US3780308A - Process and apparatus for surface sterilization of materials - Google Patents

Process and apparatus for surface sterilization of materials Download PDF

Info

Publication number
US3780308A
US3780308A US3780308DA US3780308A US 3780308 A US3780308 A US 3780308A US 3780308D A US3780308D A US 3780308DA US 3780308 A US3780308 A US 3780308A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
energy
electron
surface
beam
sterilization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
S Nablo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Energy Sciences Inc
Original Assignee
Energy Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • GPHYSICS
    • G21NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21KTECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
    • G21K5/00Irradiation devices
    • G21K5/10Irradiation devices with provision for relative movement of beam source and object to be irradiated
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/26Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by irradiation without heating
    • A23L3/263Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by irradiation without heating with corpuscular or ionising radiation, i.e. X, alpha, beta or omega radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08Radiation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00Preserving, protecting, or purifying packages or package contents in association with packaging
    • B65B55/02Sterilising, e.g. of complete packages
    • B65B55/04Sterilising wrappers or receptacles prior to, or during, packaging
    • B65B55/08Sterilising wrappers or receptacles prior to, or during, packaging by irradiation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B67OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67CCLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C7/00Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
    • B67C7/0073Sterilising, aseptic filling and closing
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S148/00Metal treatment
    • Y10S148/023Deep level dopants

Abstract

This disclosure deals with the surface sterilization and/or surface treatment of containers and other articles the walls of which have a high specific energy absorption for relatively low energy electrons, by transmitting such low energy electrons to such containers as they move through a sterile gaseous zone, only slightly to penetrate the container walls to effect surface sterilization or treatment thereof, while substantially absorbing the electrons within the walls to minimize X-ray generation.

Description

United States Patent [1 1 Nablo l Dec. 18, 1973 {54] PROCESS AND APPARATUS FOR SURFACE 2,855,517 10/1958 Rainer 250/495 TE STERILIZATION OF MATERIALS 2,384,778 9/1945 Whitman 250/43 [75] Inventor: Sam V. Nablo, Lexington, Mass. Primary Examiner james Lawrence [73] Assignee: Energy Sciences, Inc., Burlington, ASSISIHHI Examiner-c 5 Church Mass. Attorney-Rimes and Rines [22] Filed: June 7, 1971 ABSTRACT [21 I Appl' NOJ l50464 This disclosure deals with the surface sterilization and- /or surface treatment of containers and other articles 52 us. Cl. 250/492, 250/493 the walls of which have a high specific energy absorp- 511 int. Cl. HOlj 37/00 tion for relatively low energy electrons, y transmit- [58] Field of Search 250/495 TE, 43; ting Such low energy electrons to Such Containers 98 21/102; 99/253 they move through a sterile gaseous zone, only slightly to penetrate the container walls to effect surface ster- [5 References Cited ilization or treatment thereof, while substantially ab- UNITED STATES PATENTS sorbing the electrons within the walls to minimize 3,617,740 I l/l97l Skillicorn 250/495 TE X ray generation 3,654,459 4/1972 Coleman 250/495 TE 17 Claims, 7 Drawing Figures PULSER I s l- TO BULK II STERILIZER FILTERED t A I R I D g SUPPLY I E 2 5% /6 1 i A B B C 4 12 LJIUUWULZIM%W%WW I PACKAGE FILLER SEALER 8 STER I LIZER ASEPTIC FILLING APPLICATION PAIENIEDBEC 18 I975 SHEET 10F 4 9 I R w 0 I m m I V F N 3 I M V ER 1 4 I R V\ II S R UN U OE C NRN I TE I CR 2 TEY. I ALT \I P IES 2 S Y. M SN m Y M G I RR E0 NF l E 8 R I N IA I AF E TR W W v I U S E A 4 C K fi O 5 A EQE BMS: wwoo SEZ EQ PENETRATION DEPTH INTO SAM V. NABLO CONTAINER WA LL I BY ATTORNEYS v PATENIED BED l 8 (975 dE/dx 3.780.308 SHEET F 4,

I I IIIIII] I I lllll] ELECTRON STOPPING POWER 30- VARIATION WITH ENERGY FOR POLYSTYRENE (PLANE PERPENDICULARSOURCE)- E 8 2O SURFACE 15 m E v 10...

AVERAGE O l ||11 l |||||'Il ELECTRON ENERGY (KEV) Fig. 2.

A RANGE DATA FOR ENERGETIC 120 ELECTRONS 1N AIR v 8 (p=1.'2 MG/CC) 9 g uJ A g 75 2 8 D: 0 5O 2 2 l 45- o 5 Lu 30- 25 CURVE 2 O l I ELECTRON ENERGY (KEV) IN\ EI\'"IOR Fig 3 SAM v. NABLO minnow; 18 m5 3. 780.308

SHEET 30F 4 'E.\'T()R SA NABLO ATTORNEYS PAIENIEDUEB I 8 Ian 3.780.308

I SHEET II BF 4 I1 sTERILIzER FILTERED 2 3 I B B C PACKAGE FILLER sEALER 8 sTERILIzER WFILLING MATERIAL "Ill AI IN" 2 AIR IN V l l A i i INTEGRATED AIR AND FILLING SPOUT STERILIZATION HEAD Fig. 517.

TO FILLER PRE-FORM SURFACE sTERILIzATIoN OF. CONTAINER MATERIAL INVENIOR Fig. 50. SAM v. NABLO Tam/MAL ATTORNEYS PROCESS AND APPARATUS FOR SURFACE STERILIZATION OF MATERIALS The present invention relates to processes and apparatus for surface sterilization, being more particularly directed to the use of intense energetic electron beams for the sterilization and other treatment of material surfaces, particularly those used for the packaging of sterile or pasteurized goods and the like.

It has heretofore been proposed to sterilize paper, glass and plastic containers and the like with the aid of infrared, ultraviolet and microwave radiation. Reference may be made, for example, to Hsu, D. 5., Ultra High Temperature Processing and Aseptic Packaging of Dairy Products," Damana Tech, Inc., N. Y., 1970; Lawrence, C. A. et al., Disinfection, Sterilization and Preservation, Lea and Febiger, Phila., Pa., 1968; and Richards, J. W., Introduction to Industrial Sterilization, Academic Press, N. Y., 1968. Such techniques have not found commercial success because of the deleterious material damage which results in the case of infrared heating and the gross inefficiencies of the ultraviolet and microwave techniques. As a consequence, resort has been had to the use of chemical disinfectants such as H Cl or ethylene oxide, usually with high pressure air at high temperatures to purge the package surface of the chemical disinfectant. This technique, however, results in a complicated, relatively slow process which is not well suited for high speed packaging applications where sterilization times of less than a second are desired without the dwell times demanded by air or thermal drying. 2

Still another physical method for the destruction of micro-organisms has been used for some time in bulk sterilization; namely, gamma or X-ray radiation. Early suggestions of this nature are described, for example, In US. Letters Pat. Nos. 2,429,217 and 2,456,909 to Brasch. Unfortunately, most sources of such radiation (typically C0 and accelerator sources, respectively) are insufficiently intense to permit high speed sterilization of large areas at the dose levels of 1.5 to 4.5 megarads typically demanded for the application. In addition, higher energy sources are advantageously required for this purpose since the efficiency of generation of X-rays rises as the 2.9 power of the machine voltage and does not rise to useful conversion efficiencies of a few percent until energies well above 1 Mev. are generated in the accelerator. Such high energy X rays can lead to certain neutron-producing reactions in matter [-y, n) or photoneutron reactions] which can lead to deletereous activation of the irradiated or sterilized material. This problem has been studied in detail and, although generally. a small effect, is clearly one which the sterilization process should not introduce.

An object of the present invention, accordingly, is to provide a new and improved process and apparatus for surface sterilization and/or treatment that shall not be subject to the above-described disadvantages.

It has been found, in accordance with the present invention, indeed, that an improved practice for the sterilization of matter may directly utilize energetic electrons and at lower energies, so that the following ad vantages may accrue:

i. The inefficiencies involved in the conversion of the kinetic energy of energetic electrons to bremsstrahlung or X-rays need not be suffered, resulting. in high process power efficiency. Direct electron acceleration systems can work at over percent power efficiency.

ii. The problems implicit in the use of high energy systems of one-half a megavolt. and above need not be countered. The main problems here are machine size, complexity, cost and shielding, the latter becoming a very severe problem for operating personnel safety in high power installations.

iii. The electron beams can be shaped and directed to the surface or surfaces to be: treated, resulting in further energy utilization efficiency.

iv. High process rates are possible since the electron beams, transported directly to the workpiece article from the accelerator, can be delivered at very high current density. Since the dose required for sterilization or pasteurization or like process is measured in terms of the energy absorbed per unit mass of material, the current density or energy flux at the workpiece surface clearly controls the rate of treatment of that surface. In accordance with the invention, intense relativistic electron beams provide energy at extreme flux levels, well above those achievable by any other non-nuclear technique, producing a broad and completely predictable range of dose delivery rates.

Decreased workpiece damage results from high rate radiation processing. Comparative testing of common packaging materials has shown this to be the case at the same (sterilizing) doses from Co at rads/sec. As a result, both improved surface and bulk properties result in most polymeric materials when radiation processing in conducted at high radiation rates while the same bactericidal efficacy is retained. A comparison of material elongation characteristics for Co and electron radiation at high radiation rates demonstrates this:

Ultimate Ultimate Strength Elongation Control (Polystyrene) 42.6 lbs/in. 88.6% C0 Irradiated (100 rads/scc.) 410.6 77,094 Electron Irradiated (10 racls/sec) 431) 943% Control (Polyethylene 46,2 lbs/in. 135.5% Co Irradiated (100 reds/sec.) 3191 105.0% Electron Irradiated (10 rails/sec.) 411.0 136.7%

A further object of the invention, accordingly, is to provide such a novel process and apparatus with relatively low energetic electron beams matched to the energy absorbing characteristics of the article surfaces and operating with high efficiency, negligible workpiece article damage and improved characteristics, and minimal X-ray generation.

Other and further objects will be explained hereinafter and are more particularly pointed out in the appended claims. In summary, from one of its broad aspects, the invention contemplates only slight pentration of the relatively low energy electrons within the article walls to effect surface sterilization thereof and substantial absorption within the walls that minimizes X-ray generation, and maintaining the gaseous zone in which the electron beam irradiates the article, substantially sterile.

The invention will now be described with reference to the accompanying drawings,

FIGS. 1 and 2 of which are graphs showing electron dose and penetration range variations in typical packaging material;

FIG. 3 is a graph showing electron penetration ranges in air, the knowledge of which is important for efficient practice of the process taught herein;

FIG. 4 is a longitudinal section of a preferred apparatus for practicing the process of the invention;

and FIGS. 5(a), (b) and (c) are similar views of aseptic filling systems incorporating the invention.

A most important feature of the surface sterilization technique underlying the invention is the increased efficiency of low energy electron beams for such applications, both for sterilization and like treatment involving microorganisms (pasteurization, disinfestation, etc.), as well as radiation chemistry treatment (cross-linking, polymerization, vulcanization, etc.) applications. This feature is demonstrated in the curves of FIG. 1, in which the energy dissipation or dose distribution curves for fast electrons in polystyrene are plotted as a function of depth of penetration. Curve 1 shows the absorption behavior characteristic of 50 keV electrons; curve 2 relates to 100 keV particles; and curve 3 is concerned with a 1 million electronvolt beam. The ordinate of the graph of FIG. 1 provides a measure of the deliverd dose per incident electron in units of energy deposited per unit thickness of material (polystyrene in this illustration). The abscissa shows the electron penetration depth both in English units (thousandths of an inch) and in metric units of target thickness (mass per unit area). The origin of the abscissa corresponds to the material surface. The very limited penetration depth of 1.5 mils of the 50 keV beam (curve 1) is accompanied by very high specific absorption or dose delivery to the polystyrene or like article material. Energy dissipation data such as these are available as, for example, in NBS Monograph No. 1, Energy Dissipation by Fast Electrons, L. V. Spencer, U. S. Govt Printing Office, Washington, D. C., Sept. 10, 1959, over a broad range of electron energies and target materials. As shown in FIG. 1, the maximum electron penetration in the target material varies as the electron energy; e.g. for the 50 keV, the depth of penetration is 1.5 mils; 5.6 mils for 100 keV; and 174 mils for 1,000 keV. If we consider a 25 micron or one mil layer, as an example, the absorption region for each of the three curves over this shallow" penetration is given by the cross-hatched areas A, B and C respectively for curves 1, 2 and 3. Over the 1 mil region of interest (for surface treatment, for example), the average stopping power or energy dissipation for the 50 keV case (A) is seen to be MeV/gm/cm or, for unit density material such as polystyrene, polyethylene, or like polymeric material, a total beam loss in the 1 mil layer (2.5 mg/cm of 38 keV is realized. This is 76 percent energy transfer efficiency for the 50 keV system. This can be compared with the average stopping power of 6.5 MeV/mg/cm at 100 keV (curve 2) or, a beam loss of 16.5 keV; i.e. 16.5 percent energy transfer efficiency for this case. These figures can now be compared with the energies used in earlier practice, say the 1,000 keV behavior shown by curve 3. Here, the average stopping power or rate of loss of energy has dropped to 2 MeV/gm/lcm or a beam energy loss of only 5 keV for the same film thickness; i.e. 0.5 percent energy transfer efficiency for this case. As shown in the graph of FIG. 2, later discussed, this utilization efficiency drops further as the beam energy increases.

It will thus be observed that for relatively thin surface sections or thin films, dropping the energy of the beam by a factor of 10 (1 MeV to keV) gives the surprising result of having increased the efficiency of the beam for sterilization or other treatment of that section by a factor of l6.5:0.5, or by a factor of 33; this has increased to a factor of over for an energy decrease by a factor of 20. This advantage in the latter case can also be stated in terms of the fact that at the same current density in the electron beam, the dose delivered has risen by a factor of 7.5 at 20 times lower power level.

While this idealized argument neglects window absorption losses, these are, however, small even for these low energy systems. For example, in the case of a 0.0005 inch (5,7 mg/cm Titanium window with a 150 keV system, the beam energy loss in the window is 20 keV. Reduced loss can be achieved for large area extended geometries through the use of supported lower Z (e.g., Al, Be) window structures.

A comparative examination of the relative absorption or electron stopping power variation in the polystyrene film example is shown as a function of incident electron energy in FIG. 2. As shown in the characteristic curves of FIG. 1 for the same material, the stopping power, for a plane perpendicular source, will increase from the surface to some peak value and then tail off to zero at the end of the range of penetration of the electron. In general, then, for thin sections (e.g. the 0.001 inch thickness used in FIG. 1), the electron will deliver energy in a manner characterized by a stopping power lying between the surface and the peak figures. In FIG. 1, indeed, the average value of 15 MeV/gm/cm characterized the 50 keV beam of curve 1 in the 0.001 inch layer.

In FIG. 2, the average, surface" and peak stopping power values for energetic electrons in a typical bulk polymer are plotted as a function of energy. Curve f is plotted to show the average variation in a 0.001 inch film of the same material over the same energy range. The advantage of using low energy electrons is again demonstrated by the very rapid increase in average energy dissipation in the film, which, as shown by curve f, occurs as the energy is decreased from 150 keV down to the energy corresponding to bare penetration" (40 keV), where curve fonce again meets the average dissipation curve. A family of such curvesf can be plotted in a like manner for a range of film thicknesses, demonstrating a peaking at lower energies with closer approach to the peak energy dissipation curve as the film thickness decreases.

In view of the limited penetration capability of fast electrons under, say, 300 keV kinetic energy, some consideration must be given the tolerable path lengths of such beams in air as they pass from the evacuated acceleration system of the processor to the surface to be sterilized which is preferably located in the ambient environment (or in N or similar inert gas blanket at atmospheric pressure).

Range data for electrons in dry air are presented in FIG. 3, in which the penetration depth (residual range) for electrons is plotted as a function of electron energy in curve 1 thereof. Since this curve is the limiting case for which the full electron energy has been dissipated in transport, curve 2 has been plotted for a tolerable 10 percent loss case; i.e. curve 2 shows the accelerator window-surface separation distance for which an electron of energy E would dissipate 10 percent of its energy in transit. As shown on curve 2, separation distances of 2.5 centimeters or 1 inch are possible at 125 keV, while a beam energy of 75 keV would require a practicable 1 cm air path to hold losses to this percent figure.

This invention may utilize both direct current and pulsed beams since the use of such relatively low energy streams, even at modest current densities (e.g. 100keV at 100 aamperes/cm can provide surface dose rates of 10 rads/second due to the elevated specific energy absorption. The rate of irradiation is elevated some 5 to 6 orders of magnitude (10 to 10 rads/sec.) through the use of high intensity pulsed beams employing large area cold cathode techniques similar to those described by S. Nablo et al., Observations of Magnetically Self-Focusing Electron Streams, Appl. Phys. Lett., 8, No. 1,18 (1966). Using such techniques, large area intense beams can be delivered directly into air with pulse durations typically of 10-100 X 10' seconds and dose rates of 10" rads/sec. The adaptation of such techniques to the present invention is shown in FIG. 4, in which a capacitor system 1 is charged to i 100,000VDC by a transformer system 2 and switched via a triggered gap 3 to providemicrosec- 0nd or shorter pulses, say 60 nanosecond, 15,000 ampere electron beam 4' at l25keV maximum energy through the .window 6. The high reactance type current limiting transformer is preferably of the type described for example, in Electronic Transformers and Circuits, p. 210-212, Reuben Lee, John Wiley and Sons, N.Y., 1947. The storage or discharge system may be a simple L-C-R circuit in which R VL/C, described, for example, in Electronic and Radio Engineering," Ch. 3, F. E. Terman, McGraw Hill Inc., N. Y., 1955. The triggered or command fired rotary switch is used to introduce synchronized sterilization control with the remainder of the packaging system. It may be of the type described, for example, in Pulse Generators by G. N. Glasoe and J. V. Lebacqz, p. 275-294, McGraw- Hill Book Co., Inc., N. Y., 1948. Relatively low energy beams of from 50-200 kilovolts are suitable for these applications. Such a sterilizer, delivering approximately 100 joules of energy per pulse can readily sterilize 400 cm surface area of proximal containers of similar articles 7 carried past the irradiation system by a conveyor 8, at dose levels of 1.5 megarads and at repetition rates of 4 per second; i.e. 1,600 cm /second. The average power consumption of the system is 500 watts, and it may be insulated at one atmosphere of dry N or SF and can be readily shielded with one-fourth inch of lead 5 enclosing the beam area. By using such relatively low energy electrons in conjunction with high specific energy of absorption container walls, as of polystyrene and the like, before discussed, the wall surfaces are sterilized with the energy absorbed within the walls after slight penetration, minimizing the generation of X-rays, the few of which that are generated being shielded against by relatively thin lead shields 9 along the path or line of movement of the containers.

A further refinement of this invention for sterile or aseptic packaging applications utilizes the very high yields of ozone (0 which results from the application of the system under aerobic conditions. The disinfecting properties of the ozone so generated will be used to maintain a sterile condition on the process system walls as well as throughout the aseptic filling, sealing and product handling volume, as more particularly shown in the gaseous irradiation zone 4 of FIGS. 4 and 5(a).

A second variation would involve the use ofinert or anaerobic gas blanket, such as N or argon, to reduce oxygen inhibition or deterioration effects at the surface processed, and to provide energetic X-rays excited from the inner shell excitation of vacancies created by the primary electrons. These secondary X-rays are emitted isotropically and will assist in the surface sterilization of the entire area and help maintain a condition of sterility throughout the working zone volume 4 of the aseptic packager. A third variation may utilize the surface sterilizer itself to sterilize the ambient environment (gases) as well, for volume protection. A variation can utilize the surface sterilizer to maintain aseptic conditions on the container filler surface. A fifth variation may utilize an ultraviolet-rich gas, such as xenon, in the working zone volume 4 in order to enhance system surface sterilization by the intense ultraviolet bursts generated by the directed low energy beam.

The system shown in FIG. 4 will be demandcontrolled by the package dispenser which delivers the sterile package 7 to the system prior to filling. As shown in FIG. 5(a), however, the same supply may control several beam heads for intermediate processing in the aseptic filler zone 4. The aseptic packaging system of FIG. 5(a) consists of a central pulser or voltage supply 1' which is used sequentially to excite several sterilizing heads (A, B, C etc.) located in the aseptic filling and packaging zone 4. Selector switch S is employed to provide the excitation pulse to the desired sterilization head, sequentially from A, the package sterilization unit which processes the inner contact surface of the container by the method already described. For deep container geometries in which the air path restraints of FIG. 3 become troublesome, a coaxial head geometry may be used for insertion into the package itself for co-axial surface illumination. The sequencer switch then proceeds, for example, to sterilizer head B, shown in FIGS. 5(a) and (b) to be of coaxial geometry. Such a system is used to maintain the surface of the filler spout 3' in aseptic condition while in the retracted position on each operation. The sequence switch S then delivers excitation energy to head C for sterilization of the package cap itself and the sealing surfaces Master switch S is normally used to synchronize the pulser output with the sequencer switch S and the remainder of the packager functions. S may be of the well-known fast trigatron type unit, while S may be of the conventional slower rotary type configuration. The entire aseptic filling and packaging region 4 is surrounded by a low-Z enclosure or shroud 5 which is further shielded with a thin lead cover 6. Containers 7 are carried through the filler/packager region on conveyor 8.

Aseptic conditions in the working volume 4 are accomplished by the use of high efficiency particle filtration of the air (as described, for example, in Sterilization Filtration, C. W. Fifield, Ch. 45, Disinfection, Sterilization and Preservation, ed. C. A. Lawrence and S. S. Block, Lea and Febiger, Phila., 1968), so that a positive pressure of sterile air is maintained in zone 4. Another variation could utilize one of the sterilizer heads itself to sterilize air admitted from the packager environment. For example, as shown in FIG. 5(b), a co axial head, such as B, may be used to treat air driven into region 4 during each operation of filler head 3'. In this way, only a few operations of heads A-C would be required to provide an aseptic zone 4 prior to start-up insertion of containers 7 at package sterilizer head A.

The slight positive pressure maintained in zone 4 by the action of bellows-valve 9 on filler head 3 would ensure that contaminated air leakage from exhaust channels 10, 11 and 12 was precluded. In the same manner that scattered electrons and direct u.v./X-ray excitation of the air assists package surface sterilization at head A, these same effects assist in the aseptic maintenance of zone 4 from the secondary effects of heads A and C.

A further variation of this technique -is particularly adapted for the continuous sterilization of material in strip form which is used in the fabrication of the container itself. A typical application is shown schematically in FIG. (c) in which a strip electron beam sterilizer A is employed to surface sterilize packaging material M fed into the tube sealing unit T in, for example, a Tetrapak unit (as described in Aseptic Filling in Tetra-Pak Sterilization of Paper, P. Swartling and B. Lindgren, Milk and Dairy Research Report No. 66, Alnarp, Sweden). Such a unit may use roll separators R to seal the sterile zone 4 from the external septic envinonment and provide sterile stock M for conventional aseptic packaging systems while eliminating the wet (H 0 etc.) disinfecting systems normally employed in current practice. Further modifications will also occur to those skilled in this art and all such are considered to fall within the spirit and scope of the invention as defined in the appended claims.

What is claimed is:

l. A process of achieving surface sterilization of a moving line of articles by utilization of low energy electrons with energy in the range of the order of from about 50 to about 150 keV at the surface of said articles, with article penetration depths of up to the order of about 6 mils and with energy transfer efficiency such that the electron energy is substantially completely absorbed within such penetration depths, the articles having walls of high enough specific energy absorption for said low energy electrons to provide said energy transfer efficiency, that comprises, moving said articles successively through a gaseous irradiation zone, generating a single substantially uniform large-area low energy electron beam and transmitting the same in said zone to said surface of said articles with said electron energies at said surface as said articles move through said zone, in order to cause said electrons to penetrate said article walls to said depths over such large area and to effect such surface sterilization with said substantially complete absorption within the walls that minimizes X-ray generation, and abosrbing such X-rays as may be generated in said zone along the line of movement of the articles therethrough.

2. A process as claimed in claim 1 and in which the further step is performed of maintaining the said zone substantially sterile.

3. A process as claimed in claim 1 and in which said articles are disinfested by exposure to said beam.

4. A process as claimed in claim 1 and in which said electron beam is pulsed.

5. A process as claimed in claim 4 and in which the electron beam pulses are adjusted to be of duration of the order of a micro-second and less.

6. A process as claimed in claim 1 and in which said electron beam generating step is repeated at successive spaced regions along said zone.

7. A process as claimed in claim 6 and in which said articles comprise containers and the containers are filled between such successive regions of said zone.

8. A process as claimed in claim 7 and in which the containers are closed after filling, with the closure subjected to a sterilizing electron beam at one of said regions of said zone.

9. A process as claimed in claim 1 and in which said articles comprise container material prior to formation into containers, and in which the further step is performed of forming the material, after the electron beam has penetrated the same, into containers while maintaining the containers sterile.

10. Apparatus for achieving surface sterilization of a moving line of articles by utilization of low energy electrons with energy in the range of the order of from about 50 to about keV at the surface of said articles, with article penetration depths of up to the order of about 6 mils and with energy transfer efficiency such that the electron energy is substantially completely absorbed within such penetration depths, the articles having walls of high enough specific energy absorption for said low energy electrons to provide said energy transfer efficiency, that comprises, means for moving said articles successively through a gaseous irradiation zone, means for generating a single substantially uniform large-area low energy electron beam and trans mitting the same in said zone to said surface of said articles with said electron energies at said surface as said articles move through said zone, in order to cause said electrons to penetrate said article walls to said depths over such large area and to effect such surface sterilization with said substantially complete absorption within the walls that minimizes X-ray generation, and means for absorbing such X-rays as may be generated in said zone along the line of movement of the articles therethrough.

11. Apparatus as claimed in claim 10 and in which means is provided for maintaining the said zone substantially sterile.

12. Apparatus as claimed in claim 10 and in which said articles comprise container material prior to formation into containers, and in which there is further provided container-forming apparatus for receiving the electron-beam treated material and forming a container therefrom while maintaining the container sterile.

13. Apparatus as claimed in claim 10 and in which said electron beam generating means comprises a plurality of successive electron guns and corresponding windows positioned to irradiate successive regions of said zone along the line of movement of said articles.

4. Apparatus as claimed in claim 13 and in which means is provided for successively pulsing the successive guns.

15. Apparatus as claimed in claim 10 and in which said articles comprise containers, and there are provided means for filling said containers as they move through the said zone while maintaining the containers sterile.

16. Apparatus as claimed in claim 15 and in which means is provided for subjecting the filling of said filling means to electron beam irradiation.

17. Apparatus as claimed in claim 16 and in which said last-named electron-beam irradiation subjecting means is coaxially disposed about said filling means.

Claims (16)

  1. 2. A process as claimed in claim 1 and in which the further step is performed of maintaining the said zone substantially sterile.
  2. 3. A process as claimed in claim 1 and in which said articles are disinfested by exposure to said beam.
  3. 4. A process as claimed in claim 1 and in which said electron beam is pulsed.
  4. 4. Apparatus as claimed in claim 13 and in which means is provided for successively pulsing the successive guns.
  5. 5. A process as claimed in claim 4 and in which the electron beam pulses are adjusted to be of duration of the order of a micro-second and less.
  6. 6. A process as claimed in claim 1 and in which said electron beam generating step is repeated at successive spaced regions along said zone.
  7. 7. A process as claimed in claim 6 and in which said articles comprise containers and the containers are filled between such successive regions of said zone.
  8. 8. A process as claimed in claim 7 and in which the containers are closed after filling, with the closure subjected to a sterilizing electron beam at one of said regions of said zone.
  9. 9. A process as claimed in claim 1 and in which said articles comprise container material prior to formation into containers, and in which the further step is performed of forming the material, after the electron beam has penetrated the same, into containers while maintaining the containers sterile.
  10. 10. Apparatus for achieving surface sterilization of a moving line of articles by utilization of low energy electrons with energy in the range of the order of from about 50 to about 150 keV at the surface of said articles, with article penetration depths of up to the order of about 6 mils and with energy transfer efficiency such that the electron energy is substantially completely absorbed within such penetration depths, the articles having walls of high enough specific energy absorption for said low energy electrons to provide said energy transfer efficiency, that comprises, means for moving said articles successively through a gaseous irradiation zone, means for generating a single substantially uniform large-area low energy electron beam and transmitting the same in said zone to said surface of said articles with said electron energies at said surface as said articles move through said zone, in order to cause said electrons to penetrate said article walls to said depths over such large area and to effect such surface sterilization with said substantially complete absorption within the walls that minimizes X-ray generation, and means for absorbing such X-rays as may be generated in said zone along the line of movement of the articles there-through.
  11. 11. Apparatus as claimed in claim 10 and in which means is provided for maintaining the said zone substantially sterile.
  12. 12. Apparatus as claimed in claim 10 and in which said articles comprise container material prior to formation into containers, and in which there is further provided container-forming apparatus for receiving the electron-beam treated material and forming a container therefrom while maintaining the container sterile.
  13. 13. Apparatus as claimed in claim 10 and in which said electron beam generating means comprises a plurality of successive electron guns and corresponding windows positioned to irradiate successive regions of said zone along the line of movement of said articles.
  14. 15. Apparatus as claimed in claim 10 and in which said articles comprise containers, and there are provided means for filling said containers as they move through the said zone while maintaining the containers sterile.
  15. 16. Apparatus as claimed in claim 15 and in which means is provided for subjecting the filling of said filling means to electron beam irradiation.
  16. 17. Apparatus as claimed in claim 16 and in which said last-named electron-beam irradiation subjecting means is coaxially disposed about said filling means.
US3780308A 1971-06-07 1971-06-07 Process and apparatus for surface sterilization of materials Expired - Lifetime US3780308A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US15046471 true 1971-06-07 1971-06-07

Publications (1)

Publication Number Publication Date
US3780308A true US3780308A (en) 1973-12-18

Family

ID=22534649

Family Applications (1)

Application Number Title Priority Date Filing Date
US3780308A Expired - Lifetime US3780308A (en) 1971-06-07 1971-06-07 Process and apparatus for surface sterilization of materials

Country Status (6)

Country Link
US (1) US3780308A (en)
JP (1) JPS5217469B1 (en)
CA (1) CA961178A (en)
DE (1) DE2227059C3 (en)
FR (1) FR2140393B1 (en)
GB (1) GB1389061A (en)

Cited By (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2542575A1 (en) * 1974-12-09 1976-06-10 Energy Sciences Inc A method and apparatus for curing of ueberzuegen on sensitive subject by electron irradiation
US4305000A (en) * 1978-11-03 1981-12-08 Tetra Pak Developpement Ltd. Process of and apparatus for cold-cathode electron-beam generation for sterilization of surfaces and similar applications
US4367412A (en) * 1978-11-03 1983-01-04 Tetra Pak Developpement Sa Process of and apparatus for cold-cathode electron-beam generation for sterilization of surfaces and similar applications
US4439686A (en) * 1980-09-16 1984-03-27 Tetra Pak Developpement Ltd. Electron beam-irradiating apparatus with conical bushing seal-support
US4559102A (en) * 1983-05-09 1985-12-17 Sony Corporation Method for recrystallizing a polycrystalline, amorphous or small grain material
US4592799A (en) * 1983-05-09 1986-06-03 Sony Corporation Method of recrystallizing a polycrystalline, amorphous or small grain material
EP0197217A2 (en) * 1985-03-29 1986-10-15 Energy Sciences Inc. Electron-beam irradiation sterilization process
US4703256A (en) * 1983-05-09 1987-10-27 Sony Corporation Faraday cups
US4945248A (en) * 1989-04-12 1990-07-31 The United States Of America As Represented By The Secretary Of The Army Hydroactivated bionic infrared source
US5489783A (en) * 1993-04-28 1996-02-06 Tetra Laval Holdings & Finance S.A. Electron accelerator for sterilizing packaging material in an aspetic packaging machine
US5554856A (en) * 1993-11-01 1996-09-10 Biosterile Technology, Inc. Conveyer-type unit for radiation sterilization
US5557109A (en) * 1993-11-01 1996-09-17 International Research And Development Radiation sterilization unit
US5561298A (en) * 1994-02-09 1996-10-01 Hughes Aircraft Company Destruction of contaminants using a low-energy electron beam
US5645608A (en) * 1996-01-03 1997-07-08 Cooper; Theodore R. Cold water wash method
US5856675A (en) * 1997-12-09 1999-01-05 Biosterile Technology, Inc. Method of irradiation of polymer films by an electron beam
US6006387A (en) * 1995-11-30 1999-12-28 Cyclo3Pss Textile Systems, Inc. Cold water ozone disinfection
EP1004522A2 (en) * 1998-11-24 2000-05-31 Daiki Foods Yugen Kaisha Pouch for containing retort food
WO2000055884A1 (en) * 1999-03-17 2000-09-21 American International Technologies, Inc. Sterilization by a low energy electron beam
US6139796A (en) * 1995-08-11 2000-10-31 Tetra Laval Holdings & Finance Method for sterilizing flowable product packages
US6143805A (en) * 1998-02-18 2000-11-07 Closure Medical Corporation Electron beam sterilization of liquid adhesive compositions
US6210516B1 (en) 1994-02-18 2001-04-03 Ronald Sinclair Nohr Process of enhanced chemical bonding by electron seam radiation
US6221216B1 (en) * 1997-03-26 2001-04-24 Electron Processing Systems, Inc. Technique for interior electron sterilization of an open mouthed container
EP1171167A2 (en) * 1999-04-20 2002-01-16 Baxter International Inc. Method and apparatus for manipulating pre-sterilized components in an active sterile field
FR2815542A1 (en) * 2000-10-23 2002-04-26 Sidel Sa Electron beam sterilization gun suitable for PET bottle pre-forms, introduces comparatively low power axially and uniformly through neck, without scanning
WO2002058742A1 (en) * 2000-12-13 2002-08-01 Advanced Electron Beams, Inc. Decontamination apparatus
WO2002072157A1 (en) * 2001-03-08 2002-09-19 Baxter International Inc. Apparatus for and method of manufacturing a prefilled sterile container
US6458398B1 (en) 1999-10-18 2002-10-01 Eco Pure Food Safety Systems, Inc. Cold water disinfection of foods
US20030164285A1 (en) * 2002-03-04 2003-09-04 Steris Inc. Mobile radiant energy sterilizer
US20030174810A1 (en) * 2002-03-12 2003-09-18 Steris Inc. Method and apparatus for destroying microbial contamination of mail
US6628750B1 (en) * 2000-11-09 2003-09-30 Steris Inc. System for electron and x-ray irradiation of product
US6685883B2 (en) 1999-08-27 2004-02-03 Tetra Laval Holdings & Finance S.A. Method and unit for sterilizing packaging sheet material for manufacturing sealed packages of pourable food products
US6692684B1 (en) 1998-04-07 2004-02-17 Tetra Laval Holdings & Finance S.A. Method and apparatus for producing a sterile packaging container
US20040245481A1 (en) * 2000-12-13 2004-12-09 Advanced Electron Beams, Inc. Irradiation apparatus
US6833551B2 (en) 2001-03-20 2004-12-21 Advanced Electron Beams, Inc. Electron beam irradiation apparatus
US20050158218A1 (en) * 2004-01-20 2005-07-21 Serac Group Installation for sterilizing articles by electron bombardment
US6949222B1 (en) 1999-09-17 2005-09-27 Tetra Laval Holdings & Finance Sa System for monitoring and control in the sterilization of an object
WO2005108278A2 (en) * 2004-05-07 2005-11-17 Simonazzi S.P.A. Apparatus and method for sterilising bottles and/or caps and filling them
US20060151714A1 (en) * 2003-02-25 2006-07-13 Jacques Thilly Apparatus and process for filling a medicament into a container
US20070079896A1 (en) * 2002-06-19 2007-04-12 Daniel Py Sterile filling machine having needle filling station within e-beam chamber
US20070110842A1 (en) * 2005-11-15 2007-05-17 Husky Injection Molding Systems Ltd. System for molding and assembly of sterilized articles
WO2007099120A1 (en) 2006-02-28 2007-09-07 Novo Nordisk A/S A method and an apparatus for sterilizing packaging material
US20070253861A1 (en) * 2006-04-26 2007-11-01 Toshiaki Naka Apparatus and method for sterilization of vessels
WO2007140883A1 (en) * 2006-06-02 2007-12-13 Khs Ag Method and apparatus for treating bottles or containers of this type with a treatment medium
US20070283667A1 (en) * 2006-06-13 2007-12-13 Tetra Laval Holdings & Finance Sa Method of sterilizing packages
US20080073549A1 (en) * 2006-02-14 2008-03-27 Tzvi Avnery Electron beam emitter
WO2008129397A3 (en) * 2007-04-18 2008-12-24 Sipa Progettazione Automaz Sterilization system for pet containers and bottles
WO2009000850A1 (en) * 2007-06-26 2008-12-31 Krones Ag STERILIZATION WITH ß-RADIATION
US20090013645A1 (en) * 2007-07-11 2009-01-15 Stokely-Van Camp, Inc. Active sterilization zone for container filling
EP2032445A1 (en) * 2006-06-02 2009-03-11 Tetra Laval Holdings & Finance SA A method of sterilizing a packaging material by means of a sterilization agent containing hydrogen peroxide
US20090156079A1 (en) * 2007-12-14 2009-06-18 Kimberly-Clark Worldwide, Inc. Antistatic breathable nonwoven laminate having improved barrier properties
US20090173039A1 (en) * 2003-08-20 2009-07-09 Multivac, Inc. Inline processing and irradiation system
US20090266439A1 (en) * 2006-10-31 2009-10-29 Thomas Stolte Method for the filling of beverage cans in a beverage can filling plant, a method for the filling of cans in a can filling plant, and an apparatus therefor
US20100159195A1 (en) * 2008-12-24 2010-06-24 Quincy Iii Roger B High repellency materials via nanotopography and post treatment
US20110012032A1 (en) * 2009-04-30 2011-01-20 Michael Lawrence Bufano Electron beam sterilization apparatus
US20110012030A1 (en) * 2009-04-30 2011-01-20 Michael Lawrence Bufano Ebeam sterilization apparatus
EP2492202B1 (en) 2008-08-30 2014-12-17 Krones AG Electron beam sterilisation for containers
US9289522B2 (en) 2012-02-28 2016-03-22 Life Technologies Corporation Systems and containers for sterilizing a fluid

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427631A (en) * 1982-05-27 1984-01-24 Euroceltique, S.A. Povidone irradiation
DE10114660C2 (en) * 2001-03-24 2003-10-16 Alfill Engineering Gmbh & Co K Filling head for carbonated beverages
RU2430002C2 (en) 2006-06-13 2011-09-27 Тетра Лаваль Холдингз Энд Файнэнс С.А. Method to sterilise packages
WO2007145561A1 (en) * 2006-06-13 2007-12-21 Tetra Laval Holdings & Finance S.A. Method of sterilizing packages
JP4946431B2 (en) * 2006-12-28 2012-06-06 澁谷工業株式会社 Container sterilization apparatus
DE102008054110A1 (en) 2008-10-31 2010-05-06 Khs Ag An apparatus for sterilizing a container
EP2218465A1 (en) 2009-02-02 2010-08-18 KHS GmbH Apparatus for sterilising a container
FR3031903B1 (en) * 2015-01-28 2017-01-13 Sidel Participations Device and method of sterilization of thermoplastic containers by means of an electron beam pulse

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2384778A (en) * 1941-04-04 1945-09-11 Whitman Helen Irradiating bottle filling machine
US2855517A (en) * 1955-07-20 1958-10-07 Grace W R & Co Irradiation treatment of polyethylene
US3617740A (en) * 1968-10-08 1971-11-02 High Voltage Engineering Corp Modular electron source for uniformly irradiating the surface of a product
US3654459A (en) * 1969-08-18 1972-04-04 Ppg Industries Inc Controlled atmosphere chamber for treating products with ionizing radiation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2384778A (en) * 1941-04-04 1945-09-11 Whitman Helen Irradiating bottle filling machine
US2855517A (en) * 1955-07-20 1958-10-07 Grace W R & Co Irradiation treatment of polyethylene
US3617740A (en) * 1968-10-08 1971-11-02 High Voltage Engineering Corp Modular electron source for uniformly irradiating the surface of a product
US3654459A (en) * 1969-08-18 1972-04-04 Ppg Industries Inc Controlled atmosphere chamber for treating products with ionizing radiation

Cited By (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2542575A1 (en) * 1974-12-09 1976-06-10 Energy Sciences Inc A method and apparatus for curing of ueberzuegen on sensitive subject by electron irradiation
US4305000A (en) * 1978-11-03 1981-12-08 Tetra Pak Developpement Ltd. Process of and apparatus for cold-cathode electron-beam generation for sterilization of surfaces and similar applications
EP0054016A2 (en) 1978-11-03 1982-06-16 Tetra Laval Holdings & Finance SA Apparatus for electron-beam irradiation of surfaces
US4367412A (en) * 1978-11-03 1983-01-04 Tetra Pak Developpement Sa Process of and apparatus for cold-cathode electron-beam generation for sterilization of surfaces and similar applications
EP0054016A3 (en) * 1978-11-03 1983-06-22 Tetra Pak Developpement Sa Apparatus for electron-beam irradiation of surfaces
EP0011414B1 (en) * 1978-11-03 1983-07-20 Tetra Laval Holdings & Finance SA Process and apparatus for electron beam irradiation of surfaces
US4439686A (en) * 1980-09-16 1984-03-27 Tetra Pak Developpement Ltd. Electron beam-irradiating apparatus with conical bushing seal-support
US4559102A (en) * 1983-05-09 1985-12-17 Sony Corporation Method for recrystallizing a polycrystalline, amorphous or small grain material
US4592799A (en) * 1983-05-09 1986-06-03 Sony Corporation Method of recrystallizing a polycrystalline, amorphous or small grain material
US4703256A (en) * 1983-05-09 1987-10-27 Sony Corporation Faraday cups
US4652763A (en) * 1985-03-29 1987-03-24 Energy Sciences, Inc. Electron-beam irradiation sterilization process
EP0197217A2 (en) * 1985-03-29 1986-10-15 Energy Sciences Inc. Electron-beam irradiation sterilization process
EP0197217A3 (en) * 1985-03-29 1988-07-27 Energy Sciences Inc. Electron-beam irradiation sterilization process
US4945248A (en) * 1989-04-12 1990-07-31 The United States Of America As Represented By The Secretary Of The Army Hydroactivated bionic infrared source
US5489783A (en) * 1993-04-28 1996-02-06 Tetra Laval Holdings & Finance S.A. Electron accelerator for sterilizing packaging material in an aspetic packaging machine
US5554856A (en) * 1993-11-01 1996-09-10 Biosterile Technology, Inc. Conveyer-type unit for radiation sterilization
US5557109A (en) * 1993-11-01 1996-09-17 International Research And Development Radiation sterilization unit
US5561298A (en) * 1994-02-09 1996-10-01 Hughes Aircraft Company Destruction of contaminants using a low-energy electron beam
US6210516B1 (en) 1994-02-18 2001-04-03 Ronald Sinclair Nohr Process of enhanced chemical bonding by electron seam radiation
US6139796A (en) * 1995-08-11 2000-10-31 Tetra Laval Holdings & Finance Method for sterilizing flowable product packages
US6006387A (en) * 1995-11-30 1999-12-28 Cyclo3Pss Textile Systems, Inc. Cold water ozone disinfection
US6115862A (en) * 1995-11-30 2000-09-12 Cyclo3Pss Textile Systems, Inc. Cold water ozone disinfection
US5763382A (en) * 1996-01-03 1998-06-09 Cyclo3Pss Textile Systems, Inc. Cold water wash formula
US5645608A (en) * 1996-01-03 1997-07-08 Cooper; Theodore R. Cold water wash method
US6221216B1 (en) * 1997-03-26 2001-04-24 Electron Processing Systems, Inc. Technique for interior electron sterilization of an open mouthed container
US5856675A (en) * 1997-12-09 1999-01-05 Biosterile Technology, Inc. Method of irradiation of polymer films by an electron beam
US6143805A (en) * 1998-02-18 2000-11-07 Closure Medical Corporation Electron beam sterilization of liquid adhesive compositions
US6692684B1 (en) 1998-04-07 2004-02-17 Tetra Laval Holdings & Finance S.A. Method and apparatus for producing a sterile packaging container
EP1004522A2 (en) * 1998-11-24 2000-05-31 Daiki Foods Yugen Kaisha Pouch for containing retort food
EP1004522A3 (en) * 1998-11-24 2001-05-02 Daiki Foods Yugen Kaisha Pouch for containing retort food
WO2000055884A1 (en) * 1999-03-17 2000-09-21 American International Technologies, Inc. Sterilization by a low energy electron beam
US6140657A (en) * 1999-03-17 2000-10-31 American International Technologies, Inc. Sterilization by low energy electron beam
USRE39657E1 (en) * 1999-03-17 2007-05-29 Ushio America, Inc. Sterilization by low energy electron beam
EP1171167B1 (en) * 1999-04-20 2010-02-10 Baxter International Inc. Method and apparatus for manipulating pre-sterilized components in an active sterile field
US20020018731A1 (en) * 1999-04-20 2002-02-14 Bilstad Arnold C. Method and apparatus for manipulating pre-sterilized components in an active sterile field
US20050161614A1 (en) * 1999-04-20 2005-07-28 Bilstad Arnold C. Apparatus for manipulating pre-sterilized components in an active sterile field
US20060110282A1 (en) * 1999-04-20 2006-05-25 Bilstad Arnold C Method and apparatus for manipulating pre-sterilized components in an active sterile field
EP1171167A2 (en) * 1999-04-20 2002-01-16 Baxter International Inc. Method and apparatus for manipulating pre-sterilized components in an active sterile field
US7655198B2 (en) * 1999-04-20 2010-02-02 Baxter International Inc. Method and apparatus for manipulating pre-sterilized components in an active sterile field
US7264771B2 (en) 1999-04-20 2007-09-04 Baxter International Inc. Method and apparatus for manipulating pre-sterilized components in an active sterile field
US6685883B2 (en) 1999-08-27 2004-02-03 Tetra Laval Holdings & Finance S.A. Method and unit for sterilizing packaging sheet material for manufacturing sealed packages of pourable food products
US6949222B1 (en) 1999-09-17 2005-09-27 Tetra Laval Holdings & Finance Sa System for monitoring and control in the sterilization of an object
US6458398B1 (en) 1999-10-18 2002-10-01 Eco Pure Food Safety Systems, Inc. Cold water disinfection of foods
FR2815542A1 (en) * 2000-10-23 2002-04-26 Sidel Sa Electron beam sterilization gun suitable for PET bottle pre-forms, introduces comparatively low power axially and uniformly through neck, without scanning
US6628750B1 (en) * 2000-11-09 2003-09-30 Steris Inc. System for electron and x-ray irradiation of product
US7183563B2 (en) 2000-12-13 2007-02-27 Advanced Electron Beams, Inc. Irradiation apparatus
US6702984B2 (en) 2000-12-13 2004-03-09 Advanced Electron Beams, Inc. Decontamination apparatus
WO2002058742A1 (en) * 2000-12-13 2002-08-01 Advanced Electron Beams, Inc. Decontamination apparatus
US20040245481A1 (en) * 2000-12-13 2004-12-09 Advanced Electron Beams, Inc. Irradiation apparatus
WO2002072157A1 (en) * 2001-03-08 2002-09-19 Baxter International Inc. Apparatus for and method of manufacturing a prefilled sterile container
US6833551B2 (en) 2001-03-20 2004-12-21 Advanced Electron Beams, Inc. Electron beam irradiation apparatus
US20030164285A1 (en) * 2002-03-04 2003-09-04 Steris Inc. Mobile radiant energy sterilizer
US6822250B2 (en) * 2002-03-04 2004-11-23 Steris Inc. Mobile radiant energy sterilizer
US20030174810A1 (en) * 2002-03-12 2003-09-18 Steris Inc. Method and apparatus for destroying microbial contamination of mail
WO2003077957A1 (en) * 2002-03-12 2003-09-25 Steris Inc. Method and apparatus for destroying microbial contamination of mail and paper currency
US9296498B2 (en) 2002-06-19 2016-03-29 Medinstill Development Llc Methods of filling a sealed device
US20070079896A1 (en) * 2002-06-19 2007-04-12 Daniel Py Sterile filling machine having needle filling station within e-beam chamber
US20090308485A1 (en) * 2002-06-19 2009-12-17 Daniel Py Sterile Filling Machine Having Needle Filling Station and Conveyor
US7556066B2 (en) 2002-06-19 2009-07-07 Medical Instill Technologies, Inc. Sterile filling machine having needle filling station and conveyor
US8448674B2 (en) 2002-06-19 2013-05-28 Medical Instill Technologies, Inc. Sterile filling machine having filling station and E-beam chamber
US7905257B2 (en) 2002-06-19 2011-03-15 Daniel Py Sterile filling machine having needle filling station and conveyor
US20060151714A1 (en) * 2003-02-25 2006-07-13 Jacques Thilly Apparatus and process for filling a medicament into a container
US7365343B2 (en) * 2003-02-25 2008-04-29 Glaxosmithkline Biologicals S.A. Apparatus and process for filling a medicament into a container
US20090173039A1 (en) * 2003-08-20 2009-07-09 Multivac, Inc. Inline processing and irradiation system
US20050158218A1 (en) * 2004-01-20 2005-07-21 Serac Group Installation for sterilizing articles by electron bombardment
US7579607B2 (en) * 2004-01-20 2009-08-25 Serac Group Installation for sterilizing articles by electron bombardment
US7739859B2 (en) 2004-05-07 2010-06-22 Sidel S.P.A. Apparatuses and methods for sterilising and filling components of packaging units particularly bottles and/or caps
WO2005108278A3 (en) * 2004-05-07 2006-03-02 Sig Simonazzi Spa Apparatus and method for sterilising bottles and/or caps and filling them
WO2005108278A2 (en) * 2004-05-07 2005-11-17 Simonazzi S.P.A. Apparatus and method for sterilising bottles and/or caps and filling them
CN1968888B (en) 2004-05-07 2010-12-08 西得乐股份公司 Apparatuses and methods for sterilising and filling components of packaging units, particularly bottles and/or caps
US20070110842A1 (en) * 2005-11-15 2007-05-17 Husky Injection Molding Systems Ltd. System for molding and assembly of sterilized articles
US8258486B2 (en) 2006-02-14 2012-09-04 Hitachi Zosen Corporation Electron beam emitter for sterilizing containers
US7759661B2 (en) 2006-02-14 2010-07-20 Advanced Electron Beams, Inc. Electron beam emitter for sterilizing containers
US20100247373A1 (en) * 2006-02-14 2010-09-30 Advanced Electron Beams, Inc. Electron beam emitter for sterilizing containers
US20080073549A1 (en) * 2006-02-14 2008-03-27 Tzvi Avnery Electron beam emitter
US8586944B2 (en) 2006-02-14 2013-11-19 Hitachi Zosen Corporation Electron beam emitter for sterilizing containers
US20090148340A1 (en) * 2006-02-28 2009-06-11 Nova Nordisk A/S Method and an apparatus for sterilizing packaging material
WO2007099120A1 (en) 2006-02-28 2007-09-07 Novo Nordisk A/S A method and an apparatus for sterilizing packaging material
US7972558B2 (en) 2006-02-28 2011-07-05 Novo Nordisk A/S Method and an apparatus for sterilizing packaging material
US20070253861A1 (en) * 2006-04-26 2007-11-01 Toshiaki Naka Apparatus and method for sterilization of vessels
EP2032445A4 (en) * 2006-06-02 2011-12-28 Tetra Laval Holdings & Finance A method of sterilizing a packaging material by means of a sterilization agent containing hydrogen peroxide
US20090293429A1 (en) * 2006-06-02 2009-12-03 Volker Till Beverage bottling plant with method and apparatus for cleaning, filling, and closing bottles
EP2032445A1 (en) * 2006-06-02 2009-03-11 Tetra Laval Holdings & Finance SA A method of sterilizing a packaging material by means of a sterilization agent containing hydrogen peroxide
WO2007140883A1 (en) * 2006-06-02 2007-12-13 Khs Ag Method and apparatus for treating bottles or containers of this type with a treatment medium
US20090208369A1 (en) * 2006-06-02 2009-08-20 Tetra Laval Holdings & Finanace S.A. Method of sterilizing a packaging material by means of o sterilization agent containing hydrogen peroxide
US8029725B2 (en) * 2006-06-02 2011-10-04 Tetra Laval Holdings & Finance S.A. Method of sterilizing a packaging material by means of a sterilization agent containing hydrogen peroxide
US7520108B2 (en) * 2006-06-13 2009-04-21 Tetra Laval Holdings & Finance Sa Method of sterilizing packages
US20070283667A1 (en) * 2006-06-13 2007-12-13 Tetra Laval Holdings & Finance Sa Method of sterilizing packages
US9067698B2 (en) * 2006-10-31 2015-06-30 Khs Gmbh Method for the filling of beverage cans in a beverage can filling plant, a method for the filling of cans in a can filling plant, and an apparatus therefor
US20090266439A1 (en) * 2006-10-31 2009-10-29 Thomas Stolte Method for the filling of beverage cans in a beverage can filling plant, a method for the filling of cans in a can filling plant, and an apparatus therefor
WO2008129397A3 (en) * 2007-04-18 2008-12-24 Sipa Progettazione Automaz Sterilization system for pet containers and bottles
US8790589B2 (en) 2007-04-18 2014-07-29 S.I.P.A. Societa´ Industrializzazione Progettazione E Automazione S.p.A. Sterilization system for pet containers and bottles
RU2465918C2 (en) * 2007-04-18 2012-11-10 С.И.П.А Сосьета' Индустриалидзационе Проджеттационе Э Аутомационе С.П.А. System for sterilisation of vessels and bottles from pet
US20100209290A1 (en) * 2007-04-18 2010-08-19 S.I.P.A. Societa' Industrializzazione Progettazione E Automazione S.P.A. Sterilization system for pet containers and bottles
US8863790B2 (en) 2007-06-26 2014-10-21 Krones Ag Sterilization with β-radiation
CN101801422B (en) 2007-06-26 2014-01-29 克朗斯股份公司 Sterilization with beta-radiation
WO2009000850A1 (en) * 2007-06-26 2008-12-31 Krones Ag STERILIZATION WITH ß-RADIATION
US20100193069A1 (en) * 2007-06-26 2010-08-05 Manfred Ziegler Sterilization with beta-radiation
US9321620B2 (en) 2007-07-11 2016-04-26 Stokely-Van Camp, Inc. Active sterilization zone for container filling
US20090013645A1 (en) * 2007-07-11 2009-01-15 Stokely-Van Camp, Inc. Active sterilization zone for container filling
US20090013648A1 (en) * 2007-07-11 2009-01-15 Stokely-Van Camp, Inc. Active Sterilization Zone for Container Filling
US20090017747A1 (en) * 2007-07-11 2009-01-15 Stokely-Van Camp, Inc. Active Sterilization Zone for Container Filling
US9296600B2 (en) 2007-07-11 2016-03-29 Stokely-Van Camp, Inc. Active sterilization zone for container filling
US8479782B2 (en) 2007-07-11 2013-07-09 Stokely-Van Camp, Inc. Active sterilization zone for container filling
US8511045B2 (en) * 2007-07-11 2013-08-20 Stokely-Van Camp, Inc. Active sterilization zone for container filling
US8567454B2 (en) 2007-07-11 2013-10-29 Stokely-Van Camp, Inc. Active sterilization zone for container filling
US20110023420A1 (en) * 2007-07-11 2011-02-03 Stokely-Van Camp, Inc Active Sterilization Zone for Container Filling
US20090156079A1 (en) * 2007-12-14 2009-06-18 Kimberly-Clark Worldwide, Inc. Antistatic breathable nonwoven laminate having improved barrier properties
WO2009077889A1 (en) 2007-12-14 2009-06-25 Kimberly-Clark Worldwide, Inc. Antistatic breathable nonwoven laminate having improved barrier properties
EP2492202B1 (en) 2008-08-30 2014-12-17 Krones AG Electron beam sterilisation for containers
US20100159195A1 (en) * 2008-12-24 2010-06-24 Quincy Iii Roger B High repellency materials via nanotopography and post treatment
US8293173B2 (en) 2009-04-30 2012-10-23 Hitachi Zosen Corporation Electron beam sterilization apparatus
US20110012032A1 (en) * 2009-04-30 2011-01-20 Michael Lawrence Bufano Electron beam sterilization apparatus
US20110012030A1 (en) * 2009-04-30 2011-01-20 Michael Lawrence Bufano Ebeam sterilization apparatus
WO2011011079A1 (en) 2009-07-22 2011-01-27 Advanced Electron Beams Improved electron beam sterilization apparatus
US9737624B2 (en) 2012-02-28 2017-08-22 Life Technologies Corporation Systems and containers for sterilzing a fluid
US9289522B2 (en) 2012-02-28 2016-03-22 Life Technologies Corporation Systems and containers for sterilizing a fluid

Also Published As

Publication number Publication date Type
FR2140393B1 (en) 1976-08-06 grant
CA961178A (en) 1975-01-14 grant
DE2227059A1 (en) 1972-12-21 application
FR2140393A1 (en) 1973-01-19 application
DE2227059B2 (en) 1978-04-27 application
GB1389061A (en) 1975-04-03 application
DE2227059C3 (en) 1983-12-22 grant
JPS5217469B1 (en) 1977-05-16 grant
CA961178A1 (en) grant

Similar Documents

Publication Publication Date Title
US3494724A (en) Method and apparatus for controlling microorganisms and enzymes
US3490580A (en) Containers and process for asepsis
US4976920A (en) Process for dry sterilization of medical devices and materials
US3676673A (en) Apparatus for irradiation in a controlled atmosphere
US4348357A (en) Plasma pressure pulse sterilization
US5325020A (en) Circular waveguide plasma microwave sterilizer apparatus
US5114670A (en) Process for sterilizing surfaces
US3261140A (en) Microwave sterilization and vacuumizing of products in flexible packages and apparatus therefor
US5603895A (en) Plasma water vapor sterilizer and method
US5843374A (en) Method and apparatus for sterilizing packaging
US6039922A (en) UV radiation and vapor-phase hydrogen peroxide sterilization packaging
US6365102B1 (en) Method of enhanced sterilization with improved material compatibility
US4407846A (en) Method of producing a hydrophilic membrane from a polyethylene base film
US5641423A (en) Radio frequency heating apparatus for rendering medical materials
US5106594A (en) Apparatus for processing medical waste
US4944132A (en) Apparatus for the sterile packaging of contents
US6426507B1 (en) Particle beam processing apparatus
US5609820A (en) Apparatus for rendering medical materials safe
US5084239A (en) Plasma sterilizing process with pulsed antimicrobial agent treatment
US20030086821A1 (en) Apparatus for the treatment and destruction of harmful pathogens enclosed in postal and delivery items
Trump et al. Irradiation of biological materials by high energy roentgen rays and cathode rays
Ansari et al. An overview of sterilization methods for packaging materials used in aseptic packaging systems
US6929040B2 (en) Sterile filling machine having needle filling station within e-beam chamber
US5422074A (en) Methods for treating infectious wastes
US3753651A (en) Method and apparatus for surface sterilization