WO1999053091A3 - Gdnf-kodierende dna, teile davon und gdnf-varianten - Google Patents

Gdnf-kodierende dna, teile davon und gdnf-varianten Download PDF

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Publication number
WO1999053091A3
WO1999053091A3 PCT/DE1999/001111 DE9901111W WO9953091A3 WO 1999053091 A3 WO1999053091 A3 WO 1999053091A3 DE 9901111 W DE9901111 W DE 9901111W WO 9953091 A3 WO9953091 A3 WO 9953091A3
Authority
WO
WIPO (PCT)
Prior art keywords
gdnf
dna
parts
variants
coding
Prior art date
Application number
PCT/DE1999/001111
Other languages
English (en)
French (fr)
Other versions
WO1999053091A2 (de
WO1999053091A9 (de
Inventor
Thomas Meitinger
Lena Grimm
Elke Holinski-Feder
Marius Ueffing
Original Assignee
Gsf Forschungszentrum Umwelt
Thomas Meitinger
Lena Grimm
Holinski Feder Elke
Marius Ueffing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gsf Forschungszentrum Umwelt, Thomas Meitinger, Lena Grimm, Holinski Feder Elke, Marius Ueffing filed Critical Gsf Forschungszentrum Umwelt
Priority to EP99927658A priority Critical patent/EP1086220A2/de
Priority to AU44964/99A priority patent/AU4496499A/en
Publication of WO1999053091A2 publication Critical patent/WO1999053091A2/de
Publication of WO1999053091A9 publication Critical patent/WO1999053091A9/de
Publication of WO1999053091A3 publication Critical patent/WO1999053091A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Die vorliegende Erfindung betrifft eine GDNF-kodierende DNA, Teile davon und GDNF-Varianten sowie gegen sie gerichtete Antikörper. Ferner betrifft die Erfindung die Verwendung der GDNF-kodierenden DNA, Teile davon und der GDNF-Varianten.
PCT/DE1999/001111 1998-04-14 1999-04-14 Gdnf-kodierende dna, teile davon und gdnf-varianten WO1999053091A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99927658A EP1086220A2 (de) 1998-04-14 1999-04-14 Gdnf-kodierende dna, teile davon und gdnf-varianten
AU44964/99A AU4496499A (en) 1998-04-14 1999-04-14 Dna coding for gdnf, parts of said dna and gdnf variants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19816186.7 1998-04-14
DE1998116186 DE19816186A1 (de) 1998-04-14 1998-04-14 GDNF-kodierende DNA, Teile davon und GDNF-Varianten

Publications (3)

Publication Number Publication Date
WO1999053091A2 WO1999053091A2 (de) 1999-10-21
WO1999053091A9 WO1999053091A9 (de) 1999-12-02
WO1999053091A3 true WO1999053091A3 (de) 2000-03-30

Family

ID=7864285

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/001111 WO1999053091A2 (de) 1998-04-14 1999-04-14 Gdnf-kodierende dna, teile davon und gdnf-varianten

Country Status (4)

Country Link
EP (1) EP1086220A2 (de)
AU (1) AU4496499A (de)
DE (1) DE19816186A1 (de)
WO (1) WO1999053091A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002359786A1 (en) * 2001-12-19 2003-07-09 Hiroaki Mizukami Adeno-associated virus-mediated delivery of gdnf to skeletal muscles
FI20070808A0 (fi) * 2007-10-25 2007-10-25 Mart Saarma GDNF:n silmukointivariantit ja niiden käytöt
EP2067858A1 (de) 2007-12-07 2009-06-10 Universidad de Sevilla Tiermodelle für neurodegenerative Erkrankungen
UA112981C2 (uk) * 2011-04-11 2016-11-25 Елі Ліллі Енд Компані Варіант людського gdnf

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006116A1 (en) * 1991-09-20 1993-04-01 Syntex-Synergen Neuroscience Joint Venture Glial derived neurotrophic factor
WO1995017203A1 (en) * 1993-12-22 1995-06-29 The University Of Medicine And Dentistry Of New Jersey Novel nucleic acid sequences isolated from glial cells
WO1998046737A2 (en) * 1997-04-15 1998-10-22 University Of Medicine And Dentistry Of New Jersey cDNA FOR HUMAN GDNF AND PROMOTER THEREFOR WHICH ALLOWS REGULATED AND CONSTITUTIVE EXPRESSION
WO1999007843A1 (en) * 1997-08-05 1999-02-18 F. Hoffman-La Roche Ag Human glial cell line-derived neurotrophic factor promoters, vectors containing same, and methods of screening compounds therewith

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Publication number Priority date Publication date Assignee Title
US5585237A (en) * 1993-10-25 1996-12-17 Creative Biomolecules, Inc. Methods and compositions for high protein production from recombinant DNA
FR2717824B1 (fr) * 1994-03-25 1996-04-26 Rhone Poulenc Rorer Sa Virus recombinants, préparation et utilisation en thérapie génique.
US6184200B1 (en) * 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
EP0888385B1 (de) * 1996-03-14 2003-08-20 Genentech, Inc. Gdnf-rezeptor und dessen verwendung
EP0886651B1 (de) * 1996-03-14 2005-01-26 Washington University Persephin und verwandte wachstumsfaktoren
US6455277B1 (en) * 1996-04-22 2002-09-24 Amgen Inc. Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides
AU2677797A (en) * 1996-04-25 1997-11-12 Genetic Therapy, Inc. Viral vectors including polynucleotides encoding neurotrophic factors and uses therefor
AU7583898A (en) * 1997-05-20 1998-12-11 Human Genome Sciences, Inc. Gdnf receptors
WO1998052591A1 (en) * 1997-05-22 1998-11-26 Cephalon Inc. Glial cell line-derived neurotrophic factor receptors
EP0983354A2 (de) * 1997-05-30 2000-03-08 Amgen Inc. Neurotrophen faktor rezeptoren
ATE363914T1 (de) * 1997-09-09 2007-06-15 Curis Inc Synergistische wirkung des ob/bmp morphogens und gdnf/ngf neurotropher faktoren

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006116A1 (en) * 1991-09-20 1993-04-01 Syntex-Synergen Neuroscience Joint Venture Glial derived neurotrophic factor
WO1995017203A1 (en) * 1993-12-22 1995-06-29 The University Of Medicine And Dentistry Of New Jersey Novel nucleic acid sequences isolated from glial cells
WO1998046737A2 (en) * 1997-04-15 1998-10-22 University Of Medicine And Dentistry Of New Jersey cDNA FOR HUMAN GDNF AND PROMOTER THEREFOR WHICH ALLOWS REGULATED AND CONSTITUTIVE EXPRESSION
WO1999007843A1 (en) * 1997-08-05 1999-02-18 F. Hoffman-La Roche Ag Human glial cell line-derived neurotrophic factor promoters, vectors containing same, and methods of screening compounds therewith

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
D WOODBURY ET AL: "A novel promoter allows regulated and constitutive expression of the human GDNF gene", SOCIETY FOR NEUROSCIENCE ABSTRACTS, October 1997 (1997-10-01), XP002079602 *
GRIMM ET AL.: "Analysis of the human GDNF gene reveals an inducible promoter, three exons, a triplet repeat within the 3'-UTR and alternative splice products", HUMAN MOLECULAR GENETICS, vol. 7, no. 12, November 1998 (1998-11-01), pages 1873 - 1886, XP002127899 *
GRIMM ET AL.: "Genomic organization of the GDNF gene and functional analysis of the distal promoter region", EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 6, no. suppl. 1, - 13 May 1998 (1998-05-13), pages 152, XP000867017 *
N MATSUSHITA ET AL: "Cloning and structural organization of the gene encoding the mouse glial cell line-derived neurotrophic factor, GDNF", GENE,NL,ELSEVIER, AMSTERDAM, vol. 203, no. 2, December 1997 (1997-12-01), pages 149-157, XP002080111, ISSN: 0378-1119 *
SUTER-CRAZZOLARA, C. (1) ET AL: "Characterization of a human GDNF gene- promoter.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, (1997) VOL. 23, NO. 1-2, PP. 90. MEETING INFO.: 27TH ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE, PART NEW ORLEANS, LOUISIANA, USA OCTOBER 25-30, 1997, XP000866484 *
TRUPP M ET AL: "PERIPHERAL EXPRESSION AND BIOLOGICAL ACTIVITIES OF GDNF, A NEW NEUROTROPHIC FACTOR FOR AVIAN AND MAMMALIAN PERIPHERAL NEURONS", THE JOURNAL OF CELL BIOLOGY,US,ROCKEFELLER UNIVERSITY PRESS, vol. 130, no. 1, July 1995 (1995-07-01), pages 137-148, XP002047358, ISSN: 0021-9525 *

Also Published As

Publication number Publication date
DE19816186A1 (de) 1999-10-21
AU4496499A (en) 1999-11-01
WO1999053091A2 (de) 1999-10-21
WO1999053091A9 (de) 1999-12-02
EP1086220A2 (de) 2001-03-28

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