WO2002026768A3 - Haplotypes du gene por - Google Patents

Haplotypes du gene por Download PDF

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Publication number
WO2002026768A3
WO2002026768A3 PCT/US2001/030877 US0130877W WO0226768A3 WO 2002026768 A3 WO2002026768 A3 WO 2002026768A3 US 0130877 W US0130877 W US 0130877W WO 0226768 A3 WO0226768 A3 WO 0226768A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
por
gene
disclosed
por gene
Prior art date
Application number
PCT/US2001/030877
Other languages
English (en)
Other versions
WO2002026768A2 (fr
Inventor
Amir Kazemi
Stefanie E Kliem
Elizabeth M Lanz
Chad Messer
Debra A Tanguay
Original Assignee
Genaissance Pharmaceuticals
Amir Kazemi
Stefanie E Kliem
Elizabeth M Lanz
Chad Messer
Debra A Tanguay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Amir Kazemi, Stefanie E Kliem, Elizabeth M Lanz, Chad Messer, Debra A Tanguay filed Critical Genaissance Pharmaceuticals
Priority to AU2002211373A priority Critical patent/AU2002211373A1/en
Publication of WO2002026768A2 publication Critical patent/WO2002026768A2/fr
Publication of WO2002026768A3 publication Critical patent/WO2002026768A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des nouveaux allèles génétiques du gène P450 (Cytochrome) Oxydoréductase (POR) ; divers génotypes, haplotypes et paires d'haplotypes présents en général dans la population des Etats-Unis pour le gène POR ; des compositions et des méthodes d'haplotypage et/ou de génotypage du gène POR chez un individu ; enfin, les polynucléotides définis par les haplotypes selon l'invention.
PCT/US2001/030877 2000-09-29 2001-10-01 Haplotypes du gene por WO2002026768A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002211373A AU2002211373A1 (en) 2000-09-29 2001-10-01 Haplotypes of the por gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23644900P 2000-09-29 2000-09-29
US60/236,449 2000-09-29

Publications (2)

Publication Number Publication Date
WO2002026768A2 WO2002026768A2 (fr) 2002-04-04
WO2002026768A3 true WO2002026768A3 (fr) 2002-06-13

Family

ID=22889546

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/030877 WO2002026768A2 (fr) 2000-09-29 2001-10-01 Haplotypes du gene por

Country Status (2)

Country Link
AU (1) AU2002211373A1 (fr)
WO (1) WO2002026768A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407943B2 (en) 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
US7888324B2 (en) 2001-08-01 2011-02-15 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US7511131B2 (en) 2002-11-13 2009-03-31 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US20050287558A1 (en) 2004-05-05 2005-12-29 Crooke Rosanne M SNPs of apolipoprotein B and modulation of their expression
ATE513912T1 (de) 2006-05-05 2011-07-15 Isis Pharmaceuticals Inc Verbindungen und verfahren zur modulation der expression von sglt2
CN101679979A (zh) 2007-03-24 2010-03-24 基酶有限公司 施用与人载脂蛋白b互补的反义寡核苷酸
EP2141250A1 (fr) * 2008-07-02 2010-01-06 Institut National De La Recherche Agronomique (Inra) Procédé de diagnostic et de prédiction d'ataxie cérébelleuse
WO2010107838A1 (fr) 2009-03-16 2010-09-23 Isis Pharmaceuticals, Inc. Ciblage de l'apolipoprotéine b pour la réduction de l'apolipoprotéine c-iii

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 2 September 2000 (2000-09-02), CZERWINSKI ET AL.: "Polymorphism of human CYPOR: Expression of new allele", XP002908410, accession no. NCBI Database accession no. AF258341 *
O'LEARY K.A. ET AL.: "Molecular basis for cell-specific regulation of the NADPH-cytochrome p450 oxidoreductase gene", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 379, 1 July 2000 (2000-07-01), pages 97 - 108, XP002908409 *
YAMANO S. ET AL.: "Human NADPH-P450 oxidoreductase: Complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7", MOLECULAR PHARMACOLOGY, vol. 35, 1989, pages 83 - 88, XP002908411 *

Also Published As

Publication number Publication date
AU2002211373A1 (en) 2002-04-08
WO2002026768A2 (fr) 2002-04-04

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