WO2001023007A1 - Sterilisation de contenus liquides par faisceau d'electrons - Google Patents

Sterilisation de contenus liquides par faisceau d'electrons Download PDF

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Publication number
WO2001023007A1
WO2001023007A1 PCT/CA2000/001081 CA0001081W WO0123007A1 WO 2001023007 A1 WO2001023007 A1 WO 2001023007A1 CA 0001081 W CA0001081 W CA 0001081W WO 0123007 A1 WO0123007 A1 WO 0123007A1
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WO
WIPO (PCT)
Prior art keywords
vessel
volume
electron beam
liquid
conveyor
Prior art date
Application number
PCT/CA2000/001081
Other languages
English (en)
Inventor
John W. Barnard
F. Wayne Stanley
Lisa Lucht
Original Assignee
Iotron Industries Canada Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iotron Industries Canada Inc. filed Critical Iotron Industries Canada Inc.
Priority to AU73978/00A priority Critical patent/AU7397800A/en
Publication of WO2001023007A1 publication Critical patent/WO2001023007A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/007—Particle radiation, e.g. electron-beam, alpha or beta radiation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/001—Details of apparatus, e.g. for transport, for loading or unloading manipulation, pressure feed valves
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/02—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by heating materials in packages which are progressively transported, continuously or stepwise, through the apparatus
    • A23L3/04—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by heating materials in packages which are progressively transported, continuously or stepwise, through the apparatus with packages on endless chain or band conveyors
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/26—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by irradiation without heating
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/26—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by irradiation without heating
    • A23L3/263—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by irradiation without heating with corpuscular or ionising radiation, i.e. X, alpha, beta or omega radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/12—Apparatus for isolating biocidal substances from the environment
    • A61L2202/122—Chambers for sterilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts

Definitions

  • This invention relates to the sterilization by electron beam radiation of liquids in containers, particularly in circumstances where the electron beam is unable to penetrate the entire contents of the container.
  • Ionizing radiation in the form of either machine-generated radiation of intense electron beams or gamma radiation, has been used as a means to sterilize medical products for many years.
  • Gamma ray radiation has traditionally been used to sterilize large containers of liquid.
  • Gamma rays transfer energy to materials principally by Compton scattering collisions with atomic electrons. Because the probability of Compton scattering is relatively low, the primary beam of gamma rays will penetrate relatively long distances in materials before scattering occurs. The scattered gamma photons will also traverse relatively long distances before they, in turn, are scattered. As a result, gamma rays deposit energy in material over relatively large volumes, so that depth of penetration is high but absorbed dose rate is low.
  • Electron beam processing has become increasingly popular as a means of sterilizing some types of medical products.
  • These accelerators are typically capable of generating electron beams having an energy of up to 10 MeV.
  • the conventional method of radiating with an electron beam for the purpose of sterilization is to pass the product to be sterilized through a radiation zone on a mechanical conveyance while the electron beam is scanned across the product. The beam penetrates the product and deposits a dose of ionizing radiation sufficient to kill the microorganisms present in the product and reduce them to levels deemed safe for human use.
  • Electron beams can provide a higher dose rate than can be achieved with gamma radiation.
  • the electron-electron and electron-nuclear scattering which occurs when the electron beam contacts and penetrates the product is much higher than for Compton scattering.
  • 10 MeV electrons will penetrate only about 5 cm into material with a density of 1.0 gram per cubic centimetre before losing all their energy and reaching thermal equilibrium with the material. All the power in the beam is deposited over this short distance in the product and concentrated within the width of the beam.
  • the dose rates in electron beam radiation are therefore very high. Typically a dose rate of 20 kilograys per second can be achieved using a 50 kW beam. Thus although penetration is poorer, absorbed radiation dose is greater. As a consequence of the higher dose rate, irradiation time for electron beam radiation is relatively low.
  • the problem of poor penetration is overcome by carrying out multiple sided irradiation. This is achieved by radiating the product, inverting the product container, and re-irradiating the product.
  • multiple sided irradiation is carried out with, for example, a 10 MeV electron beam
  • the product will be penetrated to a depth below the surface equivalent to an areal density of about 3 grams per cubic centimetre on the first pass through the radiation zone.
  • irradiating the opposite side of the product with the same energy makes it possible to deliver reasonably uniform doses to rigid objects that have areal densities as high as 8 grams per cubic centimetre.
  • a common technique used to reduce the bacteria in sealed containers of food is to heat the container and its contents.
  • United States Patent No. 3,961.150 issued to Lewis et al. on June 1, 1976 a method of reducing bacteria by induction heating of the food container is disclosed.
  • the apparatus described in the patent provides for the reciprocal rotation of sealed containers of food. The rotation imparts relative motion between the container and the contents. The primary purpose of this motion is to prevent burning of the contents which are in close proximity to the inside surface of the container. Agitation of the contents due to the rotation of the container is not relied upon as the sole mechanism to uniformly heat the contents because even absent this rotation, conduction and convection of heat from the inside walls of the container will ensure that the entire contents of the container are heated regardless of its size.
  • any product intended for medical use be as free of microorganisms as is reasonably possible. This is especially true of medications in liquid form and other fluids which are to be injected into the body.
  • Such medical products are subject to stringent standards for sterilization and approval requirements which are prescribed by various regulatory bodies.
  • the standards are not as strict as those prescribed in respect of medical products. Because the principles of convection and conduction are inapplicable to ionizing radiation, the method for heating food products of Lewis, et al. would be ineffective to sterilize medical products by means of ionizing radiation.
  • the present invention is a method for sterilizing containers of liquid by electron beam ionizing radiation in circumstances in which the depth of the liquid in the container may be greater than the depth of penetration of the electron beam.
  • the inventors have made the surprising discovery that by irradiating the penetrable fraction of the liquid in a sealed container and simultaneously or successively mixing the contents of the container, the microbial bioburden throughout both the penetrable and unpenetrable fractions of the container is significantly reduced. With sufficient irradiation and mixing, the bioburden is reduced to the point whereby the contents are sterilized. It was previously thought by those skilled in the art that there would be insufficient predictability in determining the bioburden of the liquid entering the irradiation zone to rely on such a technique for sterilization.
  • a method for reducing microbial bioburden in a volume of liquid contained in a vessel by electron beam irradiation wherein said electron beam delivers an absorbed dose effective to reduce the microbial bioburden in a first portion of said volume and an absorbed dose ineffective to reduce the microbial burden in a second portion of said volume comprising irradiating the first portion with said electron beam to reduce microbial bioburden in said first portion; and mixing the volume of liquid to dilute the first portion with the second portion, until the microbial bioburden in the volume of liquid is reduced to a desired level.
  • an apparatus for reducing microbial bioburden in a volume of liquid comprising an electron beam source, a vessel for containing the volume of liquid and a means for agitating the vessel wherein the absorbed dose delivered by the electron beam source is effective to reduce microbial bioburden in a first portion of the volume of liquid and ineffective to reduce microbial bioburden in a second portion of said volume and wherein said means for agitating is effective to mix said first portion with said second portion.
  • FIG. 1 is a schematic representation in vertical cross section of the apparatus used to carry out the present invention.
  • FIG. 2 is a schematic representation in vertical cross section of an alternate embodiment of the apparatus used to carry out the present invention.
  • FIG. 3 is a graph which represents the survival of microorganisms as a function of radiation dose.
  • FIG. 4 is a graph which represents the surviving fraction of E. Coli after successive mixing and irradiation with 1.2 kGy electron beam.
  • Conveyor belt 10 is disposed about first conveyor sprocket 12 and second conveyor sprocket 14.
  • Conveyor drive motor 16 drives first conveyor sprocket 12 which in turn causes conveyor belt 10 to move in a clockwise direction.
  • Second conveyor sprocket 14 may be a powered driver or an idler.
  • Conveyor belt 10 has two conveyor drive chains (only one of which is shown in FIG. 1) 17 and a plurality of rollers (one of which is represented by the reference numeral 18) disposed therebetween. Rollers 18 are fixed to drive chains 17 in a manner which provides for the free rotation of the rollers. Each of rollers 18 has a roller sprocket 20 fixed to one end thereof.
  • roller sprocket 20 The centre of roller sprocket 20 is aligned with the longitudinal axis of the roller 18 to which it is attached.
  • chain 22 Within the area bounded by conveyor belt 10, chain 22 is disposed about first chain sprocket 24 and second chain sprocket 26.
  • the upper course of chain 22 lies immediately beneath a central portion of the upper course of conveyor belt 10 and is laterally positioned so that chain 22 engages roller sprockets 20.
  • the upper course of chain 22 is supported by idlers 28.
  • Independently controlled chain drive motor 30 drives first chain sprocket 24 which in turn causes chain 22 to move in either a clockwise or counterclockwise direction.
  • Linear accelerator 32 is centrally positioned above the apparatus such that the radiation zone in the beam generated by accelerator 32 is within the area above chain 22. Linear accelerator 32 emits an electron beam which is magnetically scanned across any product passing beneath it.
  • Downwardly sloping loading ramp 34 is positioned with its lower end in close proximity to conveyor sprocket 12.
  • Downwardly sloping dismounting ramp 38 is positioned with its upper end in close proximity to conveyor sprocket 14.
  • cylindrical vessels containing liquid to be sterilized (one of which is represented by reference numeral 36) are fed onto ramp 34 and descend towards conveyor belt 10 by gravity.
  • vessel 36 reaches conveyor belt 10, it is engaged between adjacent rollers 18a and 18b and transported by conveyor belt 10 in a clockwise direction towards the radiation zone.
  • Vessel 36 is conveyed in a plane normal to the direction of motion of magnetic scanning.
  • roller sprocket 20a As vessel 36 approaches chain 22, chain 22 engages roller sprocket 20a followed by roller sprocket 20b and the translational movement of chain 22 causes roller sprockets 20a and 20b to rotate which in turn causes attached rollers 18a and 18b to rotate.
  • the rotation of adjacent rollers 18a and 18b causes vessel 36 to rotate as it moves through the radiation zone.
  • chain drive motor 30 drives chain 22 in a counterclockwise direction
  • vessel 36 will be rotated in a counterclockwise direction.
  • chain drive motor 30 can be of sufficient capacity to drive chain 22 in a clockwise direction faster than drive chain 16, in which case vessel 36 rotates in a clockwise direction.
  • the conveying apparatus provides for the rotation of vessel 36 at uniform speed as it passes through the radiation zone. In this manner, the apparatus provides for the simultaneous mixing and irradiating of the liquid contents of the vessels.
  • the beam penetrates only part way into the contents of the vessel.
  • the ionizing radiation kills the microorganisms suspended in the liquid.
  • the concentration of microorganisms in the unpenetrable, unirradiated and therefore infected fraction of the liquid is diluted by mixing with the penetrable, irradiated, disinfected fraction.
  • the unpenetrable fraction becomes progressively diluted with microorganisms until the required reduction of microbial bioburden is achieved.
  • vessel 36 Once vessel 36 has made a single pass through the irradiation zone, it dismounts conveyor 10 and descends ramp 38 assisted by the force of gravity. At this point, sterilization of the liquid may be complete or one or more further pass through the radiation zone may be required.
  • Chain drive motor 30 can be a reversing drive motor to cause sprocket 24 and, in turn, chain 22 to move in either a clockwise or counterclockwise direction. This option would provide for the reciprocating rotation of vessel 36 as it passes through the radiation zone.
  • the direction of chain drive motor 30 can be adjusted to provide the best mixing action for the particular liquid.
  • the speed of conveyor drive motor 16 determines the speed at which vessel 38 passes through the radiation zone which in turn determines the exposure time in the beam and the radiation dose received.
  • the speed of chain drive motor 30 in combination with the speed of conveyor drive motor 16 determines the speed of rotation and hence the mixing of the liquid.
  • FIG. 2 An alternate embodiment of the present invention is shown in FIG. 2.
  • generally horizontal frame member 40 is mounted on one end of each of chain sprockets 24, 26 and idlers 28.
  • Frame member 40 is pivotally connected to fixed vertical supports 42, 44 in such a manner that member 40 is capable of rotational movement about a horizontal axis through pivot joints 46 and 48.
  • Ball socket 50 is fixed to frame member 40 near sprocket 26 and ball end of vertically disposed Pitman arm 52 mates with socket 50.
  • Flywheel 54 is connected to lower end of Pitman arm 52 such that when motor (not shown) drives flywheel 54, frame member 40 pivots at joints 46, 48 and consequently swivels the portion of upper course of conveyor belt 10 which at that time is proximal to chain 22.
  • Conveyor belt 10 must be sufficiently lax to allow for this movement. As conveyor belt 10 swivels, vessels 36 passing above chain are rocked and further mixing of their liquid contents occurs. This further mixing reduces the time taken to reduce the bioburden to the point of sterilization.
  • the present invention can also be practised by successively irradiating the vessel and mixing the contents. The product is passed through the scanned beam on a simple mechanical conveyance and then mixed in a suitable manner. The irradiating and mixing steps are repeated until the product is sufficiently sterilized. With this alternate technique, the irradiation must be carried out within a reasonable period of time after each mixing in order that appreciable settling of suspended organisms does not occur.
  • FIG. 3 The typical response of a microbial monoculture to radiation is shown in FIG. 3 where the log of the number of surviving microorganisms is plotted against absorbed radiation dose. The reduction in the number of microorganisms is log-linear with absorbed dose.
  • a vessel with volume v containing liquid with a bioburden of p organisms per unit volume is irradiated with electrons which can only penetrate a fraction q of the volume to achieve a log survival of -s in the irradiated volume.
  • the resulting total number of viable organisms remaining in the irradiated volume is 10 "D -p q-v organisms.
  • the number of organisms remaining in the unirradiated volume is p (l-q) v organisms.
  • the process is repeated until the desired level of bioburden reduction is achieved. For example irradiating and mixing 34 times in this example yields a 6 log bioburden reduction.
  • a T-Soya Broth culture of E. Coli 1 1775, with an initial population of 2.16 X 10 8 colony forming units (cfu) per millilitre was irradiated successively with 1.2 kGy from a 10 MeV, 800 Watt electron beam in a 1 L polyethylene bottle. Irradiation was accomplished by translating the bottle, placed on its side, through the scanned electron beam. The thickness of the liquid layer in this orientation was more than 7 centimetres. The maximum thickness that could be penetrated by the beam was about 3 centimetres. Following each pass, the bottle was mixed thoroughly and a 1 millilitre aliquot drawn off.
  • the aliquot was diluted and plated onto T-Soya Agar to determine colony forming units. The results are shown in FIG. 4. As predicted by the mathematical theory outlined above, the concentration of viable organisms declines in a log-linear fashion with successive passes. Sterilization to an SAL of 10 " from the initial concentration of 2.16 x 10 viable organisms per millilitre would be achieved after about 26 passes. As the Dio (dose to reduce the surviving fraction by one log) for E. Coli 11775 is about 0.5 kilogray. Therefore, the two log reductions in surviving fraction shown in FIG. 4 would have been achieved in only one pass, if the cultures could have been completely penetrated by the beam.
  • the methods and apparatus described above represent some embodiments of the present invention.
  • the present invention includes other apparatus which can provide irradiation and mixing either simultaneously or successively effective to reduce the bioburden of the entire liquid contents of a container even though the full thickness of the container is not fully penetrated.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Optics & Photonics (AREA)
  • Plasma & Fusion (AREA)
  • Toxicology (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

La présente invention concerne un procédé permettant de stériliser des contenus liquides par un rayonnement ionisant à faisceau d'électrons, dans lequel le niveau du liquide dans le récipient peut être supérieur au niveau pouvant être atteint par le faisceau d'électrons. Le contenu liquide est soumis à un faisceau d'électrons de sorte que le degré de contamination microbienne dans la quantité de liquide atteinte par le faisceau se trouve réduite. Le liquide est mélangé par agitation ou rotation du récipient de manière simultanée ou successive avec le rayonnement jusqu'à ce que le degré de contamination microbienne se trouve réduit dans la totalité du volume de liquide pour atteindre le point de stérilisation du liquide. Cette invention concerne également un dispositif permettant de mettre en oeuvre le procédé de stérilisation. Le procédé et le dispositif peuvent être utilisés pour la stérilisation de produits médicaux liquides.
PCT/CA2000/001081 1999-09-24 2000-09-20 Sterilisation de contenus liquides par faisceau d'electrons WO2001023007A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU73978/00A AU7397800A (en) 1999-09-24 2000-09-20 Electron beam sterilization of contained liquids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40513599A 1999-09-24 1999-09-24
US09/405,135 1999-09-24

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WO2001023007A1 true WO2001023007A1 (fr) 2001-04-05

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6843961B2 (en) 2000-06-15 2005-01-18 Gambro, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
EP1736174A1 (fr) * 2005-06-21 2006-12-27 Shibuya Kogyo Co., Ltd Stérilisateur de faisceau d'électrons
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US9861715B2 (en) 2014-09-15 2018-01-09 Observe Medical Aps Body fluid drainage device and method
JP2021028225A (ja) * 2019-08-09 2021-02-25 株式会社Ｎｈｖコーポレーション 電子線照射装置および電子線照射方法
JP2021028228A (ja) * 2019-08-09 2021-02-25 株式会社Ｎｈｖコーポレーション 電子線照射装置および電子線照射方法
CN112789349A (zh) * 2018-10-05 2021-05-11 弗劳恩霍夫应用研究促进协会 用于刺激生物反应器内的液体中所含的生物质生长的方法
CN112789060A (zh) * 2018-10-05 2021-05-11 弗劳恩霍夫应用研究促进协会 用于使液体内的生物活性成分失活的方法

Citations (5)

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US3643787A (en) * 1969-02-20 1972-02-22 Mather & Platt Ltd Sterilizing machines
US4048504A (en) * 1974-12-23 1977-09-13 Sulzer Brothers Limited Method and apparatus for treating flowable material
US4093419A (en) * 1975-10-22 1978-06-06 Licentia Patent-Verwaltungs-G.M.B.H. Device for irradiating liquid and pasty substances
EP0402012A2 (fr) * 1989-05-24 1990-12-12 Meiji Milk Products Company Limited Essai non destructif du contenu de conteneurs
WO1999042142A1 (fr) * 1998-02-18 1999-08-26 Closure Medical Corporation Sterilisation par faisceau electronique de compositions adhesives liquides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3643787A (en) * 1969-02-20 1972-02-22 Mather & Platt Ltd Sterilizing machines
US4048504A (en) * 1974-12-23 1977-09-13 Sulzer Brothers Limited Method and apparatus for treating flowable material
US4093419A (en) * 1975-10-22 1978-06-06 Licentia Patent-Verwaltungs-G.M.B.H. Device for irradiating liquid and pasty substances
EP0402012A2 (fr) * 1989-05-24 1990-12-12 Meiji Milk Products Company Limited Essai non destructif du contenu de conteneurs
WO1999042142A1 (fr) * 1998-02-18 1999-08-26 Closure Medical Corporation Sterilisation par faisceau electronique de compositions adhesives liquides

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6843961B2 (en) 2000-06-15 2005-01-18 Gambro, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
EP1736174A1 (fr) * 2005-06-21 2006-12-27 Shibuya Kogyo Co., Ltd Stérilisateur de faisceau d'électrons
US7435981B2 (en) 2005-06-21 2008-10-14 Shibuya Kogyo Co., Ltd. Electron beam sterilizer
US9861715B2 (en) 2014-09-15 2018-01-09 Observe Medical Aps Body fluid drainage device and method
RU2693473C2 (ru) * 2014-09-15 2019-07-03 Обзерв Медикал Апс Дренажное устройство для биологических жидкостей и способ его стерилизации
CN112789349A (zh) * 2018-10-05 2021-05-11 弗劳恩霍夫应用研究促进协会 用于刺激生物反应器内的液体中所含的生物质生长的方法
CN112789060A (zh) * 2018-10-05 2021-05-11 弗劳恩霍夫应用研究促进协会 用于使液体内的生物活性成分失活的方法
JP2021028225A (ja) * 2019-08-09 2021-02-25 株式会社Ｎｈｖコーポレーション 電子線照射装置および電子線照射方法
JP2021028228A (ja) * 2019-08-09 2021-02-25 株式会社Ｎｈｖコーポレーション 電子線照射装置および電子線照射方法
JP7205802B2 (ja) 2019-08-09 2023-01-17 株式会社Ｎｈｖコーポレーション 電子線照射装置および電子線照射方法
JP7246619B2 (ja) 2019-08-09 2023-03-28 株式会社Ｎｈｖコーポレーション 電子線照射装置および電子線照射方法

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