TR200201797T1 - Detection of anti-hepaptit B drug resistance - Google Patents

Detection of anti-hepaptit B drug resistance

Info

Publication number
TR200201797T1
TR200201797T1 TR2002/01797T TR200201797T TR200201797T1 TR 200201797 T1 TR200201797 T1 TR 200201797T1 TR 2002/01797 T TR2002/01797 T TR 2002/01797T TR 200201797 T TR200201797 T TR 200201797T TR 200201797 T1 TR200201797 T1 TR 200201797T1
Authority
TR
Turkey
Prior art keywords
drug resistance
detection
hbv
hepaptit
patient
Prior art date
Application number
TR2002/01797T
Other languages
Turkish (tr)
Inventor
Stuyver Lieven
Van Geyt Caroline
Original Assignee
Innogenetics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics N.V. filed Critical Innogenetics N.V.
Publication of TR200201797T1 publication Critical patent/TR200201797T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Bir mevcut bulus, bir hastadaki anti-HBV ilaci direncinin, bu hastadaki bir biyolojik örnekte bulunan HBV irklarinin DNA polimerazindaki L528M, M552V/I ve/veya V/L/M555I mutasyonlarindan en azindan birinin genetik saptanmasi sayesinde görüntülenmesi için olan bir metot ile ilgilidir. Mevcut bulus anti-HBV ilacinin direncinin çok belirgin ve duyarli bir saptanmasina olanak tasiyan yeni sondalarin tasarimi için kullanilan yeni HBV DNA polimeraz sekanslarini saglamaktadir.A present invention relates to a method for imaging anti-HBV drug resistance in a patient by genetic detection of at least one of the L528M, M552V / I and / or V / L / M555I mutations in the DNA polymerase of HBV breeds in a biological sample in this patient. The present invention provides new HBV DNA polymerase sequences used for the design of new probes, which allow a very specific and sensitive detection of anti-HBV drug resistance.

TR2002/01797T 1999-07-08 2000-07-05 Detection of anti-hepaptit B drug resistance TR200201797T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99870148 1999-07-08
US14354699P 1999-07-13 1999-07-13

Publications (1)

Publication Number Publication Date
TR200201797T1 true TR200201797T1 (en) 2003-05-21

Family

ID=30129296

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2001/00689T TR200100689T1 (en) 1999-07-08 2000-07-05 Detection of anti-hepatitis B drug resistance
TR2002/01797T TR200201797T1 (en) 1999-07-08 2000-07-05 Detection of anti-hepaptit B drug resistance

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2001/00689T TR200100689T1 (en) 1999-07-08 2000-07-05 Detection of anti-hepatitis B drug resistance

Country Status (10)

Country Link
EP (1) EP1144693A3 (en)
JP (1) JP2003505021A (en)
CN (1) CN1384888A (en)
AR (1) AR028149A1 (en)
AU (1) AU6431700A (en)
BR (1) BR0006899A (en)
CA (1) CA2339422A1 (en)
TR (2) TR200100689T1 (en)
WO (1) WO2001004358A2 (en)
ZA (1) ZA200101680B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6583279B1 (en) * 2001-01-26 2003-06-24 Becton, Dickinson And Company Sequences and methods for detection of hepatitis B virus
GR1003878B (en) * 2001-03-13 2002-04-24 Γεωργακοπουλος Ελευθεριος Δρ. Plastic vineyard-covering fabric
WO2003106714A1 (en) 2002-06-14 2003-12-24 Gen-Probe Incorporated Compositions and methods for detecting hepatitis b virus
BR0314259A (en) 2002-09-13 2005-07-26 Idenix Cayman Ltd ß-l-2'-deoxynucleotides for the treatment of resistant HBV strains and combination therapies
KR100650162B1 (en) * 2003-08-05 2006-11-27 주식회사 진인 Microarray comprising probes for drug-resistant hepatitis B virus detection, quality control and negative control, and Method for detecting drug-resistant hepatitis B virus using the same
US20100292471A1 (en) * 2006-12-18 2010-11-18 Panagene Inc. Peptide nucleic acid oligomers comprising universal bases,preparation methods thereof, and kits, devices and methods for the analysis, detection or modulation of nucleic acids using the same
JP2008283977A (en) * 2008-06-09 2008-11-27 Toshiba Corp Method for judging genotype and mutation of target nucleic acid, method for immobilizing nucleic acid fragment on insoluble substrate, method for refining and amplifying desired nucleic acid, and genotype assay kit
CN101812537B (en) * 2009-10-27 2012-08-08 重庆医科大学 Method and reagent kit for simultaneously detecting resistance site of three nucleotide analogues of hepatitis B virus
US9045803B2 (en) 2012-02-29 2015-06-02 Abbott Molecular Inc. Hepatitis B virus typing and resistance assay
JP2019533472A (en) * 2016-11-11 2019-11-21 ヤンセン バイオファーマ インク． Oligonucleotide targeting strategy of HBV CCCDNA
CN109609694B (en) * 2018-12-29 2022-03-01 上海昂朴生物科技有限公司 Kit and method for detecting hepatitis B typing and multiple drug-resistant sites based on Illumina sequencing technology

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0785996A1 (en) * 1993-07-13 1997-07-30 Abbott Laboratories Nucleotide sequences and process for amplifying and detection of hepatitis b virus
US5667974A (en) * 1995-06-07 1997-09-16 Abbott Laboratories Method for detecting nucleic acid sequences using competitive amplification
ZA973367B (en) * 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
AUPO351996A0 (en) * 1996-11-08 1996-12-05 Western Health Care Network Viral variants and methods for detecting same

Also Published As

Publication number Publication date
TR200100689T1 (en) 2002-04-22
AU6431700A (en) 2001-01-30
EP1144693A2 (en) 2001-10-17
BR0006899A (en) 2001-06-12
ZA200101680B (en) 2003-05-28
WO2001004358A2 (en) 2001-01-18
EP1144693A3 (en) 2001-11-28
AR028149A1 (en) 2003-04-30
CA2339422A1 (en) 2001-01-18
CN1384888A (en) 2002-12-11
WO2001004358A3 (en) 2001-08-30
JP2003505021A (en) 2003-02-12

Similar Documents

Publication Publication Date Title
Racanelli et al. Molecular characterization of B cell clonal expansions in the liver of chronically hepatitis C virus-infected patients
TR200201797T1 (en) Detection of anti-hepaptit B drug resistance
Giraud et al. DNA from BK virus and JC virus and from KI, WU, and MC polyomaviruses as well as from simian virus 40 is not detected in non-UV-light-associated primary malignant melanomas of mucous membranes
PT1026262E (en) Oligonucleotide primers for efficient detection of hepatitis c virus (hcv) and methods of use thereof
BR9916840A (en) Integrated portable biological detection system
ATE454468T1 (en) DETECTION OF THE INSTABILITY OF MICROSATELLITES AND USE THEREOF IN TUMOR DIAGNOSIS
DK0991421T3 (en) Detection and modulation of IAPs and NAIP in the diagnosis and treatment of proliferative disease
ATE515575T1 (en) METHODS AND PROBE FOR DETECTING CANCER
EP1687609A4 (en) Fluorescent probes for dna detection by hybridization with improved sensitivity and low background
WO2000043791A3 (en) Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
EP0774515A3 (en) Fluorescence polarization detection of nucleic acids
DE69737628D1 (en) NUCLEIC ACID PRIMERS AND SENSORS FOR DETECTING ONCOCKEN HUMAN PAPILLOMA VIRUSES
DK2038430T3 (en) Toll-Like-Receptor-4 dysfunction and its biological applications
ATE321886T1 (en) OLIGONUCLEOTIDES AND COMPLEXES CONTAINING SAME FOR DETECTING THE PRESENCE OR ABSENCE OF A TARGET NUCLEIC ACID IN A SAMPLE
ATE418072T1 (en) METHOD FOR DIAGNOSIS OF CERVICAL CANCER
ES2188997T3 (en) DETECTION AND IDENTIFICATION OF ENTEROVIRUS NO POLIOVIRUS.
ATE349533T1 (en) COMPOSITION FOR THE DIAGNOSIS AND TREATMENT OF HERPES SIMPLEX VIRUS INFECTIONS
RU2422536C1 (en) SET OF SYNTHETIC OLIGONUCLEOTIDES FOR DNA IDENTIFICATION IN BLOOD AND OTHER BIOMATERIALS OF INFECTIOUS AGENT OF LATENT VIRAL INFECTION VIRUS Torque teno virus OF Circoviridae FAMILY BY POLYMERASE CHAIN REACTION
ATE376066T1 (en) METHOD FOR ESTIMATING SENSITIVITY TO OSTEOPOROSIS DRUGS
ES2141094T3 (en) DIRECT DETECTION OF THE HEPATITIS C VIRUS RNA
MXPA02000293A (en) Cyclic amp phosphodiesterase isoforms and methods of use.
DE60025336D1 (en) METHOD AND KIT FOR EARLY DETECTION OF CANCER
WO2003104487A3 (en) Detection of epigenetic abnormalities and diagnostic method based thereon
ATE414794T1 (en) AMPLIFICATION OF HIV-1 SEQUENCES FOR DETECTION OF SEQUENCES ASSOCIATED WITH DRUG RESISTANCE MUTATIONS
MY128619A (en) Detection of human hepatitis b virus surface antigen mutants by specific amplification and its application on gene chip