WO2001038484A3 - Genes de mousse tires de physcomitrella patens, codant des proteines impliquees dans la synthese des acides gras et des lipides polyinsatures - Google Patents

Genes de mousse tires de physcomitrella patens, codant des proteines impliquees dans la synthese des acides gras et des lipides polyinsatures Download PDF

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Publication number
WO2001038484A3
WO2001038484A3 PCT/EP2000/011615 EP0011615W WO0138484A3 WO 2001038484 A3 WO2001038484 A3 WO 2001038484A3 EP 0011615 W EP0011615 W EP 0011615W WO 0138484 A3 WO0138484 A3 WO 0138484A3
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WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
physcomitrella patens
lipids
synthesis
Prior art date
Application number
PCT/EP2000/011615
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English (en)
Other versions
WO2001038484A2 (fr
Inventor
Jens Lerchl
Andreas Renz
Thomas Ehrhardt
Andreas Reindl
Petra Cirpus
Friedrich Bischoff
Markus Frank
Annette Freund
Elke Duwenig
Ralf-Michael Schmidt
Ralf Reski
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Basf Plant Science Gmbh
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Publication date
Application filed by Basf Plant Science Gmbh filed Critical Basf Plant Science Gmbh
Priority to CA002392475A priority Critical patent/CA2392475A1/fr
Priority to JP2001540237A priority patent/JP2003518369A/ja
Priority to EP00979617A priority patent/EP1282713A2/fr
Priority to BR0015905-0A priority patent/BR0015905A/pt
Priority to AU17045/01A priority patent/AU1704501A/en
Priority to MXPA02005214A priority patent/MXPA02005214A/es
Publication of WO2001038484A2 publication Critical patent/WO2001038484A2/fr
Publication of WO2001038484A3 publication Critical patent/WO2001038484A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6463—Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cette invention se rapporte à des molécules d'acide nucléique isolées, appelées molécules d'acide nucléique de LMRP (protéines liées au métabolisme des lipides), qui codent de nouvelles protéines LMRP tirées par exemple de Physcomitrella patens. Cette invention concerne également des molécules d'acide nucléique antisens, des vecteurs d'expression recombinés contenant des molécules d'acide nucléique de LMRP, et des cellules hôtes dans lesquelles sont introduits ces vecteurs d'expression, ainsi que des protéines LMRP isolées, des protéines LMRP mutées, des protéines de fusion, des peptides antigéniques et à des procédés d'amélioration de la production d'un composé souhaité à partir de cellules, d'organismes ou de plantes transformés basés sur la transformation génétique de gènes de LMRP dans ces organismes.
PCT/EP2000/011615 1999-11-25 2000-11-22 Genes de mousse tires de physcomitrella patens, codant des proteines impliquees dans la synthese des acides gras et des lipides polyinsatures WO2001038484A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002392475A CA2392475A1 (fr) 1999-11-25 2000-11-22 Genes de mousse tires de physcomitrella patens, codant des proteines impliquees dans la synthese des acides gras et des lipides polyinsatures
JP2001540237A JP2003518369A (ja) 1999-11-25 2000-11-22 多不飽和脂肪酸および脂質の合成に関与するタンパク質をコードするフィスコミトレラ・パテンス由来のコケの遺伝子
EP00979617A EP1282713A2 (fr) 1999-11-25 2000-11-22 Genes de mousse tires de i physcomitrella patens /i , codant des proteines impliquees dans la synthese des acides gras et des lipides polyinsatures
BR0015905-0A BR0015905A (pt) 1999-11-25 2000-11-22 Mólecula de ácido nucleico isolada, vetor, célula hospedeira, descendentes, sementes ou material celular reprodutìvel, método para produzir um polipeptìdeo, polipeptìdeo isolado, anticorpo, kit de teste, método para produzir um produto quìmico fino, produto quìmico fino, e, uso de um produto quìmico fino, ou de um polipeptìdeo
AU17045/01A AU1704501A (en) 1999-11-25 2000-11-22 Moss genes from physcomitrella patens encoding proteins involved in the synthesis of polyunsaturated fatty acids and lipids
MXPA02005214A MXPA02005214A (es) 1999-11-25 2000-11-22 Genes de musgo de physcomitrella patens que codifican proteinas involucradas en la sintesis de lipidos y acidos grasos poliinsaturados.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP1999/009108 WO2001038541A1 (fr) 1999-11-25 1999-11-25 Genes de mousse de physcomitrella patents codant pour des proteines impliquees dans la synthese de lipides et d'acides gras polyinsatures
EPPCT/EP99/09108 1999-11-25

Publications (2)

Publication Number Publication Date
WO2001038484A2 WO2001038484A2 (fr) 2001-05-31
WO2001038484A3 true WO2001038484A3 (fr) 2001-11-01

Family

ID=8167508

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP1999/009108 WO2001038541A1 (fr) 1999-11-25 1999-11-25 Genes de mousse de physcomitrella patents codant pour des proteines impliquees dans la synthese de lipides et d'acides gras polyinsatures
PCT/EP2000/011615 WO2001038484A2 (fr) 1999-11-25 2000-11-22 Genes de mousse tires de physcomitrella patens, codant des proteines impliquees dans la synthese des acides gras et des lipides polyinsatures

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/009108 WO2001038541A1 (fr) 1999-11-25 1999-11-25 Genes de mousse de physcomitrella patents codant pour des proteines impliquees dans la synthese de lipides et d'acides gras polyinsatures

Country Status (7)

Country Link
JP (1) JP2003518369A (fr)
AR (1) AR026571A1 (fr)
AU (2) AU1499601A (fr)
BR (1) BR0015905A (fr)
CA (1) CA2392475A1 (fr)
MX (1) MXPA02005214A (fr)
WO (2) WO2001038541A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8853432B2 (en) 2004-04-22 2014-10-07 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cell
US8946460B2 (en) 2012-06-15 2015-02-03 Commonwealth Scientific And Industrial Research Organisation Process for producing polyunsaturated fatty acids in an esterified form
US9453183B2 (en) 2004-04-22 2016-09-27 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cell

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006717A2 (fr) 1998-07-27 2000-02-10 Genentech, Inc. Efficacite de transformation amelioree de l'expression a la surface des phages par modification d'une proteine de coque
ATE540575T1 (de) 2001-03-16 2012-01-15 Basf Plant Science Gmbh Regulatoren des zucker- und lipidstoffwechsels in pflanzen
WO2003004604A2 (fr) * 2001-07-06 2003-01-16 Genentech, Inc. Ligands du domaine pdz exprimes a la surface des phages
DE10220115A1 (de) 2001-07-12 2003-01-23 Basf Ag CYP74-Enzyme und die sie kodierenden Nukleotidsequenzen sowie Verfahren zur Herstellung von pathogenresistenten Pflanzenzellen und deren Nachkommen
CA2453218C (fr) 2001-07-12 2010-02-09 Basf Plant Science Gmbh Allene oxyde synthase et divinyl ether synthase de la famille d'enzymes cyp74 isolees a partir de physcomitrella patens, sequences nucleotidiques codant pour ces enzymes, ainsi que procede pour la production de plantes resistantes aux pathogenes
DE10231589A1 (de) * 2002-07-11 2004-01-29 Basf Plant Science Gmbh Klonierung und Charakterisierung einer Lipoxygenase aus Phaeodactylum tricornutum
EP1525304A1 (fr) * 2002-07-18 2005-04-27 Basf Aktiengesellschaft Cytochrome b5 reductase nadh-dependante utilisee comme cible pour herbicides
WO2004013304A2 (fr) 2002-08-02 2004-02-12 Basf Plant Science Gmbh Regulateurs du metabolisme des glucides et du metabolisme lipidique chez les plantes iv
US7928294B2 (en) * 2004-07-12 2011-04-19 Suntory Holdings Limited Polypeptide having Δ5 desaturating activity, polynucleotide coding for the polypeptide, and use thereof
CA2661697A1 (fr) 2006-08-29 2008-03-06 Commonwealth Scientific And Industrial Research Organisation Synthese d'acides gras
EP2358882B1 (fr) 2008-11-18 2017-07-26 Commonwealth Scientific and Industrial Research Organisation Enzymes et méthodes de production d'acides gras oméga-3
SG11201604871VA (en) 2013-12-18 2016-07-28 Commw Scient Ind Res Org Lipid comprising long chain polyunsaturated fatty acids
KR102527795B1 (ko) 2014-06-27 2023-05-02 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 도코사펜타에노산을 포함하는 지질
CN106047856A (zh) * 2016-05-11 2016-10-26 中国科学院等离子体物理研究所 一种利用原生质体融合结合荧光染色筛选融合子选育aa高产菌株的方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0437710A1 (fr) * 1990-01-17 1991-07-24 Societe Des Produits Nestle S.A. ProcÀ©dé de production d'acides gras polyinsaturés
WO1996032484A2 (fr) * 1995-04-14 1996-10-17 Arch Development Corporation COMPOSITIONS A BASE D'ACETYL-CoA CARBOXYLASE ET PROCEDES D'UTILISATION

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0437710A1 (fr) * 1990-01-17 1991-07-24 Societe Des Produits Nestle S.A. ProcÀ©dé de production d'acides gras polyinsaturés
WO1996032484A2 (fr) * 1995-04-14 1996-10-17 Arch Development Corporation COMPOSITIONS A BASE D'ACETYL-CoA CARBOXYLASE ET PROCEDES D'UTILISATION

Non-Patent Citations (5)

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Title
GIRKE T ET AL: "IDENTIFICATION OF A NOVEL DELTA6-ACYL-GROUP DESATURASE BY TARGETED GENE DISRUPTION IN PHYSCOMITRELLA PATENS", PLANT JOURNAL,GB,BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, vol. 15, no. 1, 1998, pages 39 - 48, XP000881712, ISSN: 0960-7412 *
HANSEN C E ET AL: "ARACHIDONIC AND EICOSAPENTAENOIC ACIDS IN BRACHYTHECIACEAE AND HYPNACEAE MOSS SPECIES", PHYTOCHEMISTRY (OXFORD) 1990, vol. 29, no. 12, 1990, pages 3749 - 3754, XP000910469, ISSN: 0031-9422 *
RADWAN S.S.: "Sources of C20- polyunsaturated fatty acids for biotechnological use.", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 35, no. 4, July 1991 (1991-07-01), pages 421 - 430, XP000915518 *
SHORROSH B S ET AL: "STRUCTURAL ANALYSIS, PLASTID LOCALIZATION, AND EXPRESSION OF THE BIOTIN CARBOXYLASE SUBUNIT OF ACETYL-COENZYME A CARBOXYLASE FROM TOBACCO", PLANT PHYSIOLOGY,US,AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, vol. 108, 1 January 1995 (1995-01-01), pages 805 - 812, XP000619221, ISSN: 0032-0889 *
SUN ET AL: "Biochemical and molecular biological characterization of CAC2, the Arabidopsis thaliana gene coding for the biotin carboxylase subunit of the plastidic acetyl - coenzyme A carboxylase", PLANT PHYSIOLOGY,US,AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, vol. 115, no. 4, 1997, pages 1371 - 1383, XP002124755, ISSN: 0032-0889 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8853432B2 (en) 2004-04-22 2014-10-07 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cell
US9453183B2 (en) 2004-04-22 2016-09-27 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cell
US9458410B2 (en) 2004-04-22 2016-10-04 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cell
US8946460B2 (en) 2012-06-15 2015-02-03 Commonwealth Scientific And Industrial Research Organisation Process for producing polyunsaturated fatty acids in an esterified form
US9550718B2 (en) 2012-06-15 2017-01-24 Commonwealth Scientific And Industrial Research Organisation Lipid comprising polyunsaturated fatty acids
US9556102B2 (en) 2012-06-15 2017-01-31 Commonwealth Scientific And Industrial Research Organisation Process for producing ethyl esters of polyunsaturated fatty acids

Also Published As

Publication number Publication date
BR0015905A (pt) 2002-08-06
JP2003518369A (ja) 2003-06-10
WO2001038484A2 (fr) 2001-05-31
WO2001038541A1 (fr) 2001-05-31
MXPA02005214A (es) 2002-12-09
CA2392475A1 (fr) 2001-05-31
AU1499601A (en) 2001-06-04
AU1704501A (en) 2001-06-04
AR026571A1 (es) 2003-02-19

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