WO2002006269A1 - Cyclische aminosäurederivate - Google Patents
Cyclische aminosäurederivate Download PDFInfo
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- WO2002006269A1 WO2002006269A1 PCT/EP2001/007595 EP0107595W WO0206269A1 WO 2002006269 A1 WO2002006269 A1 WO 2002006269A1 EP 0107595 W EP0107595 W EP 0107595W WO 0206269 A1 WO0206269 A1 WO 0206269A1
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- coo
- cooa
- conh
- coa
- phenyl
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- 0 C*c1n[o]c(*)n1 Chemical compound C*c1n[o]c(*)n1 0.000 description 1
- MSHWTKGAZGNGGH-UHFFFAOYSA-N CC(C)C(N1)=NOC1=O Chemical compound CC(C)C(N1)=NOC1=O MSHWTKGAZGNGGH-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Definitions
- the invention relates to compounds of the formula
- R 2 , R 2 ' , R 2 " each independently of one another H, A, CF 3 , Cl, F, COA, COOH, COOA, CONH 2 , CONHA, CONA 2 , CH 2 NH 2 , CH2NHCOA, CH 2 NHCOOA, OH , OA, OCF 3 , N0 2 , S0 2 A, SO2NH 2 or S0 2 NHA,
- R 3 , R 4 together (CH 2 ) P , CO (CH 2 ) P , COO (CH 2 ) n ,
- R, R each independently of one another (CH 2 ) n -COOH, (CH 2 ) n -COO- (CH 2 ) n -Ar, Ar, Py or R 2 ,
- R 7 H A, Ar or Het,
- R 8 H (CH 2 ) n -COOH, (CH 2 ) m-COOA, (CH 2 ) m -COO- (CH 2 ) n-Ar, (CH 2 ) m-COO- (CH 2 ) n- Het, (CH 2 ) m -CONH 2 ,
- Y is missing, CH 2 , CO or S0 2 , A unbranched, branched or cyclic alkyl with 1-20 C-
- Atoms in which one or two CH 2 groups can be replaced by O or S atoms, -CH CH or -C ⁇ C and / or 1-7 H atoms by F, Ar is unsubstituted or mono-, double or triple through A, CF 3> shark, OH, OA, OCF 3 , S0 2 A, S0 2 NH 2> S0 2 NHA, S0 2 NA 2 , NH 2 ,
- n 1 or 2
- m 0, 1 or 2
- p 2, 3 or 4
- the invention also relates to the optically active forms, the racemates, the diastereomers and the hydrates and solvates, for example alcoholates, of these compounds.
- the invention was based on the task of finding new compounds with valuable properties, in particular those which can be used for the production of medicaments.
- the compounds of the formula I and their salts have very valuable pharmacological properties with good tolerability.
- they show factor Xa inhibitory properties and can therefore be used to combat and prevent thromboembolic disorders such as thrombosis, myocardial infarction, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and intermittent claudication.
- the compounds of the formula I according to the invention can furthermore be inhibitors of the coagulation factors factor VIIa, factor IXa and thrombin of the blood coagulation cascade.
- Aromatic amidine derivatives with antithrombotic activity are e.g. from EP 0 540 051 B1, WO 98/28269, WO 00/71508, WO 00/71511, WO 00/71493, WO 00/71507, WO 00/71509, WO 00/71512, WO 00/71515 or WO 00 / 71516 known.
- Cyclic guanidines for the treatment of thromboembolic diseases are e.g. described in WO 97/08165.
- Aromatic heterocycles with factor Xa inhibitory activity are e.g. known from WO 96/10022. Substituted N - [(aminoiminomethyl) phenylalkylj-azaheterocyclylamides as factor Xa inhibitors are described in WO 96/40679.
- the antithrombotic and anticoagulant effect of the compounds according to the invention is attributed to the inhibitory action against the activated coagulation protease, known under the name factor Xa, or to the inhibition of other activated serine proteases such as factor VIIa, factor IXa or thrombin.
- Factor Xa is one of the proteases involved in the complex process of blood clotting. Factor Xa catalyzes the conversion of prothrombin to thrombin. Thrombin cleaves fibrinogen into fibrin monomers which, after cross-linking, make an elementary contribution to thrombus formation. An ac Activation of thrombin can lead to the occurrence of thromboembolic disorders. However, inhibition of thrombin can inhibit fibrin formation involved in thrombus formation. The inhibition of thrombin can be measured, for example, by the method of GF Cousins et al. in Circulation 1996, 94, 1705-1712.
- Inhibition of factor Xa can thus prevent thrombin from being formed.
- the compounds of formula I according to the invention and their salts interfere with the blood coagulation process by inhibiting factor Xa and thus inhibit the formation of thrombi.
- the inhibition of factor Xa by the compounds according to the invention and the measurement of the anticoagulant and antithrombotic activity can be determined by customary in vitro or in vivo methods.
- a suitable method is e.g. by J. Hauptmann et al. in Thrombosis and Haemostasis 1990, 63, 220-223.
- the measurement of the inhibition of factor Xa can e.g. using the method of T. Hara et al. in thromb. Haemostas. 1994, 71, 314-319.
- the coagulation factor VIa initiates the extrinsic part of the coagulation cascade after binding to the tissue factor and contributes to the activation of factor X to factor Xa. Inhibition of factor VIIa thus prevents the formation of factor Xa and thus the subsequent formation of thrombin.
- the inhibition of factor VIa by the compounds according to the invention and the measurement of the anticoagulant and antithrombotic activity can be determined by customary in vitro or in vivo methods.
- a common method for measuring the inhibition of factor VIIa is e.g. by H. F. Ronning et al. in Thrombosis Research 1996, 84, 73-81.
- Coagulation factor IXa is generated in the intrinsic coagulation cascade and is also due to the activation of factor X to factor Xa tariat. Inhibition of factor IXa can therefore otherwise prevent factor Xa from being formed.
- the inhibition of factor IXa by the compounds according to the invention and the measurement of the anticoagulant and antithrombotic activity can be determined by customary in vitro or in vivo methods.
- the compounds according to the invention can furthermore be used for the treatment of tumors, tumor diseases and / or tumor metastases.
- the compounds of formula I can be used as active pharmaceutical ingredients in human and veterinary medicine, in particular for the treatment and prevention of thromboembolic disorders such as thrombosis, myocardial infarction, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty, intermittent claudication, venous Thrombosis, pulmonary embolism, arterial thrombosis, myocardial ischemia, unstable angina and thrombosis-based stroke.
- the compounds according to the invention are also used for the treatment or prophylaxis of atherosclerotic diseases such as coronary arterial disease, cerebral arterial disease or peripheral arterial disease.
- the compounds are also used in combination with other thrombolytics for myocardial infarction, as well as for prophylaxis for reocclusion after thrombolysis, percutaneous transluminal angioplasty (PTCA) and coronary bypass surgery.
- thromboembolic disorders such as thrombosis, myo
- the compounds according to the invention are also used for the prevention of rethrombosis in microsurgery, and also as anticoagulants in connection with artificial organs or in hemodialysis.
- the compounds are also used in the cleaning of catheters and medical devices in patients in vivo, or as anticoagulants for the preservation of blood, plasma and other blood products in vitro.
- the compounds according to the invention are also used in diseases in which blood coagulation makes a decisive contribution to the course of the disease or is a source of secondary pathology, such as, for example, cancer including metastasis, inflammatory diseases including arthritis, and diabetes.
- the compounds according to the invention are also used in combination with other thrombolytically active compounds, such as e.g. with the "tissue plasminogen activator" t-PA, modified t-PA, streptokinase or urokinase.
- t-PA tissue plasminogen activator
- modified t-PA modified t-PA
- streptokinase or urokinase.
- the compounds according to the invention are administered with the other substances mentioned either simultaneously or before or after.
- Simultaneous administration with aspirin is particularly preferred in order to prevent recurrence of thrombus formation.
- the compounds according to the invention are also used in combination with platelet glycoprotein receptor (Hb / llla) antagonists which inhibit platelet aggregation.
- Hb / llla platelet glycoprotein receptor
- the invention relates to the compounds of the formula I and their salts and to a process for the preparation of compounds of the formula I according to claim 1 and their salts, characterized in that they are prepared from one of their functional derivatives by treatment with a solvolysing or hydrogenolysing agent set free by
- A is also cycloalkyl and preferably means cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl.
- A therefore also means, for example, CF 3 or C 2 F.
- A very particularly preferably denotes methyl, ethyl, propyl, isopropyl, butyl, tert-butyl or CF 3 .
- Prodrug compounds are also those compounds of formula I in which R 8 ⁇ H.
- R 2 , R 2 , R 2 are preferably, for example, H or F.
- R 3 , R 4 together preferably mean, for example, (CH 2 ) 2 , (CH 2 ) 3 , (CH 2 ) 4 , (CH 2 ) 2 NHCH 2 , (CH 2 ) -N (COOA) -CH 2 , (CH 2 ) -N (CH 2 COOA) -CH 2 , (CH 2 ) -N (CH 2 COOH) -CH 2 , COCH 2 CH 2 , CO-NHCH 2 , COOCH 2> CH 2 OCH 2 ,
- R 5 preferably means, for example, S0 2 NH 2 , S0 2 NHA, CH 2 COOH, phenyl substituted simply by S0 2 NHA, S0 2 NH 2 or S0 2 A, unsubstituted or simply substituted by CONH 2 4-pyridyl.
- R 5 is preferably H or F.
- R, R and R are preferably H.
- R 6 preferably means, for example, methyl.
- R 7 preferably denotes, for example, H, methyl, ethyl, propyl, butyl or phenyl, but very particularly preferably H.
- R 8 preferably denotes, for example, H, CH 2 COOH, CH 2 CH 2 C00H, COOA, CH 2 COOA, CH 2 CH 2 COOA, COOPhenyl, CH 2 COOPhenyl, COOCH 2 phenyl, CH 2 COOCH 2 phenyl or CH 2 CONH 2 , where A is preferably alkyl having 1, 2, 3 or 4 carbon atoms.
- R 8 very particularly preferably denotes CH 2 COOH, COOA or CH 2 COOA, where A preferably denotes alkyl having 1, 2, 3 or 4 carbon atoms.
- R 8 also means, for example, S0 2 CH 3 .
- R 9 preferably denotes, for example, H, methyl, ethyl or benzyl.
- U preferably means e.g. CO.
- V preferably means e.g. NH.
- W is preferably absent.
- Y is preferably absent.
- Ar means unsubstituted or mono-, di- or trisubstituted phenyl or naphthyl.
- Preferred substituents for phenyl or naphthyl are, for example, methyl, ethyl, propyl, butyl, trifluoromethyl, F, Cl, hydroxy, methoxy, ethoxy, propoxy, isopropoxy, trifluoromethoxy, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, dimethylaminosulfonyl, amino, methyl amino, ethylamino, dimethylamino, diethylamino, formanido, acetamido, methoxycarbonylamino, ethoxycarbonylamino, methoxycarbonyl-N-methylamino, methylsulfonylamino, phenylsulfonylamino, carboxy, methoxycarbonyl,
- Ar ' preferably means e.g. unsubstituted or mono-, di- or trisubstituted phenyl.
- Preferred substituents are e.g. Methyl, methoxy, trifluoromethoxy, F, Cl, cyan acetamido, methoxycarbonyl, carboxy or methylsulfonyl.
- Het preferably means e.g. 2- or 3-furyl, 2- or 3-thienyl, 1-, 2- or 3-pyrrolyl, 1-, 2, 4- or 5-imidazolyl, 1-, 3-, 4- or 5-pyrazolyl, 2 -, 4- or 5-oxazolyl, 3-, 4- or 5-isoxazolyl, 2-, 4- or 5-thiazolyl, 3-, 4- or 5-isothiazolyl, 2-, 3- or 4-pyridyl, 2 -, 4-, 5- or 6-pyrimidinyl, further preferably 1, 2,3-triazol-1-, -4- or -5-yl, 1, 2,4-triazol-1-, -3- or 5 -yl, 1- or 5-tetrazolyl, 1, 2,3-oxadiazol-4- or -5-yl, 1, 2,4-oxadiazol-3- or - 5-yl, 1, 3,4-thiadiazol- 2- or -5-yl, 1, 2,4-thiadiazol-3- or -5-yl, 1, 2,3
- the heterocyclic radicals can also be partially or completely hydrogenated.
- Het can, for. B. also mean 2,3-dihydro-2-, -3-, -4- or -5-furyl, 2,5-dihydro-2-, -3-, -4- or 5-furyl, tetrahydro-2 - or -3-furyl, 1, 3-dioxolan-4-yl, tetrahydro-2- or -3-thienyl, 2,3-dihydro-1-, -2-, -3-, -4- or -5-pyrrolyl, 2,5-dihydro-1-, -2-, -3-, -4- or -5-pyrrolyl, 1-, 2- or 3-pyrrolidinyl, tetrahydro-1-, -2 - or -4-imidazolyl, 2,3-dihydro-1-, -2-, -3-, -4- or -5-pyrazolyl, tetrahydro-1-, -3- or -4-pyrazolyl, 1, 4
- Het particularly preferably means e.g. Furyl, thienyl, thiazolyl, imidazolyl, [2,1, 3] -benzothiadiazolyl, oxazolyl, pyridyl, indolyl, 1-methyl-piperidinyl, piperidinyl or pyrrolidinyl, pyridyl, 1-methyl-piperidin-4- is very particularly preferred yl or piperidin-4-yl.
- Py preferably means e.g. unsubstituted or simply substituted by aminocarbonyl 2-, 3- or 4-pyridyl.
- the compounds of the formula I can have one or more chiral centers and therefore exist in various stereoisomeric forms.
- Formula 1 encompasses all of these forms.
- the invention relates in particular to those compounds of the formula I in which at least one of the radicals mentioned has one of the preferred meanings indicated above.
- Some preferred groups of compounds can be expressed by the following sub-formulas Ia to Ih, which correspond to the formula I and in which the radicals not specified have the meaning given for the formula I, but in which
- Ar is phenyl
- R 2 , R 2 , R 2 each independently of one another H or F,
- Ar is phenyl
- R 1 F NH 2 , NHCOA, NHCOOA, NH- (CH 2 ) n -Ar, CN, CONH 2 ,
- R 2 , R 2 ' , R 2 " each independently of one another H or F, Ar phenyl,
- R 3 , R 4 together preferably mean, for example, (CH 2 ) 2 , (CH 2 ) 3 , (CH 2 ) 4 , (CH 2 ) 2 NHCH 2 , (CH 2 ) -N (COOA) -CH 2 , (CH 2 ) -N (CH 2 COOA) -CH 2 , (CH 2 ) -N (CH 2 COOH) -CH 2 , COCH 2 CH 2 , CO-NHCH 2 , COOCH 2 , CH 2 OCH 2 , -C [( CH 3 ) 2 ] -0-CH 2 , COOCH (A) -, CH 2 -S-CH 2 ,
- R 2 , R 2 , R 2 ' each independently of one another H or F, Ar phenyl,
- R 3 , R 4 together preferably mean, for example, (CH 2 ) 2, (CH) 3, (CH 2 ) 4 , (CH 2 ) 2 NHCH 2 , (CH 2 ) -N (COOA) -CH 2 , (CH 2 ) -N (CH 2 COOA) -CH 2 , (CH 2 ) -N (CH 2 COOH) -CH 2) COCH 2 CH 2 , CO-NHCH 2 , COOCH 2 , CH 2 OCH 2 , -C [(CH 3 ) 2 ] -0-CH 2 , COOCH (A) -, CH 2 -S-CH 2 , -C [(CH 3 ) 2 ] -S-CH 2 ,
- R 5 S0 2 NH 2 , S0 2 NHA, CH 2 COOH, simply substituted by S0 2 NHA, S0 2 NH 2 or S0 2 A, where A is alkyl with 1, 2, 3 or 4 carbon atoms or unsubstituted or simply 4-pyridyl substituted by CONH 2 ,
- R 5 , R 5 are H
- R 2 , R 2 , R 2 each independently of one another H or F, R 3 , R 4 together (CH 2 ) P , CO (CH 2 ) p , COO (CH 2 ) n ,
- P represents 2, 3 or 4;
- R 8 H (CH 2 ) n -COOH, (CH 2 ) m-COOA, (CH 2 ) m -COO- (CH 2 ) n - Ar, (CH 2 ) m-COO- (CH 2 ) n - Het, (CH 2 ) m-CONH 2 ,
- P 2 means 3 or 4
- P 2, 3 or 4 mean ⁇
- the starting materials can also be formed in situ, so that they are not isolated from the reaction mixture, but instead are immediately reacted further to give the compounds of the formula I.
- Compounds of formula I can preferably be obtained by liberating compounds of formula I from one of their functional derivatives by treatment with a solvolysing or hydrogenolysing agent.
- Preferred starting materials for solvolysis or hydrogenolysis are those which otherwise correspond to formula I, but instead of one or more free amino and / or hydroxyl groups contain corresponding protected amino and / or hydroxyl groups, preferably those which instead of an H- Atoms which are connected to an N atom carry an amino protective group, in particular those which bear an R'-N group instead of an HN group, in which R 'denotes an amino protective group and / or those which replace the H atoms of a hydroxyl group carry a hydroxyl protective group, for example those which correspond to the formula I, but instead of a group -COOH carry a group -COOR "in which R" denotes a hydroxyl protective group.
- Preferred starting materials are also the oxadiazole derivatives, which can be converted into the corresponding amidino compounds.
- the release of the amidino group from its oxadiazole derivative can e.g. by treatment with hydrogen in the presence of a catalyst (e.g. Raney nickel).
- a catalyst e.g. Raney nickel
- Suitable solvents are those specified below, in particular alcohols such as methanol or ethanol, organic acids such as acetic acid or propionic acid or mixtures thereof.
- the hydrogenolysis is generally carried out at temperatures between about 0 and 100 ° and pressures between about 1 and 200 bar, preferably at 20-30 ° (room temperature) and 1-10 bar.
- the introduction of the oxadiazole group succeeds e.g. by reaction of the cyan compounds with hydroxylamine and reaction with phosgene, dialkyl carbonate, chloroformate, N, N'-carbonyldiimidazole or acetic anhydride.
- amino protecting group is generally known and refers to groups which are suitable for protecting (blocking) an amino group from chemical reactions, but which are easily removable after the desired chemical reaction has been carried out at other locations in the molecule. Unsubstituted or substituted acyl, aryl, aralkoxymethyl or aralkyl groups are particularly typical of such groups. Since the amino protective groups are removed after the desired reaction (or sequence of reactions), their type and size is not critical, moreover, "but those with 1-20, in particular 1-8, carbon atoms are preferred.
- acyl group is related with the present process in the broadest sense, which includes acyl groups derived from aliphatic, araliphatic, aromatic or heterocyclic carboxylic acids or sulfonic acids, and in particular alkoxycarbonyl, aryloxycarbonyl and especially aralkoxycarbonyl groups.
- acyl groups are alkanoyl such as acetyl, propionyl , Butyryl; aralkanoyl such as phenylacetyl; aroyl such as benzoyl or toluyl; aryloxyalkanoyl such as POA; alkoxycarbonyl such as methoxycarbonyl, ethoxycarbonyl, 2,2,2-trichloroethoxycarbonyl, BOG (tert-butyloxycarbonyl), 2-iodoethoxycarbonyl; aralkyloxycarbonyl such as CBZ ("carbobenzoxy"), 4-methoxybenzyloxycarbonyl, FMOC; arylsulfonyl such as Mtr Groups are BOG and Mtr, as well as CBZ, Fmoc, Benzyl and Acetyl.
- alkanoyl such as acetyl, propionyl , Butyryl
- Amides such as DMF, halogenated hydrocarbons such as dichloromethane, ner also alcohols such as methanol, ethanol or isopropanol, and water. Mixtures of the abovementioned solvents are also suitable. TFA is preferably used in excess without the addition of another solvent, perchloric acid in the form of a mixture of acetic acid and 70% perchloric acid in a ratio of 9: 1.
- the reaction temperatures for the cleavage are advantageously between about 0 and about 50 °, preferably between 15 and 30 ° (room temperature).
- the groups BOC, OBut and Mtr can e.g. B. preferably with TFA in dichloromethane or with about 3 to 5N HCl in dioxane at 15-30 °, the FMOC group with an about 5 to 50% solution of dimethylamine, diethylamine or piperidine in DMF at 15 -30 °.
- Hydrogenolytically removable protective groups can, for. B. by treatment with hydrogen in the presence of a catalyst (z. B. a noble metal catalyst such as palladium, advantageously on a support such as coal).
- a catalyst z. B. a noble metal catalyst such as palladium, advantageously on a support such as coal.
- Suitable solvents are the above, especially z. B. alcohols such as methanol or ethanol or amides such as DMF.
- the hydrogenolysis is generally carried out at temperatures between about 0 and 100 ° and pressures between about 1 and 200 bar, preferably at 20-30 ° and 1-10 bar.
- Hydrogenolysis of the CBZ group succeeds e.g. B. well on 5 to 10% Pd / C in methanol or with ammonium formate (instead of hydrogen) on Pd / C in methanol / DMF at 20-30 °.
- Suitable inert solvents are e.g. Hydrocarbons such as hexane, petroleum ether, benzene, toluene or xylene; chlorinated hydrocarbons such as trichlorethylene, 1, 2-dichloroethane, carbon tetrachloride, trifluoromethylbenzene, chloroform or dichloromethane; Alcohols such as methanol, ethanol, isopropanol, n-propanol, n-butanol or tert-butanol; Ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran (THF) or dioxane; Glycol ethers such as ethylene glycol monomethyl or monoethyl ether (methyl glycol or ethyl glycol), ethylene glycol dimethyl ether (diglyme); Ketones such as acetone or butanone; Amides such as acetamide, dimethylacetamide
- NMP dimethylformamide
- DMF dimethylformamide
- Nitriles such as acetonitrile
- Sulfoxides such as Dimethyl sulfoxide (DMSO); Carbon disulphide
- Carboxylic acids such as formic acid or acetic acid
- Nitro compounds such as nitromethane or nitrobenzene
- Esters such as ethyl acetate or mixtures of the solvents mentioned.
- the biphenyl-SO 2 NH 2 group is preferably used in the form of its tert-butyl derivative.
- the tert-butyl group is split off, for example, using TFA with or without the addition of an inert solvent, preferably with the addition of a small amount of anisole (1% by volume).
- ammonia can also be added to a nitrile.
- the addition is preferably carried out in several stages by, in a manner known per se, a) converting the nitrile with H 2 S into a thioamide, which is converted into the corresponding S-alkylimidothioester using an alkylating agent, for example CH 3 I, which in turn contains NH 3 reacts to form the amidine, b) the nitrile is converted to the corresponding imidoester with an alcohol, for example ethanol in the presence of HCl, and treated with ammonia, or c) the nitrile is reacted with lithium bis (trimethylsilyl) amide and the product then hydrolyzed.
- an alkylating agent for example CH 3 I
- NH 3 alkylating agent
- Esters can e.g. with acetic acid or with NaOH or KOH in water,
- Water THF or water dioxane can be saponified at temperatures between 0 and 100 °.
- free amino groups can be acylated in the usual way with an acid chloride or anhydride or alkylated with an unsubstituted or substituted alkyl halide, advantageously in an inert solvent! such as dichloromethane or THF and / or in the presence of a base such as triethylamine or pyridine at temperatures between -60 and + 30 °.
- a base of the formula I can be converted into the associated acid addition salt using an acid, for example by reacting equivalent amounts of the base and the acid in an inert solvent such as ethanol and subsequent evaporation.
- acids that provide physiologically acceptable salts are suitable for this implementation.
- So inorganic acids can be used, for example sulfuric acid, nitric acid, hydrohalic acids such as hydrochloric acid or hydrobromic acid, phosphoric acids such as orthophosphoric acid, sulfamic acid, furthermore organic acids, in particular aliphatic, alicyclic, araliphatic, aromatic or heterocyclic mono- or polycarbonate, sulfonic or Sulfuric acids, e.g.
- compounds of formula I with bases can be converted into the corresponding metal, in particular alkali metal or alkaline earth metal, or into the corresponding ammonium salts.
- physiologically harmless organic bases e.g. Ethanolamine can be used.
- the pharmaceutical activity of the racemates or the stereo isomers of the compounds according to the invention can differ, it may be desirable to use the enantiomers.
- the end product or even the intermediates can be separated into enantiomeric compounds by chemical or physical measures known to the person skilled in the art or can already be used as such in the synthesis.
- diastereomers are formed from the mixture by reaction with an optically active release agent.
- Suitable release agents are e.g. optically active acids, such as the R and S forms of tartaric acid, diacetyltartaric acid, dibenzoyltartaric acid, mandelic acid, malic acid, lactic acid, suitable N-protected amino acids (e.g. N-benzoylproline or N-benzenesulfonylproline) or the various optically active camphorsulfonic acids.
- Aqueous or alcoholic solvent mixtures such as e.g. Hexane / isopropanol / acetonitrile e.g. in the ratio 82: 15: 3.
- the invention further relates to the use of the compounds of the formula I and / or their physiologically acceptable salts for the production of pharmaceutical preparations, in particular by a non-chemical route. They can be brought into a suitable dosage form together with at least one solid, liquid and / or semi-liquid carrier or auxiliary and, if appropriate, in combination with one or more further active ingredients.
- the invention further relates to pharmaceutical preparations containing at least one compound of the formula I and / or one of its physiologically acceptable salts.
- Suitable carriers are organic or inorganic substances which are suitable for enteral (for example oral), parenteral or topical application and do not react with the new compounds, for example water, vegetable oils, benzyl alcohols, alkylene glycols, polyethylene glycols, glycerol triacetate, gelatin . Carbohydrates such as lactose or starch, magnesium stearate, talc, petroleum jelly.
- Tablets, pills, coated tablets, capsules, powders, granules, syrups, juices or drops are used for oral use, suppositories for rectal use, solutions for parenteral use, preferably oily or aqueous solutions, furthermore suspensions, emulsions or implants for which topical application ointments, creams or powder.
- the new compounds can also be lyophilized and the lyophilizates obtained can be used, for example: for the preparation of injection preparations.
- the specified preparations can be sterilized and / or contain auxiliary substances such as lubricants, preservatives, stabilizers and / or wetting agents, emulsifiers, salts for influencing the osmotic pressure, buffer substances, coloring, flavoring and / or several other active substances, eg one or more vitamins.
- auxiliary substances such as lubricants, preservatives, stabilizers and / or wetting agents, emulsifiers, salts for influencing the osmotic pressure, buffer substances, coloring, flavoring and / or several other active substances, eg one or more vitamins.
- the compounds of formula I and their physiologically acceptable salts can be used in the control and prevention of thromboembolic disorders such as thrombosis, myocardial infarction, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and intermittent claudication.
- thromboembolic disorders such as thrombosis, myocardial infarction, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and intermittent claudication.
- the substances according to the invention are generally preferably administered in doses between about 1 and 500 mg, in particular between 5 and 100 mg, per dosage unit.
- the daily dosage is preferably between about 0.02 and 10 mg / kg body weight.
- the specific dose for each patient depends on a wide variety of factors, for example on the effectiveness of the particular compound used, on the age, body weight, general health, sex, on the diet, on the time and route of administration, on the rate of elimination and combination of drugs and severity of the respective disease to which the therapy applies. Oral application is preferred.
- 0.70 g of "CA” and 0.93 g of 4'-aminobiphenyl-2-sulfonic acid tert-butylamide are prepared by the Mukaiyama method in the presence of 0.781 g of 2-chloro-1-methylpyridinium iodide and 0.52 ml of N- Ethyl diisopropylamine in
- Example 2 Analogously to Example 2, starting from 1- (3-cyanophenyl) pyrrolidine-4-OR 0 -2-carboxylic acid and 2'-methanesulfonyl-biphenyl-4-ylamine, the compound 1 - (3-amidinophenyl) - pyrrolidin-4-OR 10 -2-carboxylic acid N- (2'-methanesulfonylbiphenyl-4-yl) -amide, where R 10 is a hydrogen protecting or solvolytically removable hydroxy protecting group.
- Example 2 Analogously to Example 2, starting from 1- (3-cyanophenyl) piperazin-4-R 11 -2-carboxylic acid and 2'-methanesulfonyl-biphenyl-4-ylamine, the compound 1 - (3-amidinophenyl) piperazin-4- R 11 -2-carboxylic acid-N- (2'-methanesulfonylbiphenyl-4-yl) -amide, where R 11 represents a hydrogen protecting or solvolytically removable amino protecting group. After the protective group has been removed, the compound 1- (3-amidinophenyl) piperazine-2-carboxylic acid N- (2'-methanesulfonylbiphenyl-4-yl) -amide is obtained.
- the compound 4- (3-amidino-phenyl) is obtained analogously, starting from 4- (3-cyano-phenyl) piperazin-1, 3-dicarboxylic acid 1-ethyl ester and 4'-aminobiphenyl-2-sulfonic acid tert-butylamide ) -3- (2'-sulfamoyl-biphenyl-4-ylcarbamoyl) -piperazine-1-carboxylic acid ethyl ester.
- Example 2 Analogously to Example 2, the compound is obtained starting from 3- (3-cyano-phenyl) -2,2-dimethyl-oxazolidine-4-carboxylic acid and 4- (4-aminophenyl) pyridine-2-carboxylic acid amide
- the compound (2R, S) is obtained from (2R, S) -1- (3-cyanophenyl) -5-oxopyrrolidin-2-carboxylic acid N- (2'-methanesulfonylbiphenyl-4-yl) amide -1- [3- (N-Hydroxyamidino) phenyl] -5-oxopyrrolidine-2-carboxylic acid N- (2'-methanesulfonylbiphenyl-4-yl) amide, FAB 494.
- Example A Injection glasses
- a solution of 100 g of an active ingredient of the formula I and 5 g of disodium hydrogenphosphate is adjusted to pH 6.5 in 3 l of double-distilled water with 2N hydrochloric acid, sterile filtered, filled into injection glasses, lyophilized under sterile conditions and sealed sterile. Each injection jar contains 5 mg of active ingredient.
- a mixture of 20 g of an active ingredient of the formula I is melted with 100 g of soy lecithin and 1400 g of cocoa butter, poured into molds and allowed to cool. Each suppository contains 20 mg of active ingredient.
- a solution of 1 g of an active ingredient is prepared of the formula I, 9.38 g of NaH 2 P0 4 • 2 H 2 0, 28.48 g Na 2 HP0 4 • 12 H 2 0 and 0.1 g of benzalkonium chloride in 940 ml of double distilled water. It is adjusted to pH 6.8, made up to 1 f and sterilized by irradiation. This solution can be used in the form of eye drops.
- Example D ointment
- 500 mg of an active ingredient of the formula I are mixed with 99.5 g of petroleum jelly under aseptic conditions.
- Example F coated tablets
- Example E tablets are pressed, which are then coated in a conventional manner with a coating of sucrose, potato starch, talc, tragacanth and colorant.
- Example G capsules
- each capsule contains 20 mg of the active ingredient.
- a solution of 1 kg of active ingredient of the formula I in 60 l of double-distilled water is sterile filtered, filled into ampoules, lyophilized under sterile conditions and sealed under sterile conditions. Each ampoule contains 10 mg of active ingredient.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002512172A JP2004523466A (ja) | 2000-07-19 | 2001-07-03 | 環状アミノ酸誘導体 |
EP01953191A EP1301506A1 (de) | 2000-07-19 | 2001-07-03 | Cyclische aminosäurederivate |
CA002415964A CA2415964A1 (en) | 2000-07-19 | 2001-07-03 | Cyclic amino acid derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10035144A DE10035144A1 (de) | 2000-07-19 | 2000-07-19 | Cyclische Aminosäurederivate |
DE10035144.1 | 2000-07-19 |
Publications (1)
Publication Number | Publication Date |
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WO2002006269A1 true WO2002006269A1 (de) | 2002-01-24 |
Family
ID=7649481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/007595 WO2002006269A1 (de) | 2000-07-19 | 2001-07-03 | Cyclische aminosäurederivate |
Country Status (6)
Country | Link |
---|---|
US (1) | US20030176465A1 (de) |
EP (1) | EP1301506A1 (de) |
JP (1) | JP2004523466A (de) |
CA (1) | CA2415964A1 (de) |
DE (1) | DE10035144A1 (de) |
WO (1) | WO2002006269A1 (de) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002057236A1 (en) * | 2001-01-19 | 2002-07-25 | Merck Patent Gmbh | Phenyl derivatives |
WO2004046138A1 (de) * | 2002-11-21 | 2004-06-03 | Merck Patent Gmbh | Carbonsäureamide |
WO2004108718A1 (de) * | 2003-06-07 | 2004-12-16 | Merck Patent Gmbh | Aroylsemicarbazidderivate gegen thromboembolische erkrankungen |
US7199142B2 (en) | 2002-06-17 | 2007-04-03 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl) benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl) pyrrolidine-3-carboxylates as edg receptor agonists |
US8202999B2 (en) | 2005-01-07 | 2012-06-19 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
US8895606B2 (en) | 2010-08-24 | 2014-11-25 | Actelion Pharmaceuticals Ltd. | Proline sulfonamide derivatives as orexin receptor antagonists |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101583593A (zh) | 2006-11-13 | 2009-11-18 | 辉瑞产品公司 | 二芳基、二吡啶基和芳基-吡啶基衍生物及其用途 |
Citations (3)
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WO1996010022A1 (en) * | 1994-09-26 | 1996-04-04 | Zeneca Limited | Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents |
WO1999042455A1 (en) * | 1998-02-19 | 1999-08-26 | Tularik Inc. | Antiviral agents |
WO2000071493A2 (en) * | 1999-05-24 | 2000-11-30 | Cor Therapeutics, Inc. | INHIBITORS OF FACTOR Xa |
-
2000
- 2000-07-19 DE DE10035144A patent/DE10035144A1/de not_active Withdrawn
-
2001
- 2001-07-03 US US10/333,278 patent/US20030176465A1/en not_active Abandoned
- 2001-07-03 JP JP2002512172A patent/JP2004523466A/ja active Pending
- 2001-07-03 WO PCT/EP2001/007595 patent/WO2002006269A1/de not_active Application Discontinuation
- 2001-07-03 EP EP01953191A patent/EP1301506A1/de not_active Withdrawn
- 2001-07-03 CA CA002415964A patent/CA2415964A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996010022A1 (en) * | 1994-09-26 | 1996-04-04 | Zeneca Limited | Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents |
WO1999042455A1 (en) * | 1998-02-19 | 1999-08-26 | Tularik Inc. | Antiviral agents |
WO2000071493A2 (en) * | 1999-05-24 | 2000-11-30 | Cor Therapeutics, Inc. | INHIBITORS OF FACTOR Xa |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002057236A1 (en) * | 2001-01-19 | 2002-07-25 | Merck Patent Gmbh | Phenyl derivatives |
US7273867B2 (en) | 2001-01-19 | 2007-09-25 | Merck Patent Gmbh | Phenyl derivatives |
US7199142B2 (en) | 2002-06-17 | 2007-04-03 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl) benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl) pyrrolidine-3-carboxylates as edg receptor agonists |
US7579346B2 (en) | 2002-11-21 | 2009-08-25 | Merck Patent Gmbh | Carboxamides |
WO2004046138A1 (de) * | 2002-11-21 | 2004-06-03 | Merck Patent Gmbh | Carbonsäureamide |
JP4732757B2 (ja) * | 2002-11-21 | 2011-07-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | カルボキサミド |
JP2006512321A (ja) * | 2002-11-21 | 2006-04-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | カルボキサミド |
AU2004245187B2 (en) * | 2003-06-07 | 2009-09-10 | Merck Patent Gmbh | Aroyl semicarbazide derivatives against thromboembolic diseases |
JP2006527217A (ja) * | 2003-06-07 | 2006-11-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 血栓塞栓性疾患に対するアロイルセミカルバジド誘導体 |
US7763611B2 (en) | 2003-06-07 | 2010-07-27 | Merck Patent Gmbh | Aroylsemicarbazide derivatives against thromboembolic diseases |
JP4668901B2 (ja) * | 2003-06-07 | 2011-04-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 血栓塞栓性疾患に対するアロイルセミカルバジド誘導体 |
WO2004108718A1 (de) * | 2003-06-07 | 2004-12-16 | Merck Patent Gmbh | Aroylsemicarbazidderivate gegen thromboembolische erkrankungen |
US8202999B2 (en) | 2005-01-07 | 2012-06-19 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
US8592486B2 (en) | 2005-01-07 | 2013-11-26 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
US8895606B2 (en) | 2010-08-24 | 2014-11-25 | Actelion Pharmaceuticals Ltd. | Proline sulfonamide derivatives as orexin receptor antagonists |
US9000029B2 (en) | 2010-08-24 | 2015-04-07 | Actelion Pharmaceuticals Ltd. | Proline sulfonamide derivatives as orexin receptor antagonists |
US9211279B2 (en) | 2010-08-24 | 2015-12-15 | Actelion Pharmaceuticals Ltd. | Proline sulfonamide derivatives as orexin receptor antagonists |
Also Published As
Publication number | Publication date |
---|---|
DE10035144A1 (de) | 2002-01-31 |
JP2004523466A (ja) | 2004-08-05 |
CA2415964A1 (en) | 2003-01-17 |
US20030176465A1 (en) | 2003-09-18 |
EP1301506A1 (de) | 2003-04-16 |
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