WO2001049331A2 - Dispositif de diffusion d'un produit volatil et procede de preparation - Google Patents
Dispositif de diffusion d'un produit volatil et procede de preparation Download PDFInfo
- Publication number
- WO2001049331A2 WO2001049331A2 PCT/FR2000/003744 FR0003744W WO0149331A2 WO 2001049331 A2 WO2001049331 A2 WO 2001049331A2 FR 0003744 W FR0003744 W FR 0003744W WO 0149331 A2 WO0149331 A2 WO 0149331A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- matrix
- volatile product
- skin
- eva
- adhesive
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
- A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
- A61L9/042—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating with the help of a macromolecular compound as a carrier or diluent
Definitions
- the present invention relates to a device for diffusing a volatile product into the atmosphere, and a method for its manufacture.
- the volatile product diffusion device of the invention is more particularly intended to be applied to the skin.
- the volatile product diffusion devices must allow rapid release of the product for 8 to 24 hours, be practical to use - in particular fine, discreet and translucent - and allow diffusion to the atmosphere in the immediate vicinity of the skin while avoiding direct contact of the product with the skin.
- Application FR 2 745 720 describes a device for the controlled diffusion of a volatile product into the atmosphere comprising a layer of a hydrophobic polymeric film of ethylene / vinyl acetate (EVA) type comprising 15 to 50% of hydrophilic inclusions, in which a volatile product is trapped. 90% of the charge of volatile product included in the polymeric film is released between 8 and 24 hours in the atmosphere.
- EVA ethylene / vinyl acetate
- the device for diffusing a volatile product also comprises a polymer film loaded with volatile product, but the polymer used is different. Indeed, it has been discovered in the context of the present invention that in order to obtain a diffusion device which has good hold on the skin, which is as thin as possible without breaking during the manufacturing process, it is necessary to choose a polymer film with certain characteristics.
- the EVA polymer comprising 15 to 50% of hydrophilic inclusions described in FR 2 745 720 does not meet these criteria.
- the device for diffusing a volatile product according to the invention can contain pulverulent products, for example polyacrylate microspheres to increase the loading capacity of the matrix or to slow down the rate of diffusion of volatile products.
- pulverulent products for example polyacrylate microspheres to increase the loading capacity of the matrix or to slow down the rate of diffusion of volatile products.
- the thickness of the matrix is considerably reduced and its hold on the skin is improved.
- the present invention relates to a device for diffusing a volatile product into the atmosphere, in particular intended to be applied to the skin, comprising a matrix intended to diffuse the volatile product, said matrix based on an ethylene / vinyl acetate (EVA), characterized in that said copolymer represents a Melt Index of between 0.5 and 20 g / 10 min, measured according to standard ASTM D 1238, and a melting point of between 65 and 90 ° C.
- EVA ethylene / vinyl acetate
- the Melt Index is between 0.5 and 10 g / 10 min.
- the EVA copolymer advantageously has a breaking stress of 2000 N / cm 2 . EVAs with a too high Melt Index are too fluid and too sticky, so that the material cannot be worked properly in the form of a film.
- the EVA copolymer is for example selected from Icorene ® MP00623-18, MP 00119-35, 02020-35 MP and mixtures thereof.
- Icorene ® MP 00119-35 is characterized by a Melt Index of 0.65 g / 10 min, and a melting point of 83 ° C.
- the Icorene ® MP 00623-18 is characterized by a Melt Index of 5.5 g / 10 min and a VICAT point of 63 ° C.
- Icorene ® MP 02020-35 is characterized by a Melt Index of 20 g / 10 min and a melting point of 83 ° C.
- the VICAT point measured according to ASTM D 1525, is 10 to 20 ° C below the melting point.
- the melting temperatures of the EVAs chosen are between 65 and 90 ° C., which makes it possible to extrude at temperatures low enough to considerably limit the losses and the degradation of the volatile product during extrusion.
- the mechanical properties of EVA give the matrix good elasticity. This property makes it possible on the one hand to easily stretch the film and to obtain finer matrices (100 ⁇ m and less).
- the matrix is advantageously a translucent film 150 ⁇ m thick between 150 and 300 ⁇ m, containing 0.5 to 30% of volatile product, preferably 10 to 20%, for example 20%, relative to the weight of the matrix .
- the device for diffusing a volatile product comprises five layers: a) the matrix based on the EVA copolymer described above containing the volatile product, b) an impermeable film making it possible to avoid the diffusion of the volatile product towards the skin, c) an adhesive making it possible to fix said matrix on said impermeable film, d) an adhesive making it possible to maintain the device on the skin, e) a peelable protection to be removed before application to the skin.
- the elasticity of the EVA used in the context of the invention also makes it possible to dampen the deformation of the matrix when the latter loses its charge of volatile product and consequently to obtain better hold of the patch on the skin. .
- the thickness of the matrix and the load of volatile product are optimized jointly, so as to limit the phenomena of delamination and to obtain good adhesion of the diffusion device.
- the delaminations will be all the more important the thicker the matrix and the higher the volatile product load.
- the lower the load of volatile product the better the adhesion. Consequently, to increase the unit charge of volatile product per diffusion device, it will be preferable to reduce the thickness of the film and to increase the concentration of volatile product.
- the adhesive (c) for fixing the matrix on the impermeable film is for example composed of a styrene-isoprene elastomer (Kraton ® D 1161 N / Shell Chemicals) and a terpene resin (Dercolyte ® A115 / DRT) combined with an antioxidant (Irganox ® 1010).
- the impermeable film (b) is advantageously a coextruded OPP film 35 ⁇ m thick or else a 23 ⁇ m polyester.
- the adhesive used to hold the patch on the skin (d) can be, depending on the case, an acrylic medical adhesive (ex from Duro-tak ® 387-2054 National Strach) or a rubber medical adhesive (ex Morstik 153 from MORTON) .
- the peelable protection to be removed can be a 75 ⁇ m polyester film with one side silicone (4P Embaiflex), a silicone film made of polypropylene or paper.
- the diffusion device has a thickness of the order of 200 to 500 ⁇ m, preferably 350 ⁇ m.
- the unit content of volatile product is between 8 and 35 mg.
- the volatile product is chosen from insect repellents of natural or synthetic origin, essential oils, perfumes, perfume compositions, terpene derivatives which can be inhaled such as menthol, camphor, eucalyptol, and their mixtures.
- the volatile product is an essential oil chosen from the essential oils of lemongrass, geranium, cedarwood, lavender, eucalyptus, lemongrass, mille-feuille, peppermint, cloves, thuja, neem and their mixtures.
- the present invention also relates to the manufacture of the device for diffusing a volatile product.
- the matrix is obtained by extrusion of an EVA powder impregnated with the volatile product.
- the main stages of the manufacturing process are as follows:
- the EVA powder and the volatile product are introduced simultaneously into the Buss mixer respectively via the dosing hopper and an injection system placed downstream of the hopper.
- the volatile product is directly introduced into the molten copolymer, and the prior impregnation step is thus avoided.
- the EVA is advantageously a powder whose grain size does not exceed 1000 ⁇ m, in order to ensure a maximum contact surface and therefore better absorption of the volatile products by the polymer.
- FIG. 1 represents the structure of a diffusion device according to the invention comprising 5 layers: a) matrix diffusing the volatile product, b) adhesive for fixing the matrix, c) waterproof film, d) adhesive for holding on the skin , e) peelable protection.
- FIG. 2 represents the speed of release of the citronella essence from the patches of example 1.
- a lemongrass anti-mosquito patch consisting of 5 layers: a matrix containing the essence of lemongrass, a matrix fixing adhesive, an impermeable film, a holding adhesive on the skin and a peelable protection.
- Icorene ® MP 02020-35 has the following characteristics:
- the adhesive for maintaining on the skin is an acrylic copolymer (Duro-tak ® ).
- Waterproof film formula The waterproof film located between the skin adhesive and the matrix fixing adhesive is made of oriented polypropylene (OPP 35 ⁇ m, Brodart). Peelable protection formula
- the peelable protection is a film of silicone-coated polyethylene terephthalate on the surface (4P EmbaIFlex).
- the powder mixture is extruded at 75 ° C to obtain a polymeric film 150 ⁇ m thick and 12 cm wide.
- the powder mixer is introduced into a BUSS mixer-kneader via a feed hopper, the molten material is kneaded and then expelled in an extruder in which the material is pressurized by an endless screw. At the exit of the extruder, the material passes through a flat die to give a film which is then calendered and then wound in a reel.
- citronella essence in the matrix after extrusion is 17.3%.
- the loss of volatile product during extrusion is 13.5%.
- the adhesive deposit is introduced into a dryer to evaporate the solvents, then complexed with OPP 35 ⁇ m.
- the complex 1 obtained (silicone paper / skin adhesive / OPP 35 ⁇ m) is packaged on a reel and cut lengthwise into 125 mm widths.
- the solvent used is a Petrol E / Methyl ketone 67133 m / m mixture.
- the dry extract represents 50% of the adhesive formula.
- the adhesive is coated at a rate of 30 g / m 2 on the OPP 35 ⁇ m face of the complex 1.
- the deposit of adhesive is introduced into a dryer to evaporate the solvents, then is complexed with the polymer matrix containing the essence of lemongrass.
- the complex 2 obtained (silicone paper / skin adhesive / OPP 35 ⁇ m / matrix adhesive / matrix) is packaged on a reel, then placed in an airtight package while awaiting laminating. 4. Laminating the peelable protector
- the complex 3 formed (75 ⁇ m silicone polyester split / LDPE carrier) is cut into 125 mm width.
- Complex 2 is freed from silicone paper and then complexed with the silicone face of the 75 ⁇ m polyester lined with the adhesive-coated LDPE coating of complex 3.
- Complex 4 (matrix / matrix adhesive / 35 ⁇ m OPP / skin adhesive / complex 3) is packaged on a reel and placed in an airtight package until stamped.
- Complex 4 is introduced into the upward stamping machine.
- the complex is cut out flat in rounds of 3 cm in diameter, then scales.
- the cut patches are placed on the LDPE transporter.
- the reels are placed in an airtight package while awaiting bagging. 6.
- the patches are placed in individual bags of suitable size in a paper / PE / aluminum / PE complex.
- the patches are placed on a heating plate thermostatically controlled at 32 ° C, the loss of citronella essence is measured for 10 h. By 10 a.m., 58.3% of the initial citronella charge is released. The release profile of the citronella essence obtained under these conditions is presented in FIG. 1.
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU30312/01A AU3031201A (en) | 1999-12-30 | 2000-12-29 | Device for diffusing a volatile product and preparation method |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR99/16732 | 1999-12-30 | ||
FR9916732A FR2803204B1 (fr) | 1999-12-30 | 1999-12-30 | Dispositif de diffusion d'un produit volatil et procede de preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001049331A2 true WO2001049331A2 (fr) | 2001-07-12 |
WO2001049331A3 WO2001049331A3 (fr) | 2002-05-23 |
Family
ID=9554043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2000/003744 WO2001049331A2 (fr) | 1999-12-30 | 2000-12-29 | Dispositif de diffusion d'un produit volatil et procede de preparation |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU3031201A (fr) |
FR (1) | FR2803204B1 (fr) |
WO (1) | WO2001049331A2 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004015784A1 (de) * | 2004-03-25 | 2005-10-20 | Beiersdorf Ag | Insektenrepellent-Pflaster |
EP1634578A1 (fr) * | 2004-07-27 | 2006-03-15 | Air Products Polymers, L.P. | Compositions cosmétiques comprenant un copolymère d'acétate de vinyle et d'éthylène |
FR2921541A1 (fr) * | 2007-10-02 | 2009-04-03 | Ab7 Ind Sa | Dispositif repulsif contre les parasites des animaux domestiques |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0348970A2 (fr) * | 1988-06-30 | 1990-01-03 | Dow Corning Corporation | Laminé à plusieurs couches pour la libération d'un parfum |
US5019434A (en) * | 1986-07-08 | 1991-05-28 | Soda Aromatic Co., Ltd. | Molded slow-release air freshener |
FR2699406A1 (fr) * | 1992-12-21 | 1994-06-24 | Commissariat Energie Atomique | Films à base de copolymères, leurs applications dans des systèmes transdermiques et leurs procédés de préparation. |
US5399404A (en) * | 1991-12-19 | 1995-03-21 | Schering-Plough Healthcare Products | Foot and shoe deodorizer patch |
FR2745720A1 (fr) * | 1996-03-08 | 1997-09-12 | Soc D Pharmacologie Et D Immun | Dispositif de diffusion d'un produit volatil dans l'atmosphere |
-
1999
- 1999-12-30 FR FR9916732A patent/FR2803204B1/fr not_active Expired - Fee Related
-
2000
- 2000-12-29 AU AU30312/01A patent/AU3031201A/en not_active Abandoned
- 2000-12-29 WO PCT/FR2000/003744 patent/WO2001049331A2/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5019434A (en) * | 1986-07-08 | 1991-05-28 | Soda Aromatic Co., Ltd. | Molded slow-release air freshener |
EP0348970A2 (fr) * | 1988-06-30 | 1990-01-03 | Dow Corning Corporation | Laminé à plusieurs couches pour la libération d'un parfum |
US5399404A (en) * | 1991-12-19 | 1995-03-21 | Schering-Plough Healthcare Products | Foot and shoe deodorizer patch |
FR2699406A1 (fr) * | 1992-12-21 | 1994-06-24 | Commissariat Energie Atomique | Films à base de copolymères, leurs applications dans des systèmes transdermiques et leurs procédés de préparation. |
FR2745720A1 (fr) * | 1996-03-08 | 1997-09-12 | Soc D Pharmacologie Et D Immun | Dispositif de diffusion d'un produit volatil dans l'atmosphere |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004015784A1 (de) * | 2004-03-25 | 2005-10-20 | Beiersdorf Ag | Insektenrepellent-Pflaster |
EP1634578A1 (fr) * | 2004-07-27 | 2006-03-15 | Air Products Polymers, L.P. | Compositions cosmétiques comprenant un copolymère d'acétate de vinyle et d'éthylène |
FR2921541A1 (fr) * | 2007-10-02 | 2009-04-03 | Ab7 Ind Sa | Dispositif repulsif contre les parasites des animaux domestiques |
WO2009080909A2 (fr) | 2007-10-02 | 2009-07-02 | Ab7 Industries Sa | Dispositif repulsif contre les parasites des animaux domestiques |
WO2009080909A3 (fr) * | 2007-10-02 | 2010-07-29 | Ab7 Industries Sa | Dispositif repulsif contre les parasites des animaux domestiques |
US9060520B2 (en) | 2007-10-02 | 2015-06-23 | Ab7 Innovation | Domestic animal parasite-repellent device |
Also Published As
Publication number | Publication date |
---|---|
FR2803204A1 (fr) | 2001-07-06 |
AU3031201A (en) | 2001-07-16 |
WO2001049331A3 (fr) | 2002-05-23 |
FR2803204B1 (fr) | 2002-05-03 |
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