WO2002008425A3 - Haplotypes du gene adrb3 - Google Patents

Haplotypes du gene adrb3 Download PDF

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Publication number
WO2002008425A3
WO2002008425A3 PCT/US2001/023223 US0123223W WO0208425A3 WO 2002008425 A3 WO2002008425 A3 WO 2002008425A3 US 0123223 W US0123223 W US 0123223W WO 0208425 A3 WO0208425 A3 WO 0208425A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
adrb3
gene
disclosed
adrb3 gene
Prior art date
Application number
PCT/US2001/023223
Other languages
English (en)
Other versions
WO2002008425A2 (fr
Inventor
Kevin Finkel
Beena Koshy
Original Assignee
Genaissance Pharmaceuticals
Kevin Finkel
Beena Koshy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Kevin Finkel, Beena Koshy filed Critical Genaissance Pharmaceuticals
Priority to AU2001280727A priority Critical patent/AU2001280727A1/en
Publication of WO2002008425A2 publication Critical patent/WO2002008425A2/fr
Publication of WO2002008425A3 publication Critical patent/WO2002008425A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne de nouveaux variants génétiques du récepteur adrénergique bêta 3. Cette invention a également trait à divers génotypes, haplotypes et paires d'haplotypes existant dans l'ensemble de la population des Etats-Unis pour le gène ADRB3. Ladite invention concerne des compositions et des méthodes d'haplotypage et/ou de génotypage du gène ADRB3 chez un individu, ainsi que des polynucléotides définis par les haplotypes susmentionnés.
PCT/US2001/023223 2000-07-21 2001-07-23 Haplotypes du gene adrb3 WO2002008425A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001280727A AU2001280727A1 (en) 2000-07-21 2001-07-23 Haplotypes of the adrb3 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22008800P 2000-07-21 2000-07-21
US60/220,088 2000-07-21

Publications (2)

Publication Number Publication Date
WO2002008425A2 WO2002008425A2 (fr) 2002-01-31
WO2002008425A3 true WO2002008425A3 (fr) 2003-09-25

Family

ID=22822002

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/023223 WO2002008425A2 (fr) 2000-07-21 2001-07-23 Haplotypes du gene adrb3

Country Status (2)

Country Link
AU (1) AU2001280727A1 (fr)
WO (1) WO2002008425A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002086122A2 (fr) * 2001-03-14 2002-10-31 Hybrigenics Interactions proteine-proteine intensifiees dans des cellules adipeuses
US8178294B2 (en) 2002-06-14 2012-05-15 Cedars-Sinai Medical Center Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
AU2003276727A1 (en) * 2002-06-14 2003-12-31 Cedars-Sinai Medical Center Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
CN107271675B (zh) * 2017-03-24 2020-06-02 郑猛 抗人adrb3单克隆抗体及其在疾病诊断和治疗中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001027312A2 (fr) * 1999-10-13 2001-04-19 Genaissance Pharmaceuticals, Inc. Isogenes cibles pour medicaments: polymorphismes dans le gene recepteur de l'acetylcholine muscarinique m1
WO2001080156A1 (fr) * 2000-04-18 2001-10-25 Genaissance Pharmaceuticals, Inc. Procede et systeme de determination d'haplotypes a partir d'une recueil de polymorphismes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001027312A2 (fr) * 1999-10-13 2001-04-19 Genaissance Pharmaceuticals, Inc. Isogenes cibles pour medicaments: polymorphismes dans le gene recepteur de l'acetylcholine muscarinique m1
WO2001080156A1 (fr) * 2000-04-18 2001-10-25 Genaissance Pharmaceuticals, Inc. Procede et systeme de determination d'haplotypes a partir d'une recueil de polymorphismes

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CLAIBORNE STEPHENS J: "SINGLE-NUCLEOTIDE POLYMORPHISMS, HAPLOTYPES AND THEIR RELEVANCE TO PHARMACOGENTICS", MOLECULAR DIAGNOSIS, NAPERVILLE, IL, US, vol. 4, no. 4, 1999, pages 309 - 317, XP002937520, ISSN: 1084-8592 *
CLARK A G ET AL: "HAPLOTYPE STRUCTURE AND POPULATION GENETIC INFERENCES FROM NUCLEOTIDE-SEQUENCE VARIATION IN HUMAN LIPOPROTEIN LIPASE", AMERICAN JOURNAL OF HUMAN GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS, CHICAGO, IL, US, vol. 63, 1998, pages 595 - 612, XP002936696, ISSN: 0002-9297 *
DATABASE EMBL [online] 1 April 1993 (1993-04-01), XP002221280, retrieved from EMBL Database accession no. X72861 *
DRYSDALE C M ET AL: "COMPLEX PROMOTER AND CODING REGION BETA2-ADRENERGIC RECEPTOR HAPLOTYPES ALTER RECEPTOR EXPRESSION AND PREDICT IN VIVO RESPONSIVENESS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 19, 12 September 2000 (2000-09-12), pages 10483 - 10488, XP002940094, ISSN: 0027-8424 *
GAUTHIER C ET AL: "beta3-Adrenoceptors in the cardiovascular system", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 21, no. 11, 1 November 2000 (2000-11-01), pages 426 - 431, XP004220561, ISSN: 0165-6147 *
JUDSON RICHARD J: "THE PREDICTIVE POWER OF HAPLOTYPES IN CLINICAL RESPONSE", PHARMOCOGENOMICS, vol. 1, no. 1, February 2000 (2000-02-01), pages 15 - 26, XP002221279 *
MICHALATOS-BELOIN S ET AL: "MOLECULAR HAPLOTYPING OF GENETIC MARKERS 10 KB APART BY ALLELE-SPECIFIC LONG-RANGE PCR", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 24, no. 23, 1996, pages 4841 - 4843, XP002939512, ISSN: 0305-1048 *
SILVER KRISTI ET AL: "Molecular scanning of the beta-3-adrenergic receptor gene in Pima Indians and Caucasians.", DIABETES-METABOLISM RESEARCH AND REVIEWS, vol. 15, no. 3, May 1999 (1999-05-01), pages 175 - 180, XP002221278, ISSN: 1520-7552 *
SPRONSEN VAN A ET AL: "THE PROMOTER AND INTRON/EXON STRUCTURE OF THE HUMAN AND MOUSE SS3-ADRENERGIC-RECEPTOR GENES", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 213, no. 3, X72861, 1993, pages 1117 - 1124, XP000910637, ISSN: 0014-2956, Retrieved from the Internet <URL:EMBL> *
ULBRECHT M ET AL: "Assoziation of beta 2-adrenoreceptor variants with bronchial hyperresponsiveness", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 161, no. 2, February 2000 (2000-02-01), pages 469 - 474, XP002188594, ISSN: 1073-449X *

Also Published As

Publication number Publication date
AU2001280727A1 (en) 2002-02-05
WO2002008425A2 (fr) 2002-01-31

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