WO2001078897A1 - Dispositif de reglage - Google Patents

Dispositif de reglage Download PDF

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Publication number
WO2001078897A1
WO2001078897A1 PCT/EP2001/000811 EP0100811W WO0178897A1 WO 2001078897 A1 WO2001078897 A1 WO 2001078897A1 EP 0100811 W EP0100811 W EP 0100811W WO 0178897 A1 WO0178897 A1 WO 0178897A1
Authority
WO
WIPO (PCT)
Prior art keywords
adjusting device
sample
holding
holding devices
loading
Prior art date
Application number
PCT/EP2001/000811
Other languages
German (de)
English (en)
Inventor
Klaus Egger
Edgar Sauer
Rainer Gauchel
Original Assignee
Mwg Biotech Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mwg Biotech Ag filed Critical Mwg Biotech Ag
Priority to AU2001228493A priority Critical patent/AU2001228493A1/en
Publication of WO2001078897A1 publication Critical patent/WO2001078897A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1037—Using surface tension, e.g. pins or wires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1039—Micropipettes, e.g. microcapillary tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
    • G01N2035/1069—Multiple transfer devices for transfer to or from containers having different spacing by adjusting the spacing between multiple probes of a single transferring head

Definitions

  • the present invention relates generally to an adjustment device, and more particularly relates to an adjustment device for an apparatus for automatically loading sample combs.
  • CH 671 526 describes a pipetting device in which the pipettes are simultaneously adapted to the microtiter plate at a distance from one another in the process for taking up reagents. This is done by rotating a roller 48, which has a number of grooves 50 formed on its surface with different pitches and projections 51 engaging therein, to which the pipettes 34 are attached. By turning this roller 48, the lugs 51 and thus the pipettes 34 are displaced uniformly relative to one another (p. 4, right column, lines 42 ff., FIGS. 5, 6). As a result, the pipettes 34 are moved from a first position, in which they are closely spaced from one another, to a second position, in which they are far apart.
  • the roller 48 can be seen, here the helical grooves 51 being closely spaced at one end, while the grooves 51 are widely spaced at the other end.
  • liquid is taken up by means of the pipettes 34, while at station III. ( Figure 3) the liquid is dispensed. Between stations I and III. the pipettes 34 are shifted and at the same time the distance between the pipettes 34 is changed. In addition to the two end positions (narrow or wide) of the pipettes 34, an intermediate distance can also be set.
  • DD 282 082 describes a device for distributing sample liquids, in which a sample distribution area 30, which contains distribution units 31-35 with tips 3, by means of a combination of a threaded rod 73, a lever 60, pins 51-54 and a pin 62 in it Width is changed. Due to the inclined position of the lever 60, the spacing of the distribution units 31-35 from one another is achieved by the engagement of the pins 51-54 and the pin 62 in the lever 60 (see FIG. 4 there). This construction allows the tips 3 to be shifted between the two end positions (close or wide distance), intermediate positions also being possible.
  • the working means also include pipette needles 44.
  • the pipette needles 44 are each mounted on separate carrier strips 42 which can be displaced by means of a pivot lever 48 such that the distance between all pipette needles 44 changes uniformly.
  • the distance between the pipette needles 44 can be changed not only in one direction (X), but also in the two other spatial directions (Y, Z).
  • the entire holding device has a very complex structure, but here too the distance between the pipette needles 44 can be changed from "narrow" (FIG. 2) to "wide” (FIG. 1).
  • US Pat. No. 5,061,449 describes a hand-operated mechanism in which a flexible strip 16 connects a plurality of pipette holders 7 so that the pipette holders 7 can be moved between two specific positions (ABSTRACT: "... can be simultaneously expanded from one dimension to another "). In one position the pipette holders 7 are arranged adjacent to one another (on the stop) and in the other position the flexible band is stretched so that the pipette holders 7 are each set to a (maximum) predetermined distance from one another.
  • Other known adjusting devices for a multi-pipetting device for example, have a very complicated structure.
  • the individual pipetting devices which are provided in a certain number, for example four, can be adjusted in a stepless manner in relation to one another.
  • a separate control and adjustment device is provided for each pipetting device, which allows the position to be adjusted relative to the carrier and thus relative to the other pipetting devices.
  • this known adjusting device when this known adjusting device is installed in a device for automatically loading sample combs, this known adjusting device would be too complicated and too voluminous.
  • the complex structure leads not only to the fact that the adjustment device is expensive as such, but also to the accuracy or repeatability of the adjustment being impaired in continuous use. In addition, the speed of the adjustment of the distance between the pipettes or samplers is too low.
  • the adjustment device which is provided in particular for a device for the automatic loading of sample combs, comprises a carrying device on which a plurality of holding devices are arranged such that they can be moved, a sample dispenser for receiving and dispensing a reagent being provided on each holding device; and includes one Actuating device which is provided for adjusting the holding devices relative to the carrying device, this adjusting device being designed such that all holding devices can be displaced jointly between two predetermined positions, and wherein the holding devices form a cavity in which the adjusting device is received
  • the adjustment device according to the invention can be quickly and easily switched between two working positions.
  • the effort for the control for switching back and forth is low, since the actuating device is designed accordingly, so that the holding devices can be moved together between the two predetermined positions.
  • the actuating device (drive) arranged inside the cavity creates a small construction volume and increases the reliability of the adjusting device in continuous operation.
  • the actuating device is particularly advantageously provided with an electric motor and with a threaded spindle, the rotation of the motor or the threaded spindle being transmitted to a holding device by means of a spindle nut. After the holding device is guided axially, the rotary movement is converted into a linear displacement of the holding device. An intermediate coupling, between the motor and the threaded spindle, compensates for play.
  • the holding device In one direction of rotation of the motor, the holding device is moved axially into a first end position, while in the opposite direction of rotation of the motor, the holding device is moved into a second end position. Both end positions are determined by means of a stop, so that the control of the motor does not have to be very precise. It is important that the motor turns far enough to bring the holding device to the stop.
  • the holding device driven in this way is connected to all other holding devices, so that the displacement of the driven holding device results in a displacement of all holding devices.
  • the connection of the holding devices to one another by screws is particularly simple, as is the subject of claims 7 to 9.
  • the adjustment device according to the present invention can demonstrate its advantages with regard to the speed of adjustment and reliability in continuous use.
  • the adjustment device according to the invention is installed as part of the automatic loading device.
  • the automatic loading of sample combs is carried out with the automatically working loading device, which is used to take up reagents, which are present, for example, on microtiter plates, with the aid of the adjusting device according to the invention and the sample dispenser attached to them, and then to deliver or load them onto the sample combs.
  • the microtiter plates have a large number of wells in which the reagents are located. These depressions are at a first certain distance from one another.
  • the samplers must therefore be adjusted to this distance between the wells.
  • the reagent After the reagent has been picked up by the sampler, it must be brought to a second specific distance which corresponds to the distance between teeth (or a multiple thereof) on the sample combs at which the reagents are to be unloaded.
  • the second distance is, for example, larger than the first distance.
  • This means that the samplers that are attached to the adjustment device must be displaced relative to one another. After the sample combs have been loaded, they can be passed on, for example, for the sequencing of DNA (genetic material) (electrophoresis).
  • the automated loading of the sample combs can be carried out quickly and without errors using the adjustment device according to the invention.
  • Another application of the loading device relates to the transfer of reagents, for example gene sections, from microtiter plates to so-called Maldi plates. These reagents on the Maldi plates are then examined by mass spectroscopy, for example to determine the length, weight, etc. of the DNA sections.
  • a microtiter plate with 96 wells can be transferred to a sample comb with 96 teeth or tracks within approx. 3 minutes.
  • FIG. 1 shows a cross section through the adjusting device according to the invention, and a side view from the right.
  • FIG. 2 shows a further cross-sectional view through the adjusting device according to the invention according to FIG. 1, and a sectional view AA; 3 shows a cross-sectional view through the adjusting device according to the invention, which is set at a large distance;
  • Fig. 4 is a perspective view of a device for automatic loading of sample combs, the adjustment device according to the invention being attached to this device for automatic loading.
  • FIG. 4 shows an automatic loading device 20 in which the adjustment device 22 according to the invention is installed.
  • An actuating device is attached to a housing-like support device 1, which consists of several components.
  • This actuating device essentially consists of an (electric) motor 4, a threaded spindle 6, an intermediate coupling 5, and a spindle nut 7.
  • the threaded spindle is shown in FIG. 1 (right side) by means of a bearing 8 on the support direction 1 stored.
  • the motor 4 or its housing is fastened to the carrying device 1 by means of a clamp 10 (left side).
  • This arrangement of the actuating device provides a simple drive unit for the adjustment device according to the invention.
  • a connection 13 is attached to a cover 17, which is fastened by means of screw connections 15.
  • connection 13 allows the adjustment device 22 to be attached to an arm 26 (Z-axis) of the automatic loading device 20.
  • two guide rods 11 are provided on the carrying device 1, which bear a plurality of holding devices 2 when viewed in the axial direction.
  • the eight holding devices 2 are in contact with one another, while in FIG. 3 the eight holding devices 2 are arranged at a distance from one another.
  • Each holding device 2 is connected to the adjacent holding device or devices 2 via at least one screw 12.
  • a sample dispenser 3 is attached to each holding device 2, which in the embodiment shown is attached to the holding device 2 in an opening 9 and is secured with a screw (not shown).
  • the samplers 3 each have a distance d from one another.
  • the samplers 3 are at a distance D from one another. In the present case, the distance D is greater than the distance d.
  • the sampler 3 used here is formed from a sampler body which has a sample receiving surface 18.
  • the sample receiving surface 18 is delimited by a circumferential edge and provided with a flat recess such that when the sample receiving surface 18 is immersed, a droplet of a liquid sample (for example in a recess in a microtiter plate) of a predetermined size adheres to the sample receiving surface 18 and by placing the sample receiving surface on 18 is delivered to a sample receiving area (for example a sample comb).
  • sample also encompasses other devices intended for receiving and dispensing small amounts of a reagent, such as a pipette.
  • the drive unit of the present adjustment device is arranged inside the holding devices 2. This results in a space-saving arrangement.
  • a cavity 16 in the following order, based on FIG. 1 and from left to right, are the motor 4, the coupling 5, and the threaded spindle 6 with the spindle nut 7.
  • the holding device 2 (the rightmost one in FIG. 1) moves to the right, if the head of the screw 12 comes into contact with a recess 19 in the holding device 2, the adjacent holding device 2 'is also moved to the right. This process is repeated for the further holding devices which are arranged to the left of the holding device 2.
  • the holding device 2 ′′ arranged on the far left in FIG. 1 is fastened, preferably screwed, to the carrying device 1 and thus forms a stop for this joint displacement of the holding devices 2 to the right 3, the heads of the screws 12 then each abut in the recesses 19 and the spindle nut 7 has reached the right end region of the threaded spindle 6.
  • the dimensions for the distance “d” 9 mm and for the distance “D” 10.8 mm are to be mentioned here.
  • these distances correspond to the distances between the wells on the microtiter plates or, on the other hand, a multiple of the distances on the teeth of the sample combs.
  • the adjusting device according to the invention can also be used for the other case, namely that a large distance (for example 9 mm) must be set between the samplers 3 when the reagents are received, while a narrow distance (for example 6 mm) is set for the dispensing of the reagents ,
  • the drive unit is provided in the embodiment shown in the figures with a motor, threaded spindle, etc.; alternatively, a drive unit acting with magnetic force or another drive source could also be used.
  • the holding devices 2 are essentially cuboid. A recess is provided in the central region of each holding device 2, all recesses forming the cavity 16 with one another.
  • Each holding device 2 has holes for the guide rods 1 1.
  • the guide rods are fastened to the support device 1 on both sides in the end region.
  • eight holding devices 2 are provided, the seven holding devices each having a recess 19 on the right-hand side, in each of which the head of the screw 12 is arranged.
  • two screws 12, two depressions 19 and two threaded bores 14 can also be attached
  • Each holding device 2 can be provided, wherein then viewed in a clockwise direction, a bore for the guide rod 11 is alternately provided with a screw 12.
  • the holding devices 2 are guided exactly on the guide rods 11.
  • the holding devices 2 are screwed together with the screws 12 in such a way that a relative displacement between the eight holding devices 2 is possible.
  • this relative displacement between the holding devices 2 leads to a narrow distance “d” between the samplers 3 and, according to FIG. 3, leads to a wide distance “D” between the samplers 3.
  • the adjusting device 22 can preferably be installed in a loading device 20, as shown in FIG. 4.
  • the loading device 20 shown schematically there serves to transfer reagents or other biological and / or chemical material from, for example, at least one microtiter plate 24 and one or more sample combs 25.
  • the adjusting device 22 can be used wherever a sample material is to be picked up by means of a plurality of sample dispensers 3 and is to be automatically dispensed again at a different location, the relative distance between the sample dispensers 3 when recording and the delivery of the sample material.
  • the loading device 20 comprises a housing 23 in which, for example, the drive and the control for an arm 28 are arranged.
  • a conventional PC can be connected via connections 29, which takes over the control of the loading device 20.
  • the Z axis 26 for the adjusting device 22 according to the invention is attached to the arm 28.
  • four microtiter plates 24 in holders 30 and also a plurality of sample combs 25 can be arranged on a working area 21.
  • the sample dispenser 3 can be set to different distances “d” or “D”.
  • a narrow distance "d”, for example 9 mm, is to be made for taking up the reagents from the wells of the microtiter plates 24, while a further distance "D" of the sample dispenser 3 is to be set for dispensing the reagents to the sample combs 25.
  • the displacement of the adjustment device 22 is carried out by the loading device 20 by moving the arm 28 and / or the Z axis 26 accordingly.
  • the following diagram describes a transfer of reagents from a 96-well microtiter plate to a sample comb with 96 tracks / teeth.
  • the first row (8 wells R1-1 to R1-8) of the microtiter plate is transferred to the teeth 1, 7, 13, 19, 25, 31, 37 and 43, as well as the second row (R2-1 to R2 -8) is transferred to teeth 2, 8, 14, 20, 26, 32, 38 and 44.
  • the 3rd, 4th and 5th row are transferred analogously until the 6th row (R6-1 to R6-8) is transferred to teeth 6, 12, 18, 24, 30, 36, 42 and 48 ,
  • the first half (teeth 1 to 48) of the sample comb is loaded.
  • the 7th to 12th rows from the microtiter plate are then transferred to the second half (teeth 49 to 96) of the sample comb corresponding to the 1st to 6th rows.
  • FIG. 4 shows that four microtiter plates 24 are arranged on the holders 30 - four sample combs 25 are also provided on the work area 21. the reagents of the four microtiter plates 24 can be transferred to the four sample combs 25 in one pass.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un dispositif de réglage destiné en particulier à un dispositif de chargement automatique de chambres d'échantillons. Ledit dispositif de réglage est composé d'un support (1) portant une pluralité d'éléments de maintien (2) disposés de manière réglable, un distributeur d'échantillon (3) destiné à recevoir et à distribuer un réactif étant logé sur chaque élément de maintien (2), et d'un élément de réglage (4, 5, 6, 7) destiné à régler les éléments de maintien (2) par rapport au support (1), cet élément de réglage (4, 5, 6, 7) étant conçu de manière que tous les éléments de maintien (2) puissent être déplacés en commun entre deux positions prédéfinies, et les éléments de maintien (2) formant un espace creux (16) recevant l'élément de réglage (4, 5, 6, 7). Cet élément de réglage (4, 5, 6, 7) représente l'unité d'entraînement pour tous les éléments de maintien (2).
PCT/EP2001/000811 2000-04-08 2001-01-25 Dispositif de reglage WO2001078897A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001228493A AU2001228493A1 (en) 2000-04-08 2001-01-25 Adjusting device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE20006547U DE20006547U1 (de) 2000-04-08 2000-04-08 Verstellvorrichtung
DE20006547.5 2000-04-08

Publications (1)

Publication Number Publication Date
WO2001078897A1 true WO2001078897A1 (fr) 2001-10-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/000811 WO2001078897A1 (fr) 2000-04-08 2001-01-25 Dispositif de reglage

Country Status (3)

Country Link
AU (1) AU2001228493A1 (fr)
DE (1) DE20006547U1 (fr)
WO (1) WO2001078897A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111482208A (zh) * 2020-04-24 2020-08-04 付小芳 一种多点等距调节装置

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE502004001011D1 (de) * 2003-05-14 2006-09-07 Tecan Trading Ag Vorrichtung zum präzisen Anfahren von Mikroplatten-Wells
DE102005030196B3 (de) * 2005-06-29 2007-02-01 Eppendorf Ag Mehrkanaldosiervorrichtung
DE102012216544A1 (de) * 2012-09-17 2014-03-20 Hamilton Bonaduz Ag Kombinierte Block- und Individualantriebsvorrichtung, insbesondere für Pipettierkanäle

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0280743A1 (fr) * 1986-09-02 1988-09-07 Fanuc Ltd. Machine electrique de moulage par injection
CH671526A5 (fr) * 1985-12-17 1989-09-15 Hamilton Bonaduz Ag
DD282082A5 (de) * 1987-05-02 1990-08-29 Teruaki Itoh Vorrichtung zum verteilen von probenfluessigkeiten
US5057281A (en) * 1990-05-07 1991-10-15 Matrix Technologies Corporation Adjustable multi-channel pipetter
US5061449A (en) * 1989-07-25 1991-10-29 Matrix Technologies, Corp. Expandable multi-channel pipetter
US5425402A (en) * 1992-10-20 1995-06-20 Mass Filling Systems, Inc. Bottling system with mass filling and capping arrays
FR2739935A1 (fr) * 1995-10-12 1997-04-18 Genomic Sa Dispositif pour le transfert d'echantillons de micro-quantites de liquides
DE29806459U1 (de) * 1998-04-08 1998-07-02 Wetzler, Gabriel, 56579 Rengsdorf Haltevorrichtung für eine Mehrzahl von gleichartigen Arbeitsmitteln, deren gegenseitiger Abstand veränderbar ist

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH671526A5 (fr) * 1985-12-17 1989-09-15 Hamilton Bonaduz Ag
EP0280743A1 (fr) * 1986-09-02 1988-09-07 Fanuc Ltd. Machine electrique de moulage par injection
DD282082A5 (de) * 1987-05-02 1990-08-29 Teruaki Itoh Vorrichtung zum verteilen von probenfluessigkeiten
US5061449A (en) * 1989-07-25 1991-10-29 Matrix Technologies, Corp. Expandable multi-channel pipetter
US5057281A (en) * 1990-05-07 1991-10-15 Matrix Technologies Corporation Adjustable multi-channel pipetter
US5425402A (en) * 1992-10-20 1995-06-20 Mass Filling Systems, Inc. Bottling system with mass filling and capping arrays
FR2739935A1 (fr) * 1995-10-12 1997-04-18 Genomic Sa Dispositif pour le transfert d'echantillons de micro-quantites de liquides
DE29806459U1 (de) * 1998-04-08 1998-07-02 Wetzler, Gabriel, 56579 Rengsdorf Haltevorrichtung für eine Mehrzahl von gleichartigen Arbeitsmitteln, deren gegenseitiger Abstand veränderbar ist

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111482208A (zh) * 2020-04-24 2020-08-04 付小芳 一种多点等距调节装置

Also Published As

Publication number Publication date
AU2001228493A1 (en) 2001-10-30
DE20006547U1 (de) 2001-08-16

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