WO2001097750A2 - Procede de fabrication d'un produit antiviral - Google Patents

Procede de fabrication d'un produit antiviral Download PDF

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Publication number
WO2001097750A2
WO2001097750A2 PCT/RU2001/000255 RU0100255W WO0197750A2 WO 2001097750 A2 WO2001097750 A2 WO 2001097750A2 RU 0100255 W RU0100255 W RU 0100255W WO 0197750 A2 WO0197750 A2 WO 0197750A2
Authority
WO
WIPO (PCT)
Prior art keywords
lignin
producing
hours
antiviral agent
product
Prior art date
Application number
PCT/RU2001/000255
Other languages
English (en)
Russian (ru)
Other versions
WO2001097750A3 (fr
Inventor
Valery Pavlovich Shipov
Evgeny Sergeevich Pigarev
Aleksandr Ivanovich Popov
Viktor Nikolaevich Ivanov
Galina Sergeevna Shitikova
Valery Afanasievich Trofimov
Original Assignee
Nobel Limited Liability Company
Trofimova, Nadezhda Vasilievna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobel Limited Liability Company, Trofimova, Nadezhda Vasilievna filed Critical Nobel Limited Liability Company
Priority to AU2001277823A priority Critical patent/AU2001277823A1/en
Publication of WO2001097750A2 publication Critical patent/WO2001097750A2/fr
Publication of WO2001097750A3 publication Critical patent/WO2001097750A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Definitions

  • the proposed invention is subject to biotechnology and may be used in the process of receiving electronic products from a wide range of products.
  • the closest to the claimed method is the method of receiving ⁇ iv ⁇ vi ⁇ usn ⁇ g ⁇ s ⁇ eds ⁇ va, in ⁇ isanny ( ⁇ , ⁇ TS, 93037252) ⁇ y ⁇ edusma ⁇ ivae ⁇ ⁇ b ⁇ ab ⁇ u ⁇ la ⁇ inida ⁇ aliya amm ⁇ niev ⁇ y s ⁇ lyu ⁇ a ⁇ b ⁇ n ⁇ v ⁇ y ⁇ isl ⁇ y, ⁇ i e ⁇ m in ⁇ aches ⁇ ve amm ⁇ niev ⁇ y s ⁇ li is ⁇ lzuyu ⁇ lign ⁇ -gumin ⁇ vye s ⁇ li ⁇ a ⁇ b ⁇ n ⁇ v ⁇ y ⁇ isl ⁇ y, ⁇ ye ⁇ edva ⁇ i ⁇ eln ⁇ sin ⁇ ezi ⁇ uyu ⁇ ⁇ isleniem lignin schel ⁇ chn ⁇ y s ⁇ ede with ⁇ sleduyuschim release lign ⁇ - humic acid and ammonia neutral
  • the objective of the proposed invention is to dispose of a product from a raw material to a product that is beneficial to the consumer.
  • P ⁇ s ⁇ avlennaya task ⁇ eshae ⁇ sya ⁇ em, ch ⁇ ⁇ edl ⁇ zhen s ⁇ s ⁇ b ⁇ lucheniya ⁇ iv ⁇ vi ⁇ usn ⁇ g ⁇ s ⁇ eds ⁇ va, ⁇ edusma ⁇ ivayuschy ⁇ b ⁇ ab ⁇ u ⁇ la ⁇ inida ⁇ aliya ⁇ d deys ⁇ viem ul ⁇ azvu ⁇ a in ⁇ ezhime ⁇ azvi ⁇ y a ⁇ us ⁇ iches ⁇ y ⁇ avi ⁇ atsii amm ⁇ niev ⁇ y s ⁇ lyu lign ⁇ -gumin ⁇ vy ⁇ ⁇ a ⁇ b ⁇ n ⁇ vy ⁇ ⁇ isl ⁇ , ⁇ luchenny ⁇ ⁇ isleniem lignin schel ⁇ chn ⁇ y s ⁇ ede, ⁇ i e ⁇ m in s ⁇ ve ⁇ s ⁇ vii with iz ⁇ b ⁇ e ⁇ enie
  • the acidification of medical lignin in an alkaline environment can be handled at a temperature of 150-170 ° ⁇ .
  • the pressure in the process separates the partial pressure of the acid in the processed product, which affects the rate of oxidation.
  • viruses of the first group of the 1st and 2nd series have been carried out after an initial evaluation of the toxicity of the equipment for the indicated culture of the cells. For example, dilutions of the preparation were used, which amounted to 1/2 of its minimum toxic dose and were accepted for the working dose of the preparation.
  • composition of the suspension is a mixture of the suspension:
  • Suspension density 1 9 Acidification is carried out in a process with mechanical stirring at a temperature of 160 ⁇ 5 ° ⁇ at a pressure of 2.5 ⁇ réelleice Pa for 1 hour. The air intake was 5 l / min.
  • the resulting solution was produced at 0.17-0.27 mass. % platinum potassium per 1 g of humic acid and create The process of developing acoustic cavitation by deactivating ultrasound with an output power of 40 W / cm and a frequency of 22 kHz for 1 min. Further, the volume of the product is up to 100 ml.
  • the potent activity of the proposed remedy in the case of a viral load of the 1st plant is established more than 10 times lower than in the condition of the condition P ⁇ iv ⁇ vy ⁇ usnaya a ⁇ ivn ⁇ s ⁇ izves ⁇ n ⁇ g ⁇ ⁇ iv ⁇ vi ⁇ usn ⁇ g ⁇ ⁇ e ⁇ a ⁇ a ⁇ a " ⁇ eman ⁇ adin" (sin ⁇ nimy " ⁇ ta ⁇ as ⁇ e", ' ⁇ -126 ") ⁇ -1- ⁇ e ⁇ il adaman ⁇ il- me ⁇ ilamin gid ⁇ l ⁇ id in ⁇ avny ⁇ usl ⁇ viya ⁇ in ⁇ n ⁇ shenii ⁇ vi ⁇ usam ge ⁇ esa s ⁇ s ⁇ avila 1,0-1,5 1 ⁇ ⁇ TSD 5 ⁇ / ml and its concentration in the culture liquid equal to 0.125 mg / ml (working dose).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Le procédé de fabrication d'un produit antiviral de l'invention consiste à traiter un platinide de sodium avec du sel d'ammonium de l'acide carbonique; on utilise à cet effet des acides humiques obtenus à partir de la lignine oxydée à usage médical, que l'on fabrique par l'oxydation de la lignine oxydée avec de l'oxygène contenu dans l'air, dans un milieu aqueux de base à une température entre 150° et 170 °C et une pression entre 2,0 et 2,5 MPa pendant 0,5 heure à 1,5 heure. La préparation ainsi obtenue manifeste une activité antivirale fortement prononcée dirigée contre les virus de l'herpès simple des sérotypes 1 et 2, de la grippe et du sarcome de Rous.
PCT/RU2001/000255 2000-06-19 2001-06-15 Procede de fabrication d'un produit antiviral WO2001097750A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001277823A AU2001277823A1 (en) 2000-06-19 2001-06-15 Method for producing an antiviral agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2000115399 2000-06-19
RU2000115399/14A RU2172176C1 (ru) 2000-06-19 2000-06-19 Способ получения противовирусного средства

Publications (2)

Publication Number Publication Date
WO2001097750A2 true WO2001097750A2 (fr) 2001-12-27
WO2001097750A3 WO2001097750A3 (fr) 2002-03-07

Family

ID=20236225

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2001/000255 WO2001097750A2 (fr) 2000-06-19 2001-06-15 Procede de fabrication d'un produit antiviral

Country Status (3)

Country Link
AU (1) AU2001277823A1 (fr)
RU (1) RU2172176C1 (fr)
WO (1) WO2001097750A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1369122A4 (fr) * 2001-02-21 2004-05-06 Nobel Ltd Liability Company Agent anticancereux
WO2013143549A1 (fr) * 2012-03-30 2013-10-03 Rdinnovation Aps Composés acides benzène polycarboxyliques et leur utilisation comme médicament

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2678986C1 (ru) * 2018-03-23 2019-02-05 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Противовирусное средство на основе гуминовых кислот

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419351A (en) * 1977-06-03 1983-12-06 Research Corporation Platinum-dioxopyrimidine complexes
US4873226A (en) * 1983-06-17 1989-10-10 Delta Metals, Inc. Method of inhibiting herpetic lesions by the use of platinum coordination compounds
RU2104016C1 (ru) * 1990-05-27 1998-02-10 Шантал Мах Способ получения водного раствора, содержащего активные вещества антивирусного действия

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419351A (en) * 1977-06-03 1983-12-06 Research Corporation Platinum-dioxopyrimidine complexes
US4873226A (en) * 1983-06-17 1989-10-10 Delta Metals, Inc. Method of inhibiting herpetic lesions by the use of platinum coordination compounds
RU2104016C1 (ru) * 1990-05-27 1998-02-10 Шантал Мах Способ получения водного раствора, содержащего активные вещества антивирусного действия

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
IZOBRETENIYA no. 1, 10 January 1997, MOSCOW, VNIIPI, page 22 & RU 93 937 252 A (NAUCHNO-PROIZVODSTVENNOE PREDPRIYATIE, ANTIVIRUS) *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1369122A4 (fr) * 2001-02-21 2004-05-06 Nobel Ltd Liability Company Agent anticancereux
EP1810684A3 (fr) * 2001-02-21 2008-04-16 Nobel Limited Liability Company Agent anticancéreux
WO2013143549A1 (fr) * 2012-03-30 2013-10-03 Rdinnovation Aps Composés acides benzène polycarboxyliques et leur utilisation comme médicament
CN104245800A (zh) * 2012-03-30 2014-12-24 Rd创新有限公司 新苯聚羧酸化合物
US9644074B2 (en) 2012-03-30 2017-05-09 Rinnovation Aps Benzene polycarboxylic acid compounds and their use as drug

Also Published As

Publication number Publication date
WO2001097750A3 (fr) 2002-03-07
RU2172176C1 (ru) 2001-08-20
AU2001277823A1 (en) 2002-01-02

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