WO2002015949A8 - Dispositif pour l'identification d'une sequence nucleotidique dans un echantillon d'adn - Google Patents

Dispositif pour l'identification d'une sequence nucleotidique dans un echantillon d'adn

Info

Publication number
WO2002015949A8
WO2002015949A8 PCT/US2001/026555 US0126555W WO0215949A8 WO 2002015949 A8 WO2002015949 A8 WO 2002015949A8 US 0126555 W US0126555 W US 0126555W WO 0215949 A8 WO0215949 A8 WO 0215949A8
Authority
WO
WIPO (PCT)
Prior art keywords
sample
chamber
nucleotide
dna sample
membrane
Prior art date
Application number
PCT/US2001/026555
Other languages
English (en)
Other versions
WO2002015949A9 (fr
WO2002015949A2 (fr
WO2002015949A3 (fr
Inventor
James Benn
Jean-Francois Manchec
Original Assignee
Genome Therapeutics Corp
James Benn
Jean-Francois Manchec
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genome Therapeutics Corp, James Benn, Jean-Francois Manchec filed Critical Genome Therapeutics Corp
Priority to AU2001286756A priority Critical patent/AU2001286756A1/en
Publication of WO2002015949A2 publication Critical patent/WO2002015949A2/fr
Publication of WO2002015949A8 publication Critical patent/WO2002015949A8/fr
Publication of WO2002015949A3 publication Critical patent/WO2002015949A3/fr
Publication of WO2002015949A9 publication Critical patent/WO2002015949A9/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4005—Concentrating samples by transferring a selected component through a membrane
    • G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

L'invention concerne un système et un procédé permettant d'identifier des séquences nucléotidiques spécifiques dans un échantillon d'ADN cible. Le système de détection comprend une cellule de détection à plaque plate équipée d'une chambre à échantillon, d'une membrane et d'une fenêtre optique assurant l'accès optique à l'intérieur de la cellule. Un échantillon d'ADN cible est mélangé avec des nucléotides étiquetés et autres substances chimiques, puis soumis à une réaction chimique. Si la séquence nucléotidique est présente, le mélange renfermera des nucléotides étiquetés dont le poids moléculaire est altéré. L'échantillon ayant subi la réaction est appliqué à la chambre et la membrane du système sépare de l'échantillon les étiquettes de poids moléculaire inférieur. Ensuite, la présence de telle ou telle étiquette dans la chambre à échantillon ou la chambre à filtrat ou sur la membrane elle-même est décelée à travers la fenêtre optique vers la chambre à échantillon ou à travers une fenêtre optique vers la chambre à filtrat pour déterminer la présence ou l'absence de la séquence.
PCT/US2001/026555 2000-08-25 2001-08-24 Dispositif pour l'identification d'une sequence nucleotidique dans un echantillon d'adn WO2002015949A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001286756A AU2001286756A1 (en) 2000-08-25 2001-08-24 Device for identifying the presence of a nucleotide sequence in a dna sample

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22823900P 2000-08-25 2000-08-25
US60/228,239 2000-08-25
US26603501P 2001-02-02 2001-02-02
US60/266,035 2001-02-02

Publications (4)

Publication Number Publication Date
WO2002015949A2 WO2002015949A2 (fr) 2002-02-28
WO2002015949A8 true WO2002015949A8 (fr) 2002-07-04
WO2002015949A3 WO2002015949A3 (fr) 2002-10-03
WO2002015949A9 WO2002015949A9 (fr) 2003-03-27

Family

ID=26922164

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/026555 WO2002015949A2 (fr) 2000-08-25 2001-08-24 Dispositif pour l'identification d'une sequence nucleotidique dans un echantillon d'adn
PCT/US2001/026611 WO2002016652A2 (fr) 2000-08-25 2001-08-24 Dispositif de traitement rapide d'echantillons d'adn, par manipulation, thermocyclage et purification integrees de liquides

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026611 WO2002016652A2 (fr) 2000-08-25 2001-08-24 Dispositif de traitement rapide d'echantillons d'adn, par manipulation, thermocyclage et purification integrees de liquides

Country Status (2)

Country Link
AU (2) AU2001286756A1 (fr)
WO (2) WO2002015949A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030077611A1 (en) 2001-10-24 2003-04-24 Sention Methods and systems for dynamic gene expression profiling
US7445893B2 (en) 2002-04-12 2008-11-04 Primera Biosystems, Inc. Sampling method for amplification reaction analysis
US7081339B2 (en) 2002-04-12 2006-07-25 Primera Biosystems, Inc. Methods for variation detection
EP1563097A4 (fr) * 2002-11-21 2006-03-15 Primera Biosystems Procede et dispositif d'echantillonnage permettant d'analyser des reactions d'amplification
EP1715954A1 (fr) 2004-02-18 2006-11-02 Applera Corporation Essais biologiques a etapes multiples sur des plates-formes d'applications micro-fluidiques modulaires
DE102005010096B3 (de) * 2005-03-04 2006-11-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Assay mit osmotisch induzierter Abtrennung und Anreicherung hochmolekularer nachzuweisender Substanzen und fluidisches Mikrosystem zu seiner Durchführung
WO2007120515A1 (fr) * 2006-04-07 2007-10-25 Corning Incorporated Microplaque fermée à écoulement continu et modes d'utilisation et procédés de fabrication de celle-ci
DE102007011866A1 (de) * 2007-03-08 2008-09-11 Friedrich-Schiller-Universität Jena Vorrichtung zur Aufnahme, Behandlung und Aufbewahrung kleinvolumiger Proben
WO2011009073A1 (fr) * 2009-07-16 2011-01-20 Abbott Laboratories Procédé d'amplification d'acides nucléiques
WO2013135878A1 (fr) 2012-03-16 2013-09-19 Stat-Diagnostica & Innovation, S.L. Cartouche de test à module de transfert intégré
JP6894617B2 (ja) * 2018-10-29 2021-06-30 Nok株式会社 マイクロ流体チップおよびマイクロ流体デバイス
EP4288206A1 (fr) * 2021-02-05 2023-12-13 Quantoom Biosciences France SAS Dispositif de réactions en plusieurs étapes thermocyclée amélioré

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591493A (en) * 1968-06-17 1971-07-06 Rashid A Zeineh Method for the treatment of biological fluids and apparatus therefor
GB8629740D0 (en) * 1986-12-12 1987-01-21 Iq Bio Ltd Immunoassay
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5010930A (en) * 1989-12-22 1991-04-30 Eastman Kodak Company Pipette and liquid transfer apparatus for dispensing liquid for analysis
US5733442A (en) * 1990-12-07 1998-03-31 Shukla; Ashok K. Microdialysis/Microelectrodialysis system
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
WO1994025876A1 (fr) * 1993-04-29 1994-11-10 Danfoss A/S Dispositif d'analyse d'un milieu fluide
WO2000044497A1 (fr) * 1999-01-29 2000-08-03 Genomic Instrumentation Services, Inc. Dispositif de pipettes
DE19950385A1 (de) * 1999-01-29 2000-08-03 Max Planck Gesellschaft Verfahren zur Isolation von Apoptose-induzierenden DNA-Sequenzen und Detektionssystem
DE10005024C2 (de) * 2000-02-04 2002-09-26 Eppendorf Ag Dialysestopfen

Also Published As

Publication number Publication date
AU2001286756A1 (en) 2002-03-04
WO2002015949A9 (fr) 2003-03-27
WO2002016652A3 (fr) 2003-07-10
AU2001286784A1 (en) 2002-03-04
WO2002015949A2 (fr) 2002-02-28
WO2002016652A2 (fr) 2002-02-28
WO2002015949A3 (fr) 2002-10-03

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