WO2001066781A1 - Immortalite conditionnelle de cellules - Google Patents

Immortalite conditionnelle de cellules Download PDF

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Publication number
WO2001066781A1
WO2001066781A1 PCT/GB2001/001029 GB0101029W WO0166781A1 WO 2001066781 A1 WO2001066781 A1 WO 2001066781A1 GB 0101029 W GB0101029 W GB 0101029W WO 0166781 A1 WO0166781 A1 WO 0166781A1
Authority
WO
WIPO (PCT)
Prior art keywords
cell
oncogene
cells
myc
conditionally
Prior art date
Application number
PCT/GB2001/001029
Other languages
English (en)
Inventor
John Sinden
Ziping Dong
Original Assignee
Reneuron Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reneuron Limited filed Critical Reneuron Limited
Priority to AU37610/01A priority Critical patent/AU3761001A/en
Publication of WO2001066781A1 publication Critical patent/WO2001066781A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Selon l'invention, une cellule recombinée de mammifère comprend un oncogène inductible sous condition et un polynucléotide exogène codant pour un élément de la famille oncogène myc.
PCT/GB2001/001029 2000-03-10 2001-03-09 Immortalite conditionnelle de cellules WO2001066781A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37610/01A AU3761001A (en) 2000-03-10 2001-03-09 Conditional immortalisation of cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0005856.0 2000-03-10
GB0005856A GB0005856D0 (en) 2000-03-10 2000-03-10 Genetic constructs

Publications (1)

Publication Number Publication Date
WO2001066781A1 true WO2001066781A1 (fr) 2001-09-13

Family

ID=9887410

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/001029 WO2001066781A1 (fr) 2000-03-10 2001-03-09 Immortalite conditionnelle de cellules

Country Status (3)

Country Link
AU (1) AU3761001A (fr)
GB (1) GB0005856D0 (fr)
WO (1) WO2001066781A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035879A2 (fr) * 2001-10-26 2003-05-01 Reneuron Limited Promoteurs destines a reguler la differenciation cellulaire
EP1645626A1 (fr) * 2004-09-30 2006-04-12 Reneuron Limited Lignée cellulaire
WO2012059223A1 (fr) * 2010-11-02 2012-05-10 Helmholtz-Zentrum für Infektionsforschung GmbH Procédés et vecteurs pour l'immortalisation de cellules

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003882A1 (fr) * 1987-10-09 1989-05-05 Immunex Corporation Vecteurs retroviraux de transformation de promoteurs multiples
WO1989003872A1 (fr) * 1987-10-29 1989-05-05 Amrad Corporation Limited Production de lignees cellulaires precurseurs neurales
WO1989009816A1 (fr) * 1988-04-12 1989-10-19 Massachusetts Institute Of Technology Procede de manipulation des types cellulaires d'eucaryotes
WO1996024669A1 (fr) * 1995-02-10 1996-08-15 The Regents Of The University Of California Lignees de cellules pancreatiques humaines: developpements et utilisations
WO1997010329A1 (fr) * 1995-09-12 1997-03-20 Reneuron Limited Transplantation neurale a l'aide de cellules neuroepitheliales pluripotentes
WO1997030168A1 (fr) * 1996-02-20 1997-08-21 The Regents Of The University Of California Systeme retroviral modulable destine a la modification genetique de cellules
WO1997039117A1 (fr) * 1996-04-17 1997-10-23 The University Of Liverpool Lignees de cellules a immortalisation conditionnelle derivant d'animaux transgeniques
WO1999053028A1 (fr) * 1998-04-14 1999-10-21 Signal Pharmaceuticals, Inc. Lignees de cellules du snp et leur methode d'utilisation
WO2000009669A1 (fr) * 1998-08-12 2000-02-24 Signal Pharmaceuticals, Inc. Lignees cellulaires du mesencephale humain et procedes d'utilisation desdites lignees cellulaires
WO2001021790A1 (fr) * 1999-09-17 2001-03-29 Reneuron Limited Immortalisation conditionnelle de cellules

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003882A1 (fr) * 1987-10-09 1989-05-05 Immunex Corporation Vecteurs retroviraux de transformation de promoteurs multiples
WO1989003872A1 (fr) * 1987-10-29 1989-05-05 Amrad Corporation Limited Production de lignees cellulaires precurseurs neurales
WO1989009816A1 (fr) * 1988-04-12 1989-10-19 Massachusetts Institute Of Technology Procede de manipulation des types cellulaires d'eucaryotes
WO1996024669A1 (fr) * 1995-02-10 1996-08-15 The Regents Of The University Of California Lignees de cellules pancreatiques humaines: developpements et utilisations
WO1997010329A1 (fr) * 1995-09-12 1997-03-20 Reneuron Limited Transplantation neurale a l'aide de cellules neuroepitheliales pluripotentes
WO1997030168A1 (fr) * 1996-02-20 1997-08-21 The Regents Of The University Of California Systeme retroviral modulable destine a la modification genetique de cellules
WO1997039117A1 (fr) * 1996-04-17 1997-10-23 The University Of Liverpool Lignees de cellules a immortalisation conditionnelle derivant d'animaux transgeniques
WO1999053028A1 (fr) * 1998-04-14 1999-10-21 Signal Pharmaceuticals, Inc. Lignees de cellules du snp et leur methode d'utilisation
WO2000009669A1 (fr) * 1998-08-12 2000-02-24 Signal Pharmaceuticals, Inc. Lignees cellulaires du mesencephale humain et procedes d'utilisation desdites lignees cellulaires
WO2001021790A1 (fr) * 1999-09-17 2001-03-29 Reneuron Limited Immortalisation conditionnelle de cellules

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BERNARD O ET AL: "ROLE OF THE C-MYC AND THE N-MYC PROTO-ONCOGENES IN THE IMMORTALIZATION OF NEURAL PRECURSORS", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 24, no. 1, 1989, pages 9 - 20, XP001010016, ISSN: 0360-4012 *
GRAY JEFFREY A ET AL: "Prospects for the clinical application of neural transplantation with the use of conditionally immortalized neuroepithelial stem cells.", PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON B BIOLOGICAL, vol. 354, no. 1388, August 1999 (1999-08-01), Aug., 1999, pages 1407 - 1421, XP001010006, ISSN: 0962-8436 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035879A2 (fr) * 2001-10-26 2003-05-01 Reneuron Limited Promoteurs destines a reguler la differenciation cellulaire
WO2003035879A3 (fr) * 2001-10-26 2003-09-25 Reneuron Ltd Promoteurs destines a reguler la differenciation cellulaire
EP1645626A1 (fr) * 2004-09-30 2006-04-12 Reneuron Limited Lignée cellulaire
JP2006122045A (ja) * 2004-09-30 2006-05-18 Reneuron Ltd 細胞株
US7416888B2 (en) 2004-09-30 2008-08-26 Reneuron Limited Cell lines
US7419827B2 (en) 2004-09-30 2008-09-02 Reneuron Limited Cell lines
US7666672B2 (en) 2004-09-30 2010-02-23 Reneuron Limited Cell lines
WO2012059223A1 (fr) * 2010-11-02 2012-05-10 Helmholtz-Zentrum für Infektionsforschung GmbH Procédés et vecteurs pour l'immortalisation de cellules
US9453203B2 (en) 2010-11-02 2016-09-27 Helmholtz-Zentrum Fur Infektionsforschung Methods and vectors for cell immortalisation
EP3257943A3 (fr) * 2010-11-02 2018-01-10 Helmholtz-Zentrum für Infektionsforschung GmbH Procédés et vecteurs pour l'immortalisation de cellules

Also Published As

Publication number Publication date
GB0005856D0 (en) 2000-05-03
AU3761001A (en) 2001-09-17

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