WO2002012467A3 - Enzymes métabolisant les médicaments - Google Patents

Enzymes métabolisant les médicaments

Info

Publication number
WO2002012467A3
WO2002012467A3 PCT/US2001/024382 US0124382W WO0212467A3 WO 2002012467 A3 WO2002012467 A3 WO 2002012467A3 US 0124382 W US0124382 W US 0124382W WO 0212467 A3 WO0212467 A3 WO 0212467A3
Authority
WO
WIPO (PCT)
Prior art keywords
metabolizing enzymes
drug metabolizing
dme
provides
polynucleotides
Prior art date
Application number
PCT/US2001/024382
Other languages
English (en)
Other versions
WO2002012467A2 (fr
Inventor
Mariah R Baughn
Christopher M Bruns
Debopriya Das
Original Assignee
Incyte Genomics Inc
Mariah R Baughn
Christopher M Bruns
Debopriya Das
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Mariah R Baughn, Christopher M Bruns, Debopriya Das filed Critical Incyte Genomics Inc
Priority to US10/343,593 priority Critical patent/US20040110259A1/en
Priority to CA002417769A priority patent/CA2417769A1/fr
Priority to AU2001278154A priority patent/AU2001278154A1/en
Priority to EP01956121A priority patent/EP1305425A2/fr
Priority to JP2002517758A priority patent/JP2004518407A/ja
Publication of WO2002012467A2 publication Critical patent/WO2002012467A2/fr
Publication of WO2002012467A3 publication Critical patent/WO2002012467A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La présente invention concerne des enzymes humaines métabolisant les médicaments ou 'DME' (pour 'Drug Metabolizing Enzymes') et des polynucléotides identifiant et codant les DME. L'invention concerne également des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes et des antagonistes. L'invention concerne aussi des procédés permettant de diagnostiquer, de traiter ou de prévenir des troubles liés à l'expression aberrante des DME.
PCT/US2001/024382 2000-08-04 2001-08-03 Enzymes métabolisant les médicaments WO2002012467A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/343,593 US20040110259A1 (en) 2001-08-03 2001-08-03 Drug metabolizing enzymes
CA002417769A CA2417769A1 (fr) 2000-08-04 2001-08-03 Enzymes metabolisant les medicaments
AU2001278154A AU2001278154A1 (en) 2000-08-04 2001-08-03 Drug metabolizing enzymes
EP01956121A EP1305425A2 (fr) 2000-08-04 2001-08-03 Medicament metabolisant les enzymes
JP2002517758A JP2004518407A (ja) 2000-08-04 2001-08-03 薬物代謝酵素

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US22305500P 2000-08-04 2000-08-04
US60/223,055 2000-08-04
US22472800P 2000-08-11 2000-08-11
US60/224,728 2000-08-11
US22644000P 2000-08-18 2000-08-18
US60/226,440 2000-08-18
US22806700P 2000-08-24 2000-08-24
US60/228,067 2000-08-24
US23006300P 2000-08-31 2000-08-31
US60/230,063 2000-08-31
US23224400P 2000-09-13 2000-09-13
US60/232,244 2000-09-13
US23426900P 2000-09-20 2000-09-20
US60/234,269 2000-09-20

Publications (2)

Publication Number Publication Date
WO2002012467A2 WO2002012467A2 (fr) 2002-02-14
WO2002012467A3 true WO2002012467A3 (fr) 2002-12-27

Family

ID=27569375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024382 WO2002012467A2 (fr) 2000-08-04 2001-08-03 Enzymes métabolisant les médicaments

Country Status (5)

Country Link
EP (1) EP1305425A2 (fr)
JP (1) JP2004518407A (fr)
AU (1) AU2001278154A1 (fr)
CA (1) CA2417769A1 (fr)
WO (1) WO2002012467A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020098174A1 (en) * 2000-03-31 2002-07-25 Rosana Kapeller-Libermann 33166, a human hydrolase-like molecule and uses thereof
MXPA02010267A (es) * 2000-04-20 2003-05-23 Cytochroma Inc Citocromo (p450 tec) humano expresado de timo.
US7150981B2 (en) 2000-06-29 2006-12-19 Seikagaku Corporation Sulfate transferase and DNA encoding this enzyme
WO2002026945A2 (fr) * 2000-09-27 2002-04-04 Bayer Aktiengesellschaft Regulation d'une enzyme humaine de type aminotransferase
WO2002044357A2 (fr) 2000-11-30 2002-06-06 Millennium Pharmaceuticals, Inc. Procedes d'utilisation de 18903 dans le traitement de la douleur et des troubles lies a la douleur
SI2311874T1 (sl) 2004-07-22 2017-12-29 Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics Vezavne molekule

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006830A1 (fr) * 1996-08-09 1998-02-19 The University Of Sydney Polynucleotides synthetiques
US5744355A (en) * 1994-10-18 1998-04-28 Mayo Foundation For Medical Education And Research cDNA cloning and expression of human liver estrogen sulfotransferase
US5756299A (en) * 1996-12-09 1998-05-26 Incyte Pharmaceuticals, Inc. Human carbonyl reductase
US6060253A (en) * 1997-01-23 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Agents that bind to and inhibit human cytochrome P450 2D6
WO2001092495A2 (fr) * 2000-05-26 2001-12-06 Millennium Pharmaceuticals, Inc. Nouvelle lysyl oxydase humaine 47765 et ses utilisations

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744355A (en) * 1994-10-18 1998-04-28 Mayo Foundation For Medical Education And Research cDNA cloning and expression of human liver estrogen sulfotransferase
WO1998006830A1 (fr) * 1996-08-09 1998-02-19 The University Of Sydney Polynucleotides synthetiques
US5756299A (en) * 1996-12-09 1998-05-26 Incyte Pharmaceuticals, Inc. Human carbonyl reductase
US6060253A (en) * 1997-01-23 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Agents that bind to and inhibit human cytochrome P450 2D6
WO2001092495A2 (fr) * 2000-05-26 2001-12-06 Millennium Pharmaceuticals, Inc. Nouvelle lysyl oxydase humaine 47765 et ses utilisations

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE SWALL [online] EBI Hinxton, UK; 24 November 1998 (1998-11-24), LANGENAU D M ET AL.: "Progestin-upregulated mRNAs in the yellow perch ovary", XP002199863, Database accession no. AF103901 *
ITO HIROMU ET AL: "Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 26, 29 June 2001 (2001-06-29), pages 24023 - 24029, XP002199860, ISSN: 0021-9258 *
TRACKMAN P C ET AL: "CLONING OF RAT AORTA LYSYL OXIDASE COMPLEMENTARY DNA COMPLETE CODONS AND PREDICTED AMINO ACID SEQUENCE", BIOCHEMISTRY, vol. 29, no. 20, 1990, pages 4863 - 4870, XP002199862, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
CA2417769A1 (fr) 2002-02-14
AU2001278154A1 (en) 2002-02-18
JP2004518407A (ja) 2004-06-24
EP1305425A2 (fr) 2003-05-02
WO2002012467A2 (fr) 2002-02-14

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