WO2001039615A1 - Utilisation de compositions a base de sucre - Google Patents

Utilisation de compositions a base de sucre Download PDF

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Publication number
WO2001039615A1
WO2001039615A1 PCT/GB2000/004608 GB0004608W WO0139615A1 WO 2001039615 A1 WO2001039615 A1 WO 2001039615A1 GB 0004608 W GB0004608 W GB 0004608W WO 0139615 A1 WO0139615 A1 WO 0139615A1
Authority
WO
WIPO (PCT)
Prior art keywords
trehalose
use according
exercise
nutritional composition
blood glucose
Prior art date
Application number
PCT/GB2000/004608
Other languages
English (en)
Inventor
Julian Michael Cooper
Michael Andrew Acaster
Christopher Heath
Michael Gleeson
Ruth Louise Botham
Original Assignee
British Sugar Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Sugar Plc filed Critical British Sugar Plc
Priority to AU17183/01A priority Critical patent/AU1718301A/en
Publication of WO2001039615A1 publication Critical patent/WO2001039615A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof

Definitions

  • the present invention relates to the use of trehalose for the preparation of nutritional compositions for consumption during or shortly before physical exercise.
  • carbohydrate containing beverages is beneficial for endurance exercise performance. It has become a common practice in many sports for the participants to ingest sports drinks during both competition and training, for example in cycling, triathlon, marathon, football or rugby. It is also known for participants in recreational pursuits such as walking and disco dancing to consume carbohydrate containing beverages to improve endurance performance. The beverages are also consumed to improve mental- alertness during such activities.
  • Most drinks for use during exercise are isotonic. That is to say, they have a dire osmoiality close to that of blood plasma, which is about 290 mmol/kg. Isotonic drinks are rapidly emptied from the stomach and absorbed in the intestine. Increasing the osmoiality of the drinks by adding more glucose slows the rate of gastric emptying and initially draws fluid from the circulation into the gut, causing an undesirable dehydrating effect. Hence, most sports drinks contain glucose at a concentration of 4-6% w/v, together with a small amount of sodium (10-60 mmol/l, usually as sodium citrate) which optimises the rate of glucose and water absorption.
  • Glucose is cotransported with sodium from the gut lumen into the gut epithelial cells, and water follows by osmosis.
  • the addition of sodium at concentrations of 40-80 mmol/l aids retention of fluid in the body, and a concentration close to 60 mmol/l has been recommended for drinks designed to promote post-exercise recovery.
  • Trehalose ⁇ -D-glucopyranosyl- ⁇ -D-glycopyranoside
  • trehalose is, in fact, readily absorbed by the body.
  • the mechanism for absorption is thought to be that trehalase enzyme in the microvilli of the small intestine breaks the trehalose down into its constituent glucose monomers, which are then absorbed through the intestinal wall.
  • WO96/08979 describes isotonic or hypotonic sports beverages containing trehalose.
  • the sports beverages containing trehalose are said to be useful for providing rehydration and nutrition during athletic exercise.
  • the use of trehalose rather than glucose is said to be desirable because of the lower osmotic pressure at a given weight concentration of trehalose (a disaccharide) compared to glucose (a monosaccharide).
  • trehalose would be superior to glucose for sustained maintenance of blood glucose levels after prolonged exercise.
  • EP-A-0619951 describes energy supplements containing trehalose. Data are presented showing that relatively small orally administered doses of trehalose
  • JP-A-9173017 describes edible compositions containing trehalose that are said to improve strength and stamina during exercise. There is no disclosure of prolonged exercise, nor is there any suggestion of improved recovery after exercise.
  • compositions containing trehalose during and/or shortly before physical exercise provides an improvement in exercise endurance time that is not significantly better than that achieved with glucose.
  • the trehalose does not only provides a rapid boost to blood glucose levels; it also sustains the blood glucose level of the subject at near-normal levels for at least one hour following the exercise.
  • the trehalose thereby promotes post-exercise recovery, particularly following prolonged exercise for 20 minutes or more.
  • the trehalose reduces physical and mental impairment (fatigue) following such exercise.
  • the long-term response to orally administered trehalose is quite different from the response to orally administered glucose, where a hypoglycaemic dip is observed following vigorous exercise that can give rise to feelings of increased exhaustion and reduced alertness of the subject.
  • the present invention provides the use of trehalose for the preparation of a nutritional composition for oral administration to a subject during and/or shortly before prolonged physical exercise to maintain the blood glucose level of the subject for a sustained period after said exercise.
  • the present invention provides the use of trehalose for the preparation of a nutritional composition for oral administration to a subject during and/or shortly before prolonged physical exercise to reduce physical and mental impairment of the subject following said exercise.
  • the present invention provides the use of trehalose for the preparation of a nutritional composition for oral administration to a subject during and/or shortly before prolonged physical exercise to promote post-exercise recovery.
  • the nutritional composition is selected from the group consisting of chocolate confectionery, sugar confectionery, biscuits, fondants, jellies, jams, sauces, puddings, syrups, soft drinks, sweet or savoury snack foods, cakes and other baked goods, ice cream, energy and cereal bars, alcoholic beverages and combinations thereof. More preferably, the nutritional composition is a soft drink, and most preferably it is a sports drink.
  • the nutritional composition is in a unit dosage format. That is to say it is in a form adapted for consumption by a single human subject at substantially one time, for example a confectionery bar, an energy or cereal bar, or a bottle or can containing 100-500ml of beverage.
  • the unit dosage form contains more than 12g of trehalose, more preferably more than 20g of trehalose.
  • the nutritional composition is packaged in the unit dosage format.
  • the composition used in the present invention comprises at least 10% w/w of trehalose, preferably at least 20% w/w of trehalose, more preferably at least 30% w/w trehalose, and most preferably at least 40% or 50% by weight of trehalose, based on the dry weight of the composition.
  • the composition is a soft drink, it may be somewhat hypertonic, but it is preferably an isotonic or hypotonic solution.
  • the osmolarity of the soft drink is 400 mOsm or less, more preferably it is 300 mOsm or less, and most preferably it is 250 mOsm or less.
  • the concentration of trehalose in the soft drink is preferably 2 to 25 wt.%, more preferably 5 to 15 wt.%.
  • the step of preparation may comprise diluting a solid or liquid concentrate with water or carbonated water.
  • the soft drink also comprises at least one salt in an amount sufficient to enhance uptake of the water through the gastrointestinal tract.
  • the salt is selected from the group consisting of salts of sodium, potassium, magnesium and calcium.
  • the salt is present in an amount of 10-100mmol/l, more preferably 40 to 80 mmol/l.
  • compositions may contain other nutrients.
  • Suitable nutrients include monosaccharides such as fructose, mannose, galactose and glucose, and disaccharides other than trehalose such as sucrose, maltose and lactose.
  • Suitable nutrients further include vitamins, minerals, amino acids, peptides and proteins.
  • Suitable vitamins include vitamin C, the B vitamins, pantothenic acid, thiamin, niacin, niacinamide, riboflavin and biotin.
  • Suitable minerals include iron, zinc, chromium, calcium, copper and magnesium.
  • Suitable amino acids include the 20 amino acids utilised by humans.
  • compositions may further include appropriate amounts of colouring, artificial and natural flavours, sweeteners and preservatives.
  • the compositions may further include one or more stimulants such as taurine and caffeine.
  • the step of oral administration preferably comprises administration of at least 0.1 g of trehalose per kg body weight of the person, preferably at least 0.3g/kg and more preferably at least 0.5 g/kg.
  • the step of oral administration comprises administration of a dose containing more than 12 g of trehalose to the human subject, preferably at least 20g and more preferably at least 25g.
  • the physical exercise is vigorous exercise, and more preferably the physical exercise is exercise substantially to exhaustion. Suitable forms of exercise include running, football, tennis, basketball, squash, housework, dancing and the like. Preferably, the duration of the exercise is at least 20 minutes, more preferably 30 minutes or more.
  • the present invention is based on the surprising discovery that consumption of trehalose provides a sustained boost to blood glucose levels that lasts for considerably longer than the boost given by an equivalent molar quantity of glucose.
  • consumption of trehalose seems to maintain the blood glucose level for an extended period even after exercise to exhaustion.
  • the term "maintain" used herein in relation to blood glucose levels signifies that the trehalose provides a blood glucose level that is higher in a statistically significant amount than is observed for a placebo containing an equivalent amount of water and no carbohydrate.
  • the blood glucose level is maintained at a level at least 0.25 mmol/l above the level for a carbohydrate-free placebo of equal liquid volume, and more preferably at least 0.40 mmol/l above that level.
  • the blood glucose level is maintained for at least 90 minutes following administration, and more preferably for at least 150 minutes after administration.
  • the trehalose is administered no more than one hour before the start of exercise, and more preferably no more than 10 minutes before the exercise, and most preferably during the exercise.
  • the administration during the exercise may be in addition to administration before the start of exercise.
  • the blood glucose level is maintained for at least one hour following the physical exercise, and more preferably for at least 90 minutes following the physical exercise.
  • FIG. 1 shows a graph of blood plasma glucose concentration against time during a cycle ride to exhaustion at 70% VO 2 max. Data are shown for subjects given a placebo (filled circles), a 5 wt.% glucose sports drink (open circles) and a 10 wt.% trehalose sports drink (open squares).
  • Figure 2 shows graphs of plasma insulin concentration against time measured for the subjects in the experiment of Figure 1.
  • Procedure 1 The effects of a trehalose solution on metabolic responses, perception of effort, and endurance performance during exercise to exhaustion at a constant exercise intensity were assessed as follows.
  • the aerobic fitness of the subjects was quantified by measurement of their maximal oxygen uptake (VO 2 max). Maximal oxygen uptake was determined using a continuous incremental protocol on an electrically braked cycle ergometer (Lode Excalibur (Registered Trade Mark), Holland). Following a 3-minute warm-up at 120W, subjects began cycling at an initial work rate of 150W with increments of 30W every 2 minutes until fatigue. During the second minute of each work rate an expired gas sample was collected into a Douglas bag.
  • a paramagnetic oxygen analyser (Servomex 1420B (Registered Trade Mark), Crowborough, UK) and an infrared carbon dioxide analyser (Servomex 1415B) were used along with a dry gas meter (Harvard Apparatus Ltd, Edenbridge, UK) for determination of minute ventilation, V0 2 and VC0 2 .
  • the BASES criteria for attainment of VO 2 max were adopted. From the V0 2 -work rate relationship, the work rate equivalent to 70% V0 2 max was interpolated.
  • Subjects performed three bouts of exercise on separate occasions at least one week apart. Following an overnight fast, subjects cycled on cycle ergometer at a work rate equivalent to 70% VO 2 max until exhaustion. On each of these occasions the subjects were randomly assigned to one of three experimental treatments: glucose (5% w/v), trehalose (10% w/v) or placebo solutions. Each solution was flavoured with sugar-free lemon cordial and contained 20 mmol/l trisodium citrate.
  • the osmoiality of the drinks was measured using a freezing point osmometer (Advanced Instruments) and was 110, 361 , and 386 mOsm/kg for the PLA, GLU, and T10 drinks, respectively (note that 80 mOsm/kg of each drink was attributable to the added trisodium citrate).
  • the treatments were blinded to the subjects.
  • Blood was placed into EDTA tubes (4.5 ml) and lithium heparin tubes (7 ml). An aliquot from the EDTA tube was used to determine haemoglobin concentration and haematocrit so that plasma volume changes can be estimated according to Dill and Costill (1974). The remainder was used for analysis of differential white blood cell counts (not reported here).
  • Blood from the heparinised tube was centrifuged at 1500 g for 10 minutes at 4°C to obtain plasma. The latter was stored at -70°C prior to analysis for glucose and lactate (Sigma Chemicals kits), insulin and cortisol (by radioimmunoassay using ICN Biomedicals antibody coated tube kits), and total protein (Biuret method; Sigma Chemicals). The coefficient of variation for the assays was ⁇ 2.4% for glucose, ⁇ 7.3% for lactate, ⁇ 3.4% for protein ⁇ 3 5% for insulin and ⁇ 2.4% for cortisol.
  • the mean VO 2 max of the subjects was 53.1 ⁇ 1.9 ml/kg/min and the mean work rate equivalent to 70% VO 2 max used in the exercise trials was 198 ⁇ 12 W.
  • the mean total fluid intakes (up to the end of exercise) were 1113 ⁇ 86 ml, 1257 ⁇ 84 ml and 1163 ⁇ 102 ml for the placebo (PLA) 5% w/v glucose (GLU) and 10% w/v trehalose (T10) drinks, respectively.
  • the mean total sugar intakes (up to the end of exercise) were 62.8 ⁇ 4.2 g and 116.3 ⁇ 10.2 g for the glucose and trehalose treatments, respectively.
  • Heart rate was similar on all three trials and averaged 165 ⁇ 4 beats/min after 30 minutes of cycling and 172 ⁇ 5 beats/min at exhaustion. Perceived exertion was not significantly affected by glucose or trehalose ingestion compared with placebo.
  • the mean resting plasma insulin concentration before consumption of the drinks was 14 mU/l.
  • the change in plasma insulin concentration during the three exercise trials is shown in Figure 2.
  • There was a significant Time*Trial interaction F ,32 5.27; P ⁇ 0.05) for the plasma insulin responses.
  • F ,32 5.27; P ⁇ 0.05
  • a sports drink for use in accordance with the present invention is prepared from the following ingredients: Trehalose dihydrate 83.3 g
  • Lemon juice concentrate 25 ml
  • the ingredients are dissolved in 0.5 litres of water at 25°C, and when fully dissolved the liquid is made up to 1.0 litres with water. The solution is allowed to stand for 30 minutes before use.
  • the sports drink will normally be consumed in an amount of 100 to 500 ml during or shortly before vigorous exercise.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Non-Alcoholic Beverages (AREA)

Abstract

L'invention concerne l'utilisation de tréhalose dans la préparation d'une composition nutritionnelle, destinée à être bue par une personne pendant, ou peu de temps après, un exercice physique, aux fins de maintien, chez cette personne, du taux de glucose sanguin pendant une période prolongée, c'est-à-dire pendant et après ledit exercice. De préférence, cette composition nutritionnelle est une boisson pour sportifs.
PCT/GB2000/004608 1999-12-02 2000-12-01 Utilisation de compositions a base de sucre WO2001039615A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU17183/01A AU1718301A (en) 1999-12-02 2000-12-01 Use of sugar compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9928535.5 1999-12-02
GB9928535A GB2356788A (en) 1999-12-02 1999-12-02 Trehalose for use in exercise

Publications (1)

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WO2001039615A1 true WO2001039615A1 (fr) 2001-06-07

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1500335A1 (fr) * 2003-07-23 2005-01-26 Cerestar Holding Bv Produits alimentaires contenant de la tréhalose pour libération continuelle de l'énergie de hydrates de carbone et réduction de réponse glycémique/insulinémique
WO2005013720A2 (fr) * 2003-07-23 2005-02-17 Cerestar Holding B.V. Produits comestibles a isomaltulose ou trehalose pour liberation soutenue d'energie en hydrates de carbone et oxadation accrue de graisses
WO2012013975A1 (fr) 2010-07-27 2012-02-02 Omniceutica Limited Compositions nutritionnelles
US8293299B2 (en) 2009-09-11 2012-10-23 Kraft Foods Global Brands Llc Containers and methods for dispensing multiple doses of a concentrated liquid, and shelf stable Concentrated liquids
WO2017102738A1 (fr) 2015-12-13 2017-06-22 Verburgh Kris Procédés et compositions destinés à ralentir le vieillissement de cellules et d'organismes
US11013248B2 (en) 2012-05-25 2021-05-25 Kraft Foods Group Brands Llc Shelf stable, concentrated, liquid flavorings and methods of preparing beverages with the concentrated liquid flavorings

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1462011A1 (fr) * 2003-03-24 2004-09-29 Cerestar Holding B.V. Produits comestibles contenant de l'isomaltulose et de la tréhalose à libération prolongée d'énergie d'hydrate de carbone et à réponse glycémique/insulimique réduite
WO2004084655A1 (fr) * 2003-03-24 2004-10-07 Cerestar Holding B.V. Produits comestibles renfermant de l'isomaltulose et de la trehaolose qui permettent une liberation soutenue d'energie a partir d'hydrates de carbone, limitent les reactions glycemiques/insulinemiques et preservent l'osmolalite
EP1791443A1 (fr) 2004-08-20 2007-06-06 Cargill, Incorporated Systemes d'ingredients comprenant du trehalose, produits alimentaires contenant du trehalose, et methodes de production de ceux-ci
US8231925B2 (en) 2004-08-20 2012-07-31 Cargill, Incorporated Ingredient systems comprising trehalose, food products containing trehalose, and methods of making same

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4022058A1 (de) * 1990-07-11 1992-01-16 Oetker Nahrungsmittel Honigpulver und verfahren zu seiner herstellung
EP0532807A1 (fr) * 1991-09-20 1993-03-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Saccharide pour fournir un complément d'énergie à un corps vivant, et ses usages
EP0619951A2 (fr) * 1993-03-16 1994-10-19 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Source de saccharide enrichie en énergie et ses usages
WO1996008979A1 (fr) * 1994-09-22 1996-03-28 Quadrant Holdings Cambridge Limited Compositions de rehydratation et de nutrition a utiliser pendant une activite sportive, et leurs procedes de preparation
JPH09173017A (ja) * 1995-12-28 1997-07-08 Lotte Co Ltd トレハロース含有飲食物
EP0834516A1 (fr) * 1996-10-07 1998-04-08 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Sirop avec trehalose en haute teneur
JPH1189547A (ja) * 1997-09-18 1999-04-06 Morinaga & Co Ltd ミネラル含有飲料又はゼリー
EP0983726A1 (fr) * 1998-08-24 2000-03-08 Riken Composition contenant des acides aminés et du tréhalose

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4022058A1 (de) * 1990-07-11 1992-01-16 Oetker Nahrungsmittel Honigpulver und verfahren zu seiner herstellung
EP0532807A1 (fr) * 1991-09-20 1993-03-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Saccharide pour fournir un complément d'énergie à un corps vivant, et ses usages
EP0619951A2 (fr) * 1993-03-16 1994-10-19 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Source de saccharide enrichie en énergie et ses usages
WO1996008979A1 (fr) * 1994-09-22 1996-03-28 Quadrant Holdings Cambridge Limited Compositions de rehydratation et de nutrition a utiliser pendant une activite sportive, et leurs procedes de preparation
JPH09173017A (ja) * 1995-12-28 1997-07-08 Lotte Co Ltd トレハロース含有飲食物
EP0834516A1 (fr) * 1996-10-07 1998-04-08 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Sirop avec trehalose en haute teneur
JPH1189547A (ja) * 1997-09-18 1999-04-06 Morinaga & Co Ltd ミネラル含有飲料又はゼリー
EP0983726A1 (fr) * 1998-08-24 2000-03-08 Riken Composition contenant des acides aminés et du tréhalose

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199737, Derwent World Patents Index; Class D13, AN 1997-396989, XP002163278 *
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 09 30 July 1999 (1999-07-30) *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1500335A1 (fr) * 2003-07-23 2005-01-26 Cerestar Holding Bv Produits alimentaires contenant de la tréhalose pour libération continuelle de l'énergie de hydrates de carbone et réduction de réponse glycémique/insulinémique
WO2005013720A2 (fr) * 2003-07-23 2005-02-17 Cerestar Holding B.V. Produits comestibles a isomaltulose ou trehalose pour liberation soutenue d'energie en hydrates de carbone et oxadation accrue de graisses
WO2005013720A3 (fr) * 2003-07-23 2005-04-07 Cerestar Holding Bv Produits comestibles a isomaltulose ou trehalose pour liberation soutenue d'energie en hydrates de carbone et oxadation accrue de graisses
US8293299B2 (en) 2009-09-11 2012-10-23 Kraft Foods Global Brands Llc Containers and methods for dispensing multiple doses of a concentrated liquid, and shelf stable Concentrated liquids
US8603557B2 (en) 2009-09-11 2013-12-10 Kraft Foods Group Brands Llc Containers and methods for dispensing multiple doses of a concentrated liquid, and shelf stable concentrated liquids
WO2012013975A1 (fr) 2010-07-27 2012-02-02 Omniceutica Limited Compositions nutritionnelles
CN103037715A (zh) * 2010-07-27 2013-04-10 欧姆尼塞缇卡公司 营养组合物
US11013248B2 (en) 2012-05-25 2021-05-25 Kraft Foods Group Brands Llc Shelf stable, concentrated, liquid flavorings and methods of preparing beverages with the concentrated liquid flavorings
WO2017102738A1 (fr) 2015-12-13 2017-06-22 Verburgh Kris Procédés et compositions destinés à ralentir le vieillissement de cellules et d'organismes

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GB2356788A (en) 2001-06-06
GB9928535D0 (en) 2000-02-02
AU1718301A (en) 2001-06-12

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