WO2002010032A2 - Systemes de stockage et dispositif associe - Google Patents

Systemes de stockage et dispositif associe Download PDF

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Publication number
WO2002010032A2
WO2002010032A2 PCT/EP2001/008723 EP0108723W WO0210032A2 WO 2002010032 A2 WO2002010032 A2 WO 2002010032A2 EP 0108723 W EP0108723 W EP 0108723W WO 0210032 A2 WO0210032 A2 WO 0210032A2
Authority
WO
WIPO (PCT)
Prior art keywords
cover
cavity
storage
piercing
reaction chambers
Prior art date
Application number
PCT/EP2001/008723
Other languages
English (en)
Other versions
WO2002010032A3 (fr
Inventor
Nicholas David Long
Michael Thomas Pearson
Keith Rawson
Original Assignee
Cambridge Life Sciences Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Life Sciences Plc filed Critical Cambridge Life Sciences Plc
Publication of WO2002010032A2 publication Critical patent/WO2002010032A2/fr
Publication of WO2002010032A3 publication Critical patent/WO2002010032A3/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B65D75/367—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/36—One sheet or blank being recessed and the other formed or relatively stiff flat sheet material, e.g. blister packages
    • B65D2575/361—Details
    • B65D2575/362—Details with special means for gaining access to the contents
    • B65D2575/365—Details with special means for gaining access to the contents partially or totally releasing one sheet from the other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/36—One sheet or blank being recessed and the other formed or relatively stiff flat sheet material, e.g. blister packages
    • B65D2575/361—Details
    • B65D2575/368—Details with reclosing means

Definitions

  • This invention relates, in one embodiment, to storage devices and, in another embodiment, to associated apparatus - for example to testing apparatus including such storage devices.
  • the pack comprises a plastic substrate 1 in which a plurality of storage cavities 3 has been formed.
  • the storage cavities and typically the whole of the substrate, are covered with a piercable foil cover (not visible).Within each of the cavities there is provided a solid tablet (not visible).
  • the plastics substrate 1 is typically thin enough, or of such suitable material - at least in the region of each cavity, to enable it to be deformed towards the cover to drive the tablet in a given cavity towards the cover to pierce the same so that the tablet may be removed from the pack for use.
  • the tablet acts as a tool for piercing the cover, and these previously proposed blister packs have become very popular for the supply and storage of pharmaceuticals.
  • Another previously proposed storage device particularly for fluids, comprises a cavity formed in a plastics body over which a cover is provided.
  • Such storage devices have been used for a variety of different purposes, and one common use is for the storage of small quantities of milk that can be removed from the storage device to whiten tea or coffee, for example.
  • the user To remove the milk or other fluid from the storage device, the user must first peal the cover from the body by pulling on a portion of the cover to break the seal between the cover and the body.
  • some of the liquid, in this case milk to spill from the body when the device is opened.
  • DE 4400083 A1 describes a blister pack for finely dispersed solid contents, which blister pack comprises a container foil comprising at least one cavity and a cover foil.
  • the described elements make it possible to easily remove solid contents to a large amount from a blister pack without impairing the finely dispersed form of the solid contents.
  • a first embodiment of the invention provides a storage device for fluids, the device comprising means defining a storage cavity; a cover for said cavity, and piercing means integral with said cavity defining means for piercing said cover.
  • This embodiment of the invention alleviates the above described problems as the contents of the storage device are no longer responsible for piercing the cover - that being undertaken by the piercing means - with the effect that the storage device is now suitable for the storage of fluid (although it will be appreciated that the device may still be used for the storage of solids if desired).
  • one advantage of a particular preferred aspect of this first embodiment is that it reduces the likelihood of fluid stored in the device becoming trapped in the cavity when the cover is pierced as the cover is pushed away from the device. In other words, one can be confident that when the cover is pierced substantially all of the fluid, for example, within the device may then be removed. Because of this, the storage device according to the first embodiment of this invention also finds utility in the field of testing apparatus.
  • a storage device for fluids comprising means defining a storage cavity; a cover for said cavity, and piercing means external to said cavity defining means and operable to drive the cavity defining means to reduce the volume of the cavity and to cause the cover to be pierced from within the cavity.
  • the testing apparatus comprises a plastics body 10 in which a pair of reaction chambers 12 are formed.
  • the chambers 12 are closable with a lid 14, and have provided therein freeze-dried reagents 16.
  • This previously proposed testing apparatus further comprises a dropper bottle 18 for solvent such as buffer solution, for example.
  • the testing apparatus is operable to test for the presence of Helicobacter pylori and the freeze-dried reagents include urea.
  • a biopsy is taken from the patient's gut and placed in the reaction chambers. Buffer solution is added from the dropper bottle to reconstitute the freeze-dried reagents, and the test is left for half an hour or so to allow the reaction to take place. If the patient has Helicobacter pylori in their gut, then the reaction mixture will turn pink and if Helicobacter pylon are not present then the reaction mixture will remain a yellow/orange colour. Whilst this previously proposed testing apparatus has previously been operated with great success, various problems have been encountered.
  • reaction time i.e. the time required for the reagents to indicate whether or not the patient sample contains Helicobacter pylon
  • the reaction time is heavily dependent upon the amount of solvent placed in the reaction chambers. With a few drops of solvent, the reaction time should be in the region of thirty minutes, however with more solvent the reaction time can increase to several hours. This is undesirable for a "while you wait" test.
  • testing apparatus comprising one or more reaction chambers, means for sealing said reaction chambers, and means for dispensing a predetermined amount of fluid into said one or more reaction chambers.
  • This aspect of the invention alleviates the above mentioned reaction time problems by enabling a predetermined amount of fluid (which may be a solvent, a liquid reagent or a powder) to be dispensed into the reaction chambers.
  • a predetermined amount of fluid which may be a solvent, a liquid reagent or a powder
  • the dispensing means comprises an integral component of said testing apparatus. More preferably, the dispensing means comprises an integral component of said sealing means.
  • Figure 1 is a schematic representation of the underside of a previously proposed blister pack
  • Figure 2 is a cross-sectional view of a storage device according to a first embodiment of the invention
  • Figure 3 is a schematic representation of a previously proposed testing apparatus
  • Figure 4 is a schematic representation of a testing apparatus according to a second embodiment of the invention that includes storage devices similar to those shown in Figure 2
  • Figure 5 is a cross-sectional view along the line IV- IV of Figure 4.
  • Figure 1 shows a previously proposed blister pack, which comprises a plastics substrate 1 in which a plurality of storage cavities 3 have been formed.
  • the storage cavities and typically the whole of the substrate, are covered with a piercable foil cover.
  • Within each of the cavities there is provided a solid tablet.
  • the plastics substrate 1 is typically thin enough, or of such suitable material (at least in the region of each cavity) to enable it to be deformed towards the cover. Deforming the substrate in this way drives the tablet in a given cavity towards the cover 5 to pierce the same so that the tablet may be removed from the pack for use.
  • these blister packs are useful for the supply of tablets, they are unsuitable for the storage of fluids as the cover cannot easily be pierced by deforming a fluid filled cavity towards it.
  • FIG 2 is a schematic representation of a storage device 30 according to a first embodiment of the invention that is suitable for the storage of fluids (although it will be appreciated that it could also be used for the storage of solids).
  • the fluid may be a solvent, a reagent or a solute (in liquid or powder form).
  • the illustrative storage device is shown storing a liquid 31 that may be a chemical reagent or a solvent, or both or a fluid, milk for example.
  • Figure 2 shows a single storage device, it will be appreciated that blister packs similar to those of Figure 1 may be formed that comprise a plurality of storage devices such as those shown in Figure 2.
  • the storage device 30 comprises a support material 32 (preferably of plastics material with low moisture vapour transmission rate) in which a cavity 34 has been formed.
  • the cavity 34 contains a predetermined quantity of fluid 31 and is covered with a cover 36 that is preferably of foil or similar material so that it may easily be pierced and also have low moisture vapour transmission rate to give stability to the contents of the storage device over the storage lifetime.
  • the substrate 32 is typically thin enough, or of such suitable material - at least in the region of the cavity 34, to enable it to be deformed towards the cover 36.
  • piercing means 38 that in this embodiment comprises a spike. Whilst it is preferred for manufacturing simplicity that the piercing means comprises a spike, it will be appreciated that many alternative arrangements may instead be provided.
  • the piercing means is formed as an integral component of the substrate, and preferably as an integral component of the portion of the substrate that defines the cavity.
  • the substrate 32 in the region of the cavity may be deformed, by squeezing for example, towards the cover to drive the piercing means (i.e. the spike) to pierce the cover.
  • the cover Once the cover has been pierced fluid, for example, within the storage device may then be dispensed therefrom.
  • the likelihood of fluid being trapped within the storage device is reduced as fractured cover portions will be driven away from the support material, and thus there will be less chance that they will interfere with fluid flow from the storage device.
  • the means for piercing the cavity may be external to the device and operable to drive the substrate towards the cover so that the pressure in the cavity is increased to the point at which the cover bursts.
  • the external piercing means may simply pierce the substrate and cover without relying on an increase in pressure to cause cover fracture. This embodiment of the invention alleviates the spillage problems associated with pulling the cover from the substrate, and also avoids the problems associated with fluid being retained in the device once the cover has been pierced.
  • the piercing means may simply comprise a spike.
  • FIG 3 is a schematic representation of a previously proposed testing apparatus.
  • the testing apparatus comprises a plastics body 10 in which a pair of reaction chambers 12 are formed.
  • the chambers 12 are closable with a lid 14, and have provided therein freeze-dried reagents 16.
  • This previously proposed testing apparatus further comprises a dropper bottle 18 for solvent such as buffer solution, for example.
  • the plastics body is extended so that the bottle 18 may be stored in the region 19 of the body shown in ghost.
  • samples of tissue from a patient's body are placed in the reaction chambers and the freeze-dried reagents are then reconstituted by the addition of drops of buffer from the dropper bottle 18.
  • the lid 14 is then closed and the apparatus is left until the test is completed.
  • Figure 4 is a schematic representation of a testing apparatus 40 according to a second embodiment of the invention that includes storage devices similar to those shown in Figure 2; and Figure 5 is a cross- sectional view along the line V- -V of Figure 4.
  • the testing apparatus 40 comprises a main body 42 in which a pair of reaction chambers 44 have been formed.
  • the reaction chambers 44 can be sealed by a lid 46, which is pivotally attached to the main body 42.
  • the lid has a pair of storage devices 48 integrally formed therewith, one for each of the two reaction chambers 44.
  • the storage devices 48 are similar to those shown in Figure 2 and each comprise a cavity 50, which is covered by a cover 52 (preferably of foil).
  • the base of each of the cavities include piercing means 54 (which in this embodiment are a spike) that are drive- able towards the cover to pierce the same, and thereby to release the fluid stored within.
  • the apparatus of Figure 4 in this illustrative example, is suitable for use as a "while you wait" test for Helicobacter pylori. It will be appreciated, however, that the testing apparatus may be used for a variety of different diagnostic tests.
  • the storage devices store buffer solution as a solvent
  • the reaction chambers each include a freeze-dried reagent 16 that includes urea.
  • patient samples in this case biopsies from the patient's gut
  • the lid is closed to seal the chambers.
  • the storage devices are then operated by pressing on the wall of each cavity to drive the spikes towards their respective covers. Once the spikes have pierced the covers, the fluid within the storage devices is then free to run into the reaction chambers to reconstitute the freeze-dried reagents so that the test can take place. If the patient does have Helicobacter pylon in their gut, then the reaction mixture will turn pink. On the other hand, if the patient does not have Helicobacter pylon, then the reaction mixture will remain yellow/orange.
  • the second embodiment of the invention avoids problems associated with increased reaction times, as only a predetermined quantity of fluid is dispensed into the reaction chambers and is therefore simpler to use.
  • the apparatus of the second embodiment is more environmentally friendly than previously proposed devices.
  • the cover of the said storage device may have attached to the outside an absorbent pad, such as glass fibre or paper. Once the foil is pierced the fluid is absorbed into the absorbent pad which can be used for controlling the rate of fluid delivery for example if the storage device was coupled to a lateral flow immunoassay test strip or flow through immunoassay device.
  • an absorbent pad such as glass fibre or paper.
  • the storage device described herein may be used with the diagnostic testing apparatus, and in particular as a storage device for wash and/or reagent solution.

Abstract

Une première forme de réalisation de cette invention concerne un système de stockage de fluides. Ce système comprend des moyens définissant une cavité de stockage, un opercule fermant cette cavité, et des moyens de perforation formés d'un seul tenant avec la cavité et permettant de perforer l'opercule. Une seconde forme de réalisation de cette invention concerne un dispositif de test comprenant une ou plusieurs chambres de réaction, des moyens permettant de fermer hermétiquement ces chambres de réaction et des moyens permettant de distribuer une quantité de fluide prédéterminée dans ces chambres de réaction.
PCT/EP2001/008723 2000-07-31 2001-07-27 Systemes de stockage et dispositif associe WO2002010032A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0018740.1 2000-07-31
GB0018740A GB2365414A (en) 2000-07-31 2000-07-31 Storage devices for fluids

Publications (2)

Publication Number Publication Date
WO2002010032A2 true WO2002010032A2 (fr) 2002-02-07
WO2002010032A3 WO2002010032A3 (fr) 2002-11-07

Family

ID=9896674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008723 WO2002010032A2 (fr) 2000-07-31 2001-07-27 Systemes de stockage et dispositif associe

Country Status (2)

Country Link
GB (1) GB2365414A (fr)
WO (1) WO2002010032A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7662745B2 (en) 2003-12-18 2010-02-16 Kimberly-Clark Corporation Stretchable absorbent composites having high permeability
US7772456B2 (en) 2004-06-30 2010-08-10 Kimberly-Clark Worldwide, Inc. Stretchable absorbent composite with low superaborbent shake-out
US7811948B2 (en) 2003-12-19 2010-10-12 Kimberly-Clark Worldwide, Inc. Tissue sheets containing multiple polysiloxanes and having regions of varying hydrophobicity
US7872168B2 (en) 2003-10-31 2011-01-18 Kimberely-Clark Worldwide, Inc. Stretchable absorbent article
US8324446B2 (en) 2004-06-30 2012-12-04 Kimberly-Clark Worldwide, Inc. Unitary absorbent core with binding agents
EP1783497A3 (fr) * 2003-08-20 2013-03-13 Sysmex Corporation Analyseur d'échantillon, détecteur d'acide nucléique et procédé de détection de l'acide nucléique

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US3715189A (en) * 1970-06-15 1973-02-06 Secretary Of The Treasury Qualitative analysis device
FR2245947A1 (en) * 1973-09-27 1975-04-25 Erba Carlo Spa Analytical cartridge for spectrophotometric determinations - useful for routine testing in biochemical work
DE2533052A1 (de) * 1975-07-24 1977-01-27 Behringwerke Ag Verschluss fuer reaktionsgefaess
US4136202A (en) * 1976-12-17 1979-01-23 Societe D'assistance Technique Pour Produits Nestle S.A. Capsule for beverage preparation
EP0290019A2 (fr) * 1987-05-08 1988-11-09 Abbott Laboratories Fermeture pour flacon
US4785931A (en) * 1987-09-24 1988-11-22 Letica Corporation Molded plastic closure having integral stacking support ribs and rupturable mix compartments
US5255812A (en) * 1992-07-01 1993-10-26 Hsu Yu T Container cap
WO1997025925A2 (fr) * 1996-01-19 1997-07-24 Huliot Plastics Industries Collecte et transport d'un echantillon de matiere pateuse
WO1997048492A1 (fr) * 1996-06-19 1997-12-24 Orion-Yhtymä Oyj Bouchon creux contenant des reactifs et technique d'analyse utilisant ce bouchon
WO1998003265A1 (fr) * 1996-07-18 1998-01-29 Kyoritsu Chemical-Check Lab., Corp. Recipient a reactif tenant dans un bouchon, pour reactifs d'analyse

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1783497A3 (fr) * 2003-08-20 2013-03-13 Sysmex Corporation Analyseur d'échantillon, détecteur d'acide nucléique et procédé de détection de l'acide nucléique
US7872168B2 (en) 2003-10-31 2011-01-18 Kimberely-Clark Worldwide, Inc. Stretchable absorbent article
US8852381B2 (en) 2003-10-31 2014-10-07 Kimberly-Clark Worldwide, Inc. Stretchable absorbent article
US10285868B2 (en) 2003-10-31 2019-05-14 Kimberly-Clark Worldwide, Inc. Method for making a stretchable absorbent article
US7662745B2 (en) 2003-12-18 2010-02-16 Kimberly-Clark Corporation Stretchable absorbent composites having high permeability
US7811948B2 (en) 2003-12-19 2010-10-12 Kimberly-Clark Worldwide, Inc. Tissue sheets containing multiple polysiloxanes and having regions of varying hydrophobicity
US7772456B2 (en) 2004-06-30 2010-08-10 Kimberly-Clark Worldwide, Inc. Stretchable absorbent composite with low superaborbent shake-out
US8324446B2 (en) 2004-06-30 2012-12-04 Kimberly-Clark Worldwide, Inc. Unitary absorbent core with binding agents

Also Published As

Publication number Publication date
WO2002010032A3 (fr) 2002-11-07
GB0018740D0 (en) 2000-09-20
GB2365414A (en) 2002-02-20

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