WO2002026988A3 - Enzymes humaines métabolisant les médicaments - Google Patents

Enzymes humaines métabolisant les médicaments Download PDF

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Publication number
WO2002026988A3
WO2002026988A3 PCT/US2001/030662 US0130662W WO0226988A3 WO 2002026988 A3 WO2002026988 A3 WO 2002026988A3 US 0130662 W US0130662 W US 0130662W WO 0226988 A3 WO0226988 A3 WO 0226988A3
Authority
WO
WIPO (PCT)
Prior art keywords
metabolizing enzymes
drug metabolizing
human drug
dme
provides
Prior art date
Application number
PCT/US2001/030662
Other languages
English (en)
Other versions
WO2002026988A9 (fr
WO2002026988A2 (fr
Inventor
Yalda Azimzai
Mariah R Baughin
Mark L Borowsky
Li Ding
Brendan M Duggan
Original Assignee
Incyte Genomics Inc
Yalda Azimzai
Mariah R Baughin
Mark L Borowsky
Li Ding
Brendan M Duggan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Yalda Azimzai, Mariah R Baughin, Mark L Borowsky, Li Ding, Brendan M Duggan filed Critical Incyte Genomics Inc
Priority to US10/381,898 priority Critical patent/US20040086887A1/en
Priority to JP2002530751A priority patent/JP2004526414A/ja
Priority to EP01975624A priority patent/EP1395656A2/fr
Priority to AU2001294929A priority patent/AU2001294929A1/en
Priority to CA002422530A priority patent/CA2422530A1/fr
Publication of WO2002026988A2 publication Critical patent/WO2002026988A2/fr
Publication of WO2002026988A9 publication Critical patent/WO2002026988A9/fr
Publication of WO2002026988A3 publication Critical patent/WO2002026988A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/80—Cytochromes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des enzymes humaines métabolisant les médicaments ou (DME) et des polynucléotides identifiant et codant les DME. L'invention concerne également des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes et des antagonistes. L'invention concerne aussi des procédés permettant de diagnostiquer, de traiter ou de prévenir des troubles liés à l'expression aberrante des DME.
PCT/US2001/030662 2000-09-29 2001-09-28 Enzymes humaines métabolisant les médicaments WO2002026988A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/381,898 US20040086887A1 (en) 2001-09-28 2001-09-28 Drug metabolizing enzymes
JP2002530751A JP2004526414A (ja) 2000-09-29 2001-09-28 薬物代謝酵素
EP01975624A EP1395656A2 (fr) 2000-09-29 2001-09-28 Enzymes humains de metabolisation de medicaments
AU2001294929A AU2001294929A1 (en) 2000-09-29 2001-09-28 Human drug metabolizing enzymes
CA002422530A CA2422530A1 (fr) 2000-09-29 2001-09-28 Enzymes humaines metabolisant les medicaments

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US23694700P 2000-09-29 2000-09-29
US60/236,947 2000-09-29
US23886400P 2000-10-06 2000-10-06
US60/238,864 2000-10-06
US24232300P 2000-10-20 2000-10-20
US60/242,323 2000-10-20
US24758100P 2000-11-09 2000-11-09
US60/247,581 2000-11-09
US24951900P 2000-11-16 2000-11-16
US60/249,519 2000-11-16
US25283400P 2000-11-22 2000-11-22
US60/252,834 2000-11-22
US25056700P 2000-11-30 2000-11-30
US60/250,567 2000-11-30

Publications (3)

Publication Number Publication Date
WO2002026988A2 WO2002026988A2 (fr) 2002-04-04
WO2002026988A9 WO2002026988A9 (fr) 2002-07-04
WO2002026988A3 true WO2002026988A3 (fr) 2003-01-30

Family

ID=27569418

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/030662 WO2002026988A2 (fr) 2000-09-29 2001-09-28 Enzymes humaines métabolisant les médicaments

Country Status (5)

Country Link
EP (1) EP1395656A2 (fr)
JP (1) JP2004526414A (fr)
AU (1) AU2001294929A1 (fr)
CA (1) CA2422530A1 (fr)
WO (1) WO2002026988A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002239398A1 (en) * 2000-11-30 2002-06-11 Millenium Pharmaceuticals, Inc. 25206, a novel human short-chain dehydrogenase/reductase family member and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463395A1 (fr) * 1990-06-22 1992-01-02 F. Hoffmann-La Roche Ag Dépistage des métabolisateurs faibles de drogues

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463395A1 (fr) * 1990-06-22 1992-01-02 F. Hoffmann-La Roche Ag Dépistage des métabolisateurs faibles de drogues

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FALANY ET AL.: "Glycine and taurine conjugation of bile acids by a single enzyme", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 30, 29 July 1994 (1994-07-29), pages 19375 - 19379, XP002200640 *
GASDASKA P Y ET AL: "Cloning, sequencing and functional expression of a novel human thioredoxin reductase", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 442, no. 1, 8 January 1999 (1999-01-08), pages 105 - 111, XP004259013, ISSN: 0014-5793 *
JOHNSON ET AL.: "Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 16, 5 June 1991 (1991-06-05), pages 10227 - 10233, XP002200639 *
VESSEY D A ET AL: "DETERMINATION OF THE SEQUENCE OF THE ARYLACETYL ACYL- COA:AMINO ACID N-ACYLTRANSFERASE FROM BOVINE LIVER MITOCHONDRIA AND ITS HOMOLOGY TO THE ARALKYL ACYL- COA:AMINO ACID N-ACYLTRANSFERASE", JOURNAL OF BIOCHEMICAL TOXICOLOGY, VCH PUBLISHERS, DEERFIELD, FL, US, vol. 12, no. 5, 1998, pages 275 - 279, XP002931296, ISSN: 0887-2082 *

Also Published As

Publication number Publication date
EP1395656A2 (fr) 2004-03-10
JP2004526414A (ja) 2004-09-02
WO2002026988A9 (fr) 2002-07-04
WO2002026988A2 (fr) 2002-04-04
AU2001294929A1 (en) 2002-04-08
CA2422530A1 (fr) 2002-04-04

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