WO2001042495A3 - Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn - Google Patents

Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn Download PDF

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Publication number
WO2001042495A3
WO2001042495A3 PCT/FR2000/003427 FR0003427W WO0142495A3 WO 2001042495 A3 WO2001042495 A3 WO 2001042495A3 FR 0003427 W FR0003427 W FR 0003427W WO 0142495 A3 WO0142495 A3 WO 0142495A3
Authority
WO
WIPO (PCT)
Prior art keywords
products
nucleic acids
support
dna chip
fixed nucleic
Prior art date
Application number
PCT/FR2000/003427
Other languages
English (en)
Other versions
WO2001042495A2 (fr
Inventor
Oleg Melnyk
Christophe Olivier
Nathalie Ollivier
David Hot
Ludovic Huot
Yves Lemoine
Isabelle Wolowczuk
Tam Huynh-Dinh
Catherine Gouyette
Helene Gras-Masse
Original Assignee
Pasteur Institut
Centre Nat Rech Scient
Oleg Melnyk
Christophe Olivier
Nathalie Ollivier
David Hot
Ludovic Huot
Yves Lemoine
Isabelle Wolowczuk
Huynh Dinh Tam
Catherine Gouyette
Gras Masse Helene
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Centre Nat Rech Scient, Oleg Melnyk, Christophe Olivier, Nathalie Ollivier, David Hot, Ludovic Huot, Yves Lemoine, Isabelle Wolowczuk, Huynh Dinh Tam, Catherine Gouyette, Gras Masse Helene filed Critical Pasteur Institut
Priority to CA002393641A priority Critical patent/CA2393641A1/fr
Priority to AU25241/01A priority patent/AU2524101A/en
Priority to EP00988891A priority patent/EP1235839A2/fr
Priority to JP2001544367A priority patent/JP2003516159A/ja
Publication of WO2001042495A2 publication Critical patent/WO2001042495A2/fr
Publication of WO2001042495A3 publication Critical patent/WO2001042495A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00693—Means for quality control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50—Detection characterised by immobilisation to a surface
    • C12Q2565/501—Detection characterised by immobilisation to a surface being an array of oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)

Abstract

La présente invention se rapporte à des produits comprenant un support sur lequel sont fixés des acides nucléiques, à leur procédé de préparation et à leur utilisation comme puce à ADN. La présente invention se rapporte également à des supports fonctionnalisés, à des oligonucléotides et à des ADN modifiés en position 5' par un groupement sélectionné dans le groupe constitué par l'acide tartrique, la sérine, la thréonine, leurs dérivés et le groupement α-oxoaldéhyde, ainsi qu'à leurs procédés de préparation. La présente invention se rapporte, en outre, à un procédé de fixation d'un acide nucléique sur un support.
PCT/FR2000/003427 1999-12-07 2000-12-07 Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn WO2001042495A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002393641A CA2393641A1 (fr) 1999-12-07 2000-12-07 Comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn
AU25241/01A AU2524101A (en) 1999-12-07 2000-12-07 Products comprising a support whereon are fixed nucleic acids and their use as dna chip
EP00988891A EP1235839A2 (fr) 1999-12-07 2000-12-07 Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn
JP2001544367A JP2003516159A (ja) 1999-12-07 2000-12-07 核酸が固定されている支持体を含むプロダクト、およびｄｎａチップとしてのそれらの使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR99/15392 1999-12-07
FR9915392A FR2801904B1 (fr) 1999-12-07 1999-12-07 Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn

Publications (2)

Publication Number Publication Date
WO2001042495A2 WO2001042495A2 (fr) 2001-06-14
WO2001042495A3 true WO2001042495A3 (fr) 2001-12-13

Family

ID=9552954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/003427 WO2001042495A2 (fr) 1999-12-07 2000-12-07 Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn

Country Status (7)

Country Link
US (1) US20030162185A1 (fr)
EP (1) EP1235839A2 (fr)
JP (1) JP2003516159A (fr)
AU (1) AU2524101A (fr)
CA (1) CA2393641A1 (fr)
FR (1) FR2801904B1 (fr)
WO (1) WO2001042495A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2825095B1 (fr) * 2001-05-28 2003-09-26 Dev Des Antigenes Combinatoire Dispositif de presentation de polypeptides, utilisable comme "puce" pour la detection miniaturisee de molecules
US20030149246A1 (en) * 2002-02-01 2003-08-07 Russell John C. Macromolecular conjugates and processes for preparing the same
FR2840409B1 (fr) * 2002-05-28 2004-08-27 Dev Des Antigenes Combinatoire Dispositif de presentation de peptides ou de proteines, son procede de preparation et ses utilisations
WO2005103066A1 (fr) * 2004-04-09 2005-11-03 Burzynski, Stanislaw, R. Procede de fixation de sondes moleculaires sur un support solide
US20060121501A1 (en) * 2004-10-22 2006-06-08 Stanislaw Burzynski Method for immobilizing molecular probes to a semiconductor oxide surface
KR100956447B1 (ko) * 2008-05-16 2010-05-06 한국전자통신연구원 바이오센서의 기판의 패턴의 제조 방법 및 이를 이용한바이오센서
DE102013011304A1 (de) * 2013-07-02 2015-01-22 Technische Universität Dresden Verfahren und Anordnung zur Erfassung von Bindungsereignissen von Molekülen
CA2957964A1 (fr) 2014-09-03 2016-03-10 Immunogen, Inc. Conjugues comprenant des agents de liaison cellulaire et des agents cytotoxiques
WO2020119706A1 (fr) * 2018-12-12 2020-06-18 深圳华大生命科学研究院 Biopuce, procédé de fabrication et application correspondants
CN112067684A (zh) * 2019-06-11 2020-12-11 复旦大学 一种基于噻唑烷化学固相富集糖肽并质谱分析的方法
CN112552208B (zh) * 2021-01-25 2022-06-10 井冈山大学 一种用于滴眼液质量检测的荧光分子及其制备和应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FRUCHART J -S ET AL: "A new linker for the synthesis of C-terminal peptide alpha-oxo-aldehydes", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 40, no. 34, 20 August 1999 (1999-08-20), pages 6225 - 6228, XP004174018, ISSN: 0040-4039 *
M. BEIER, J.D. HOHEISEL: "Versatile derivatisation of solid support media for covalent bonding on DNA-microchips", NUCLEIC ACIDS RESEARCH, vol. 27, no. 9, 1999, pages 1970 - 1977, XP002145887 *

Also Published As

Publication number Publication date
FR2801904B1 (fr) 2002-02-08
EP1235839A2 (fr) 2002-09-04
US20030162185A1 (en) 2003-08-28
JP2003516159A (ja) 2003-05-13
WO2001042495A2 (fr) 2001-06-14
FR2801904A1 (fr) 2001-06-08
AU2524101A (en) 2001-06-18
CA2393641A1 (fr) 2001-06-14

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