WO2001096535A3 - Nukleinsäure codierend eine bindungsstelle einer protein kinase der mitogenen signalisierungskaskade für ein die glykolyse katalysierendes enzym - Google Patents

Nukleinsäure codierend eine bindungsstelle einer protein kinase der mitogenen signalisierungskaskade für ein die glykolyse katalysierendes enzym Download PDF

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Publication number
WO2001096535A3
WO2001096535A3 PCT/DE2001/002246 DE0102246W WO0196535A3 WO 2001096535 A3 WO2001096535 A3 WO 2001096535A3 DE 0102246 W DE0102246 W DE 0102246W WO 0196535 A3 WO0196535 A3 WO 0196535A3
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WO
WIPO (PCT)
Prior art keywords
nucleic acid
glycolysis
protein kinase
acid coding
signalling cascade
Prior art date
Application number
PCT/DE2001/002246
Other languages
English (en)
French (fr)
Other versions
WO2001096535A2 (de
Inventor
Ulf R Rapp
Erich Eigenbrodt
Original Assignee
Ulf R Rapp
Schebo Biotech Ag
Erich Eigenbrodt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ulf R Rapp, Schebo Biotech Ag, Erich Eigenbrodt filed Critical Ulf R Rapp
Priority to EP01951397A priority Critical patent/EP1290189A2/de
Priority to US10/311,527 priority patent/US20040115631A1/en
Priority to AU7234301A priority patent/AU7234301A/xx
Publication of WO2001096535A2 publication Critical patent/WO2001096535A2/de
Publication of WO2001096535A3 publication Critical patent/WO2001096535A3/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/0104—Pyruvate kinase (2.7.1.40)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die Erfindung lehrt eine Nukleinsäure codierend für zumindest eine Teilsequenz einer Protein Kinase der mitogenen Signalisierungskaskade, wobei die Teilsequenz für eine Bindungsstelle für ein die Glykolyse katalysierendes Enzym codiert, oder stille Mutation einer solchen Nukleinsäure oder mit einer solchen Nukleinsäure oder deren stillen Mutation hybridisierende Nukleinsäure.
PCT/DE2001/002246 2000-06-14 2001-06-14 Nukleinsäure codierend eine bindungsstelle einer protein kinase der mitogenen signalisierungskaskade für ein die glykolyse katalysierendes enzym WO2001096535A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01951397A EP1290189A2 (de) 2000-06-14 2001-06-14 Nukleinsäure codierend eine bindungsstelle einer protein kinase der mitogenen signalisierungskaskade für ein die glykolyse katalysierendes enzym
US10/311,527 US20040115631A1 (en) 2000-06-14 2001-06-14 Nucleic acid coding for a bonding site of a protein kinase of the mitogenic signalling cascade of a clycolysis-catalysing enzyme
AU7234301A AU7234301A (en) 2000-06-14 2001-06-14 Nucleic acid coding for a bonding site of a protein kinase of the mitogenic signalling cascade of a glycolysis-catalysing enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10029131A DE10029131A1 (de) 2000-06-14 2000-06-14 Nukleinsäure codierend eine Bindungsstelle einer Protein Kinase der mitogenen Signalisierungskaskade für ein die Glykolyse katalysierendes Enzym
DE10029131.7 2000-06-14

Publications (2)

Publication Number Publication Date
WO2001096535A2 WO2001096535A2 (de) 2001-12-20
WO2001096535A3 true WO2001096535A3 (de) 2002-07-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/002246 WO2001096535A2 (de) 2000-06-14 2001-06-14 Nukleinsäure codierend eine bindungsstelle einer protein kinase der mitogenen signalisierungskaskade für ein die glykolyse katalysierendes enzym

Country Status (5)

Country Link
US (1) US20040115631A1 (de)
EP (1) EP1290189A2 (de)
AU (1) AU7234301A (de)
DE (1) DE10029131A1 (de)
WO (1) WO2001096535A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002026246A2 (en) * 2000-09-29 2002-04-04 Gsf-Forschungszentrum Für Umwelt Und Gesundheit, Gmbh Pharmaceutical compositions comprising polynucleotides encoding a raf protein
AU2003209886A1 (en) * 2002-03-14 2003-09-22 Qlt Inc. Cancer associated araf1 protein kinase and its uses
WO2004016646A2 (en) * 2002-08-12 2004-02-26 Amynon Bio Tech Gmbh Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk)
CN104379161A (zh) * 2012-03-15 2015-02-25 乔治亚州立大学研究基金会 促进血管生长的蛋白质及其用途
US9921221B2 (en) * 2012-07-26 2018-03-20 Joslin Diabetes Center, Inc. Predicting and treating diabetic complications

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656612A (en) * 1994-05-31 1997-08-12 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHENG XIAODONG ET AL: "Effects of conserved residues on the regulation of rabbit muscle pyruvate kinase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 11, 1996, pages 6313 - 6321, XP002187624, ISSN: 0021-9258 *
DATABASE EMBL 16 July 1988 (1988-07-16), ISHIKAWA F ET AL: "Rat A-raf mRNA", XP002187627 *
DATABASE EMBL 7 June 1987 (1987-06-07), BECK T W ET AL: "Human mRNA for A-raf-1 oncogene", XP002187626 *
HAGEMANN CARSTEN ET AL: "Isotype-specific functions of Raf kinases.", EXPERIMENTAL CELL RESEARCH, vol. 253, no. 1, 25 November 1999 (1999-11-25), pages 34 - 46, XP002187623, ISSN: 0014-4827 *
ZWERSCHKE WERNER ET AL: "Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 4, 16 February 1999 (1999-02-16), Feb. 16, 1999, pages 1291 - 1296, XP002187625, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
US20040115631A1 (en) 2004-06-17
AU7234301A (en) 2001-12-24
WO2001096535A2 (de) 2001-12-20
EP1290189A2 (de) 2003-03-12
DE10029131A1 (de) 2002-01-03

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