WO2001083702A3 - Novel members of the lysyl oxidases family of amine oxidases related applications - Google Patents
Novel members of the lysyl oxidases family of amine oxidases related applications Download PDFInfo
- Publication number
- WO2001083702A3 WO2001083702A3 PCT/US2001/014472 US0114472W WO0183702A3 WO 2001083702 A3 WO2001083702 A3 WO 2001083702A3 US 0114472 W US0114472 W US 0114472W WO 0183702 A3 WO0183702 A3 WO 0183702A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- proteins
- lox
- family
- present
- antibodies
- Prior art date
Links
- 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 title abstract 4
- 102000004316 Oxidoreductases Human genes 0.000 title 1
- 108090000854 Oxidoreductases Proteins 0.000 title 1
- 102000004669 Protein-Lysine 6-Oxidase Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 11
- 102000004169 proteins and genes Human genes 0.000 abstract 9
- 102100021949 Lysyl oxidase homolog 3 Human genes 0.000 abstract 3
- 102100026858 Protein-lysine 6-oxidase Human genes 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 101150070593 lox gene Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 101001043321 Homo sapiens Lysyl oxidase homolog 1 Proteins 0.000 abstract 2
- 101001043352 Homo sapiens Lysyl oxidase homolog 2 Proteins 0.000 abstract 2
- 101001043354 Homo sapiens Lysyl oxidase homolog 3 Proteins 0.000 abstract 2
- 101001043351 Homo sapiens Lysyl oxidase homolog 4 Proteins 0.000 abstract 2
- 102100021948 Lysyl oxidase homolog 2 Human genes 0.000 abstract 2
- 102100021968 Lysyl oxidase homolog 4 Human genes 0.000 abstract 2
- 230000003197 catalytic effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 102100021958 Lysyl oxidase homolog 1 Human genes 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000004166 bioassay Methods 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000014107 chromosome localization Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 108020001580 protein domains Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011820 transgenic animal model Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
- C12N9/0024—D-Amino acid oxidase (1.4.3.3)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001261194A AU2001261194A1 (en) | 2000-05-03 | 2001-05-03 | Novel members of the lysyl oxidases family of amine oxidases related applications |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20158700P | 2000-05-03 | 2000-05-03 | |
US60/201,587 | 2000-05-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001083702A2 WO2001083702A2 (en) | 2001-11-08 |
WO2001083702A3 true WO2001083702A3 (en) | 2005-03-03 |
Family
ID=22746439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/014472 WO2001083702A2 (en) | 2000-05-03 | 2001-05-03 | Novel members of the lysyl oxidases family of amine oxidases related applications |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2001261194A1 (en) |
WO (1) | WO2001083702A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8163494B2 (en) | 2002-11-27 | 2012-04-24 | Technion Research & Development Foundation Ltd. | Method for assessing metastatic properties of breast cancer |
US8461303B2 (en) | 2007-08-02 | 2013-06-11 | Gilead Biologics, Inc. | LOX and LOXL2 inhibitors and uses thereof |
US8927700B2 (en) | 2009-08-21 | 2015-01-06 | Gilead Biologics, Inc. | Catalytic domains from lysyl oxidase and LOXL2 |
US9107935B2 (en) | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2387329T3 (en) * | 2000-08-08 | 2012-09-20 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and procedures useful for modulating angiogenesis |
CA2418952A1 (en) | 2000-08-08 | 2002-02-14 | Wyeth | A novel member of the lysyl oxidase gene family |
GB2438999B (en) * | 2003-06-13 | 2008-01-16 | Engelhard Lyon | Stimulation of the synthesis and of the activity of an isoform of lysyl oxidase-like LOXL for stimulating the formation of elastic fibres |
FR2855969B1 (en) * | 2003-06-13 | 2012-11-30 | Coletica | STIMULATION OF THE ACTIVITY OF A LYSYL OXIDASE ISOFORM TO FIGHT CERTAIN PATHOLOGIES DUE TO AN INCOMPLETE, ABSENT OR DISORGANIZED ELASTOGENESIS |
FR2855968B1 (en) * | 2003-06-13 | 2012-11-30 | Coletica | STIMULATION OF THE SYNTHESIS AND ACTIVITY OF A LYSYL OXIDASE-LIKE LOXL ISOFORM TO STIMULATE THE FORMATION OF ELASTIC FIBERS |
EP1706139A4 (en) | 2004-01-23 | 2009-06-17 | Massachusetts Eye & Ear Infirm | Lysyl oxidase-like 1 (loxl1) and elastogenesis |
FR2892635B1 (en) | 2005-10-28 | 2012-11-09 | Engelhard Lyon | SUBSTANCE FOR RESTORING NORMAL CO-EXPRESSION AND INTERACTION BETWEEN LOX AND NRAGE PROTEINS |
IL184627A0 (en) | 2007-07-15 | 2008-12-29 | Technion Res & Dev Foundation | Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue |
JP6059859B2 (en) * | 2009-11-16 | 2017-01-11 | ビーエーエスエフ ビューティ ケア ソリューションズ フランス エスエーエスBASF Beauty Care Solutions France S.A.S. | Stimulation of synthesis and activity of LOXL (lysyl oxidase-like) isoforms to stimulate the formation of elastic fibers |
JP6134142B2 (en) * | 2010-02-04 | 2017-05-24 | ギリアド バイオロジクス, インク.Gilead Biologics, Inc. | Antibody binding to lysyl oxidase-like 2 (LOXL2) and method of use thereof |
EP2694554A1 (en) | 2011-04-08 | 2014-02-12 | Gilead Biologics, Inc. | Methods and compositions for normalization of tumor vasculature by inhibition of loxl2 |
EA201692202A1 (en) | 2014-06-11 | 2017-06-30 | Джилид Сайэнс, Инк. | METHODS OF TREATING CARDIOVASCULAR DISEASES |
EP2990480A1 (en) * | 2014-08-29 | 2016-03-02 | Christian-Albrechts-Universität zu Kiel | Anti-LOXL4 antibodies and derivatives there |
JP2015147798A (en) * | 2015-04-20 | 2015-08-20 | ビーエーエスエフ ビューティ ケア ソリューションズ フランス エスエーエス | Stimulation of synthesis and of activity of isoform of loxl (lysyl oxidase-like) for stimulating formation of elastic fiber |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6140056A (en) * | 1999-01-27 | 2000-10-31 | Millennium Pharmaceuticals, Inc. | MSP-18 protein and nucleic acid molecules and uses therefor |
-
2001
- 2001-05-03 AU AU2001261194A patent/AU2001261194A1/en not_active Abandoned
- 2001-05-03 WO PCT/US2001/014472 patent/WO2001083702A2/en active Search and Examination
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6140056A (en) * | 1999-01-27 | 2000-10-31 | Millennium Pharmaceuticals, Inc. | MSP-18 protein and nucleic acid molecules and uses therefor |
Non-Patent Citations (2)
Title |
---|
ITO H. ET AL.: "Molecular cloning and biological activity of a novel lysyl oxidase gene expressed in cartillage", J. BIOL. CHEM., vol. 276, no. 2, 5 April 2001 (2001-04-05), pages 24023 - 24029, XP002199860 * |
MAKI J.M.: "Cloning and characterization of a four human lysyl oxidase isoenzyme", BIOCHEM. J., vol. 355, 15 April 2001 (2001-04-15), pages 381 - 387, XP002983391 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8163494B2 (en) | 2002-11-27 | 2012-04-24 | Technion Research & Development Foundation Ltd. | Method for assessing metastatic properties of breast cancer |
US8461303B2 (en) | 2007-08-02 | 2013-06-11 | Gilead Biologics, Inc. | LOX and LOXL2 inhibitors and uses thereof |
US8679485B2 (en) | 2007-08-02 | 2014-03-25 | Gilead Biologics, Inc. | Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis |
US9176139B2 (en) | 2007-08-02 | 2015-11-03 | Gilead Biologics, Inc. | LOX and LOXL2 inhibitors and uses thereof |
US9107935B2 (en) | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
US9289447B2 (en) | 2009-01-06 | 2016-03-22 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
US8927700B2 (en) | 2009-08-21 | 2015-01-06 | Gilead Biologics, Inc. | Catalytic domains from lysyl oxidase and LOXL2 |
Also Published As
Publication number | Publication date |
---|---|
AU2001261194A1 (en) | 2001-11-12 |
WO2001083702A2 (en) | 2001-11-08 |
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