WO2001036008A2 - Dispositifs en spirale etanches flexibles - Google Patents

Dispositifs en spirale etanches flexibles Download PDF

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Publication number
WO2001036008A2
WO2001036008A2 PCT/US2000/031314 US0031314W WO0136008A2 WO 2001036008 A2 WO2001036008 A2 WO 2001036008A2 US 0031314 W US0031314 W US 0031314W WO 0136008 A2 WO0136008 A2 WO 0136008A2
Authority
WO
WIPO (PCT)
Prior art keywords
coating
covering
cyclohexanone
group
ethanol
Prior art date
Application number
PCT/US2000/031314
Other languages
English (en)
Other versions
WO2001036008A3 (fr
Inventor
Donald M. Copenhagen
Daniel G. Hullihen, Jr.
Rachel L. Schott
Richard J. Whitbourne
Original Assignee
Sts Biopolymers, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sts Biopolymers, Inc. filed Critical Sts Biopolymers, Inc.
Priority to EP00978657A priority Critical patent/EP1233724A4/fr
Priority to AU16097/01A priority patent/AU1609701A/en
Publication of WO2001036008A2 publication Critical patent/WO2001036008A2/fr
Publication of WO2001036008A3 publication Critical patent/WO2001036008A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Definitions

  • the present invention relates to insertable medical devices with modified surface
  • vascular and other stents are also examples of insertable medical devices.
  • the typical vascular stent configuration includes metal screen-like scaffolds which are inserted in a
  • U.S. Patent No. 5,383,928 issued to Scott et al. describes a stent which is at least partially covered with a sleeve which contains one or more drugs, and which removably
  • Thin coatings of TEFLON ® also have been used on coil guide wires. Although such
  • coatings can be flexible, they require baking at very high temperatures ( ⁇ 370°C), and adhering
  • the present invention comprises a medical device comprising an insertable substrate, an elastic polymeric covering adherent to the substrate, and a polymeric coating adherent to
  • the covering such that the coating and covering possess desirable surface characteristics
  • devices include but are not limited to guide wires, forceps, trochars, stents and catheters.
  • polymeric covering and coating is designed to be sufficiently flexible to allow the substrate
  • the substrate may be a relatively rigid structure such as a vascular stent, in which case the flexible polymeric covering and coating is designed to be capable of
  • the covering and coating are designed to provide a lubricious surface.
  • Other devices require non-lubricious surfaces in order to ensure that they remain in place once inserted.
  • the coating is designed to provide such a non -lubricious surface.
  • invention contemplates a stent design which has a flexible elastic plastic coating permanently
  • the coating expands with the stent and retains its integrity
  • the substrate can be composed of a variety
  • suitable coatings preferably include a variety of
  • hydrogels comprising one or more components selected from the group consisting of polyvinylpyrrolidone, epoxy resin, acrylic polymer, acrylic resin, and aliphatic polyisocyanate.
  • a binding layer or precoat can be applied to the substrate to enhance the binding
  • Such precoats can contain polymers including but not limited
  • these coatings can be any coatings which enhance adhesion onto substrates.
  • these coatings can be any coatings which enhance adhesion onto substrates.
  • these coatings can be any coatings which enhance adhesion onto substrates.
  • crosslinking agents including but not limited to melamine resins, isocyanates,
  • agents such as antibiotics, anticoagulants, antiplatelet agents, antineoplastic agents, anti-oxidants
  • angiogenic agents and angiogenic agents are incorporated into the coating.
  • angiogenic agents and angiogenic agents are incorporated into the coating.
  • the coating may contain one or more drugs to, for example, prevent thrombus formation
  • the present invention also includes a method of modifying the surface properties of
  • the invention also incorporates physiologically or
  • insertable medical devices is dependent to varying degrees on the surface properties of the
  • a surface that is lubricious can permit the easier, safer and less uncomfortable
  • a device that has a non-lubricious surface can be more securely fixed in a desired location, providing added safety and ease of use, and the inclusion
  • Such modifications include, but are not limited to, stylets, guide wires, flexible forceps used
  • the present invention provides a surface to such medical devices such that improved
  • the medical devices can be provided to such medical devices.
  • the medical devices are configured to provide surface characteristics to such medical devices.
  • contemplated in this invention comprise a substrate, a covering and a coating.
  • the substrate is a substrate, a covering and a coating.
  • the substrate is
  • Such a substrate often has physical
  • the polymeric covering is
  • adherent to the substrate surface is flexible, such that it can be bent and flexed repeatedly
  • the covering preferably is elastic, and able to
  • the covering preferably is elastic and flexible when applied to devices such as endoscopic forceps or guide wires.
  • the covering can be applied in one or
  • Covering the polymeric covering is a polymeric coating, which provides the desired
  • the coating can be of the same composition as
  • the covering or can be of a different composition.
  • the coating also has the properties of flexibility and elasticity, and optionally can be hydrophobic, hydrophilic or of intermediate
  • the coating can be applied with one or more layers which may have the same or different composition, is one layer thick or optionally can be several layers thick. Together,
  • the covering and the coating are preferably less than 100 ⁇ m thick, and more preferably less
  • the polymeric covering and coating preferably are sufficiently flexible so
  • the flexible polymeric layer(s) preferably also are
  • the coating and covering preferably are applied to the substrate optionally by
  • Coating preferably is performed optionally by spraying or by
  • the stent comprises a rigid but expandable framework.
  • coating and covering of the present invention preferably is sufficiently adherent, flexible and elastic such that when the stent is expanded, the coating and covering forms an adherent sheath that is attached to the struts of the stent and stretches between them, providing a greatly
  • coating is non-lubricious, aiding in maintaining the stent in a desired location once the stent
  • agents include, but are not
  • antibiotics include antibiotics, anticoagulants, anti-platelet agents, antineoplastic agents, thrombogenic
  • one or more bonding layers can be used as a primer for the substrate
  • the bonding layers preferably are less than
  • the substrate of the device can be composed of a variety of materials. Examples include, but are not limited to, metals such as titanium, silver, gold, platinum, aluminum,
  • chromium chromium, stainless steel or tantalum, and shape memory materials, including but not limited
  • nickel/titanium alloys copper/zinc alloys, and nickel/aluminum alloys.
  • Other examples are possible.
  • polymeric materials including but not limited to biodegradable materials such as
  • polyurethanes silicones, polyamides, polyimides, cellulose esters, cellulose ethers,
  • Examples of compounds that are used for the covering include but are not limited to
  • polyurethane polyvinyl acetals, acrylate polymers and copolymers, vinyl acetate polymers and
  • the covering is comprised of a hybrid polymer mixture, an example of which includes, but is not limited to, polyurethane
  • the covering is applied by dipping the covering
  • the concentration of the polyurethane polymer is from about 10% to about 30% w/w.
  • covering preferably is oven cured such as at about 85°C for from about 30 minutes to about
  • a bonding layer can be applied to the substrate as a precoat before the
  • a prefe ⁇ ed layer that can be used comprises a composition comprising
  • cyclohexanone from about 3% to about 4% w/w polyurethane resin, from about 2.5 % to
  • the coating layer of the present invention is preferably a hydrogel.
  • used to form the hydrogel preferably comprise a mixture of at least one and more preferably
  • At least two, components selected from the group consisting of ethanol, polyvinylpyrrolidone, benzyl alcohol, cyclohexanone, tetrahydrofuran, xylene, epoxy resin, acrylic resin or polymer,
  • a prefe ⁇ ed hydrogel composition comprises from about 10% to about
  • Another prefe ⁇ ed composition comprises from about 10%> to about 20%> w/w ethanol, from
  • tetrahydroafuran from about 2% to about 3% w/w xylene, from about 0.5% to about 1.5%>
  • hydrogel composition comprises from about 35%> to about 45%> w/w ethanol, from about 20%
  • One embodiment of the present invention incorporates physiologic and/or
  • the coating comprises an outer layer comprised of a composition comprised of
  • tetrahydrofuran from about 12% to about 20% w/w cyclohexanone, from about 10% to about
  • the present invention includes a method of providing desirable surface properties to
  • the method comprises applying one or more layers of the
  • compositions disclosed herein to the substrate surface in order to provide the appropriate surface for the function of the medical device.
  • Epotuf 38-505 (Reichold, Research Triangle Park, NC) is an epoxy resin.
  • Paraloid ® AT-63 (Rohm and Haas, Co., Philadelphia, PA) is a crosslinkable acrylic polymer
  • the sample was tested for adhesion under both wet and dry conditions.
  • the sample was dipped in Genti an Violet, Huckers Gram Stain Solution [(CH 3 ) 2 NC 6 H 4 ] 2 C:C 6 H 4 :N(CH 3 ) 2 C1; VWR, West Chester, PA , Cat No. VW3567-1] for 5 - 10
  • the tape was easy to see visually because it was stained with the blue dye.
  • the tape was
  • the coating passed the wet and dry adhesion tests.
  • the sample was lubricious when wet.
  • the coated sample was oven dried at 85°C for about 60 minutes, and tested as
  • Example 1 The sample was very flexible and the coating passed the wet and dry adhesion tests. The sample was lubricious when wet.
  • the coated sample was oven cured for about one hour at 75 °C.
  • the sample then was
  • Example 4 tested as described n Example 1. The sample and passed the wet and dry adhesion tests. The sample was moderately lubricious when wet. Example 4
  • a stainless steel mandril was dipped in the precoat solution below for 20 seconds.
  • coated sample was dried for about 45 minutes at 75°C.
  • Paraloid ® AT-746 (Rohm and Haas, Co., Philadelphia, PA) is a crosslinkable acrylic polymer
  • Example 3 was coated over the polyurethane layers as described in Example 1. The sample
  • Example 5 was tested as described in Example 1 , and exhibited good flexibility and good wet and dry adhesion, and showed moderate wet lubricity.
  • Example 3 The sample was cured at 65 °C for 20 minutes after each coating
  • Example 2 The sample was dipped in the following hydrogel solution using the method of Example 1 :
  • Paclitaxel 1.0 %(w/w)
  • HBAC Benzalkonium heparinate
  • the sample was oven dried for one hour at 75°C.
  • the sample passed the wet and dry
  • Example 4 As in Example 4, The sample was oven dried for 20 minutes at 60°C after each coating
  • the sample was oven dried for one hour at 75 °C.
  • the sample was tested for adhesion
  • a stainless steel madril was dipped in a Precoat having the following composition for 20 seconds and then withdrawn at 30 mm/second.
  • Example 6 solution of Example 6 was coated over the polyurethane layers as described in Example 6.
  • Example 2 The sample was tested as described in Example 1 and was flexible and had good wet and dry adhesion. The sample was moderately lubricious when wet.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un dispositif médical possédant un recouvrement et un revêtement de surface qui confèrent au dispositif des caractéristiques de surface désirées tout en altérant éventuellement la zone de surface du dispositif, de façon que dans le cas de dispositifs réutilisables ils sont plus faciles à nettoyer et dans le cas de dispositifs tels que des stents, le recouvrement et le revêtement constituent une gaine adhérante de façon permanente offrant une zone de surface plus grande. Le recouvrement et le revêtement peuvent éventuellement être utilisés comme un réservoir de médicament destiné à administrer le médicament à des emplacements spécifiques.
PCT/US2000/031314 1999-11-18 2000-11-15 Dispositifs en spirale etanches flexibles WO2001036008A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00978657A EP1233724A4 (fr) 1999-11-18 2000-11-15 Dispositifs en spirale etanches flexibles
AU16097/01A AU1609701A (en) 1999-11-18 2000-11-15 Flexible sealed coil-like devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44289199A 1999-11-18 1999-11-18
US09/442,891 1999-11-18

Publications (2)

Publication Number Publication Date
WO2001036008A2 true WO2001036008A2 (fr) 2001-05-25
WO2001036008A3 WO2001036008A3 (fr) 2001-12-13

Family

ID=23758557

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/031314 WO2001036008A2 (fr) 1999-11-18 2000-11-15 Dispositifs en spirale etanches flexibles

Country Status (3)

Country Link
EP (1) EP1233724A4 (fr)
AU (1) AU1609701A (fr)
WO (1) WO2001036008A2 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10202467A1 (de) * 2002-01-23 2003-07-24 Polyzenix Gmbh Vorrichtung auf Basis von Nitinol, ein Verfahren zu dessen Herstellung sowie dessen Verwendung
WO2004052420A2 (fr) * 2002-12-06 2004-06-24 Surmodics, Inc. Barrieres pour revetements polymeriques
US7265199B2 (en) 2000-04-11 2007-09-04 Celonova Biosciences Germany Gmbh Poly-tri-fluoro-ethoxypolyphosphazene coverings and films
US7771468B2 (en) 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
US7922764B2 (en) 2006-10-10 2011-04-12 Celonova Bioscience, Inc. Bioprosthetic heart valve with polyphosphazene
US8101275B2 (en) 2001-08-17 2012-01-24 Celonova Biosciences, Inc. Device based on nitinol, a process for its production, and its use
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
CN110180038A (zh) * 2019-06-21 2019-08-30 西南大学 具药物缓释功能超高柔性涂层的锌合金血管支架材料
US10973770B2 (en) 2004-10-25 2021-04-13 Varian Medical Systems, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US11167064B2 (en) 2016-07-14 2021-11-09 Hollister Incorporated Hygienic medical devices having hydrophilic coating

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110694118A (zh) * 2019-09-23 2020-01-17 江苏理工学院 一种抗菌抗凝血脑室腹腔分流管硅胶管体及其制备方法和应用

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US5804318A (en) * 1995-10-26 1998-09-08 Corvita Corporation Lubricious hydrogel surface modification
US5837008A (en) * 1993-04-26 1998-11-17 Medtronic, Inc. Intravascular stent and method

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US5091205A (en) * 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
CA2007743A1 (fr) * 1989-01-26 1990-07-26 Sachiko Hattori Sonde vasculaire avec lubrification durable
US5503631A (en) * 1992-10-09 1996-04-02 Terumo Kabushiki Kaisha Lubricious catheter balloon for vasodilation
US5772609A (en) * 1993-05-11 1998-06-30 Target Therapeutics, Inc. Guidewire with variable flexibility due to polymeric coatings
DE19713214A1 (de) * 1997-03-28 1998-12-10 Ruebben Alexander Dr Med Covered Stent zur verlängerten Offenhaltung von Hohlorganen oder der Behandlung von Gefäßaneurysmen

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US5837008A (en) * 1993-04-26 1998-11-17 Medtronic, Inc. Intravascular stent and method
US5804318A (en) * 1995-10-26 1998-09-08 Corvita Corporation Lubricious hydrogel surface modification

Non-Patent Citations (1)

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Title
See also references of EP1233724A2 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7265199B2 (en) 2000-04-11 2007-09-04 Celonova Biosciences Germany Gmbh Poly-tri-fluoro-ethoxypolyphosphazene coverings and films
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US7771468B2 (en) 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
US8287590B2 (en) 2001-03-16 2012-10-16 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
US8101275B2 (en) 2001-08-17 2012-01-24 Celonova Biosciences, Inc. Device based on nitinol, a process for its production, and its use
DE10202467A1 (de) * 2002-01-23 2003-07-24 Polyzenix Gmbh Vorrichtung auf Basis von Nitinol, ein Verfahren zu dessen Herstellung sowie dessen Verwendung
WO2004052420A3 (fr) * 2002-12-06 2004-07-22 Surmodics Inc Barrieres pour revetements polymeriques
WO2004052420A2 (fr) * 2002-12-06 2004-06-24 Surmodics, Inc. Barrieres pour revetements polymeriques
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US9597419B2 (en) 2004-10-25 2017-03-21 Boston Scientific Limited Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US10973770B2 (en) 2004-10-25 2021-04-13 Varian Medical Systems, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US7922764B2 (en) 2006-10-10 2011-04-12 Celonova Bioscience, Inc. Bioprosthetic heart valve with polyphosphazene
US11167064B2 (en) 2016-07-14 2021-11-09 Hollister Incorporated Hygienic medical devices having hydrophilic coating
CN110180038A (zh) * 2019-06-21 2019-08-30 西南大学 具药物缓释功能超高柔性涂层的锌合金血管支架材料

Also Published As

Publication number Publication date
AU1609701A (en) 2001-05-30
EP1233724A2 (fr) 2002-08-28
EP1233724A4 (fr) 2004-03-10
WO2001036008A3 (fr) 2001-12-13

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