CA2425456A1 - Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite - Google Patents

Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite Download PDF

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Publication number
CA2425456A1
CA2425456A1 CA002425456A CA2425456A CA2425456A1 CA 2425456 A1 CA2425456 A1 CA 2425456A1 CA 002425456 A CA002425456 A CA 002425456A CA 2425456 A CA2425456 A CA 2425456A CA 2425456 A1 CA2425456 A1 CA 2425456A1
Authority
CA
Canada
Prior art keywords
probe
analytical instrument
laser
protein
affinity capture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002425456A
Other languages
English (en)
Inventor
James R. Mcnabb
Alexander Laboda
Werner Ens
Victor L. Spicer
Kenneth G. Standing
Scot Weinberger
Pete Tornatore
Raymond G. Bryan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aspira Womens Health Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2425456A1 publication Critical patent/CA2425456A1/fr
Abandoned legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Plasma & Fusion (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne un instrument d'analyse comportant une interface à sonde de détection d'affinité, une source d'ionisation à désorption laser, et un spectromètre de masse en tandem. L'invention concerne également des procédés faisant appel à cet instrument pour la découverte et l'identification de protéines ainsi que pour la caractérisation d'interactions moléculaires.
CA002425456A 2000-10-11 2000-10-11 Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite Abandoned CA2425456A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/028163 WO2002031491A2 (fr) 2000-10-11 2000-10-11 Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite

Publications (1)

Publication Number Publication Date
CA2425456A1 true CA2425456A1 (fr) 2002-04-18

Family

ID=21741880

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002425456A Abandoned CA2425456A1 (fr) 2000-10-11 2000-10-11 Dispositif et procedes pour la spectrometrie de masse en tandem a detection d'affinite

Country Status (8)

Country Link
EP (1) EP1327256A2 (fr)
JP (1) JP2004524511A (fr)
KR (1) KR20040010541A (fr)
CN (1) CN1502116A (fr)
AU (1) AU2001210807A1 (fr)
CA (1) CA2425456A1 (fr)
IL (1) IL154932A0 (fr)
WO (1) WO2002031491A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125258A1 (de) 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
AU2002358219A1 (en) * 2001-12-21 2003-07-15 Sense Proteomic Limited Protein analysis using mass spectrometry
US7064319B2 (en) * 2003-03-31 2006-06-20 Hitachi High-Technologies Corporation Mass spectrometer
JP4605344B2 (ja) * 2003-06-10 2011-01-05 直久 友杉 シェーグレン症候群患者の検定方法
JP4522910B2 (ja) * 2005-05-30 2010-08-11 株式会社日立ハイテクノロジーズ 質量分析方法及び質量分析装置
KR100805775B1 (ko) * 2005-08-08 2008-02-21 한국기초과학지원연구원 변형된 폴리펩티드(Ｍｏｄｉｆｉｅｄｐｏｌｙｐｅｐｔｉｄｅ)의 서열 및 변형 정보를 분석하는방법
WO2012035412A2 (fr) * 2010-09-15 2012-03-22 Dh Technologies Development Pte. Ltd. Acquisition indépendante des données d'appariement de bibliothèque de spectres de production et de spectres de référence
JP6174685B2 (ja) * 2012-05-18 2017-08-02 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド タンデム質量分析計内のインターリービング窓幅を使用するためのシステムおよび方法
KR101559101B1 (ko) * 2013-11-28 2015-10-12 한국기초과학지원연구원 혈액유래 암 진단용 펩티드 마커 및 이를 이용한 암 진단방법
CN113049663B (zh) * 2021-01-27 2023-10-20 中国科学院成都生物研究所 一维线材样品转储及质谱分析的装置和使用方法
CN115184530B (zh) * 2022-08-19 2023-11-24 北京中医药大学 一种多级在线能量分辨质谱法及其在结构精准鉴定中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements

Also Published As

Publication number Publication date
CN1502116A (zh) 2004-06-02
IL154932A0 (en) 2003-10-31
JP2004524511A (ja) 2004-08-12
WO2002031491A3 (fr) 2003-01-09
WO2002031491A2 (fr) 2002-04-18
KR20040010541A (ko) 2004-01-31
EP1327256A2 (fr) 2003-07-16
AU2001210807A1 (en) 2002-04-22

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Legal Events

Date Code Title Description
FZDE Discontinued