BR0006899A - Detection of resistance to anti-hepatitis b drugs - Google Patents

Detection of resistance to anti-hepatitis b drugs

Info

Publication number
BR0006899A
BR0006899A BR0006899-3A BR0006899A BR0006899A BR 0006899 A BR0006899 A BR 0006899A BR 0006899 A BR0006899 A BR 0006899A BR 0006899 A BR0006899 A BR 0006899A
Authority
BR
Brazil
Prior art keywords
resistance
drugs
detection
hbv
hepatitis
Prior art date
Application number
BR0006899-3A
Other languages
Portuguese (pt)
Inventor
Lieven Stuyver
Geert Maertens
Caroline Van Geyt
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Publication of BR0006899A publication Critical patent/BR0006899A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"DETECçãO DE RESISTêNCIA A MEDICAMENTOS ANTI-HEPATITE B" A presente invenção se refere a um processo para a monitoração de resistência a medicamentos anti-HBV em um paciente por detecção genética de pelo menos uma das mutações L528M, M552V/I e/ou V/L/M5551 na DNA polimerase das cepas de HBV presentes em uma amostra biológica do paciente. A presente invenção propõe novas seq³ências de DNA polimerase de HBV a serem usadas para a construção de novas sondas que permitem uma detecção muito específica e sensível de resistência a medicamentos anti-HBV."DETECTION OF RESISTANCE TO ANTI-HEPATITIS B DRUGS" The present invention relates to a process for monitoring resistance to anti-HBV drugs in a patient by genetic detection of at least one of the L528M, M552V / I and / or V mutations / L / M5551 in the DNA polymerase of HBV strains present in a biological sample from the patient. The present invention proposes new HBV DNA polymerase sequences to be used for the construction of new probes that allow a very specific and sensitive detection of resistance to anti-HBV drugs.

BR0006899-3A 1999-07-08 2000-07-05 Detection of resistance to anti-hepatitis b drugs BR0006899A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99870148 1999-07-08
US14354699P 1999-07-13 1999-07-13
PCT/EP2000/006306 WO2001004358A2 (en) 1999-07-08 2000-07-05 Detection of anti-hepatitis b drug resistance

Publications (1)

Publication Number Publication Date
BR0006899A true BR0006899A (en) 2001-06-12

Family

ID=30129296

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0006899-3A BR0006899A (en) 1999-07-08 2000-07-05 Detection of resistance to anti-hepatitis b drugs

Country Status (10)

Country Link
EP (1) EP1144693A3 (en)
JP (1) JP2003505021A (en)
CN (1) CN1384888A (en)
AR (1) AR028149A1 (en)
AU (1) AU6431700A (en)
BR (1) BR0006899A (en)
CA (1) CA2339422A1 (en)
TR (2) TR200100689T1 (en)
WO (1) WO2001004358A2 (en)
ZA (1) ZA200101680B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6583279B1 (en) * 2001-01-26 2003-06-24 Becton, Dickinson And Company Sequences and methods for detection of hepatitis B virus
GR1003878B (en) * 2001-03-13 2002-04-24 Γεωργακοπουλος Ελευθεριος Δρ. Plastic vineyard-covering fabric
AU2003253651C1 (en) 2002-06-14 2010-06-03 Gen-Probe Incorporated Compositions and methods for detecting hepatitis B virus
WO2004024095A2 (en) * 2002-09-13 2004-03-25 Idenix (Cayman) Limited ß-L-2'-DEOXYNUCLEOSIDES FOR THE TREATMENT OF RESISTANT HBV STRAINS AND COMBINATION THERAPIES
KR100650162B1 (en) * 2003-08-05 2006-11-27 주식회사 진인 Microarray comprising probes for drug-resistant hepatitis B virus detection, quality control and negative control, and Method for detecting drug-resistant hepatitis B virus using the same
US20100292471A1 (en) * 2006-12-18 2010-11-18 Panagene Inc. Peptide nucleic acid oligomers comprising universal bases,preparation methods thereof, and kits, devices and methods for the analysis, detection or modulation of nucleic acids using the same
JP2008283977A (en) * 2008-06-09 2008-11-27 Toshiba Corp Method for judging genotype and mutation of target nucleic acid, method for immobilizing nucleic acid fragment on insoluble substrate, method for refining and amplifying desired nucleic acid, and genotype assay kit
CN101812537B (en) * 2009-10-27 2012-08-08 重庆医科大学 Method and reagent kit for simultaneously detecting resistance site of three nucleotide analogues of hepatitis B virus
US9045803B2 (en) 2012-02-29 2015-06-02 Abbott Molecular Inc. Hepatitis B virus typing and resistance assay
CA3043637A1 (en) * 2016-11-11 2018-05-17 Janssen Biopharma, Inc. Oligonucleotide targeting strategy for hbv cccdna
CN109609694B (en) * 2018-12-29 2022-03-01 上海昂朴生物科技有限公司 Kit and method for detecting hepatitis B typing and multiple drug-resistant sites based on Illumina sequencing technology

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995002690A1 (en) * 1993-07-13 1995-01-26 Abbott Laboratories Nucleotide sequences and process for amplifying and detection of hepatitis b virus
US5667974A (en) * 1995-06-07 1997-09-16 Abbott Laboratories Method for detecting nucleic acid sequences using competitive amplification
ZA973367B (en) * 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
AUPO351996A0 (en) * 1996-11-08 1996-12-05 Western Health Care Network Viral variants and methods for detecting same

Also Published As

Publication number Publication date
TR200201797T1 (en) 2003-05-21
ZA200101680B (en) 2003-05-28
AU6431700A (en) 2001-01-30
TR200100689T1 (en) 2002-04-22
JP2003505021A (en) 2003-02-12
WO2001004358A2 (en) 2001-01-18
WO2001004358A3 (en) 2001-08-30
CA2339422A1 (en) 2001-01-18
CN1384888A (en) 2002-12-11
EP1144693A3 (en) 2001-11-28
AR028149A1 (en) 2003-04-30
EP1144693A2 (en) 2001-10-17

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Legal Events

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