WO2001097795A3 - Systems and methods for treating a mucosal surface - Google Patents

Systems and methods for treating a mucosal surface Download PDF

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Publication number
WO2001097795A3
WO2001097795A3 PCT/US2001/019979 US0119979W WO0197795A3 WO 2001097795 A3 WO2001097795 A3 WO 2001097795A3 US 0119979 W US0119979 W US 0119979W WO 0197795 A3 WO0197795 A3 WO 0197795A3
Authority
WO
WIPO (PCT)
Prior art keywords
amines
mucosal surface
irm
treating
systems
Prior art date
Application number
PCT/US2001/019979
Other languages
French (fr)
Other versions
WO2001097795A2 (en
Inventor
John C Hedenstrom
Michael J Jozwiakowski
Mark Martinez
Kenneth R Phares
Kenneth F Trofatter Jr
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/676,339 external-priority patent/US6486168B1/en
Priority to SK1781-2002A priority Critical patent/SK17812002A3/en
Priority to AU2001270081A priority patent/AU2001270081A1/en
Priority to EP01948622A priority patent/EP1296644A2/en
Priority to EEP200200705A priority patent/EE200200705A/en
Priority to UA20021210399A priority patent/UA81099C2/en
Priority to CA002410208A priority patent/CA2410208A1/en
Priority to MXPA02012524A priority patent/MXPA02012524A/en
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Priority to BR0112386-6A priority patent/BR0112386A/en
Priority to PL36197501A priority patent/PL361975A1/en
Priority to JP2002503272A priority patent/JP2004508851A/en
Priority to NZ523073A priority patent/NZ523073A/en
Priority to HU0301233A priority patent/HUP0301233A2/en
Priority to IL15308701A priority patent/IL153087A0/en
Publication of WO2001097795A2 publication Critical patent/WO2001097795A2/en
Publication of WO2001097795A3 publication Critical patent/WO2001097795A3/en
Priority to NO20026067A priority patent/NO20026067L/en
Priority to HR20021024A priority patent/HRP20021024A2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A system for treating a condition associated with a mucosal surface, the system comprising an immune response modifier (IRM) compound chosen from imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, imidazonaphthyridine amines, oxazoloquinoline amines, thiazoloquinoline amines, 1,2-bridged imidazoquinoline amines, and pharmaceutically acceptable salts thereof and an applicator device for applying the IRM compound to the mucosal surface. This system of IRM compounds and applicator may be used to treat conditions associated with mucosal surfaces such as cervical dysphasia and cervical intraepithelial neoplasia.
PCT/US2001/019979 2000-06-22 2001-06-22 Systems and methods for treating a mucosal surface WO2001097795A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
BR0112386-6A BR0112386A (en) 2000-06-22 2001-06-22 System and methods for treating a mucosal surface
PL36197501A PL361975A1 (en) 2000-06-22 2001-06-22 Systems and methods for treating a mucosal surface
AU2001270081A AU2001270081A1 (en) 2000-06-22 2001-06-22 Systems and methods for treating a mucosal surface
JP2002503272A JP2004508851A (en) 2000-06-22 2001-06-22 Systems and methods for treating mucosal surfaces
UA20021210399A UA81099C2 (en) 2000-06-22 2001-06-22 System for treating a mucosal surface comprising an immune response modifier
CA002410208A CA2410208A1 (en) 2000-06-22 2001-06-22 Systems and methods for treating a mucosal surface
MXPA02012524A MXPA02012524A (en) 2000-06-22 2001-06-22 Systems and methods for treating a mucosal surface.
SK1781-2002A SK17812002A3 (en) 2000-06-22 2001-06-22 Systems and methods for treating a mucosal surface
IL15308701A IL153087A0 (en) 2000-06-22 2001-06-22 Systems and methods for treating a mucosal surface
EP01948622A EP1296644A2 (en) 2000-06-22 2001-06-22 Systems and methods for treating a mucosal surface
EEP200200705A EE200200705A (en) 2000-06-22 2001-06-22 Systems and methods for treating mucosa
NZ523073A NZ523073A (en) 2000-06-22 2001-06-22 Systems and methods for treating a mucosal surface
HU0301233A HUP0301233A2 (en) 2000-06-22 2001-06-22 Compositions and methods for treating a mucosal surface
NO20026067A NO20026067L (en) 2000-06-22 2002-12-17 Systems and methods for treating a mucosal surface
HR20021024A HRP20021024A2 (en) 2000-06-22 2002-12-20 Systems and methods for treating mucosal surface

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21342000P 2000-06-22 2000-06-22
US60/213,420 2000-06-22
US09/676,339 US6486168B1 (en) 1999-01-08 2000-09-29 Formulations and methods for treatment of mucosal associated conditions with an immune response modifier
US09/676,339 2000-09-29

Publications (2)

Publication Number Publication Date
WO2001097795A2 WO2001097795A2 (en) 2001-12-27
WO2001097795A3 true WO2001097795A3 (en) 2002-04-04

Family

ID=26908067

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019979 WO2001097795A2 (en) 2000-06-22 2001-06-22 Systems and methods for treating a mucosal surface

Country Status (17)

Country Link
EP (1) EP1296644A2 (en)
JP (1) JP2004508851A (en)
CN (1) CN1273110C (en)
AU (1) AU2001270081A1 (en)
BR (1) BR0112386A (en)
CA (1) CA2410208A1 (en)
CZ (1) CZ20024175A3 (en)
EE (1) EE200200705A (en)
HR (1) HRP20021024A2 (en)
HU (1) HUP0301233A2 (en)
IL (1) IL153087A0 (en)
MX (1) MXPA02012524A (en)
NO (1) NO20026067L (en)
NZ (1) NZ523073A (en)
PL (1) PL361975A1 (en)
SK (1) SK17812002A3 (en)
WO (1) WO2001097795A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211649D0 (en) 2002-05-21 2002-07-03 Novartis Ag Organic compounds
DE60332377D1 (en) 2002-10-21 2010-06-10 Eisai Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES MEDIATED BY THE HUMANE PAPILLOMA VIRUS
WO2005041847A2 (en) * 2003-10-22 2005-05-12 University Hospitals Of Cleveland Method and apparatus for applying medication to internal tissue
JP2008530022A (en) * 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド Aqueous gel formulation containing immune response modifier

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024436A2 (en) * 1996-12-03 1998-06-11 Minnesota Mining And Manufacturing Company Gel formulations for topical drug delivery
WO2000040228A2 (en) * 1999-01-08 2000-07-13 3M Innovative Properties Company Formulations comprising imiquimod or other immune response modifiers for treating mucosal conditions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024436A2 (en) * 1996-12-03 1998-06-11 Minnesota Mining And Manufacturing Company Gel formulations for topical drug delivery
WO2000040228A2 (en) * 1999-01-08 2000-07-13 3M Innovative Properties Company Formulations comprising imiquimod or other immune response modifiers for treating mucosal conditions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
R. L. MILLER ET AL.: "Review Article. Imiquimod applied topically: a novel immune response modifier and a new class of drug", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 21, January 1999 (1999-01-01), Elmsford, NY, USA, pages 1 - 14, XP000900725 *

Also Published As

Publication number Publication date
CN1273110C (en) 2006-09-06
NO20026067D0 (en) 2002-12-17
CN1437463A (en) 2003-08-20
CA2410208A1 (en) 2001-12-27
NZ523073A (en) 2005-04-29
BR0112386A (en) 2003-06-10
SK17812002A3 (en) 2003-05-02
HUP0301233A2 (en) 2003-08-28
IL153087A0 (en) 2003-06-24
JP2004508851A (en) 2004-03-25
HRP20021024A2 (en) 2005-02-28
MXPA02012524A (en) 2003-04-10
EP1296644A2 (en) 2003-04-02
CZ20024175A3 (en) 2003-06-18
WO2001097795A2 (en) 2001-12-27
EE200200705A (en) 2004-08-16
NO20026067L (en) 2003-02-17
PL361975A1 (en) 2004-10-18
AU2001270081A1 (en) 2002-01-02

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