WO2001004358A3 - Detection of anti-hepatitis b drug resistance - Google Patents

Detection of anti-hepatitis b drug resistance Download PDF

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Publication number
WO2001004358A3
WO2001004358A3 PCT/EP2000/006306 EP0006306W WO0104358A3 WO 2001004358 A3 WO2001004358 A3 WO 2001004358A3 EP 0006306 W EP0006306 W EP 0006306W WO 0104358 A3 WO0104358 A3 WO 0104358A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug resistance
detection
hbv
present
hepatitis
Prior art date
Application number
PCT/EP2000/006306
Other languages
French (fr)
Other versions
WO2001004358A2 (en
Inventor
Lieven Stuyver
Geert Maertens
Geyt Caroline Van
Original Assignee
Innogenetics Nv
Lieven Stuyver
Geert Maertens
Geyt Caroline Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv, Lieven Stuyver, Geert Maertens, Geyt Caroline Van filed Critical Innogenetics Nv
Priority to CA002339422A priority Critical patent/CA2339422A1/en
Priority to EP00951337A priority patent/EP1144693A3/en
Priority to BR0006899-3A priority patent/BR0006899A/en
Priority to AU64317/00A priority patent/AU6431700A/en
Priority to KR1020017003000A priority patent/KR20010075005A/en
Priority to JP2001509556A priority patent/JP2003505021A/en
Publication of WO2001004358A2 publication Critical patent/WO2001004358A2/en
Publication of WO2001004358A3 publication Critical patent/WO2001004358A3/en
Priority to HK02102897.8A priority patent/HK1042928A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a method for the monitoring of anti-HBV drug resistance in a patient by genetic detection of at least one of the mutations L528M, M552V/I and/or V/L/M555I in the DNA polymerase of the HBV strains present in a biological sample of said patient. The present invention provides new HBV DNA polymerase sequences to be used for the design of new probes allowing a very specific and sensitive detection of anti-HBV drug resistance.
PCT/EP2000/006306 1999-07-08 2000-07-05 Detection of anti-hepatitis b drug resistance WO2001004358A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002339422A CA2339422A1 (en) 1999-07-08 2000-07-05 Detection of anti-hepatitis b drug resistance
EP00951337A EP1144693A3 (en) 1999-07-08 2000-07-05 Detection of anti-hepatitis b drug resistance
BR0006899-3A BR0006899A (en) 1999-07-08 2000-07-05 Detection of resistance to anti-hepatitis b drugs
AU64317/00A AU6431700A (en) 1999-07-08 2000-07-05 Detection of anti-hepatitis B drug resistance
KR1020017003000A KR20010075005A (en) 1999-07-08 2000-07-05 Detection of anti-hepatitis b drug resistance
JP2001509556A JP2003505021A (en) 1999-07-08 2000-07-05 Detection of anti-hepatitis B drug resistance
HK02102897.8A HK1042928A1 (en) 1999-07-08 2002-04-17 Detection of anti-hepatitis b drug resistance

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP99870148.6 1999-07-08
EP99870148 1999-07-08
US14354699P 1999-07-13 1999-07-13
US60/143,546 1999-07-13

Publications (2)

Publication Number Publication Date
WO2001004358A2 WO2001004358A2 (en) 2001-01-18
WO2001004358A3 true WO2001004358A3 (en) 2001-08-30

Family

ID=30129296

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/006306 WO2001004358A2 (en) 1999-07-08 2000-07-05 Detection of anti-hepatitis b drug resistance

Country Status (10)

Country Link
EP (1) EP1144693A3 (en)
JP (1) JP2003505021A (en)
CN (1) CN1384888A (en)
AR (1) AR028149A1 (en)
AU (1) AU6431700A (en)
BR (1) BR0006899A (en)
CA (1) CA2339422A1 (en)
TR (2) TR200100689T1 (en)
WO (1) WO2001004358A2 (en)
ZA (1) ZA200101680B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6583279B1 (en) * 2001-01-26 2003-06-24 Becton, Dickinson And Company Sequences and methods for detection of hepatitis B virus
GR1003878B (en) * 2001-03-13 2002-04-24 Γεωργακοπουλος Ελευθεριος Δρ. Plastic vineyard-covering fabric
ATE519861T1 (en) 2002-06-14 2011-08-15 Gen Probe Inc COMPOSITIONS FOR DETECTING HEPATITIS B VIRUS
BR0314259A (en) * 2002-09-13 2005-07-26 Idenix Cayman Ltd ß-l-2'-deoxynucleotides for the treatment of resistant HBV strains and combination therapies
KR100650162B1 (en) * 2003-08-05 2006-11-27 주식회사 진인 Microarray comprising probes for drug-resistant hepatitis B virus detection, quality control and negative control, and Method for detecting drug-resistant hepatitis B virus using the same
EP2094863B1 (en) * 2006-12-18 2014-08-06 Panagene, Inc. Peptide nucleic acid oligomers comprising universal bases, preparation methods thereof, and kits, devices and methods for the analysis, detection or modulation of nucleic acids using the same
JP2008283977A (en) * 2008-06-09 2008-11-27 Toshiba Corp Method for judging genotype and mutation of target nucleic acid, method for immobilizing nucleic acid fragment on insoluble substrate, method for refining and amplifying desired nucleic acid, and genotype assay kit
CN101812537B (en) * 2009-10-27 2012-08-08 重庆医科大学 Method and reagent kit for simultaneously detecting resistance site of three nucleotide analogues of hepatitis B virus
US9045803B2 (en) 2012-02-29 2015-06-02 Abbott Molecular Inc. Hepatitis B virus typing and resistance assay
US20180179542A1 (en) * 2016-11-11 2018-06-28 Alios Biopharma, Inc. OLIGONUCLEOTIDE TARGETING STRATEGY FOR cccDNA
CN109609694B (en) * 2018-12-29 2022-03-01 上海昂朴生物科技有限公司 Kit and method for detecting hepatitis B typing and multiple drug-resistant sites based on Illumina sequencing technology

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995002690A1 (en) * 1993-07-13 1995-01-26 Abbott Laboratories Nucleotide sequences and process for amplifying and detection of hepatitis b virus
US5667974A (en) * 1995-06-07 1997-09-16 Abbott Laboratories Method for detecting nucleic acid sequences using competitive amplification
WO1997040193A2 (en) * 1996-04-19 1997-10-30 Innogenetics N.V. Method for typing and detecting hbv
WO1998021317A1 (en) * 1996-11-08 1998-05-22 Western Health Care Network Viral variants and methods for detecting same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995002690A1 (en) * 1993-07-13 1995-01-26 Abbott Laboratories Nucleotide sequences and process for amplifying and detection of hepatitis b virus
US5667974A (en) * 1995-06-07 1997-09-16 Abbott Laboratories Method for detecting nucleic acid sequences using competitive amplification
WO1997040193A2 (en) * 1996-04-19 1997-10-30 Innogenetics N.V. Method for typing and detecting hbv
WO1998021317A1 (en) * 1996-11-08 1998-05-22 Western Health Care Network Viral variants and methods for detecting same

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
BARTHOLOMEUSZ A ET AL: "MUTATIONS IN THE HEPATITIS B VIRUS POLYMERASE GENE THAT ARE ASSOCIATED WITH RESISTANCE TO FAMCICLOVIR AND LAMIVUDINE", INTERNATIONAL ANTIVIRAL NEWS,GB,CHURCHILL LIVINGSTONE, EDINBURGH, vol. 5, no. 8, 1 January 1997 (1997-01-01), pages 123 - 124, XP002044248, ISSN: 0965-2310 *
DATABASE EMBL EMBL; 6 January 1999 (1999-01-06), "Hepatitis B virus strain 29915 surface antigen (S) gene", XP002163888 *
DATABASE EMBL EMBL; 6 January 1999 (1999-01-06), "Hepatitis B virus strain 3073 surface antigen (S) gene", XP002163890 *
DATABASE EMBL EMBL; 6 January 1999 (1999-01-06), "Hepatitis B virus strain 3074 surface antigen (S) gene", XP002163891 *
DATABASE EMBL EMBL; 6 January 1999 (1999-01-06), "Hepatitis B virus strain 3075 surface antigen (S) gene", XP002163892 *
DATABASE EMBL EMBL; 6 January 1999 (1999-01-06), "Hepatitis B virus strain 3076 surface antigen (S) gene", XP002163889 *
DATABASE EMBL EMBL; 6 January 1999 (1999-01-06), "Hepatitis B virus strain 3077 surface antigen (S) gene", XP002163893 *
DATABASE EMVRL EMBL; 6 January 1999 (1999-01-06), VAN GEYT ET AL.: "A line probe assay for hepatitis B genotypes and applications", XP002129610 *
NIESTERS ET AL: "Identification of more than one mutation in the hepatitis B virus polymerase gene arising during prolonged lamivudine treatment", THE JOURNAL OF INFECTIOUS DISEASES, vol. 177, no. 5, May 1998 (1998-05-01), pages 1382 - 1385, XP000863499 *
PILLAY D ET AL: "MUTATIONS IN THE HEPATITIS B VIRUS DNA POLYMERASE ASSOCIATED WITH ANTIVIRAL RESISTANCE", INTERNATIONAL ANTIVIRAL NEWS,GB,CHURCHILL LIVINGSTONE, EDINBURGH, vol. 6, 1998, pages 167 - 169, XP000863519, ISSN: 0965-2310 *
PREISLER-ADAMS ET AL: "Complete nucleotide sequence of a hepatitis B virus, subtype adw2, and identification of three types of C open reading frame", NUCLEIC ACIDS RESEARCH, vol. 21, no. 9, 1993, pages 2258, XP002129609 *
SCHINAZI ET AL (EDS): "Therapies of viral hepatitis", 1998, INTERNATIONAL MEDICAL PRESS, LONDON UK, XP000863551 *
STUYVER LIEVEN ET AL: "Line probe assay for monitoring drug resistance in hepatitis B virus-infected patients during antiviral therapy.", JOURNAL OF CLINICAL MICROBIOLOGY., vol. 38, no. 2, February 2000 (2000-02-01), pages 702 - 707, XP002154176, ISSN: 0095-1137 *

Also Published As

Publication number Publication date
TR200201797T1 (en) 2003-05-21
EP1144693A3 (en) 2001-11-28
AR028149A1 (en) 2003-04-30
JP2003505021A (en) 2003-02-12
AU6431700A (en) 2001-01-30
CN1384888A (en) 2002-12-11
TR200100689T1 (en) 2002-04-22
BR0006899A (en) 2001-06-12
CA2339422A1 (en) 2001-01-18
EP1144693A2 (en) 2001-10-17
WO2001004358A2 (en) 2001-01-18
ZA200101680B (en) 2003-05-28

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