WO2002005188A1 - Apparatus and kits for locking and disinfecting implanted catheters - Google Patents

Apparatus and kits for locking and disinfecting implanted catheters Download PDF

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Publication number
WO2002005188A1
WO2002005188A1 PCT/US2001/021656 US0121656W WO0205188A1 WO 2002005188 A1 WO2002005188 A1 WO 2002005188A1 US 0121656 W US0121656 W US 0121656W WO 0205188 A1 WO0205188 A1 WO 0205188A1
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WO
WIPO (PCT)
Prior art keywords
catheter
lower alcohol
solution
range
implantable catheter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/021656
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English (en)
French (fr)
Inventor
Charles D. Finch
John H. Wang
Paul F. Marad
James M. Brugger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vasca Inc
Original Assignee
Vasca Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27086509&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002005188(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/611,421 external-priority patent/US6679870B1/en
Priority to JP2002508720A priority Critical patent/JP2004516041A/ja
Priority to AU7330001A priority patent/AU7330001A/xx
Priority to AU2001273300A priority patent/AU2001273300B2/en
Priority to DE60138391T priority patent/DE60138391D1/de
Application filed by Vasca Inc filed Critical Vasca Inc
Priority to DK01952563T priority patent/DK1312008T3/da
Priority to EP01952563A priority patent/EP1312008B1/en
Priority to AT01952563T priority patent/ATE428464T1/de
Priority to CA002414481A priority patent/CA2414481A1/en
Publication of WO2002005188A1 publication Critical patent/WO2002005188A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M2025/0019—Cleaning catheters or the like, e.g. for reuse of the device, for avoiding replacement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir

Definitions

  • the present invention relates generally to medical methods and kits. More particularly, the present invention relates to methods and kits for flushing an interior lumen of an implanted catheter prior to closing the catheter between successive uses.
  • Implanted catheters enjoy widespread use in a number of medical procedures.
  • IV intravenous
  • Hemodialysis and hemofiltration both rely on separate draw and return catheters implanted in a vein to allow extra corporeal treatment of the blood.
  • Peritoneal dialysis in contrast, relies on a single catheter implanted in the peritoneum to permit introduction and withdrawal of dialysate to permit in situ dialysis.
  • catheters implanted over long periods of time raises a number of concerns.
  • the catheters can become infected requiring treatment of the patient and often times removal of the catheter. This is a particular problem with transcutaneous catheters where the skin penetration is a common route of infection.
  • implanted catheters can often become plugged or fouled over time. This is a particular problem with intravascular catheters where clotting and thrombus formation within the catheter lumen can be problematic.
  • Locking typically involves first flushing the catheter with saline to remove blood and other substances from the catheter lumen. After the catheter has been flushed, an anticoagulant solution, typically heparin, is then injected to displace the saline and fill the lumen.
  • the heparin-locking solution both excludes blood from the lumen and actively inhibits clotting and thrombus formation within the lumen. While some thrombus may still form at the distal tip of the catheter, the formation is usually minimal and presents few problems. It has further been proposed to combine various anti-microbial substances with the locking solution in order to inhibit infection at the same time that thrombus is being inhibited.
  • heparin locks While generally effective, the use of heparin locks suffers from a number of disadvantages.
  • the need to prepare a heparin solution at the end of every catheter treatment session is time-consuming and presents an opportunity for error by a caregiver. Hemodialysis and hemofiltration patients will have to undergo such heparin locks at least several times a week, while patients on IV may have to undergo such heparin locks several times a day. Over time, the inconvenience and expense of performing heparin locks can build up.
  • the need to combine a separate anti-microbial agent in the heparin lock solution further complicates the procedure and adds expense, and the addition of an anti-microbial agent to the heparin lock will generally be effective only within the lumen and at the openings from the lumen.
  • U.S. Patent No. 4,929,242 describes a solution containing glycerol and having a density similar to that of blood for providing a heparin lock on an intravenous catheter.
  • U.S. Patent No. 5,077,281 describes an anti-microbial solution containing a taurolin compound for inhibiting coagulation in dialysis catheters and other vascular prostheses.
  • PCT WO 00/01391 describes an anti-microbial lock comprising a taurinamide derivative.
  • the present invention provides apparatus and kits for the improved locking and/or disinfection of subcutaneously and transcutaneously implantable catheters.
  • the catheters typically will have a distal end which is open to a body lumen.
  • the catheters will be intravascular catheters where the distal end is implantable in or attached to a blood vessel, usually a vein, but in some cases an artery.
  • exemplary intravascular catheters include hemodialysis and hemofiltration catheters, intravenous catheters, and the like.
  • Intravenous catheters can be used for a wide variety of purposes, including fluid infusion, drug delivery, and the like.
  • Catheters attached other than to the vasculature include peritoneal dialysis catheters which are open to the peritoneal cavity, and the like.
  • the catheters of the present invention may be transcutaneously implantable or subcutaneously implantable.
  • transcutaneously implantable it is meant that the distal end of the catheter is attached to or implantable within a target body lumen and a proximal end of the catheter is located externally to the patient. An intermediate portion of the catheter will thus pass through or penetrate the patient's skin, and the proximal end of the catheter will usually have a hub to permit selective attachment of infusion tubes, syringes, solution bags, and the like. Most commonly, the proximal attachment hub will have a luer fitting.
  • subcutaneously implantable it is meant that the entire catheter can be implantable beneath the skin and no portion of the catheter extends through the skin.
  • Such subcutaneously implantable catheters are typically attached to a fully implanted hub at their proximal ends.
  • the hub permits percutaneous access via a needle or other penetrating element.
  • the needle or other penetrating element is removed and all portions of the catheter and proximal hub are then located beneath the skin. Examples of such subcutaneously implantable catheters and proximal access hubs are described in the commonly assigned, copending applications described above, as well as U.S. Patent No. 5,807,356, the full disclosures of which have previously been incorporated herein by reference.
  • both transcutaneously and subcutaneously implantable catheters are subject to fouling and plugging, particularly in and about their distal ends which are implantable in or attached to a blood vessel or other body lumen.
  • the present invention provides catheters, compostions, and kits which provide implantable catheters having a solution of a lower alcohol and an additive in one or more lumen(s) thereof.
  • the lower alcohol is typically ethanol, propanol, or butanol, preferably isopropanol.
  • these lower alcohols are effective in inhibiting fouling and plugging of the lumen, particularly in inhibiting clot formation within the lumens of intravascular catheters.
  • the ability to inhibit clot formation without the need to prepare and use heparin solutions is a significant advantage.
  • the lower alcohols have the additional ability to inhibit infection.
  • the additive may comprise either an anti-microbial substance, typically taurolidine or triclosan, or an anti-coagulant substance, typically riboflavin, sodium citrate, ethylene diamine tetraacetic acid, or citric acid.
  • This solution combination of a lower alcohol and an additive is particularly effective since alcohol increases the effectiveness of the anti-microbial or anti-coagulant additives, while the additives in return reduce the possible toxic effects of the alcohol.
  • both the reduction of catheter fouling and the inhibition of infection can be achieved with the use of commonly available, widely accepted materials which are introduced to the catheter lumen in a convenient fashion, as described in more detail below.
  • the ability to inhibit or prevent infection of the implantable catheter can be improved by utilizing catheters where at least a portion of the catheter body is sufficiently porous to allow the lower alcohol and additive material to permeate the catheter body and, preferably, pass outwardly into the tissue region surrounding the catheter. While the use of such porous or partially porous catheter bodies can be beneficial with many anti-microbial locking solutions, such as that taught in U.S. Patent No. 5,077,281, the full disclosure of which has been incorporated herein by reference, it is particularly useful with the lower alcohols of the present invention. It will be appreciated that the lower alcohols have relatively low molecular weights and polar structures which will enable them to readily penetrate into and optionally through many porous materials.
  • Exemplary porous materials for construction of the catheter body include silicone rubber, expanded PTFE (e.g., GORE-TEX ® , medical membranes) and the like. Such materials may be formed into the tubular catheter bodies or may be incorporated as separate component(s) into the catheter bodies.
  • a solution is used for the manufacture of a material, which may be medicament, for locking an implantable catheter, the solution comprising a lower alcohol and an additive.
  • the lumen of the catheter is open to a body lumen, typically a blood vessel, the peritoneum, or the like.
  • the lower alcohol is selected from the group consisting of ethanol, propanol, and butanol, with the presently preferred alcohol being isopropanol.
  • the lower alcohol may be pure, but will more usually be in aqueous solution, typically at 1% to 99% by volume, usually from 5% to 95% by volume.
  • the additive may comprise either an anti-microbial selected from the group consisting of taurolidine and triclosan, or an anti-coagulant selected from the group consisting of riboflavin, sodium citrate, ethylene diamine tetraacetic acid, and citric acid.
  • the implantable catheter may be a transcutaneous catheter attached at its distal end to the blood vessel, the peritoneal cavity, or the like. Alternatively, the implantable catheter may be a subcutaneously implantable catheter which is attached at its distal end to a blood vessel, the peritoneal cavity, or the like.
  • an anti-microbial solution is used in the manufacture of a material for disinfecting an implantable catheter.
  • exemplary and preferred antimicrobial solutions include at least one lower alcohol, preferably ethanol, propanol, or butanol, and most preferably isopropanol, and at least one other anti-microbial, preferably taurolidine or triclosan, or anti-coagulant compound, preferably riboflavin, sodium citrate, ethylene diamine tetraacetic acid, or citric acid, as described above.
  • the implantable catheters may be subcutaneously or transcutaneously implantable.
  • a locking composition for filling an implantable catheter comprises at least one lower alcohol and at least one other antimicrobial or anti-coagulant compound.
  • the lower alcohol is selected from the group consisting of ethanol, propanol, and butanol, with the presently preferred alcohol being isopropanol.
  • the at least one other anti-microbial is selected from the group consisting of taurolidine and triclosan
  • the at least one anti-coagulant is selected from the group consisting of riboflavin, sodium citrate, ethylene diamine tetraacetic acid, and citric acid.
  • a kit for locking an implantable catheter comprises a container (optionally a syringe) holding a volume of a solution of a lower alcohol and an additive and instructions for use setting forth a method comprising filing a lumen of the catheter with the solution.
  • the kit may further comprise a package for holding both the container and the instructions for use, such as a box, tray, tube, pouch, or the like.
  • the lower alcohol is typically selected from the group consisting of ethanol, propanol, and butanol, preferably being isopropanol.
  • the additive is either an anti-microbial, typically taurolidine or triclosan, or an anti-coagulant, typically riboflavin, sodium citrate, ethylene diamine tetraacetic acid, or citric acid.
  • the volume of the solution in the container is typically in the range from 1 ml to 20 ml, preferably from 2 ml to 10 ml, usually being about 2 ml to 4 ml. Additionally, the container will usually comprise a syringe to permit direct introduction of the solution into the implantable catheter.
  • FIG. 1 A and IB illustrate methods according to the present invention for locking and disinfecting a transcutaneous catheter.
  • Figs. 2A-2C illustrate methods according to the present invention for locking and disinfecting a subcutaneously implanted catheter.
  • Figs. 3A-3C illustrate methods according to the present invention for locking and disinfecting a peritoneal dialysis catheter.
  • Fig. 4 illustrates a preferred aspect of the present invention where an antimicrobial locking fluid permeates into an implanted catheter body and preferably into the tissue surrounding the catheter body.
  • Fig. 5 illustrates a kit constructed in accordance with the principles of the present invention.
  • a method according to the present invention for locking a transcutaneously implanted venous catheter 10 will be described.
  • the venous catheter 10 will be implanted through a patient's skin S into a vein V for infusion of the patient.
  • a tube 12 containing an IV solution will normally be connected to the proximal hub 14 of the catheter 10.
  • the IV line 12 will be disconnected, and the catheter 10 usually flushed with saline or other flushing solution.
  • a solution of a lower alcohol and an additive can be introduced to fill the inner lumen of the catheter 10, as shown in Fig. IB.
  • a sufficient volume of the solution (as set forth above) will be introduced to completely fill the lumen, with minimum excess passing from distal end 16 of the catheter. The loss of excess solution into a blood vessel or most other body lumens, however, will generally not be a problem.
  • the "column" of the solution will then occupy the inner lumen, and the proximal hub 14 will be sealed, helping retain the solution in place. It has been found that the solution of the lower alcohol with the additive will effectively inhibit clotting and coagulation at the distal end 16 as well as inhibit infection throughout the catheter.
  • a subcutaneously implanted catheter 20 used for hemodialysis access When it is desired to reattach the patient to the IV source, the solution will be removed and the catheter lumen flushed with saline.
  • a target blood vessel BV typically a vein
  • an implanted port 22 During hemodialysis, blood may be withdrawn through the catheter 20, through the port 22 and externally through a needle N and connecting line 23 used to percutaneously access the port 22.
  • the port and catheter could be used to return treated blood to the patient.
  • the port and catheter combinations are typically used in pairs to permit both blood withdrawal and blood return.
  • saline When it is desired to end a hemodialysis (or hemofiltration) treatment, saline will be introduced through the needle N (typically from a syringe which is attached to the connecting line 23) to flush the lumen, as shown in Fig. 2B. After the flush is complete, a container such as syringe 26 containing the solution of the lower alcohol with an additive is injected through the port 22/line 23 and into the lumen of catheter 20 to displace the saline and lock the catheter. The solution will remain in place within the catheter 20 after the needle end is withdrawn and the valve 22 closed to seal off the proximal end of the catheter 20.
  • residual solution in the needle will be dispersed in the tissue tract TT left by the needle as well as in portions of the port 22 upstream of its internal valve.
  • the presence of the alcohol or other anti-microbial additives in the solution will further inhibit infection in both the port and tissue tract.
  • the methods of the present invention may also be used to lock non- vascular catheters, such as peritoneal dialysis catheters 30, as shown in Figs. 3A-3C.
  • non-vascular catheters such as peritoneal dialysis catheters 30, as shown in Figs. 3A-3C.
  • the used dialysate will be withdrawn from the catheter 30, as shown in Fig. 3A.
  • the dialysis catheter 30 may optionally be flushed with saline, as shown in Fig. 3B.
  • the solution of the lower alcohol with the additive is introduced to the peritoneal dialysis catheter 30, as shown in Fig. 3C, so that it fills the lumen of the catheter, as described previously with the vascular catheters.
  • the use of an alcohol lock with an additive for peritoneal dialysis catheters is particularly advantageous in inhibiting infections.
  • the use of lower alcohols with other antimicrobial or anti-coagulant materials for locking a catheter can be enhanced by utilizing an implanted catheter which is formed at least partly from a porous material.
  • an implanted catheter which is formed at least partly from a porous material.
  • the lumen 40 of the porous catheter body 42 is filled with a solution of a lower alcohol and another anti-microbial or anti-coagulant compound, the solution will be able to penetrate into the catheter body and preferably outwardly into the tissue T surrounding the catheter, as shown by the arrows in Fig. 4.
  • the anti-microbial properties of the solution will not be limited to the interior lumen of the catheter, but will also be effective on the surface of the catheter and in the tissue region immediately surrounding the catheter body.
  • a locking composition for filling an implantable catheter comprises at least one lower alcohol and at least one other anti-microbial or anti-coagulant compound.
  • Preferred compositions include lower alcohol in the range between about 1% to 99% with taurolidine in the range between about 1% to 99%, lower alcohol in the range between about 1% to 99% with triclosan in the range between about 1% to 99%, lower alcohol in the range between about 1% to 99% with riboflavin in the range between about 1% to 99%, lower alcohol in the range between about 1% to 99% with sodium citrate in the range between about 1% to 99%, lower alcohol in the range between about 1% to 99% with ethylene diamine tetraacetic acid in the range between about 1% to 99%, and lower alcohol in the range between about 1% to 99% with citric acid in the range between about 1% to 99%).
  • a preferred concentration of the anti-coagulant is about 4 % by volume.
  • the concentration of the locking composition comprises isopropanol by about 17.5 % volume and sodium citrate by about 4 % volume.
  • Saline, water, or standard heparin solution may also be added to any of the above described compositions.
  • kits according to the present invention will comprise at least a container 60, such as a syringe, for holding a volume of the solution of the lower alcohol and the additive.
  • the volume will typically be within the ranges set forth above.
  • the kit will contain instructions for use (IFU) setting forth a method for locking and/or disinfecting an implanted catheter by introducing the solution from the container into a lumen of the catheter body between successive uses of the catheter.
  • the kits will further contain a package 62, such as any conventional medical device package, including boxes, tubes, trays, pouches and the like.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • External Artificial Organs (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
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  • Media Introduction/Drainage Providing Device (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/US2001/021656 2000-07-07 2001-07-09 Apparatus and kits for locking and disinfecting implanted catheters Ceased WO2002005188A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002414481A CA2414481A1 (en) 2000-07-07 2001-07-09 Apparatus and kits for locking and disinfecting implanted catheters
AT01952563T ATE428464T1 (de) 2000-07-07 2001-07-09 Vorrichtung und kits zum feststellen und desinfizieren eingesetzter katheter
AU7330001A AU7330001A (en) 2000-07-07 2001-07-09 Apparatus and kits for locking and disinfecting implanted catheters
AU2001273300A AU2001273300B2 (en) 2000-07-07 2001-07-09 Apparatus and kits for locking and disinfecting implanted catheters
DE60138391T DE60138391D1 (de) 2000-07-07 2001-07-09 Vorrichtung und kits zum feststellen und desinfizieren eingesetzter katheter
JP2002508720A JP2004516041A (ja) 2000-07-07 2001-07-09 挿入カテーテルをロックして消毒するための装置およびキット
DK01952563T DK1312008T3 (da) 2000-07-07 2001-07-09 Apparat og kits til at fastgöre og desinficere implanterede katetre
EP01952563A EP1312008B1 (en) 2000-07-07 2001-07-09 Apparatus and kits for locking and disinfecting implanted catheters

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/611,421 2000-07-07
US09/611,421 US6679870B1 (en) 1999-07-23 2000-07-07 Methods and kits for locking and disinfecting implanted catheters
US09/859,886 2001-05-16
US09/859,886 US6685694B2 (en) 1999-07-23 2001-05-16 Methods and kits for locking and disinfecting implanted catheters

Publications (1)

Publication Number Publication Date
WO2002005188A1 true WO2002005188A1 (en) 2002-01-17

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PCT/US2001/021656 Ceased WO2002005188A1 (en) 2000-07-07 2001-07-09 Apparatus and kits for locking and disinfecting implanted catheters

Country Status (8)

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US (1) US6685694B2 (enExample)
EP (1) EP1312008B1 (enExample)
JP (2) JP2004516041A (enExample)
AU (2) AU7330001A (enExample)
CA (1) CA2414481A1 (enExample)
CY (1) CY1109200T1 (enExample)
DE (1) DE60138391D1 (enExample)
WO (1) WO2002005188A1 (enExample)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007525247A (ja) * 2003-06-02 2007-09-06 ボストン サイエンティフィック リミテッド 医療器具
DE102007009506B3 (de) * 2007-02-25 2008-04-30 Kleophas, Werner, Dr. Doppellumenkatheteranordnung
WO2008077441A1 (de) 2006-12-23 2008-07-03 Farco-Pharma Gmbh Zusammensetzung, insbesondere für das blockieren von kathetern
US9649411B2 (en) 2006-02-28 2017-05-16 Becton, Dickinson And Company Antimicrobial compositions and methods for locking catheters
US10524982B2 (en) 2015-05-08 2020-01-07 Icu Medical, Inc. Medical connectors configured to receive emitters of therapeutic agents
US10828484B2 (en) 2015-08-21 2020-11-10 Medline Industries, Inc. Disinfecting cap
US10940240B2 (en) 2016-02-12 2021-03-09 Medical Components, Inc. Catheter locking solution and catheter locking therapy
US11351353B2 (en) 2008-10-27 2022-06-07 Icu Medical, Inc. Packaging container for antimicrobial caps
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AU2001273300B2 (en) 2007-10-25
US6685694B2 (en) 2004-02-03
US20020010438A1 (en) 2002-01-24
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JP2004516041A (ja) 2004-06-03
EP1312008A4 (en) 2004-07-07
AU7330001A (en) 2002-01-21
DE60138391D1 (de) 2009-05-28
EP1312008A1 (en) 2003-05-21
CA2414481A1 (en) 2002-01-17
JP2013255823A (ja) 2013-12-26
CY1109200T1 (el) 2014-07-02

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