WO2001036287A1 - Couvercle de recipient et dispositif de manutention de liquides - Google Patents

Couvercle de recipient et dispositif de manutention de liquides Download PDF

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Publication number
WO2001036287A1
WO2001036287A1 PCT/JP2000/007673 JP0007673W WO0136287A1 WO 2001036287 A1 WO2001036287 A1 WO 2001036287A1 JP 0007673 W JP0007673 W JP 0007673W WO 0136287 A1 WO0136287 A1 WO 0136287A1
Authority
WO
WIPO (PCT)
Prior art keywords
lid
container
liquid
opening
operating
Prior art date
Application number
PCT/JP2000/007673
Other languages
English (en)
Japanese (ja)
Inventor
Shintaro Nishimura
Hiroshi Sasaki
Hajime Miyoshi
Itsuro Tahara
Tadafumi Uekawa
Takeshi Matsushita
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Dainippon Seiki Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co., Ltd., Dainippon Seiki Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Publication of WO2001036287A1 publication Critical patent/WO2001036287A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/004—Multifunctional apparatus for automatic manufacturing of various chemical products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00283—Reactor vessels with top opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B01J2219/00344—Caps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0403—Sample carriers with closing or sealing means
    • G01N2035/0405—Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers

Definitions

  • the present invention particularly relates to a container lid device and a liquid handling device suitable for a container used for a liquid handling device such as an automatic synthesis device for a pharmacological evaluation sample.
  • the present applicants have proposed an automatic synthesizer suitable for the synthesis of various kinds of samples for pharmacological evaluation in a small amount, which is disclosed in Japanese Patent Application Laid-Open No. 11-333394.
  • this device a large number of containers are used, and some of the containers are provided with lids, while the remaining containers are not provided with lids, and the liquid in these containers is always air. Is touching.
  • the container is not provided with a lid, the following problems may occur depending on the nature of the liquid contained in the container.
  • the vaporized gas may flow out of the container and adversely affect the surroundings.
  • Reactions that dislike moisture and oxygen are generally carried out in an inert gas environment, but using a container without a lid to perform this reaction. Such reactions cannot be performed.
  • Specific examples of such a reaction include an acylation reaction using a carbodiimidazole active substance, a reduction reaction using a diisobutylaluminum hydride (DIBAL) reagent, a coupling reaction using a jet resin, a n-reaction.
  • DIBAL diisobutylaluminum hydride
  • Examples of the reaction include a reaction using butyllithium and a Darnall reagent, and a reaction using a palladium catalyst.
  • the container is provided with a lid, there is no such problem, but it is necessary to automatically open and close the lid when sucking and discharging the liquid, which is generally difficult.
  • An object of the present invention is to solve the above-mentioned problems, to prevent the liquid from coming into contact with the air and outflow of vaporized gas by closing the container with a lid, and to automatically and easily open the lid.
  • An object of the present invention is to provide a container lid device and a liquid handling device that can be opened and closed. Disclosure of the invention
  • the container lid device is a container mounting portion fixed to the container mouth so as to open the upper part of the container mouth opening, and the container mounting portion is rotatable.
  • a lid that opens and closes the opening of the container opening that is attached and communicates with the opening of the container or the opening of the container, and is attached to the container mounting part so that it can be moved up and down so that the opening above the opening of the container opens.
  • the operating part is provided with an operating part urging means for urging the operating part upward, and when the operating part moves downward, the lid is opened and the operating part moves upward. In this case, the lid is closed.
  • the suction and discharge of the liquid to and from the container equipped with the lid device are performed using, for example, a nozzle or a tube.
  • the lid may be opened to the extent that liquid can be sucked and discharged from the container, for example, a nozzle can be inserted into the container.
  • the container mounting portion and the operating portion do not need to completely open the entire upper portion of the container opening, and can absorb and discharge liquid to and from the container without completely closing the upper portion of the container opening. For example, it is only necessary to open the container so that a nozzle or the like can be inserted.
  • the actuating part biasing means is preferably constituted by a suitable spring.
  • the operating part When no downward force is applied to the operating part, the operating part is moved upward by the operating part urging means, and the lid is closed. Therefore, the liquid in the container does not come into contact with air, and the gas vaporized in the container does not flow out of the container.
  • the lid When the operating part is pushed down and moved downward, the lid opens. Since the container mounting part and the operating part are open (not closed) above the mouth opening of the container, opening or closing the lid enables the liquid to be sucked into or discharged from the container. Then, when the force for pushing the operating portion downward is eliminated, the operating portion is moved upward by the operating portion biasing means, and the lid is closed.
  • the lid can be automatically and easily opened and closed by pushing or not pushing the operating portion downward, and the liquid can be sucked and discharged from the container with the lid opened. it can.
  • the container lid device of claim 1 the container can be sealed with the lid to prevent the liquid from touching the air or the vaporized gas from flowing out, and the lid can be automatically and easily opened and closed. can do.
  • the container lid device is the device according to claim 1, further comprising lid urging means for urging the lid in the closing direction, and actuates when the operating unit moves downward.
  • a part of the part (lid engaging part) is engaged with a part of the lid and the lid is opened, and when the operating part moves upward, the operating part separates from the lid and the lid is biased by the lid urging means. It is characterized by being closed.
  • the lid biasing means is preferably constituted by a suitable spring.
  • the lid engaging portion may be formed integrally with the operating portion, or may be configured by attaching another member to the operating portion.
  • the operating part moves upward by the operating part urging means and separates from the lid, and the lid is closed by the lid urging means.
  • this internal pressure overcomes the urging force of the lid urging means and the lid opens, and a part of the gas becomes external.
  • the lid engaging part engages with a part of the lid and the lid opens. Then, when the force for pushing the operating part downward is eliminated, the operating part is moved upward by the operating part urging means and separated from the lid, and the lid is securely closed by the lid urging means.
  • the lid can be easily opened by moving the operating portion downward, and the lid is biased by the lid urging means by moving the operating portion upward. Can be securely closed. Further, even when the internal pressure in the container abnormally rises as described above, the lid is opened to allow some of the gas in the container to escape to the outside, thereby preventing the container from exploding.
  • the container lid device according to claim 3 is the device according to claim 2, further comprising a lid holding position for holding the lid in the closed position and a lid for allowing the lid to rotate from the closed position to the open position.
  • a part of the operating part (lid holding member engaging part) engages with a part of the lid holding member and moves it to the lid release position.
  • the lid holding member biasing means is preferably constituted by a suitable spring.
  • the lid holding member engaging portion may be formed integrally with the operating portion, or may be configured by attaching another member to the operating portion.
  • the lid when the operating portion moves upward, the lid can be reliably held at the closed position by the lid urging means and the lid holding member. Further, even when the internal pressure in the container is abnormally increased as described above, the internal pressure overcomes the urging force of the lid urging means and the lid holding member urging means, and the lid is opened. Part of the gas in the container can escape to the outside, preventing the container from exploding.
  • the container lid device is the device according to claim 3, wherein the container mounting portion force S, the container mounting portion main body that is fixed around the mouth of the container and extends upward, and the container mounting portion main body is located above the container mouth. It has a cylindrical communication member fixed inside the extended container mounting portion main body and communicating with the mouth of the container, and the lid is adapted to open and close the upper opening of the communication member. It does.
  • the communication member is formed in an airtight manner, but the container mounting portion main body does not need to be formed in an airtight manner. According to the container lid device of claim 4, only the communication member among the container mounting portions need only be formed in an airtight manner, and the configuration of the container mounting portion is simplified.
  • the container lid device is the device according to any one of claims 1 to 4, wherein the container mounting portion is fixed to the mouth portion of the container in a tight manner, and the cylindrical operating portion is provided. It is attached to the periphery of the container mounting part so as to be tightly and vertically movable so that the mouth opening of the container communicates with the outside air only through the upper end opening of the operating part. It is.
  • the lid is opened by pushing the operating part downward, and liquid is sucked and discharged from the container, for example, the upper end opening of the operating part is closed by a member pushing the operating part.
  • the space inside the container and the inside of the working part is isolated from the outside air, so that the liquid in the container can be prevented from touching the air and the gas vaporized in the container can be prevented from flowing out. Further, by supplying an inert gas such as nitrogen gas into the working section and the space in the container during the liquid suction and discharge as described above, the gas in the container is reliably prevented from coming into contact with air.
  • an inert gas such as nitrogen gas
  • the container lid device of claim 5 it is possible to prevent the liquid in the container from touching the air and the liquid vaporized in the container from flowing out when the liquid is sucked and discharged.
  • an inert gas is supplied to the working section and the space in the container, so that the liquid in the container can be reliably prevented from contacting the air.
  • the liquid handling apparatus wherein the plurality of containers into which the liquid is contained, and a liquid suction / discharge nozzle which is moved relative to the container in a horizontal direction above the container and is moved vertically in relation to the container.
  • a liquid handling device provided with a liquid suction / discharge means for sucking liquid from the container and discharging the liquid to the container by using the lid device according to any one of claims to 5 at the mouth of the required container. Attached, liquid sucked
  • the discharging means is provided with a lid opening / closing member that pushes the operating portion of the lid device downward when the discharging means moves vertically relative to the container and moves downward.
  • the liquid suction / discharge means moves in the horizontal direction, and the lid opening / closing member of the liquid suction / discharge means and the liquid suction / discharge nozzle move in the vertical direction.
  • the lid opening / closing member When the lid opening / closing member is relatively moving upward with respect to the container, the operating portion of the lid device is moved upward by the operating portion urging means, and the lid is closed. Therefore, there is no possibility that the liquid inside the container comes into contact with air or the vaporized gas inside the container flows out of the container.
  • the lid opening / closing member moves relatively downward with respect to the container, this pushes the operating part of the lid device downward, and the lid opens, and while the lid is open, a nozzle is used. The liquid can be sucked and discharged from the container.
  • the lid opening / closing member moves upward relative to the container, the operating section is moved upward by the operating section urging means, and the lid is closed. In this way, the lid can be automatically and easily opened and closed only by moving the lid opening / closing member and the container in the vertical direction, and the nozzle can suck and discharge liquid while the lid is open.
  • the liquid handling apparatus further comprising: a raw material container storage section for storing a plurality of raw material containers containing at least a liquid raw material, a nozzle chip storage section for storing a plurality of disposable nozzle tips, and a plurality of reaction vessels.
  • a rotary shaker having a reaction container storage table to be shaken, and a liquid which is moved between the respective storage sections and the reaction container storage table of the rotary shaker, and the nozzle tip is automatically attached and detached and is moved in the vertical direction.
  • a claim is provided at an opening of a required container.
  • a lid opening / closing member that pushes the operating part of the lid device downward when the liquid suction / drainage means moves up and down and moves downward when the container lid device according to any one of 1 to 5 is attached.
  • liquid raw material is used to include all liquid raw materials, solid raw materials or liquid raw materials dissolved in a solvent.
  • the raw materials include reagents and the like.
  • the lid opening / closing member When the lid opening / closing member is moving upward, the operating part of the lid device is moved upward by the operating part urging means, and the lid is closed. When the lid opening / closing member moves downward, the operating part of the lid device is pushed downward, and the lid is opened. When the lid opening / closing member moves upward, the operating section is moved upward by the operating section urging means, and the lid is closed. In this way, the lid can be automatically and easily opened and closed simply by moving the lid opening and closing member in the vertical direction, and the nozzle can suck and discharge liquid while the lid is open.
  • the container can be closed tightly with the lid to prevent the liquid from touching the air or the vaporized gas from flowing out, and to automatically and easily cover the lid. It can be opened and closed and liquid can be sucked and discharged while the lid is open.
  • a disposable nozzle tip is used. For each kind of liquid material, the previously used nozzle tip is discarded and a new nozzle tip is used. Since it is good, there is no need for cleaning, and there is no danger of contamination due to mixing of liquid materials.
  • the reaction vessel is shaken using a rotary shaker to stir the reaction solution in the reaction vessel, and there is no need to stir the reaction solution using a stirrer. For this reason, the noise is small, the stirrer does not need to be washed as in the conventional case, and there is no possibility that the liquid material or the solvent is mixed to cause contamination.
  • the liquid handling device according to claim 8 is the liquid handling device according to claim 6 or 7, wherein a lid device for the container according to claim 5 is attached to an opening of a required container, and the lid opening / closing member is a liquid suction / drainage device.
  • a cylinder surrounding the chisel When the lower end opening of the body suction / discharge nozzle is inside the cylinder, the lower end opening is made to communicate with the outside air only through the lower end opening of the cylinder, and the lid opening / closing member is located below the working part.
  • a required portion of the cylindrical body and a required portion of the operating portion are in close contact with each other when moved, so that a space in the operating portion and a space in the cylindrical body are shielded from outside air.
  • the cylinder With the lower end opening of the nozzle inside the cylinder, the cylinder prevents the liquid sucked by the nozzle from coming into contact with air. Also, when the lid opening / closing member moves downward with respect to the operating part and the lid is opened, the cylinder and the operating part come into close contact with each other, so that the space in the operating part and the space in the cylinder are shut off from the outside air. When the liquid is sucked and discharged by the nozzle, the liquid in the container is prevented from touching the air and the liquid vaporized in the container is prevented from flowing out.
  • the liquid sucked by the nozzle is prevented from coming into contact with the air, and the liquid in the container is exposed to the air when the nozzle sucks and discharges the liquid. It is possible to prevent the liquid vaporized inside from flowing out.
  • the liquid handling device is the liquid handling device according to claim 8, wherein the liquid suction / discharge means is further provided at a closed position immediately below the cylinder of the lid opening / closing member and at a lateral side immediately below the cylinder. It is characterized by having a liquid receiving / shutter that moves between a distant standby position.
  • the lid opening / closing member and the nozzle are relatively moved in the vertical direction, so that the lid of the lid device can be opened / closed and the liquid can be sucked and discharged from the container.
  • the liquid receiving / shutter also moves the cylindrical body. The lower end opening is closed, the cylinder is almost sealed, and the liquid sucked into the nozzle Is prevented from touching the air.
  • a dripping from the nozzle occurs, it is received by the liquid receiving / shutter which is in the closed position, and is prevented from dropping to other parts.
  • the liquid receiving / shutter is used to substantially close the cylindrical body of the lid opening / closing member to prevent the liquid sucked by the nozzle from coming into contact with air. At the same time, it is possible to receive the liquid dripping from the liquid suction / drain nozzle and prevent the liquid from dropping.
  • the liquid handling apparatus according to claim 10 is the liquid handling apparatus according to claim 9, wherein the liquid suction / discharge means further includes an inert gas supply means for supplying an inert gas into the cylinder of the lid opening / closing member. This is the feature.
  • the liquid receiving / shutter With the lower end opening of the nozzle positioned inside the cylinder, the liquid receiving / shutter is moved to the closed position, and the cylinder is almost sealed, and the inert gas is supplied to the cylinder by the inert gas supply means. This ensures that the cylinder is filled with inert gas and the liquid sucked into the nozzle is prevented from coming into contact with air.
  • the inert gas is supplied into the cylinder and the container. The liquid in the container is reliably prevented from touching the air when the liquid is sucked and discharged.
  • the liquid sucked by the nozzle is reliably prevented from coming into contact with the air, and the liquid in the container is brought into contact with the air when the liquid is sucked and discharged. It can be reliably prevented, and therefore can handle liquids that are inconvenient when exposed to air.
  • FIG. 1 is a partially cut-away flat view of an automatic synthesizer according to an embodiment of the present invention.
  • FIG. FIG. 2 is a partially cutaway front view of FIG.
  • FIG. 3 is a partially cutaway plan view of the container lid device.
  • FIG. 4 is a partially cutaway side view of FIG.
  • FIG. 5 is a sectional view taken along line VV of FIG.
  • FIG. 6 is a drawing corresponding to FIG. 5, showing a state different from FIG.
  • FIG. 7 is a drawing corresponding to FIG. 5, showing a state different from that of FIG.
  • FIG. 8 is a partially cutaway right side view showing the dispensing apparatus.
  • FIG. 9 is a partially cutaway plan view of FIG.
  • FIG. 10 is a cross-sectional view taken along line XX of FIG.
  • FIG. 11 is a sectional view taken along line XI-XI in FIG. BEST MODE FOR CARRYING OUT THE INVENTION
  • FIG. 10 is a cross-
  • FIG. 1 and 2 show the entire configuration of the automatic synthesis apparatus.
  • FIG. 1 is a partially cutaway plan view
  • FIG. 2 is a partially cutaway front view.
  • the lower side of Fig. 1 (the front side of the paper in Fig. 2) is the front
  • the upper side of Fig. 1 (the back side of the paper in Fig. 2) is the rear
  • the left and right when viewed from the front are the left and right. That is, the left and right in FIGS. 1 and 2 are left and right.
  • the basic configuration of the automatic synthesizing apparatus is the same as that described in the above-mentioned JP-A-11-133394 publication.
  • the main part of the automatic synthesizing apparatus is provided in a substantially rectangular parallelepiped housing (1) provided with a door (not shown) on the entire surface. That is, the first raw material container storage section (2), the second raw material container storage section (solvent container storage section) (3), the sample storage section (4), and the nozzle tip storage section (5) are provided in the housing (1). ), Nozzle tip disposal section (6), rotary shaker (7), dispensing device (8), reaction liquid drying device (9), and horizontal movement of dispensing device (8) and drying device (9) A device (10) is provided.
  • the first raw material container storage section (2) is provided at the lower rightmost part of the housing (1), and various kinds of liquid raw materials are placed in predetermined positions of the storage section (2).
  • a plurality of raw material containers (11) housed therein are stored. Liquid raw materials contained in the raw material container (11) include aniline, cyclohexylamine, and piperazine.
  • the second raw material container storage section (3) is provided at the lower left portion in the housing (1). At a predetermined position of the storage section (3), a plurality of solvent containers (raw material containers) containing various types of solvents are provided. (12) is stored. Solvents contained in the solvent container (12) include water, ethyl acetate, dimethylformamide, dichloromethane and the like.
  • the sample storage section (4) is for storing a synthesized sample or a sample being synthesized, and is provided immediately in front of the second raw material container storage section (3).
  • the nozzle tip storage section (5) is located immediately to the left of the first raw material container storage section (2), and contains a plurality of new disposable nozzle tips (13).
  • the nozzle tip (13) is classified into a plurality of types according to the type of liquid to be dispensed and the dispensed amount.
  • the nozzle tip disposal section (6) is provided in front of the nozzle tip storage section (5), and is used to remove a used nozzle tip (13) from a dispensing device (8) described later.
  • a nozzle tip removal section (14) and a used nozzle tip storage container (not shown) for storing the removed nozzle tip (13) are provided.
  • the rotary shaker (7) is provided substantially at the center of the casing (1) between the second raw material container storage section (3) and the nozzle tip storage section (5).
  • This shaker (7) has a configuration similar to that described in the above-mentioned Japanese Patent Application Laid-Open No. 11-33394, and is a reaction vessel storage table driven by a driving device (15). (16) is provided.
  • the storage table (16) stores a plurality of reaction vessels (17).
  • the raw material container (11), the solvent container (12), and the reaction container (17) are arranged vertically with their mouths facing up.
  • the device (18) is mounted. 3 to 7 show the details of the upper part of the raw material container (11) and the lid device (18) attached thereto.
  • the mouth (19) of the container (11) has a slightly cylindrical shape that is slightly longer in the vertical direction, and a male screw (20) is formed on the outer periphery thereof.
  • the lid device (18) includes a container mounting portion (21) fixed to the mouth (19), a lid (22) and a lid holding member (23) rotatably mounted on the mounting portion (21), and a mounting device.
  • An operating section (24) is provided movably up and down on the section (21).
  • the mounting section (21) includes a container mounting section main body (25) and a communication member (26).
  • the lower part of the mounting part body (25) has a stepped cylindrical shape with a large diameter.
  • a stepped hole (27) penetrating vertically is formed at the center of the mounting body (25).
  • the inside diameter of the lower large diameter part of the hole (27) is slightly larger than the outer diameter of the mouth part (19).
  • the inside diameter of the mouth part (19) is A corresponding female thread (28) is formed.
  • the inner diameter of the upper small diameter portion of the hole (27) is slightly smaller than the inner diameter of the lower large diameter portion, and a female screw (29) is formed below the small diameter portion.
  • the communication member (26) has a stepped cylindrical shape with a uniform inner diameter and a slightly larger outer diameter at the bottom.
  • the inner diameter of the communication member (26) is substantially equal to the inner diameter of the mouth (19).
  • the outer diameter of the lower large diameter part of the communication member (26) is slightly smaller than the inner diameter of the lower large diameter part of the mounting part body (25).
  • the outer diameter of the remaining upper small diameter part of the communication member (26) is slightly smaller than the inner diameter of the upper small diameter part of the mounting part body (25).
  • a male screw (31) corresponding to the female screw (29) of the section is formed.
  • the communication member (26) is inserted into the hole (27) of the mounting part body (25) from below, and the male screw (31) is screwed into the female screw (29) until the step parts are pressed against each other. It is fixed by a lock screw (32) screwed from the outside in the radial direction in 25).
  • the upper end of the communication member (26) is located above the bottom surface of the recess (30) of the mounting part body (25) and below the upper end of the mounting part body (25). I have.
  • the lower end of the communication member (26) is located above the lower large-diameter portion of the mounting portion body (25). Immediately below the communication member (26) in the large-diameter portion, the inner diameter of the communication member (26) is set.
  • An annular seal member (33) having substantially the same inner diameter is mounted.
  • a guide groove (34) extending vertically is formed on the outer peripheral surface of the mounting portion main body (25).
  • the mounting part body (25) is made of a plastic material such as PEEK resin
  • the communication member (26) is made of a plastic material such as PTFE resin (teflon).
  • the male screw (28) of the lower large diameter part of the mounting part body (25) is screwed from below with the male screw (20) of the mouth (19).
  • the lower end of the communication member (26) and the mouth (19) With the seal member (33) sandwiched between the upper end of the mounting member and the mounting portion main body (25), the mounting portion main body (25) is firmly fixed to the mouth portion (19).
  • the communication member (26) is communicated with the container (11) via the seal member (33), and the container ( The interior of 11) can communicate with the outside air only through the upper end opening of the communication member (26).
  • the lid (22) has a disk shape, and an engaging portion (22a) formed on a part of the outer periphery so as to protrude outward is attached to a lower surface of the lid (22) via a mounting member (113) fixed by welding.
  • the mounting part main body (25) is provided on the upper outside and is rotatably mounted on a horizontal shaft (35) extending tangentially to the mounting part main body (25).
  • a vertically long slot (114) is formed in the mounting member (113) with the lid (22) closed, and an intermediate portion of the shaft (35) is inserted into the long hole (114). (113) moves slightly in the longitudinal direction of the slot (114) with respect to the shaft (35).
  • a stopper (115) for regulating the open position of the lid (22) is provided on the body at a portion of the mounting portion main body (25) below the shaft (35).
  • a disk-shaped sealing member (36) is fixed to the lower surface of the lid (22).
  • the outer diameter of the sealing member (36) is slightly smaller than the inner diameter of the recess (30) of the mounting part body (25), and the thickness of the sealing member (36) is slightly smaller than the depth of the recess (30). Small,
  • the lid (22) pivots between the closed position shown in FIG. 5 or FIG. 6 and the open position shown in FIG. You.
  • a torsion coil spring (37) is provided on the shaft (35) as a lid urging means for urging the lid (22) in the closing direction to hold the lid in the closed position.
  • the lid (22) In the closed position, the lower surface of the lid (22) around the seal member (36) and the mounting portion body (25) due to the dimensional cumulative error due to the elongated hole (114) and the spring (37) of the mounting member (113). The contact with the upper end is prevented, so that the seal member (36) is pressed against the entire upper end of the communication member (26), and in the open position, the mounting member (113) is stopped by the stopper ( By pressing against 115), the lid (22) is stopped at a fixed position.
  • the shaft (35) When the lid (22) is in the closed position, the shaft (35) is located slightly above the vertical center of the slot (114), and when the lid (22) is in the open position, the shaft (35) is long. It is located at the upper end of the hole (114).
  • the lid (22) is made of stainless steel (SUS304 or SUS316), and the sealing member (36) is made of perfluoro rubber.
  • the lid holding members (23) are provided at two locations on the upper part of the mounting portion main body (25), separated by 90 degrees on both sides from the engaging portions (22a) of the lid (22).
  • Each lid holding member (23) is rotatably attached to a horizontal axis (38) provided outside the upper part of the mounting part body (25) and extending in a tangential direction of the mounting part body (25).
  • the lid holding member (23) is formed with a holding portion (23a) and an engaging portion (23b) projecting in a direction substantially 90 degrees from each other in a circumferential direction around the axis (38).
  • the lid holding member (23) rotates between a lid holding position shown in FIG. 5 and a lid release position shown in FIG.
  • the holding portion (23a) In the lid holding position, the holding portion (23a) extends radially inward of the mounting portion (21), protrudes above the outer peripheral portion of the lid (22) in the closed position, and the engaging portion (23b) extends in the radial direction. It extends outside. Lid open position In this case, the holding part (23a) pivots radially outward from the lid (22) in the closed position and extends upward, and the engaging part (23b) extends diagonally downward and outward radially. I have.
  • a torsion coil spring (39) is provided on the shaft (38) as a lid holding member urging means for urging the lid holding member (23) toward the lid holding position.
  • the operating part (24) has a cylindrical shape in which the lower end is opened and the part excluding the outer peripheral part of the top wall is removed, and the lower part is raised around the middle part of the mounting part body (25). It is fitted so that it can move up and down in close contact.
  • a pin-shaped guide stopper that protrudes radially inward from the working part (24) and fits into the guide groove (34) in the mounting part body (25) on the lower inner peripheral surface of the working part (24). (40) is fixed.
  • the operating part (24) moves between the upper lid closed position shown in FIG. 5 or FIG. 6 and the lower lid opened position shown in FIG.
  • the stopper (40) is located at the upper end of the guide groove (34), and the upper end of the actuating section (24) is located above the upper end of the mounting section (21).
  • the lid (22) and the lid holding member (23) at the lid holding position are located inside the upper part of the operating portion (24). Regardless of the position of the working part (24), the space inside the working part (24) communicates with the outside air only through the opening in the top wall, and therefore, the opening (19) of the container (1 1) The opening communicates with the outside air only through the upper end opening of the operating portion (24).
  • a lid engaging member (41) is fixed to the inner peripheral surface of the operating portion (24) at a position corresponding to the engaging portion (22a) of the lid (22), and is attached to the lid holding member (23) on the inner peripheral surface. At a corresponding position, a lid holding member engaging portion (42) is formed on the body.
  • the lid engaging member (41) has a leaf spring shape, extends obliquely upward along the inner surface of the operating portion (24), and then extends radially inward of the operating portion (24).
  • a semi-cylindrical lid engaging portion (41a) protruding downward is formed at the tip of.
  • the lid engaging part (41a) When the operating part (24) is in the lid closed position, the lid engaging part (41a) is far above the upper surface of the engaging part (22a) of the lid (22) in the closed position, Actuator (24) with lid open When the cover is in the closed position, the lid engaging portion (41a) is located slightly below the engaging portion (22a) of the lid (22) in the closed position.
  • the lid holding member engaging portion (42) is slightly above the upper surface of the engaging portion (23b) of the lid holding member (23) at the lid holding position when the operating portion (24) is at the lid closed position.
  • the operating portion (24) When the operating portion (24) is at the lid release position, the operating portion (24) is located slightly below the upper surface of the engaging portion (23b) of the lid holding member (23) at the lid holding position.
  • the operating part (24) and the lid engaging member (41) are preferably made of a metal material such as stainless steel.
  • the upper part of the vertical pin (43) is embedded and fixed at a position that divides the outer periphery of the top wall of the operating part (24) into four equal parts in the circumferential direction.
  • the lower part of the pin (43) is inserted into the hole (44) formed in the upper surface of the outer peripheral part of the middle part of the mounting part body (25) so that it can move up and down from above.
  • a compression coil spring (45) which constitutes the actuating portion urging means, is fitted around the pin (43), and its upper and lower ends are at the lower surface of the top wall of the actuating portion (24) and the bottom surface of the hole (44). We are in pressure contact.
  • each container (11), (12) and (17) are different from each other, but the shape and dimensions of the mouth (19) are all the same.
  • the same lid device (18) is fixed to the mouth (19) of (17).
  • the horizontal moving device (10) moves the dispensing device (8) in the left and right direction and the front and rear direction, and also moves the drying device (9) in the left and right direction. 2 and FIG. 2 show some of the details in FIGS. 8 to 10.
  • the horizontal moving device (10) includes a left-right moving body (first moving body) (46) and a front-rear moving body (second moving body) (47).
  • the first moving body (46) has an inverted L-shape and is composed of a vertical support (48) and a girder (49) fixed to the upper end of the support (48) and extending horizontally forward. .
  • the lower part of the column (48) is located at the lower rear end of the housing (1) and extends in the left-right direction.
  • the first moving body (46) is moved in the left-right direction by the rotation of the ball screw (52) supported by the drain (50) and driven by the electric motor (51).
  • a guide rail (53) that extends horizontally in the front-rear direction is fixed to the left part of the girder (49) of the first moving body (46), and the second moving body (47) slides back and forth on the right side. It is supported.
  • a ball screw (54) driven by an electric motor (not shown) is arranged in parallel above the guide rail (53) of the girder (49). Accordingly, the second moving body (47) is moved in the front-rear direction along the spar (49).
  • the dispensing device (8) constitutes a liquid suction / discharge means for sucking liquid from the container and discharging the liquid to the container, and also serves as a nozzle device (55), a lid opening / closing device (56), and a liquid receiver.
  • a shutter device (57) and a nitrogen gas supply device (58) are provided, the details of which are shown in FIGS.
  • the nozzle device (55) is composed of a vertical cylindrical nozzle for sucking and discharging liquid (59), a nozzle lifting device (60), a pressure supply device (61), a nozzle (59) and a pressure supply device (61). And a liquid level detection device (not shown).
  • the nozzle (59) is composed of a tubular nozzle base (62) extending vertically and a tubular disposable nozzle tip (13) detachably attached to the lower end thereof.
  • the lower part of the nozzle tip (13) is tapered, and the lower end is a liquid inlet / outlet (hereinafter abbreviated as "supply / outlet”) (13a).
  • the inner diameter of the nose tip (13) is preferably from 0.3 to 1.5 mm, and in this example, it is 0.8 mm.
  • a non-adhesive resin such as a fluororesin such as a chemical titanium resin or a silicon resin (silicone resin).
  • the nozzle elevating device (60) is configured as follows.
  • a guide block (63) is fixed to the right front portion of the second moving body (47), and a vertically long elevating member (first elevating member) (64) is moved up and down on the block (63). It is freely supported.
  • a guide rail (65) extending upward and downward is fixed to the front left side of the first elevating member (64), and the guide rail (65) is vertically slidably supported by the guide block (63).
  • a rack (first rack) (66) extending vertically and having teeth formed on the left surface is fixed to the left side on the rear side of the first lifting member (64).
  • a spline shaft (67) that extends horizontally in the front-rear direction and is rotationally driven by an electric motor (not shown) is provided on the spar (49) of the first moving body (46).
  • a boss (68a) of a pinion (first pinion) (68) is rotatably supported on the second moving body (47), and a ball spline mounted at the center of the boss (68a) is provided.
  • the spline shaft (67) is passed through a leave (not shown), so that the pinion (68) and the spline shaft (67) do not rotate with each other but move relatively in the axial direction (front and rear directions). I have.
  • the pinion (68) meshes with the teeth of the rack (66) of the first lifting member (64).
  • the rotation of the spline shaft (67) causes the rotation of the pinion (68), and the engagement with the rack (66)
  • the first lifting member (64) moves up and down.
  • a web portion of a U-shaped guide member (69) having upper and lower flanges (69a, 69b) is fixed to the upper right surface of the first elevating member (64), and is positioned above the nozzle base (62). The part is guided by the upper and lower flanges (69a, 69b) so as to be able to move up and down.
  • a ring (70) is fixed, and a compression coil spring for biasing the nozzle base (62) downward around the nozzle base (62) between the retaining ring (70) and the upper flange (69a). (71) is attached.
  • the spring (71) is for absorbing the impact when the nozzle tip (13) is attached to the nozzle base (62).
  • the nozzle (13) is attached to the first lifting member (64).
  • the spring (71) holds the retaining ring (70) of the nozzle base (62) at a fixed lower end position where the retaining ring (70) is pressed against the upper surface of the lower flange (69b).
  • the first lifting member (64) moves up and down between a predetermined upper end position and a lower end position.
  • the pressure supply device (61), the pipe connecting the nozzle (59) and the pressure supply device (61) and the liquid level detection device are those described in the above-mentioned JP-A-11-133394. Is the same as
  • the lid opening / closing device (56) includes a lid opening / closing member (72) and a lid opening / closing member lifting / lowering device.
  • the lid opening / closing member (72) includes a vertical cylindrical body (74) having an open top and bottom and a cylindrical body.
  • a guide block (75) concentrically fixed to the upper end of the cylinder (74) is provided so as to close the upper end opening of (74).
  • the cylindrical body (74) has an outer cylinder (76) having a window (76a) formed by removing portions excluding upper and lower ends at two locations in the circumferential direction of the cylinder, and an inner cylinder (76) from above. It has a transparent inner cylinder (77) inserted and fixed.
  • a flange is formed at the lower end of the guide block (75), and this flange portion is fixed to the upper end of the outer cylinder (75) so as to close the upper end opening of the inner cylinder (77).
  • linear motion ball bearings (75a) (75b) are provided on the inner periphery of the guide block (75).
  • An annular cushioning member (78) made of a suitable elastic material such as rubber or plastic is fixed to the lower end of the outer cylinder (76).
  • the outer cylinder (76) is made of stainless steel and the inner cylinder (77) is made of glass.
  • the lid opening / closing member lifting / lowering device (73) is configured as follows. Upper and lower guide blocks (79) and (80) are fixed to the rear part on the right side of the second moving body (47), and the vertically long lifting members are fixed to these blocks (79) and (80). (Second lifting member) (81) is supported to be able to move up and down freely. A vertically extending guide rail (82) is fixed to the left side on the rear side of the second elevating member (81), and this guide rail (82) can slide up and down on the guide blocks (79) and (80). It is supported by. A rack (second rack) (83) extending vertically and having teeth formed on the left surface is fixed to the left side of the front side of the second lifting member (81).
  • a spline shaft (85) that extends horizontally in the front-rear direction and is rotationally driven by an electric motor (84) is provided at the spar (49) of the first moving body (46).
  • a boss (86a) of a pinion (second pinion) (86) is rotatably supported on the second moving body (47), and a sleeve of a ball spline attached to the center of the boss (86a).
  • the spline shaft (85) is passed through (not shown) so that the pinion (86) and the spline shaft (85) do not rotate with each other but move relatively in the axial direction (front-back direction). I have.
  • the pinion (86) meshes with the teeth of the rack (83) of the second lifting member (81).
  • the pinion (86) When the second moving body (47) moves forward and backward along the spar (49), the pinion (86) also moves forward and backward along the spline axis (85), Regardless of the position of the second moving body (47) in the front-rear direction, the pinion (86) rotates by rotating the spline shaft (85) with the electric motor (84). The second lifting member (81) moves up and down with the rack (83) that engages.
  • Two guide blocks (87, 88) are fixed to the right surface of the second elevating body (81), and the vertically long elevating member (third member) is attached to these blocks (87, 88). Elevating member) (89) is supported so as to be able to move up and down.
  • a vertically extending guide rail (90) is fixed to the rear left side of the third elevating body (89), and this guide rail (90) is vertically slidably supported by the guide blocks (87) and (88). Have been.
  • An upper guide block (87) is attached to the upper end surface of the third lifting member (89).
  • a horizontal plate-like stopper (91) protruding upward from is secured by screws (116).
  • a bracket (93) that extends horizontally above the third elevating member (89) is fixed to the upper right surface of the second elevating member (81), and a vertical guide bin ( The upper part of 92) is fixed to the bracket (93). Between the upper surface of the stopper (91) and the lower surface of the bracket (93), a compression coil spring (urging the third lifting member (89) downward against the second lifting member (81)) 94) is attached.
  • the spring (94) is positioned by the head of the screw (116) and the guide bin (92).
  • the third lifting member (89) presses the stopper (91) against the second lifting member (81) by means of the spring (94) against the upper surface of the upper guide block (87). It is held at a certain lower end position.
  • the bracket (93) is integrally formed with a portion that hangs down from the rear edge, and an anomaly detection proximity sensor (95) that detects the stud (91) is attached to the front surface of the hanging portion. Have been.
  • the rear part of the guide block (75) of the lid opening / closing member (72) is fixed to the front part of the third elevating member (89), and the second elevating member (81) raises and lowers the second part.
  • the lid opening / closing member (72) moves up and down between a predetermined upper end position and a lower end position together with the elevating member (89).
  • the lid opening / closing member (72) is arranged concentrically with the nozzle (59), the lower part of the nozzle base (62) is inserted into the guide block (75), and slides on the linear motion ball bearings (75a) (75b). It is movably supported.
  • the nozzle tip (13) at the upper end position is located at the center of the lower part in the cylinder (74) at the upper end position.
  • Light transmission holes (96) and (97) are formed on one diameter of the part slightly above the middle part of the outer cylinder (76), and a nozzle tip is detected in these outer cylinders (76).
  • Photoelectric sensors (98) and (99) are provided.
  • Light transmission holes (100) (101) are formed on one diameter of the portion near the lower end of the outer cylinder (76), and a photoelectric sensor (102) for lid detection is formed in these outer cylinders (76). ) (103) is provided.
  • the liquid receiving / shuttering device (57) is configured as follows.
  • a guide rail (104) extending horizontally in the left-right direction is arranged below the second moving body (47) on the left side of the nozzle (59), and a left-right moving body (third moving body) (105) is located below the guide rail (104).
  • the third moving body (105) extends horizontally in the left-right direction and has teeth formed on the upper surface, and the rack (106) is fixed.
  • a boss (not shown) of a pinion (108) is rotatably supported below the second moving body (47), and a drive shaft (107) is passed through the center of the boss, and the pinion (108) is passed through.
  • the drive shaft (107) and the drive shaft (107) do not rotate with each other, but move relative to each other in the axial direction (front-back direction).
  • the pinion (108) meshes with the teeth of the rack (106) of the third moving body (105).
  • the pinion (108) also moves in the front-rear direction along the drive shaft (107). Regardless of the position of the body (47) in the front-rear direction, the rotation of the drive shaft (107) causes the rotation of the pinion (108) and the engagement with the rack (106).
  • the third moving body (105) moves left and right.
  • the upper end of a plate-like arm (109) extending downward is fixed to the right end surface of the third moving body (105).
  • the lower end of the arm (109) is bent to the right at a right angle, and a short cylindrical bottomed shutter (110) with a bottom is attached to this portion.
  • the shutter (110) moves between the closed position at the right end located immediately below the cylinder (74) at the upper end position and the standby position at the left end. You can move between.
  • the outer diameter of the shutter (110) is slightly larger than the inner diameter of the cylinder (74), and the shutter (110) closes the lower end opening of the cylinder (74) when moved to the closed position. It has become.
  • the nitrogen gas supply device (58) is inactive in the cylinder (74) of the lid opening / closing member (72). It constitutes an inert gas supply means for supplying gas, and includes an introduction pipe (111) and an exhaust pipe (112), some of which are attached to the outer peripheral surface of the outer cylinder (76).
  • the introduction pipe (111) is provided with a pipe for introducing nitrogen gas into the cylinder (74) from above and below, and is connected to an appropriate nitrogen gas supply source.
  • the exhaust pipe (112) has a pipe for discharging air from the lower part of the cylinder (74), and is connected to a suitable exhaust device.
  • the reaction liquid drying apparatus (9) is the same as that described in JP-A-11-133394.
  • the automatic synthesizing operation in the above automatic synthesizing apparatus is the same as that described in the above publication.
  • the liquid is sucked from the raw material container (11) equipped with the lid device (18), and the liquid is introduced into the reaction container (17) equipped with the lid device (18). Will be described.
  • the lid opening / closing member (72) and the nozzle (59) of the dispensing device (8) are at the upper end position, and the lid opening / closing member ( The cylinder (74) of (72) is separated upward from the lid device (18). Then, as shown in FIG. 5, the operating portion (24) of the lid device (18) is held at the upper lid closed position by the elastic force of the spring (45), and the lid (22) is moved by the spring (37). The lid holding member (23) is at the lid holding position by the elastic force of the spring (39) while being stopped at the closed position by the elastic force of the spring (39). And hold it in the closed position.
  • the lid engaging portion (41a) is located above the engaging portion (22a) of the lid (22) at the closed position, and the lid holding member engaging portion (42) is at the lid holding position at the lid holding position. It is located slightly above the engagement portion (23b) of the member (23). Further, a seal member (36) on the lower surface of the lid (22) is pressed against the upper end of the communication member (26) to seal the upper end opening. As a result, the liquid in the container does not come into contact with air, and the vaporized liquid in the container flows out of the container and adversely affects the surroundings. There is no blur.
  • the lid (22) opens slightly against the elastic force of the springs (37, 39) due to the internal pressure, and Gas is released to the outside.
  • the lid (22) returns to the closed position again and is held in the closed position by the lid holding member (23). Therefore, the explosion of the container due to the abnormal increase of the container pressure is prevented.
  • the dispensing device (8) When a liquid is sucked into the nozzle tip (13) from the container (11) equipped with the lid device (18), the dispensing device (8) is first moved in the horizontal direction, and the lid opening / closing member (72) is moved. Is stopped just above the target container (11). Then, the shutter (110) is moved to the standby position. Next, the supply of nitrogen gas into the cylinder (74) by the nitrogen gas supply device (58) is started, and the second elevating member (81) Lowers to a predetermined lower end position. When the second elevating member (81) descends, the third elevating member (89) and the lid opening / closing member (72) descend together, and as shown by a chain line in FIG.
  • the cushioning member (78) comes into contact with the upper surface of the outer peripheral portion of the operating portion (24) of the lid device (18).
  • the cylinder (74) further descends, it is pushed by this, and the operating portion (24) moves downward, and first, the engaging portion (23b) of the lid holding member (23).
  • Push down to rotate the lid holding member (23) to the lid release position as shown in FIG. As a result, the holding portion (23a) of the lid holding member (23) rotates to the outside in the radial direction of the lid (22), and the holding of the lid (22) is released. Even when the lid holding member (23) rotates to the lid release position, the lid (22) remains stopped at the closed position by the elastic force of the spring (37).
  • the lid engaging portion (41a) pushes the engaging portion (22a) of the lid (22) downward, and the lid ( Open 22) and stop the lid (22) at the open position where the mounting member (113) comes into contact with the stopper (115) as shown in FIG.
  • the third elevating member (89) and the lid opening / closing member (72) further lower slightly and stop at the lower end position.
  • the operating part (24) also has the lid (22) at the lower end position. After that, the lid (22) and the actuating part (24) at this time move down slightly, and then stop at the lid open position at the lower end.
  • the second elevating member (81) slightly descends and stops at the lower end position.
  • the upper guide block (87) of the second elevating member (81) moves slightly downward from the stopper (91) of the third elevating member (89), and the proximity sensor (95) ) Moves slightly downward with respect to the stopper (91), but if the lid (22) opens normally, the amount of movement of the proximity sensor (95) with respect to the stopper (91) is small. Therefore, the proximity sensor (95) does not operate.
  • the shock absorbing member (78) at the lower end thereof comes into contact with the operating portion (24), so that the impact is reduced. Further, since the cushioning member (78) seals the space between the cylinder (74) and the operating part (24), the container (11), the communication member (26), the operating part (24), and the cylinder (74) The space inside is shut off from the outside air.
  • the second elevating member (81) moves up to the upper end position.
  • the second lifting member (81) starts rising from the lower end position, only the second lifting member (81) rises until the upper guide block (87) presses against the stopper (91), After that, the second lifting member (81) and Finally, the lid opening / closing member (72) rises.
  • the lid opening / closing member (72) starts to ascend from the lower end position, the operating portion (24) and the lid engaging portion (41a) rise, and accordingly, the engaging portion (22a) of the lid (22) follows. Pivots upward, the lid (22) pivots toward the closed position, and eventually stops at the closed position.
  • the lid holding member engaging part (42) also rises, and the lid holding member follows.
  • the lid holding member (23) is The holding portion (23a) is located radially outward from the lid (22) and is held in a state where the holding of the lid (22) is released.
  • the lid opening / closing member (72) further rises and the operating part (24) further rises, the lid engaging part (41a) separates from the engaging part (22a) of the lid (22) and moves upward.
  • the lid is moved and, at the same time, the lid holding member engaging portion (42) is raised, whereby the lid holding member (23) rotates to the lid holding position and holds the lid (22) in the closed position.
  • the shutter (110) is moved to the closed position, and the lower end opening of the cylindrical body (74) is closed. Since the transparent body (77) is attached inside the outer cylinder (76) having the window (76a), the cylindrical body (74) passes through the inner cylinder (77) of the window (76a). However, the height of the liquid sucked into the nozzle tip (13) ⁇ the state of the liquid running out at the lower end of the nozzle tip (13) can be visually checked. Also, even if liquid dripping occurs from the lower end of the nozzle tip (13), it is received by the shutter (110). Also, the supply of nitrogen gas is continued so that the tip of the nozzle tip (13) does not come into contact with air after the liquid is sucked.
  • the dispensing device (8) When discharging the liquid sucked into the nozzle tip (13) into the reaction vessel (17) equipped with the lid device (18) as described above, first, the dispensing device (8) Is moved in the horizontal direction, and the lid opening / closing member (72) is stopped immediately above the target container (17). Then, the shutter (110) is moved to the standby position, and the lower end opening of the cylinder (74) is opened while supplying nitrogen gas into the cylinder (74). Next, the second elevating member (81) is lowered to a predetermined lower end position, and the lid (22) of the lid device (18) is opened as described above.
  • the nozzle (59) starts to descend at a high speed, and the lower end of the nozzle tip (13) reaches a position where a predetermined liquid discharge position in the container (17) is reached. Stop.
  • the nozzle (59) stops the supply of nitrogen gas by the nitrogen gas supply device (58) stops. Then, the liquid in the nozzle tip (13) is discharged into the container (17), and thereafter, the nozzle (59) rises to the upper end position.
  • the operation of discharging the liquid from the nozzle tip (13) to the container (17) is the same as that described in Japanese Patent Application Laid-Open No. H11-133394.
  • the nozzle (59) stops at the upper end position the supply of nitrogen gas by the nitrogen gas supply device (58) starts, and the second elevating member (81) moves up to the upper end position.
  • the lid (22) of the lid device (18) is closed and held in the closed position by the lid holding member (23), and the lid opening / closing member (72) is raised to the upper end position as described above. And stop.
  • the shutter (110) is moved to the closed position, and the lower end opening of the cylinder (74) is closed.
  • the lid opening / closing member (72) When the second elevating / lowering member (81) is lowered to open the lid (22) and the lid opening / closing member (72) is lowered, an abnormality occurs, and the lid opening / closing member (72) is positioned at the lower end of the lid opening position. Stop before reaching, the lid (22) may not open to the fully open position. In such a case, even after the lid opening / closing member (72) stops halfway, the second elevating member (81) continues to descend with respect to the third elevating member (89), and the third elevating member (89) When the proximity sensor (95) on the side of the second lifting member (81) drops by a predetermined distance with respect to the side collar (91), the proximity sensor (95) is activated, and an abnormality is detected.
  • the configuration of each part of the automatic synthesis device and the configuration of each part of the lid device (18) are not limited to those of the above-described embodiment, and can be appropriately changed.
  • the present invention can be applied to a liquid handling apparatus other than the automatic synthesis apparatus.
  • the liquid handling apparatus according to the present invention is particularly suitable for a liquid handling apparatus such as an automatic synthesis apparatus for a sample for pharmacological evaluation.
  • the container lid device according to the present invention is particularly suitable for a container lid device used in a liquid handling device as described above.
  • the container can be sealed with the lid to prevent the liquid from coming into contact with air or the vaporized gas from flowing out, and the lid can be automatically and easily opened and closed. be able to.

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Abstract

L'invention porte: sur un couvercle (18) comprenant un support (21) de récipient fixé au goulot (19) du récipient (11) de manière à ouvrir vers le haut une ouverture pratiquée dans le goulot (19) du récipient (11); et sur un couvercle (22) ouvrant et fermant une ouverture pratiquée dans l'élément de communication (26) du support (21) du récipient, monté pivotant sur ledit support (21) et communiquant avec le goulot (19) du récipient (11), sur un élément fonctionnel (24) installé sur le support (21) du récipient et mobile verticalement de manière à ouvrir vers le haut une ouverture pratiquée dans le goulot (19) du récipient (11), et sur un ressort rappelant vers le haut la partie (24) fonctionnelle laquelle se déplace vers le bas pour ouvrir le couvercle (22) et vers le haut pour le (22) fermer.
PCT/JP2000/007673 1999-11-12 2000-11-01 Couvercle de recipient et dispositif de manutention de liquides WO2001036287A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11-323268 1999-11-12
JP32326899A JP2001139047A (ja) 1999-11-12 1999-11-12 容器の蓋装置および液体取り扱い装置

Publications (1)

Publication Number Publication Date
WO2001036287A1 true WO2001036287A1 (fr) 2001-05-25

Family

ID=18152901

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2000/007673 WO2001036287A1 (fr) 1999-11-12 2000-11-01 Couvercle de recipient et dispositif de manutention de liquides

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JP (1) JP2001139047A (fr)
WO (1) WO2001036287A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114217086A (zh) * 2022-02-22 2022-03-22 江苏睿玻生物科技有限公司 生物样本的自动分装系统及方法、脱帽组件、可读介质

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008239247A (ja) * 2007-03-27 2008-10-09 J Tec:Kk キャップ
JP5881103B2 (ja) * 2012-02-03 2016-03-09 株式会社ハルモニア フライヤ装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6233503U (fr) * 1985-08-12 1987-02-27
JPH01213163A (ja) * 1988-02-08 1989-08-25 Isho Sai 蓋開閉装置付密封容器
WO1998041320A1 (fr) * 1997-03-14 1998-09-24 Dainippon Seiki Co., Ltd. Appareil automatique pour syntheses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6233503U (fr) * 1985-08-12 1987-02-27
JPH01213163A (ja) * 1988-02-08 1989-08-25 Isho Sai 蓋開閉装置付密封容器
WO1998041320A1 (fr) * 1997-03-14 1998-09-24 Dainippon Seiki Co., Ltd. Appareil automatique pour syntheses

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114217086A (zh) * 2022-02-22 2022-03-22 江苏睿玻生物科技有限公司 生物样本的自动分装系统及方法、脱帽组件、可读介质
CN114217086B (zh) * 2022-02-22 2022-05-13 江苏睿玻生物科技有限公司 生物样本的自动分装系统及方法、脱帽组件、可读介质

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