WO2001086293A8 - A method for designing and screening random libraries of compounds - Google Patents

A method for designing and screening random libraries of compounds

Info

Publication number
WO2001086293A8
WO2001086293A8 PCT/IB2001/000810 IB0100810W WO0186293A8 WO 2001086293 A8 WO2001086293 A8 WO 2001086293A8 IB 0100810 W IB0100810 W IB 0100810W WO 0186293 A8 WO0186293 A8 WO 0186293A8
Authority
WO
WIPO (PCT)
Prior art keywords
designing
compounds
random libraries
screening random
screening
Prior art date
Application number
PCT/IB2001/000810
Other versions
WO2001086293A2 (en
Inventor
Mikhail Popkov
Rosemonde Mandeville
Oleg Romar
Valery Alakhov
Original Assignee
Supratek Pharma Inc
Biophage Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Supratek Pharma Inc, Biophage Inc filed Critical Supratek Pharma Inc
Priority to CA002408652A priority Critical patent/CA2408652A1/en
Priority to JP2001583186A priority patent/JP2003532431A/en
Priority to EP01931986A priority patent/EP1309869A1/en
Priority to AU2001258667A priority patent/AU2001258667A1/en
Publication of WO2001086293A2 publication Critical patent/WO2001086293A2/en
Publication of WO2001086293A8 publication Critical patent/WO2001086293A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PCT/IB2001/000810 2000-05-12 2001-05-11 A method for designing and screening random libraries of compounds WO2001086293A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002408652A CA2408652A1 (en) 2000-05-12 2001-05-11 A method for designing and screening random libraries of compounds
JP2001583186A JP2003532431A (en) 2000-05-12 2001-05-11 Methods for designing and screening random libraries of compounds
EP01931986A EP1309869A1 (en) 2000-05-12 2001-05-11 Designing and screening random libraries of compounds
AU2001258667A AU2001258667A1 (en) 2000-05-12 2001-05-11 A method for designing and screening random libraries of compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57047700A 2000-05-12 2000-05-12
US09/570,477 2000-05-12

Publications (2)

Publication Number Publication Date
WO2001086293A2 WO2001086293A2 (en) 2001-11-15
WO2001086293A8 true WO2001086293A8 (en) 2003-03-06

Family

ID=24279792

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/000810 WO2001086293A2 (en) 2000-05-12 2001-05-11 A method for designing and screening random libraries of compounds

Country Status (5)

Country Link
EP (1) EP1309869A1 (en)
JP (1) JP2003532431A (en)
AU (1) AU2001258667A1 (en)
CA (1) CA2408652A1 (en)
WO (1) WO2001086293A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030224480A1 (en) * 2001-12-27 2003-12-04 Fujitsu Limited Method of designing multifunctional base sequence
JP4953046B2 (en) * 2005-07-29 2012-06-13 独立行政法人産業技術総合研究所 A novel functional peptide creation system that combines a random peptide library or a peptide library that mimics an antibody hypervariable region and an in vitro peptide selection method using RNA-binding proteins

Also Published As

Publication number Publication date
EP1309869A1 (en) 2003-05-14
CA2408652A1 (en) 2001-11-15
JP2003532431A (en) 2003-11-05
AU2001258667A1 (en) 2001-11-20
WO2001086293A2 (en) 2001-11-15

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