WO2002079414A8 - Souris transgeniques contenant des ruptures du gene des canaux de chlorure clcn7 - Google Patents

Souris transgeniques contenant des ruptures du gene des canaux de chlorure clcn7

Info

Publication number
WO2002079414A8
WO2002079414A8 PCT/US2002/009646 US0209646W WO02079414A8 WO 2002079414 A8 WO2002079414 A8 WO 2002079414A8 US 0209646 W US0209646 W US 0209646W WO 02079414 A8 WO02079414 A8 WO 02079414A8
Authority
WO
WIPO (PCT)
Prior art keywords
transgenic mice
chloride channel
mice containing
gene disruptions
channel gene
Prior art date
Application number
PCT/US2002/009646
Other languages
English (en)
Other versions
WO2002079414A2 (fr
WO2002079414A3 (fr
Inventor
Keith D Allen
Original Assignee
Deltagen Inc
Keith D Allen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc, Keith D Allen filed Critical Deltagen Inc
Priority to AU2002306942A priority Critical patent/AU2002306942A1/en
Publication of WO2002079414A2 publication Critical patent/WO2002079414A2/fr
Publication of WO2002079414A8 publication Critical patent/WO2002079414A8/fr
Publication of WO2002079414A3 publication Critical patent/WO2002079414A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des animaux transgéniques ainsi que des compositions et des méthodes relatifs à la caractérisation de la fonction génique. Spécifiquement, la présente invention concerne des souris transgéniques présentant des mutations dans un gène CLCN7. Ces souris transgéniques sont utiles en tant que cobaye de maladies et pour identifier des agents modulant l'expression du gène ainsi que la fonction du gène, et en tant que traitements potentiels contre divers états pathologiques et conditions pathologiques.
PCT/US2002/009646 2001-03-29 2002-03-29 Souris transgeniques contenant des ruptures du gene des canaux de chlorure clcn7 WO2002079414A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002306942A AU2002306942A1 (en) 2001-03-29 2002-03-29 Transgenic mice containing clcn7 chloride channel gene disruptions

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US28032401P 2001-03-29 2001-03-29
US60/280,324 2001-03-29
US32466401P 2001-09-24 2001-09-24
US60/324,664 2001-09-24
US10953602A 2002-03-28 2002-03-28
US10/109,536 2002-03-28

Publications (3)

Publication Number Publication Date
WO2002079414A2 WO2002079414A2 (fr) 2002-10-10
WO2002079414A8 true WO2002079414A8 (fr) 2003-03-27
WO2002079414A3 WO2002079414A3 (fr) 2003-09-12

Family

ID=27380675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/009646 WO2002079414A2 (fr) 2001-03-29 2002-03-29 Souris transgeniques contenant des ruptures du gene des canaux de chlorure clcn7

Country Status (2)

Country Link
AU (1) AU2002306942A1 (fr)
WO (1) WO2002079414A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003062821A1 (fr) * 2002-01-23 2003-07-31 Bristol-Myers Squibb Company Modulateurs du canal a chlorure clc-7 et procedes permettant leur identification et leur utilisation dans le traitement et la prevention de l'osteoporose et des conditions pathologiques associees
GB0227243D0 (en) * 2002-11-21 2002-12-31 Univ Aberdeen Genetic markers for bone mass
GB0525898D0 (en) * 2005-12-20 2006-02-01 Pharmo Bioscience As Screening compounds for activity in modulating chloride ion transport
JP6795492B2 (ja) * 2014-05-23 2020-12-02 ウニヴェルシタ デッリ ストゥディ デラクイア ＣＬＣＮ７（ＡＤＯ２ ＣＬＣＮ７依存性）遺伝子変異によって引き起こされる常染色体優性大理石骨病２型（ＡＤＯ２）療法のための短鎖干渉ＲＮＡ（ｓｉＲＮＡ）

Also Published As

Publication number Publication date
WO2002079414A2 (fr) 2002-10-10
WO2002079414A3 (fr) 2003-09-12
AU2002306942A1 (en) 2002-10-15

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