WO2001067855A3 - Souris transgeniques contenant des interruptions de genes ciblees - Google Patents

Souris transgeniques contenant des interruptions de genes ciblees Download PDF

Info

Publication number
WO2001067855A3
WO2001067855A3 PCT/US2001/008664 US0108664W WO0167855A3 WO 2001067855 A3 WO2001067855 A3 WO 2001067855A3 US 0108664 W US0108664 W US 0108664W WO 0167855 A3 WO0167855 A3 WO 0167855A3
Authority
WO
WIPO (PCT)
Prior art keywords
transgenic mice
targeted gene
mice containing
gene disruptions
containing targeted
Prior art date
Application number
PCT/US2001/008664
Other languages
English (en)
Other versions
WO2001067855A2 (fr
Inventor
Keith D Allen
Catherine Guenther
Russell Phillips
Original Assignee
Deltagen Inc
Keith D Allen
Catherine Guenther
Russell Phillips
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc, Keith D Allen, Catherine Guenther, Russell Phillips filed Critical Deltagen Inc
Priority to JP2001566337A priority Critical patent/JP2004500102A/ja
Priority to EP01918805A priority patent/EP1304920A2/fr
Priority to IL15175901A priority patent/IL151759A0/xx
Priority to CA002402912A priority patent/CA2402912A1/fr
Priority to AU2001245843A priority patent/AU2001245843A1/en
Publication of WO2001067855A2 publication Critical patent/WO2001067855A2/fr
Publication of WO2001067855A3 publication Critical patent/WO2001067855A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne des animaux transgéniques ainsi que des compositions et des procédés concernant la caractérisation de la fonction du gène. De manière spécifique, la présente invention traite de souris transgéniques présentant des interruptions de gènes, qui présentent une grande utilité comme modèles pour des maladies et permettent d'identifier des agents qui modulent l'expression et la fonction du gène. En outre, l'invention traite de traitements potentiels de diverses maladies et conditions.
PCT/US2001/008664 2000-03-16 2001-03-16 Souris transgeniques contenant des interruptions de genes ciblees WO2001067855A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2001566337A JP2004500102A (ja) 2000-03-16 2001-03-16 標的遺伝子破壊を含むトランスジェニックマウス
EP01918805A EP1304920A2 (fr) 2000-03-16 2001-03-16 Souris transgeniques contenant des interruptions de genes ciblees
IL15175901A IL151759A0 (en) 2000-03-16 2001-03-16 Transgenic mice containing targeted gene disruptions
CA002402912A CA2402912A1 (fr) 2000-03-16 2001-03-16 Souris transgeniques contenant des interruptions de genes ciblees
AU2001245843A AU2001245843A1 (en) 2000-03-16 2001-03-16 Transgenic mice containing targeted gene disruptions

Applications Claiming Priority (36)

Application Number Priority Date Filing Date Title
US19034800P 2000-03-16 2000-03-16
US60/190,348 2000-03-16
US19112800P 2000-03-22 2000-03-22
US19112900P 2000-03-22 2000-03-22
US19124000P 2000-03-22 2000-03-22
US19114200P 2000-03-22 2000-03-22
US19123500P 2000-03-22 2000-03-22
US19123600P 2000-03-22 2000-03-22
US60/191,240 2000-03-22
US60/191,128 2000-03-22
US60/191,142 2000-03-22
US60/191,129 2000-03-22
US60/191,236 2000-03-22
US60/191,235 2000-03-22
US20423000P 2000-05-15 2000-05-15
US20422700P 2000-05-15 2000-05-15
US60/204,227 2000-05-15
US60/204,230 2000-05-15
US21521400P 2000-06-29 2000-06-29
US60/215,214 2000-06-29
US21624900P 2000-07-06 2000-07-06
US21676500P 2000-07-06 2000-07-06
US21626400P 2000-07-06 2000-07-06
US60/216,765 2000-07-06
US60/216,249 2000-07-06
US60/216,264 2000-07-06
US21807500P 2000-07-12 2000-07-12
US60/218,075 2000-07-12
US21916700P 2000-07-19 2000-07-19
US21918200P 2000-07-19 2000-07-19
US60/219,182 2000-07-19
US60/219,167 2000-07-19
US22148500P 2000-07-27 2000-07-27
US60/221,485 2000-07-27
US22317300P 2000-08-07 2000-08-07
US60/223,173 2000-08-07

Publications (2)

Publication Number Publication Date
WO2001067855A2 WO2001067855A2 (fr) 2001-09-20
WO2001067855A3 true WO2001067855A3 (fr) 2003-02-13

Family

ID=27586188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/008664 WO2001067855A2 (fr) 2000-03-16 2001-03-16 Souris transgeniques contenant des interruptions de genes ciblees

Country Status (6)

Country Link
EP (1) EP1304920A2 (fr)
JP (1) JP2004500102A (fr)
AU (1) AU2001245843A1 (fr)
CA (1) CA2402912A1 (fr)
IL (1) IL151759A0 (fr)
WO (1) WO2001067855A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2000260840A1 (en) * 2000-07-11 2002-01-21 Deltagen, Inc. Methods of creating constructs useful for introducing sequences into embryonic stem cells
US20020116729A1 (en) * 2000-12-06 2002-08-22 Allen Keith D. Transgenic mice containing NTTP1 phosphatase gene disruptions
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
EP2878335B1 (fr) 2013-11-10 2018-01-03 Brainsgate Ltd. Implant et système d'implantation pour stimulateur neural
EP3093043B1 (fr) 2015-05-13 2018-11-14 Brainsgate Ltd. Implant et système de distribution pour stimulateur neural

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026100A1 (fr) * 1993-05-18 1994-11-24 Institut National De La Sante Et De La Recherche Medicale Souris produite par genie genetique et comportant des modifications dans les genes codant les proteines du recepteur de l'acide retinoique
WO1999029725A1 (fr) * 1997-12-12 1999-06-17 Merck & Co., Inc. MOLECULES D'ADN CODANT LE RECEPTEUR PROTEIQUE NUCLEAIRE HUMAIN nNR5
WO2000008052A1 (fr) * 1998-08-07 2000-02-17 Tularik Inc. Nouveau recepteur hormonal nucleaire retinien

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026100A1 (fr) * 1993-05-18 1994-11-24 Institut National De La Sante Et De La Recherche Medicale Souris produite par genie genetique et comportant des modifications dans les genes codant les proteines du recepteur de l'acide retinoique
WO1999029725A1 (fr) * 1997-12-12 1999-06-17 Merck & Co., Inc. MOLECULES D'ADN CODANT LE RECEPTEUR PROTEIQUE NUCLEAIRE HUMAIN nNR5
WO2000008052A1 (fr) * 1998-08-07 2000-02-17 Tularik Inc. Nouveau recepteur hormonal nucleaire retinien

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AKHMEDOV N B ET AL: "A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 9 MAY 2000, vol. 97, no. 10, 9 May 2000 (2000-05-09), pages 5551 - 5556, XP002203637, ISSN: 0027-8424 *
CHEN FANG ET AL: "Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Muller glial cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 26, 21 December 1999 (1999-12-21), Dec. 21, 1999, pages 15149 - 15154, XP002203636, ISSN: 0027-8424 *
HAIDER NEENA B ET AL: "Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 mice.", HUMAN MOLECULAR GENETICS, vol. 10, no. 16, 2001, pages 1619 - 1626, XP002203638, ISSN: 0964-6906 *
HAIDER NEENA B ET AL: "Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate.", NATURE GENETICS, vol. 24, no. 2, February 2000 (2000-02-01), pages 127 - 131, XP002203635, ISSN: 1061-4036 *
KOBAYASHI M ET AL: "IDENTIFICATION OF A PHOTORECEPTOR CELL-SPECIFIC NUCLEAR RECEPTOR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, April 1999 (1999-04-01), pages 4814 - 4819, XP002927708, ISSN: 0027-8424 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation

Also Published As

Publication number Publication date
CA2402912A1 (fr) 2001-09-20
IL151759A0 (en) 2003-04-10
JP2004500102A (ja) 2004-01-08
AU2001245843A1 (en) 2001-09-24
EP1304920A2 (fr) 2003-05-02
WO2001067855A2 (fr) 2001-09-20

Similar Documents

Publication Publication Date Title
WO2002079440A8 (fr) Souris transgeniques contenant des ruptures du gene gpcr5-1
WO2002079424A3 (fr) SOURIS TRANSGENIQUES CONTENANT DES DISRUPTIONS DE GENES Gβ3GALT2
WO2002046390A3 (fr) Souris transgeniques a disruptions geniques de tyrosine phosphatase rptpb
WO2002079438A3 (fr) Disruptions du gene ogr1, compositions et procedes associes
WO2002079439A3 (fr) Souris transgeniques presentant des disruptions du gene mglur7 du recepteur de glutamate metabotropique
WO2002079444A3 (fr) Souris transgeniques presentant des disruptions geniques de la serine / threonine kinase msk2
WO2003026395A3 (fr) Disruptions geniques mo54, compositions et procedes correspondants
WO2001067855A3 (fr) Souris transgeniques contenant des interruptions de genes ciblees
WO2002003789A3 (fr) Souris transgéniques contenant des disruptions géniques gpcr ciblées
WO2002040662A3 (fr) Souris transgenique contenant des disruptions geniques ciblees
WO2002045498A3 (fr) Souris transgenique presentant des disruptions geniques ciblees de proteine canal
WO2002048345A3 (fr) Souris transgeniques presentant des disruptions geniques du recepteur de glutamate (grik5)
WO2002001950A3 (fr) Souris transgeniques contenant des interruptions de genes cibles
WO2002081658A8 (fr) Souris transgeniques comportant des disruptions geniques sur le canal des ions calcium cacnb4
WO2002003793A3 (fr) Souris transgeniques contenant des disruptions genetiques ciblees
WO2002045495A3 (fr) Souris transgeniques contenant disruptions geniques ciblees
WO2002003788A3 (fr) Souris transgeniques contenant des disruptions ciblees du gene de la phosphatase
WO2002079414A8 (fr) Souris transgeniques contenant des ruptures du gene des canaux de chlorure clcn7
WO2002079433A3 (fr) Souris transgeniques presentant des disruptions du gene tmem3 de la beta-1,3-n-acetylglucosaminyltransferase
WO2003026403A3 (fr) Disruptions du gene ctsz, compositions et methodes correspondantes
WO2002079412A3 (fr) Souris transgenique presentant des disruption geniques dues a la presence d'une enzyme de desubiquitination de type usp3
WO2002003787A3 (fr) Souris transgéniques contenant des disruptions géniques ciblées
WO2002048346A3 (fr) Souris transgeniques contenant des disruptions geniques d'une proteine a ancrage membranaire specifique du cerveau
WO2002003791A8 (fr) Souris transgeniques contenant des interruptions de genes
WO2002046391A3 (fr) Souris transgeniques contenant des interruptions de gene nor1

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US US US US US US US US US US US US US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 566337

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 151759

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2402912

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001245843

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2001918805

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001918805

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2001918805

Country of ref document: EP

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)