WO2002010190A3 - Haplotypes du gene il12b - Google Patents

Haplotypes du gene il12b Download PDF

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Publication number
WO2002010190A3
WO2002010190A3 PCT/US2001/023927 US0123927W WO0210190A3 WO 2002010190 A3 WO2002010190 A3 WO 2002010190A3 US 0123927 W US0123927 W US 0123927W WO 0210190 A3 WO0210190 A3 WO 0210190A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
il12b
gene
disclosed
il12b gene
Prior art date
Application number
PCT/US2001/023927
Other languages
English (en)
Other versions
WO2002010190A2 (fr
Inventor
Chad Messer
Angela Sanchis
Original Assignee
Genaissance Pharmaceuticals
Chad Messer
Angela Sanchis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Chad Messer, Angela Sanchis filed Critical Genaissance Pharmaceuticals
Priority to AU2001283042A priority Critical patent/AU2001283042A1/en
Publication of WO2002010190A2 publication Critical patent/WO2002010190A2/fr
Publication of WO2002010190A3 publication Critical patent/WO2002010190A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention porte sur de nouveaux variants génétiques du gène de l'Interleukine 12B (IL12B). L'invention porte également sur divers génotypes, haplotypes et paires d'haplotypes existant dans la population des Etats-Unis pour le gène IL12B. L'invention porte encore sur des compositions et sur des procédés pour haplotyper et/ou génotyper le gène IL12B chez un individu, ainsi que sur des polynucléotides définis par les haplotypes précités.
PCT/US2001/023927 2000-07-29 2001-07-30 Haplotypes du gene il12b WO2002010190A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001283042A AU2001283042A1 (en) 2000-07-29 2001-07-30 Haplotypes of the il12b gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22143600P 2000-07-29 2000-07-29
US60/221,436 2000-07-29

Publications (2)

Publication Number Publication Date
WO2002010190A2 WO2002010190A2 (fr) 2002-02-07
WO2002010190A3 true WO2002010190A3 (fr) 2002-05-02

Family

ID=22827822

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/023927 WO2002010190A2 (fr) 2000-07-29 2001-07-30 Haplotypes du gene il12b

Country Status (2)

Country Link
AU (1) AU2001283042A1 (fr)
WO (1) WO2002010190A2 (fr)

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995002701A1 (fr) * 1993-07-15 1995-01-26 Boehringer Mannheim Gmbh Procede d'identification de cellules humaines et animales susceptibles de proliferer de maniere illimitee ou de generer des tumeurs
WO1995003331A1 (fr) * 1993-07-23 1995-02-02 Zeneca Limited Double transgene de la classe ii du complexe majeur d'histocompatibilite humain et ses utilisations
US5436391A (en) * 1991-11-29 1995-07-25 Mitsubishi Corporation Synthetic insecticidal gene, plants of the genus oryza transformed with the gene, and production thereof
US5451659A (en) * 1991-11-08 1995-09-19 Mochida Pharmaceutical Co., Ltd. Polypeptide, DNA fragment encoding the same, drug composition containing the same and process for producing the same
US5496712A (en) * 1990-11-06 1996-03-05 Protein Polymer High molecular weight collagen-like protein polymers
US5547855A (en) * 1992-12-11 1996-08-20 Allelix Biopharmaceuticals Inc. Kainate-binding human CNS glutamate receptors EAA3C and EAA3D, DNA encoding them, and expression of the DNA in transformed cells
US5552281A (en) * 1993-04-06 1996-09-03 Forsyth Dental Infirmary For Children Human osteoclast-specific and -related genes
WO1996027664A2 (fr) * 1995-03-03 1996-09-12 Consiglio Nazionale Delle Ricerche Produit de transcription anti-sens exprime dans les lymphocytes b et oligonucleotides de synthese utiles pour inhiber son activite
US5578444A (en) * 1991-06-27 1996-11-26 Genelabs Technologies, Inc. Sequence-directed DNA-binding molecules compositions and methods
US5589336A (en) * 1994-11-10 1996-12-31 New York Blood Center Diagnostic method and kit for determining Kell blood group genotype
US5639612A (en) * 1992-07-28 1997-06-17 Hitachi Chemical Company, Ltd. Method for detecting polynucleotides with immobilized polynucleotide probes identified based on Tm
US5646042A (en) * 1992-08-26 1997-07-08 Ribozyme Pharmaceuticals, Inc. C-myb targeted ribozymes
US5670367A (en) * 1991-08-26 1997-09-23 Immuno Aktiengesellschaft Recombinant fowlpox virus
US5712124A (en) * 1991-01-31 1998-01-27 Becton, Dickinson And Company Strand displacement amplification
US5747645A (en) * 1995-02-08 1998-05-05 Zymogenetics, Inc. Cytoplasmic antiproteinase-2 and cytoplasmic antiproteinase-3 and coding sequences

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5496712A (en) * 1990-11-06 1996-03-05 Protein Polymer High molecular weight collagen-like protein polymers
US5712124A (en) * 1991-01-31 1998-01-27 Becton, Dickinson And Company Strand displacement amplification
US5578444A (en) * 1991-06-27 1996-11-26 Genelabs Technologies, Inc. Sequence-directed DNA-binding molecules compositions and methods
US5670367A (en) * 1991-08-26 1997-09-23 Immuno Aktiengesellschaft Recombinant fowlpox virus
US5451659A (en) * 1991-11-08 1995-09-19 Mochida Pharmaceutical Co., Ltd. Polypeptide, DNA fragment encoding the same, drug composition containing the same and process for producing the same
US5436391A (en) * 1991-11-29 1995-07-25 Mitsubishi Corporation Synthetic insecticidal gene, plants of the genus oryza transformed with the gene, and production thereof
US5639612A (en) * 1992-07-28 1997-06-17 Hitachi Chemical Company, Ltd. Method for detecting polynucleotides with immobilized polynucleotide probes identified based on Tm
US5646042A (en) * 1992-08-26 1997-07-08 Ribozyme Pharmaceuticals, Inc. C-myb targeted ribozymes
US5547855A (en) * 1992-12-11 1996-08-20 Allelix Biopharmaceuticals Inc. Kainate-binding human CNS glutamate receptors EAA3C and EAA3D, DNA encoding them, and expression of the DNA in transformed cells
US5552281A (en) * 1993-04-06 1996-09-03 Forsyth Dental Infirmary For Children Human osteoclast-specific and -related genes
WO1995002701A1 (fr) * 1993-07-15 1995-01-26 Boehringer Mannheim Gmbh Procede d'identification de cellules humaines et animales susceptibles de proliferer de maniere illimitee ou de generer des tumeurs
WO1995003331A1 (fr) * 1993-07-23 1995-02-02 Zeneca Limited Double transgene de la classe ii du complexe majeur d'histocompatibilite humain et ses utilisations
US5589336A (en) * 1994-11-10 1996-12-31 New York Blood Center Diagnostic method and kit for determining Kell blood group genotype
US5747645A (en) * 1995-02-08 1998-05-05 Zymogenetics, Inc. Cytoplasmic antiproteinase-2 and cytoplasmic antiproteinase-3 and coding sequences
WO1996027664A2 (fr) * 1995-03-03 1996-09-12 Consiglio Nazionale Delle Ricerche Produit de transcription anti-sens exprime dans les lymphocytes b et oligonucleotides de synthese utiles pour inhiber son activite

Non-Patent Citations (28)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] "Sequence 25", XP002908198, accession no. EMBL Database accession no. I18418 *
DATABASE GENBANK [online] "Sequence 6", XP002908193, accession no. EMBL Database accession no. A56870 *
DATABASE GENBANK [online] ABKEN H.J. ET AL.: "Sequence 20", XP002908305, accession no. EMBL Database accession no. A42888 *
DATABASE GENBANK [online] DORNER F. ET AL.: "Sequence 52", XP002908192, accession no. EMBL Database accession no. I66532 *
DATABASE GENBANK [online] EDWARDS C.A. ET AL.: "Sequence 489", XP002908194, accession no. EMBL Database accession no. I29617 *
DATABASE GENBANK [online] February 1995 (1995-02-01), "Human (clone: 1sitp105) T-cell receptor delta chain (v-delta-1) mRNa", XP002908197, accession no. EMBL Database accession no. L32401 *
DATABASE GENBANK [online] February 1996 (1996-02-01), GAUBATY J.W. ET AL.: "Mus musculus clone NSAT42 nonsatellite RNA sequence", XP002908189, accession no. EMBL Database accession no. U26230 *
DATABASE GENBANK [online] FUJIMOTO H. ET AL.: "Sequence 23", XP002908307, accession no. EMBL Database accession no. I13489 *
DATABASE GENBANK [online] January 1995 (1995-01-01), WOLF S.F. ET AL.: "Human natural killer cells stimulatory factor (NKSF) mRNA, complete cds, clone p40", XP002908188, accession no. NCBI Database accession no. M65290 *
DATABASE GENBANK [online] July 1996 (1996-07-01), HOPPE-SEYLER ET AL.: "Oligonucleotide seq ID No: 8", XP002908196, accession no. EMBL Database accession no. A17998 *
DATABASE GENBANK [online] KAMBOJ R. ET AL.: "Sequence 6", XP002908308, accession no. EMBL Database accession no. I25020 *
DATABASE GENBANK [online] LEE S. ET AL.: "Sequence 57", XP002908302, accession no. EMBL Database accession no. I32672 *
DATABASE GENBANK [online] March 1997 (1997-03-01), SCOTT P. ET AL.: "Human interleukin-12 40 kD subunit protein", XP002908311, accession no. EMBL Database accession no. AAW07398 *
DATABASE GENBANK [online] MITSUHASHI M. ET AL.: "Sequence 637", XP002908306, accession no. EMBL Database accession no. I46658 *
DATABASE GENBANK [online] MORISHITA H. ET AL.: "Sequence 64", XP002908191, accession no. EMBL Database accession no. I14714 *
DATABASE GENBANK [online] November 2000 (2000-11-01), HUANG D. ET AL.: "Homosapiens interleukin 12 p40 subunit (IL12B) gene, IL12B-1 allele, complete cds", XP002908187, accession no. EMBL Database accession no. AY008847 *
DATABASE GENBANK [online] October 1994 (1994-10-01), HERRERAMARTINEZ L.S. ET AL.: "Oligonucleotide", XP002908190, accession no. EMBL Database accession no. A16463 *
DATABASE GENBANK [online] September 1997 (1997-09-01), OKAMOTO H.: "Oligonucleotide for detecting HCV", XP002908309, accession no. EMBL Database accession no. E08908 *
DATABASE GENBANK [online] SPRECHER C.A.: "Sequence 8", XP002908199, accession no. EMBL Database accession no. AR005200 *
DATABASE GENBANK [online] STASHENKO P. ET AL.: "Sequence 13", XP002908195, accession no. EMBL Database accession no. I25652 *
DATABASE GENBANK [online] STINVHCOMB D.T. ET AL.: "Sequence 310", XP002908301, accession no. EMBL Database accession no. I52569 *
DATABASE GENBANK [online] WALKER G.T.: "Sequence 10", XP002908304, accession no. EMBL Database accession no. I82308 *
DATABASE GENBANK [online] WHITTAKER J.L. ET AL.: "Sequence 2", XP002908200, accession no. EMBL Database accession no. A42453 *
DATABASE GENBANK January 1996 (1996-01-01), OSTRANDER E.A. ET AL.: "Dog (clone: CXX.390) primer for STS 390, 3' end", XP002908303 *
DATABASE GENBANK October 1993 (1993-10-01), EFREMOV D.G. ET AL.: "Ig epsilon CDR3/FW4 (clone N6/d) (human mRNa partial, 77 nt)", XP002908310 *
HUANG D. ET AL.: "Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit", GENES IMMUN., vol. 1, no. 8, 2000, pages 515 - 520, XP002908312 *
MORAHAN G. ET AL.: "Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele", NATURE GENETICS, vol. 27, no. 2, February 2001 (2001-02-01), pages 218 - 221, XP002908313 *
NOGUCHI E. ET AL.: "Identification of missense mutation in the IL12B gene: lack of association between IL12B polymorphisms and asthma and allergic rhinitis in the japanese population", GENES AND IMMUNITY, vol. 2, no. 7, November 2001 (2001-11-01), pages 401 - 403, XP002908314 *

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Publication number Publication date
WO2002010190A2 (fr) 2002-02-07
AU2001283042A1 (en) 2002-02-13

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