WO2002040662A3 - Souris transgenique contenant des disruptions geniques ciblees - Google Patents

Souris transgenique contenant des disruptions geniques ciblees Download PDF

Info

Publication number
WO2002040662A3
WO2002040662A3 PCT/US2001/044961 US0144961W WO0240662A3 WO 2002040662 A3 WO2002040662 A3 WO 2002040662A3 US 0144961 W US0144961 W US 0144961W WO 0240662 A3 WO0240662 A3 WO 0240662A3
Authority
WO
WIPO (PCT)
Prior art keywords
transgenic mice
targeted gene
mice containing
gene disruptions
containing targeted
Prior art date
Application number
PCT/US2001/044961
Other languages
English (en)
Other versions
WO2002040662A2 (fr
Inventor
Keith D Allen
Catherine Guenther
Michael W Leviten
Original Assignee
Deltagen Inc
Keith D Allen
Catherine Guenther
Michael W Leviten
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc, Keith D Allen, Catherine Guenther, Michael W Leviten filed Critical Deltagen Inc
Priority to AU2002217989A priority Critical patent/AU2002217989A1/en
Publication of WO2002040662A2 publication Critical patent/WO2002040662A2/fr
Publication of WO2002040662A3 publication Critical patent/WO2002040662A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des animaux transgéniques ainsi que des compositions et des méthodes associées à la caractérisation d'une fonction génique. L'invention concerne, en particulier, une souris transgénique présentant des mutations dans un gène cible. Cette souris transgénique est utilisée comme modèle pour des maladies et des agents d'identification qui modulent l'expression et la fonction géniques, et comme traitement potentiel pour différents états et troubles pathologiques..
PCT/US2001/044961 2000-11-15 2001-11-15 Souris transgenique contenant des disruptions geniques ciblees WO2002040662A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002217989A AU2002217989A1 (en) 2000-11-15 2001-11-15 Transgenic mice containing targeted gene disruptions

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24940300P 2000-11-15 2000-11-15
US60/249,403 2000-11-15
US25230100P 2000-11-20 2000-11-20
US25223700P 2000-11-20 2000-11-20
US60/252,301 2000-11-20
US60/252,237 2000-11-20

Publications (2)

Publication Number Publication Date
WO2002040662A2 WO2002040662A2 (fr) 2002-05-23
WO2002040662A3 true WO2002040662A3 (fr) 2003-11-27

Family

ID=27400209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044961 WO2002040662A2 (fr) 2000-11-15 2001-11-15 Souris transgenique contenant des disruptions geniques ciblees

Country Status (2)

Country Link
AU (1) AU2002217989A1 (fr)
WO (1) WO2002040662A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1445320A1 (fr) * 2003-02-05 2004-08-11 ARTEMIS Pharmaceuticals GmbH Gene targeting automatique à l aide de marqueurs détectables non toxiques
WO2005079566A2 (fr) * 2004-02-12 2005-09-01 Lexicon Genetics Incorporated Nouvelles disruptions geniques, compositions et procedes associes
US20100031378A1 (en) 2008-08-04 2010-02-04 Edwards Joel A Novel gene disruptions, compositions and methods relating thereto
WO2006026222A2 (fr) * 2004-08-25 2006-03-09 Genentech, Inc. Disruptions geniques; compositions et methodes y relatives
CA2601677A1 (fr) * 2005-03-11 2006-09-21 Genentech, Inc. Nouvelles disruptions geniques, compositions et methodes afferentes
CN108490178B (zh) * 2018-02-13 2019-08-30 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 用于npc诊断及预后预测的标志物及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037636A1 (fr) * 1998-12-21 2000-06-29 The Walter And Eliza Hall Institute Of Medical Research Boite socs contenant des peptides
WO2002030184A1 (fr) * 2000-10-09 2002-04-18 Amrad Operations Pty Ltd Modulation de la signalisation de cytokine ou d'hormone chez un animal, integrant la regulation progressive de l'expression de la sequence socs chez l'animal

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037636A1 (fr) * 1998-12-21 2000-06-29 The Walter And Eliza Hall Institute Of Medical Research Boite socs contenant des peptides
WO2002030184A1 (fr) * 2000-10-09 2002-04-18 Amrad Operations Pty Ltd Modulation de la signalisation de cytokine ou d'hormone chez un animal, integrant la regulation progressive de l'expression de la sequence socs chez l'animal

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MASUHARA M ET AL: "Cloning and characterization of novel CIS family genes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 239, 1 October 1997 (1997-10-01), pages 439 - 446, XP002088457, ISSN: 0006-291X *
METCALF D ET AL: "Gigantism in mice lacking suppressor of cytokine signaling-2", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 405, 29 July 2000 (2000-07-29), pages 1069 - 1073, XP002958016, ISSN: 0028-0836 *
STARR R ET AL: "Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, November 1998 (1998-11-01), pages 14395 - 14399, XP002958018, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2002040662A2 (fr) 2002-05-23
AU2002217989A1 (en) 2002-05-27

Similar Documents

Publication Publication Date Title
WO2002079440A8 (fr) Souris transgeniques contenant des ruptures du gene gpcr5-1
WO2002079424A3 (fr) SOURIS TRANSGENIQUES CONTENANT DES DISRUPTIONS DE GENES Gβ3GALT2
WO2002046390A3 (fr) Souris transgeniques a disruptions geniques de tyrosine phosphatase rptpb
WO2002079438A3 (fr) Disruptions du gene ogr1, compositions et procedes associes
WO2003026395A3 (fr) Disruptions geniques mo54, compositions et procedes correspondants
WO2002003789A3 (fr) Souris transgéniques contenant des disruptions géniques gpcr ciblées
WO2002040662A3 (fr) Souris transgenique contenant des disruptions geniques ciblees
WO2001067855A3 (fr) Souris transgeniques contenant des interruptions de genes ciblees
WO2002048345A3 (fr) Souris transgeniques presentant des disruptions geniques du recepteur de glutamate (grik5)
WO2002045498A3 (fr) Souris transgenique presentant des disruptions geniques ciblees de proteine canal
WO2002001950A3 (fr) Souris transgeniques contenant des interruptions de genes cibles
WO2002081658A3 (fr) Souris transgeniques comportant des disruptions geniques sur le canal des ions calcium cacnb4
WO2002048342A3 (fr) Souris transgeniques presentant des interruptions du gene trp6 au niveau du canal ion calcium
WO2002003788A3 (fr) Souris transgeniques contenant des disruptions ciblees du gene de la phosphatase
WO2002003793A3 (fr) Souris transgeniques contenant des disruptions genetiques ciblees
WO2002037957A3 (fr) Souris transgeniques contenant des disruptions geniques de la proteine kinase de perk
WO2002079414A3 (fr) Souris transgeniques contenant des ruptures du gene des canaux de chlorure clcn7
WO2002003787A3 (fr) Souris transgéniques contenant des disruptions géniques ciblées
WO2003026403A3 (fr) Disruptions du gene ctsz, compositions et methodes correspondantes
WO2002079433A3 (fr) Souris transgeniques presentant des disruptions du gene tmem3 de la beta-1,3-n-acetylglucosaminyltransferase
WO2002003791A3 (fr) Souris transgeniques contenant des interruptions de genes
WO2002079412A3 (fr) Souris transgenique presentant des disruption geniques dues a la presence d'une enzyme de desubiquitination de type usp3
WO2002055687A3 (fr) Souris transgeniques presentant des disruptions geniques cibles
WO2002048346A3 (fr) Souris transgeniques contenant des disruptions geniques d'une proteine a ancrage membranaire specifique du cerveau
WO2002046391A3 (fr) Souris transgeniques contenant des interruptions de gene nor1

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP