WO2002079414A3 - Souris transgeniques contenant des ruptures du gene des canaux de chlorure clcn7 - Google Patents
Souris transgeniques contenant des ruptures du gene des canaux de chlorure clcn7 Download PDFInfo
- Publication number
- WO2002079414A3 WO2002079414A3 PCT/US2002/009646 US0209646W WO02079414A3 WO 2002079414 A3 WO2002079414 A3 WO 2002079414A3 US 0209646 W US0209646 W US 0209646W WO 02079414 A3 WO02079414 A3 WO 02079414A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- transgenic mice
- chloride channel
- mice containing
- gene disruptions
- channel gene
- Prior art date
Links
- 241000699660 Mus musculus Species 0.000 title abstract 3
- 238000011830 transgenic mouse model Methods 0.000 title abstract 3
- 108010062745 Chloride Channels Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 101150092724 CLCN7 gene Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Molecular Biology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002306942A AU2002306942A1 (en) | 2001-03-29 | 2002-03-29 | Transgenic mice containing clcn7 chloride channel gene disruptions |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28032401P | 2001-03-29 | 2001-03-29 | |
US60/280,324 | 2001-03-29 | ||
US32466401P | 2001-09-24 | 2001-09-24 | |
US60/324,664 | 2001-09-24 | ||
US10953602A | 2002-03-28 | 2002-03-28 | |
US10/109,536 | 2002-03-28 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002079414A2 WO2002079414A2 (fr) | 2002-10-10 |
WO2002079414A8 WO2002079414A8 (fr) | 2003-03-27 |
WO2002079414A3 true WO2002079414A3 (fr) | 2003-09-12 |
Family
ID=27380675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/009646 WO2002079414A2 (fr) | 2001-03-29 | 2002-03-29 | Souris transgeniques contenant des ruptures du gene des canaux de chlorure clcn7 |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2002306942A1 (fr) |
WO (1) | WO2002079414A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003062821A1 (fr) * | 2002-01-23 | 2003-07-31 | Bristol-Myers Squibb Company | Modulateurs du canal a chlorure clc-7 et procedes permettant leur identification et leur utilisation dans le traitement et la prevention de l'osteoporose et des conditions pathologiques associees |
GB0227243D0 (en) * | 2002-11-21 | 2002-12-31 | Univ Aberdeen | Genetic markers for bone mass |
GB0525898D0 (en) * | 2005-12-20 | 2006-02-01 | Pharmo Bioscience As | Screening compounds for activity in modulating chloride ion transport |
JP6795492B2 (ja) * | 2014-05-23 | 2020-12-02 | ウニヴェルシタ デッリ ストゥディ デラクイア | CLCN7(ADO2 CLCN7依存性)遺伝子変異によって引き起こされる常染色体優性大理石骨病2型(ADO2)療法のための短鎖干渉RNA(siRNA) |
-
2002
- 2002-03-29 WO PCT/US2002/009646 patent/WO2002079414A2/fr not_active Application Discontinuation
- 2002-03-29 AU AU2002306942A patent/AU2002306942A1/en not_active Abandoned
Non-Patent Citations (11)
Title |
---|
BRANDT ET AL.: "CIC-6 and CIC-7 are two novel broadly expressed members of the CLC chloride channel family", FEBS LETTERS, vol. 377, no. 1, 11 December 1995 (1995-12-11), pages 15 - 20, XP002902613 * |
CAPECCHI M.R.: "Targeted gene replacement", SCIENTIFIC AM., vol. 270, no. 3, March 1994 (1994-03-01), pages 34 - 41, XP002911711 * |
DAVIDSON ET AL.: "The CF mouse: an important tool for studying cystic fibrosis", EXPERT REVIEWS IN MOLECULAR MEDICINE, 12 March 2001 (2001-03-12), pages 1 - 27, XP002964209, Retrieved from the Internet <URL:www-ermm.cbcu.cam.ac.uk/01002551a.pdf> * |
GUNTHER ET AL.: "The CIC-5 chloride channel knock-out mouse - an animal model for Dent's disease", PFLUGERS ARCHIV. EUROPEAN J. OF PHYSIOLOGY, vol. 445, no. 4, January 2003 (2003-01-01), pages 456 - 462, XP002964210 * |
KORNAK ET AL.: "Loss of the CIC-7 chloride channel leads to osteopetrosis in mice and man", CELL, vol. 104, 26 January 2001 (2001-01-26), pages 205 - 215, XP002902614 * |
MANKODI ET AL.: "Myotonia is associated with loss of transmembrane chloride conductance and aberrant splicing of Clcn1, the skeletal muscule chloride channel, in a transgenic model of myotonic dystrophy", AM. J. HUMAN GENETICS, vol. 69, no. 4 SUPPLEMENT, October 2001 (2001-10-01), pages 211 ABSTRACT #180, XP002964211 * |
MASON ET AL.: "Whole body analysis of the knockout gene mouse model for cystic fibrosis using thermal and fast neutron activation analysis", J. RADIOANALYTICAL AND NUCLEAR CHEM., vol. 236, no. 1-2, 1998, pages 107 - 112, XP002964205 * |
NEHRKE ET AL.: "Loss of hyperpolarization-activated Cl-current in salivary acinar cells from Clcn2 knockout mice", J. BIOLOGICAL CHEM., vol. 277, no. 26, 28 June 2002 (2002-06-28), pages 23604 - 23611, XP002964208 * |
RAI ET AL.: "Establishment of conditionally immortalized CIC-3 deficient epithelial cell line from small intestine of Clcn3-/-, H-2Kb-ts A58 double transgenic mice", J. AM. SOC. NEPHROLOGY, vol. 12, no. PROGRAM AND ABSTRACT ISSUE, September 2001 (2001-09-01), pages 39A ABSTRACT #A0203, XP002964212 * |
UCHIDA ET AL.: "Physiological role of CLC-K1 chloride channel in the kidney", NEPHROL. DIAL. TRANSPLANT., vol. 15, no. SUPPL. 6, 2000, pages 14 - 15, XP002964207 * |
YOSHIKAWA ET AL.: "CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis", GENES TO CELLS, vol. 7, no. 6, June 2002 (2002-06-01), pages 597 - 605, XP002964206 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002079414A8 (fr) | 2003-03-27 |
WO2002079414A2 (fr) | 2002-10-10 |
AU2002306942A1 (en) | 2002-10-15 |
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