior of ligands which specifically bind to target molecules
JP2009146905A (ja) * 2003-03-31 2009-07-02 Hitachi High-Technologies Corp 質量分析計
CN115184530A (zh) * 2022-08-19 2022-10-14 北京中医药大学 一种多级在线能量分辨质谱法及其在结构精准鉴定中的应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4605344B2 (ja) * 2003-06-10 2011-01-05 直久 友杉 シェーグレン症候群患者の検定方法
JP4522910B2 (ja) * 2005-05-30 2010-08-11 株式会社日立ハイテクノロジーズ 質量分析方法及び質量分析装置
KR100805775B1 (ko) * 2005-08-08 2008-02-21 한국기초과학지원연구원 변형된 폴리펩티드(Ｍｏｄｉｆｉｅｄｐｏｌｙｐｅｐｔｉｄｅ)의 서열 및 변형 정보를 분석하는방법
CN106055895B (zh) * 2010-09-15 2021-02-19 Dh科技发展私人贸易有限公司 产物离子谱的数据独立获取及参考谱库匹配
US9202677B2 (en) * 2012-05-18 2015-12-01 Dh Technologies Development Pte. Ltd. Systems and methods for using interleaving window widths in tandem mass spectrometry
KR101559101B1 (ko) * 2013-11-28 2015-10-12 한국기초과학지원연구원 혈액유래 암 진단용 펩티드 마커 및 이를 이용한 암 진단방법
CN113049663B (zh) * 2021-01-27 2023-10-20 中国科学院成都生物研究所 一维线材样品转储及质谱分析的装置和使用方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLAWAS A S ET AL: "Protein patterning" BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 19, no. 7-9, 5 April 1998 (1998-04-05), pages 595-609, XP004120826 ISSN: 0142-9612 *
J. R. YATES: "Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database" ANALYTICAL CHEMISTRY., vol. 67 , 15 April 1995 (1995-04-15), pages 1426 -1436, XP002209924 AMERICAN CHEMICAL SOCIETY. COLUMBUS., US ISSN: 0003-2700 cited in the application *
OKANO K ET AL: "Position-specific release of DNA from a chip by using photothermal denaturation" SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 64, no. 1-3, June 2000 (2000-06), pages 88-94, XP004199291 ISSN: 0925-4005 *
YAN-HUI LIU: "Use of a nitrocellulose film substrate in matrix-assisted laser desorption / ionization mass spectrometry for DNA mapping and screening" ANALYTICAL CHEMISTRY., vol. 67, 1 October 1995 (1995-10-01), pages 3482-3490, XP002209923 AMERICAN CHEMICAL SOCIETY. COLUMBUS., US ISSN: 0003-2700 cited in the application *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7074334B2 (en) 2001-05-23 2006-07-11 Klaus Wanner Method for determining the binding behavior of ligands which specifically bind to target molecules
GB2384778A (en) * 2001-12-21 2003-08-06 Sense Proteomic Ltd Probe for mass spectrometry
JP2009146905A (ja) * 2003-03-31 2009-07-02 Hitachi High-Technologies Corp 質量分析計
CN115184530A (zh) * 2022-08-19 2022-10-14 北京中医药大学 一种多级在线能量分辨质谱法及其在结构精准鉴定中的应用
CN115184530B (zh) * 2022-08-19 2023-11-24 北京中医药大学 一种多级在线能量分辨质谱法及其在结构精准鉴定中的应用

Also Published As

Publication number Publication date
AU2001210807A1 (en) 2002-04-22
IL154932A0 (en) 2003-10-31
WO2002031491A3 (fr) 2003-01-09
JP2004524511A (ja) 2004-08-12
CA2425456A1 (fr) 2002-04-18
KR20040010541A (ko) 2004-01-31
CN1502116A (zh) 2004-06-02
EP1327256A2 (fr) 2003-07-16

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