WO2002004605A3 - Stimulation de la regeneration et de la differenciation cellulaires dans l'oreille interne - Google Patents

Stimulation de la regeneration et de la differenciation cellulaires dans l'oreille interne Download PDF

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Publication number
WO2002004605A3
WO2002004605A3 PCT/US2001/021793 US0121793W WO0204605A3 WO 2002004605 A3 WO2002004605 A3 WO 2002004605A3 US 0121793 W US0121793 W US 0121793W WO 0204605 A3 WO0204605 A3 WO 0204605A3
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WO
WIPO (PCT)
Prior art keywords
inner ear
cells
differentiation
stimulation
cellular regeneration
Prior art date
Application number
PCT/US2001/021793
Other languages
English (en)
Other versions
WO2002004605A2 (fr
Inventor
Jonathan Kil
Rendu Gu
Corinne Grigeur
Hubert Lowenheim
Original Assignee
Sound Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sound Pharmaceuticals Inc filed Critical Sound Pharmaceuticals Inc
Priority to KR1020037000388A priority Critical patent/KR100896489B1/ko
Priority to AU8821901A priority patent/AU8821901A/xx
Priority to CA2412764A priority patent/CA2412764C/fr
Priority to EP01967939A priority patent/EP1307542A2/fr
Priority to CN018126065A priority patent/CN1441841B/zh
Priority to JP2002509459A priority patent/JP2004502785A/ja
Priority to AU2001288219A priority patent/AU2001288219C1/en
Publication of WO2002004605A2 publication Critical patent/WO2002004605A2/fr
Publication of WO2002004605A3 publication Critical patent/WO2002004605A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Analytical Chemistry (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des méthodes destinées à stimuler la formation des cellules de l'oreille interne, et notamment des cellules auditives internes et des cellules support de l'oreille interne. Les méthodes de la présente invention consistent à endommager et/ou tuer les cellules de l'oreille interne et à stimuler la formation de nouvelles cellules de l'oreille interne.
PCT/US2001/021793 2000-07-11 2001-07-10 Stimulation de la regeneration et de la differenciation cellulaires dans l'oreille interne WO2002004605A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020037000388A KR100896489B1 (ko) 2000-07-11 2001-07-10 내이에서 세포 재생 및 분화의 자극
AU8821901A AU8821901A (en) 2000-07-11 2001-07-10 Stimulation of cellular regeneration and differentiation in the inner ear
CA2412764A CA2412764C (fr) 2000-07-11 2001-07-10 Stimulation de la regeneration et de la differenciation cellulaires dans l'oreille interne
EP01967939A EP1307542A2 (fr) 2000-07-11 2001-07-10 Stimulation de la regeneration et de la differenciation cellulaires dans l'oreille interne
CN018126065A CN1441841B (zh) 2000-07-11 2001-07-10 对内耳的细胞再生和分化的刺激
JP2002509459A JP2004502785A (ja) 2000-07-11 2001-07-10 内耳における細胞の再生および分化の刺激
AU2001288219A AU2001288219C1 (en) 2000-07-11 2001-07-10 Stimulation of cellular regeneration and differentiation in the inner ear

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61409900A 2000-07-11 2000-07-11
US09/614,099 2000-07-11

Publications (2)

Publication Number Publication Date
WO2002004605A2 WO2002004605A2 (fr) 2002-01-17
WO2002004605A3 true WO2002004605A3 (fr) 2003-02-27

Family

ID=24459860

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021793 WO2002004605A2 (fr) 2000-07-11 2001-07-10 Stimulation de la regeneration et de la differenciation cellulaires dans l'oreille interne

Country Status (7)

Country Link
EP (1) EP1307542A2 (fr)
JP (1) JP2004502785A (fr)
KR (1) KR100896489B1 (fr)
CN (1) CN1441841B (fr)
AU (2) AU8821901A (fr)
CA (1) CA2412764C (fr)
WO (1) WO2002004605A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
WO2008076556A2 (fr) 2006-11-15 2008-06-26 Massachusetts Eye & Ear Infirmary Génération de cellules de l'oreille interne
JP2010512149A (ja) 2006-12-07 2010-04-22 ウィルソン ウォルフ マニュファクチャリング コーポレイション 細胞培養に効果的な装置および方法
DE102010007281A1 (de) * 2010-02-08 2011-08-11 EMC microcollections GmbH, 72070 Neue Aminoalkyl-oxazol- und Aminoalkyl-thiazolcarbonsäureamide und ihre Anwendung zur Stimulation der endogenen situ Regeneration von Haarsinneszellen im Corti'schen Organ des Innenohres beim Säuger
CN103998454A (zh) * 2011-08-03 2014-08-20 夸克制药公司 用于治疗听力障碍和平衡障碍的双链寡核苷酸化合物
AU2013208012A1 (en) 2012-01-12 2014-07-03 Quark Pharmaceuticals, Inc. Combination therapy for treating hearing and balance disorders
EP3943090A1 (fr) 2016-01-29 2022-01-26 Massachusetts Eye & Ear Infirmary Expansion et différenciation des cellules de support de l'oreille interne, et méthodes d'utilisation de ces dernières
CN114736924A (zh) * 2021-01-07 2022-07-12 中国科学院脑科学与智能技术卓越创新中心 异位联合过表达Atoh1和Ikzf2再生耳蜗外毛细胞及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023084A1 (fr) * 1998-10-21 2000-04-27 Jonathan Kil Procedes pour stimuler la regeneration des cellules de l'oreille interne

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593290B1 (en) * 1996-11-01 2003-07-15 Genentech, Inc. Treatment of inner ear hair cells
DE19807426A1 (de) * 1998-02-23 1999-10-14 Otogene Biotechnologische Fors Verfahren zur Behandlung von Erkrankungen oder Störungen des Innenohrs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023084A1 (fr) * 1998-10-21 2000-04-27 Jonathan Kil Procedes pour stimuler la regeneration des cellules de l'oreille interne

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHARDIN S ET AL: "Regeneration and mammalian auditory hair cells.", SCIENCE, vol. 267, no. 5198, 3 February 1995 (1995-02-03), pages 707 - 711, XP002207537, ISSN: 0036-8075 *
PARIETTI C ET AL: "Attempt at hair cell neodifferentiation in developing and adult amikacin intoxicated rat cochleae.", BRAIN RESEARCH, vol. 813, no. 1, 30 November 1998 (1998-11-30), pages 57 - 66, XP002207536, ISSN: 0006-8993 *

Also Published As

Publication number Publication date
WO2002004605A2 (fr) 2002-01-17
AU2001288219C1 (en) 2009-12-03
AU2001288219B9 (en) 2009-11-19
EP1307542A2 (fr) 2003-05-07
KR100896489B1 (ko) 2009-05-08
CA2412764C (fr) 2014-06-03
CA2412764A1 (fr) 2002-01-17
KR20030046386A (ko) 2003-06-12
AU2001288219B2 (en) 2006-11-23
CN1441841B (zh) 2013-03-20
CN1441841A (zh) 2003-09-10
JP2004502785A (ja) 2004-01-29
AU8821901A (en) 2002-01-21

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