WO2002016597A3 - Lipid metabolism enzymes - Google Patents

Lipid metabolism enzymes Download PDF

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Publication number
WO2002016597A3
WO2002016597A3 PCT/US2001/026365 US0126365W WO0216597A3 WO 2002016597 A3 WO2002016597 A3 WO 2002016597A3 US 0126365 W US0126365 W US 0126365W WO 0216597 A3 WO0216597 A3 WO 0216597A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid metabolism
lmm
metabolism enzymes
provides
polynucleotides
Prior art date
Application number
PCT/US2001/026365
Other languages
French (fr)
Other versions
WO2002016597A2 (en
Inventor
Jennifer A Griffin
Chandra S Arvizu
Ameena R Gandhi
Yan Lu
Monique G Yao
Mariah R Baughn
Narinder K Chawla
April J A Hafalia
Li Ding
Catherine M Tribouley
Debopriya Das
Michael Thornton
Preeti Lal
Original Assignee
Incyte Genomics Inc
Jennifer A Griffin
Chandra S Arvizu
Ameena R Gandhi
Yan Lu
Monique G Yao
Mariah R Baughn
Narinder K Chawla
April J A Hafalia
Li Ding
Catherine M Tribouley
Debopriya Das
Michael Thornton
Preeti Lal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Jennifer A Griffin, Chandra S Arvizu, Ameena R Gandhi, Yan Lu, Monique G Yao, Mariah R Baughn, Narinder K Chawla, April J A Hafalia, Li Ding, Catherine M Tribouley, Debopriya Das, Michael Thornton, Preeti Lal filed Critical Incyte Genomics Inc
Priority to JP2002522270A priority Critical patent/JP2004527216A/en
Priority to AU2001286678A priority patent/AU2001286678A1/en
Priority to EP01966141A priority patent/EP1339854A2/en
Priority to US10/362,628 priority patent/US20040048269A1/en
Priority to CA002417787A priority patent/CA2417787A1/en
Publication of WO2002016597A2 publication Critical patent/WO2002016597A2/en
Publication of WO2002016597A3 publication Critical patent/WO2002016597A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention provides human lipid metabolism enzymes (LMM) and polynucleotides which identify and encode LMM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LMM.
PCT/US2001/026365 2000-08-23 2001-08-22 Lipid metabolism enzymes WO2002016597A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2002522270A JP2004527216A (en) 2000-08-23 2001-08-22 Lipid metabolizing enzymes
AU2001286678A AU2001286678A1 (en) 2000-08-23 2001-08-22 Lipid metabolism enzymes
EP01966141A EP1339854A2 (en) 2000-08-23 2001-08-22 Lipid metabolism enzymes
US10/362,628 US20040048269A1 (en) 2001-08-22 2001-08-22 Lipid metabolism enzymes
CA002417787A CA2417787A1 (en) 2000-08-23 2001-08-22 Lipid metabolism enzymes

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US22742900P 2000-08-23 2000-08-23
US60/227,429 2000-08-23
US23137000P 2000-09-08 2000-09-08
US60/231,370 2000-09-08
US23321200P 2000-09-15 2000-09-15
US60/233,212 2000-09-15
US23688500P 2000-09-29 2000-09-29
US60/236,885 2000-09-29

Publications (2)

Publication Number Publication Date
WO2002016597A2 WO2002016597A2 (en) 2002-02-28
WO2002016597A3 true WO2002016597A3 (en) 2003-06-26

Family

ID=27499475

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026365 WO2002016597A2 (en) 2000-08-23 2001-08-22 Lipid metabolism enzymes

Country Status (5)

Country Link
EP (1) EP1339854A2 (en)
JP (1) JP2004527216A (en)
AU (1) AU2001286678A1 (en)
CA (1) CA2417787A1 (en)
WO (1) WO2002016597A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002038773A2 (en) 2000-11-08 2002-05-16 Millennium Pharmaceuticals, Inc. A human phospholipase c and uses thereof
US6867030B2 (en) * 2001-03-29 2005-03-15 Applera Corporation Isolated human lipase proteins, nucleic acid molecules encoding human lipase proteins, and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986001532A1 (en) * 1984-08-21 1986-03-13 Celltech Limited Polypeptide and polypeptide composition
WO1999024587A2 (en) * 1997-11-07 1999-05-20 Incyte Pharmaceuticals, Inc. Human phospholipase a2 protein and dna encoding it
WO2002036754A2 (en) * 2000-10-31 2002-05-10 Bayer Aktiengesellschaft Nucleotide and polypeptide sequence of human lysosomal acid lipase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986001532A1 (en) * 1984-08-21 1986-03-13 Celltech Limited Polypeptide and polypeptide composition
WO1999024587A2 (en) * 1997-11-07 1999-05-20 Incyte Pharmaceuticals, Inc. Human phospholipase a2 protein and dna encoding it
WO2002036754A2 (en) * 2000-10-31 2002-05-10 Bayer Aktiengesellschaft Nucleotide and polypeptide sequence of human lysosomal acid lipase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANDERSON R A ET AL: "Cloning and expression of cDNA encoding human lysosomal acid lipase/cholestreryl ester hydrolase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 266, no. 33, 25 November 1991 (1991-11-25), pages 22479 - 22484, XP002192752, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
CA2417787A1 (en) 2002-02-28
AU2001286678A1 (en) 2002-03-04
WO2002016597A2 (en) 2002-02-28
EP1339854A2 (en) 2003-09-03
JP2004527216A (en) 2004-09-09

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