WO2001079234A3 - Haplotypes du gene apoe - Google Patents

Haplotypes du gene apoe Download PDF

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Publication number
WO2001079234A3
WO2001079234A3 PCT/US2001/012303 US0112303W WO0179234A3 WO 2001079234 A3 WO2001079234 A3 WO 2001079234A3 US 0112303 W US0112303 W US 0112303W WO 0179234 A3 WO0179234 A3 WO 0179234A3
Authority
WO
WIPO (PCT)
Prior art keywords
apoe
haplotypes
gene
apoe gene
disclosed
Prior art date
Application number
PCT/US2001/012303
Other languages
English (en)
Other versions
WO2001079234A2 (fr
Inventor
Julie Y Choi
Stephanie E Kliem
Beena Koshy
Helen H Lee
Original Assignee
Genaissance Pharmaceuticals
Julie Y Choi
Stephanie E Kliem
Beena Koshy
Helen H Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Julie Y Choi, Stephanie E Kliem, Beena Koshy, Helen H Lee filed Critical Genaissance Pharmaceuticals
Priority to AU2001255403A priority Critical patent/AU2001255403A1/en
Publication of WO2001079234A2 publication Critical patent/WO2001079234A2/fr
Publication of WO2001079234A3 publication Critical patent/WO2001079234A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux polymorphismes à simple nucléotide du gène de l'apolipoprotéine E (APOE) humaine. Cette invention concerne également : différents génotypes, haplotypes et paires d'haplotypes du gène APOE, qui existent dans la population ; des compositions et des procédés permettant l'haplotypage et/ou le génotypage du gène APOE chez un individu ; des polynucléotides contenant un ou plusieurs polymorphismes APOE de l'invention.
PCT/US2001/012303 2000-04-14 2001-04-16 Haplotypes du gene apoe WO2001079234A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001255403A AU2001255403A1 (en) 2000-04-14 2001-04-16 Haplotypes of the apoe gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19718800P 2000-04-14 2000-04-14
US60/197,188 2000-04-14

Publications (2)

Publication Number Publication Date
WO2001079234A2 WO2001079234A2 (fr) 2001-10-25
WO2001079234A3 true WO2001079234A3 (fr) 2002-01-24

Family

ID=22728397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/012303 WO2001079234A2 (fr) 2000-04-14 2001-04-16 Haplotypes du gene apoe

Country Status (2)

Country Link
AU (1) AU2001255403A1 (fr)
WO (1) WO2001079234A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2409774A1 (fr) * 2000-05-23 2001-11-29 Variagenics, Inc. Methodes d'analyse genetique d'adn servant a detecter des variances de sequence
US7435541B2 (en) 2000-05-23 2008-10-14 Sequenom, Inc. Restriction enzyme genotyping
EP1465998A2 (fr) * 2002-01-08 2004-10-13 Bayer HealthCare AG Polymorphismes mononucleotidiques servant a predire une maladie cardiovasculaire et l'efficacite de medicaments
JP4143756B2 (ja) * 2002-06-21 2008-09-03 財団法人名古屋産業科学研究所 心筋梗塞のリスク診断方法
US20050277129A1 (en) * 2004-01-22 2005-12-15 Genaissance Pharmaceuticals APOE genetic markers associated with age of onset of Alzheimer's disease
WO2007092380A2 (fr) * 2006-02-06 2007-08-16 Berkeley Heartlab, Inc. gEnotypage de l'apolipoprotEine E et systEme de gestion de la santE basE sur internet pour l'accompagnement

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARTIGA ET AL.: "Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene", FEBS LETTERS, vol. 421, no. 2, January 1998 (1998-01-01), pages 105 - 108, XP002947338 *
NICKERSON ET AL.: "Sequence diversity and large-scale typing of SNPs in the human apoliprotein E gene", GENOME RESEARCH, vol. 10, no. 10, October 2000 (2000-10-01), pages 1532 - 1545, XP002947337 *
PAIK ET AL.: "Nucleotide sequence and structure of the human apolipoprotein E gene", PROC. NATL. ACAD. SCI. USA, vol. 82, May 1985 (1985-05-01), pages 3445 - 3449, XP002947336 *
SAMBROOK ET AL.: "Molecular cloning: a laboratory manual", 1989, COLD SPRING HARBOR LABORATORY PRESS, COLD SPRING HARBOR, XP002947335 *

Also Published As

Publication number Publication date
WO2001079234A2 (fr) 2001-10-25
AU2001255403A1 (en) 2001-10-30

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