AU2002346915A1 - A method of forming a dynamic combinatorial library using a scaffold - Google Patents
A method of forming a dynamic combinatorial library using a scaffoldInfo
- Publication number
- AU2002346915A1 AU2002346915A1 AU2002346915A AU2002346915A AU2002346915A1 AU 2002346915 A1 AU2002346915 A1 AU 2002346915A1 AU 2002346915 A AU2002346915 A AU 2002346915A AU 2002346915 A AU2002346915 A AU 2002346915A AU 2002346915 A1 AU2002346915 A1 AU 2002346915A1
- Authority
- AU
- Australia
- Prior art keywords
- scaffold
- forming
- combinatorial library
- dynamic combinatorial
- dynamic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32880201P | 2001-10-15 | 2001-10-15 | |
US60/328,802 | 2001-10-15 | ||
US35673102P | 2002-02-15 | 2002-02-15 | |
US60/356,731 | 2002-02-15 | ||
PCT/EP2002/011520 WO2003034071A2 (en) | 2001-10-15 | 2002-10-15 | A method of forming a dynamic combinatorial library using a scaffold |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002346915A1 true AU2002346915A1 (en) | 2003-04-28 |
Family
ID=26986521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002346915A Abandoned AU2002346915A1 (en) | 2001-10-15 | 2002-10-15 | A method of forming a dynamic combinatorial library using a scaffold |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2002346915A1 (en) |
WO (2) | WO2003034071A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE354096T1 (en) | 2002-12-23 | 2007-03-15 | Astex Therapeutics Ltd | SYNTHESIS AND SCREENING OF LIGANDS USING X-RAY CRYSTALLOGRAPHY |
EP1623216A2 (en) * | 2003-04-11 | 2006-02-08 | SGX Pharmaceuticals, Inc. | Compound libraries and methods for drug discovery |
EP1496039B1 (en) * | 2003-07-11 | 2018-02-14 | Kirschfeld, Andreas | A method for the generation of a dynamic combinatorial library |
EP1496038A1 (en) * | 2003-07-11 | 2005-01-12 | Therascope AG | A method for the generation of a dynamic combinatorial library using nitrones |
WO2009068321A1 (en) * | 2007-11-26 | 2009-06-04 | Forschungsverbund Berlin E.V. | Site-directed high throughput screening |
DE102011117128A1 (en) * | 2011-10-28 | 2013-05-02 | Christian-Albrechts-Universität Zu Kiel | Compounds for the treatment of influenza |
JP6754997B2 (en) * | 2013-08-26 | 2020-09-16 | 国立大学法人 東京大学 | A large cyclic peptide, a method for producing the same, and a screening method using a large cyclic peptide library. |
CN107325040B (en) * | 2016-04-28 | 2019-05-03 | 广州市恒诺康医药科技有限公司 | Cyclohexene derivative or its pharmaceutically acceptable salt and application thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6008058A (en) * | 1993-06-18 | 1999-12-28 | University Of Louisville | Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis |
WO1995034577A1 (en) * | 1994-06-16 | 1995-12-21 | Smithkline Beecham Corporation | Template directed cyclization |
US5958702A (en) * | 1995-02-06 | 1999-09-28 | Benner; Steven Albert | Receptor-assisted combinatorial chemistry |
DE19619373A1 (en) * | 1996-05-14 | 1997-11-20 | Hoechst Ag | New substance library and the resulting supramolecular complexes |
US20020068301A1 (en) * | 1997-05-28 | 2002-06-06 | Hung-Sen Lai | Cyclic peptide libraries and methods of use thereof to identify binding motifs |
TW477783B (en) * | 1997-12-12 | 2002-03-01 | Gilead Sciences Inc | Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same |
CA2284459C (en) * | 1999-10-04 | 2012-12-11 | Neokimia Inc. | Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery |
EP1130009A1 (en) * | 2000-03-01 | 2001-09-05 | Therascope AG | Generation and screening of a dynamic combinatorial library |
-
2002
- 2002-10-15 AU AU2002346915A patent/AU2002346915A1/en not_active Abandoned
- 2002-10-15 WO PCT/EP2002/011520 patent/WO2003034071A2/en not_active Application Discontinuation
- 2002-10-15 WO PCT/EP2002/011526 patent/WO2003033437A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2003034071A3 (en) | 2004-03-11 |
WO2003033437A2 (en) | 2003-04-24 |
WO2003033437A3 (en) | 2003-12-18 |
WO2003034071A2 (en) | 2003-04-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |