WO2007084567A3 - Detection and discrimination of hepatitis c virus, human immunodeficiency virus type-1 and hepatitis b virus - Google Patents

Detection and discrimination of hepatitis c virus, human immunodeficiency virus type-1 and hepatitis b virus Download PDF

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Publication number
WO2007084567A3
WO2007084567A3 PCT/US2007/001241 US2007001241W WO2007084567A3 WO 2007084567 A3 WO2007084567 A3 WO 2007084567A3 US 2007001241 W US2007001241 W US 2007001241W WO 2007084567 A3 WO2007084567 A3 WO 2007084567A3
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WO
WIPO (PCT)
Prior art keywords
hepatitis
virus
geq
arrays
human immunodeficiency
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Application number
PCT/US2007/001241
Other languages
French (fr)
Other versions
WO2007084567A2 (en
Inventor
Chu Chieh Hsia
Gerardo Kaplan
Vladimir E Chizhikov
Angamurhu Selvapandiyan
Amy X Yang
Hira Nakhasi
Raj K Puri
Original Assignee
Us Gov Health & Human Serv
Chu Chieh Hsia
Gerardo Kaplan
Vladimir E Chizhikov
Angamurhu Selvapandiyan
Amy X Yang
Hira Nakhasi
Raj K Puri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Us Gov Health & Human Serv, Chu Chieh Hsia, Gerardo Kaplan, Vladimir E Chizhikov, Angamurhu Selvapandiyan, Amy X Yang, Hira Nakhasi, Raj K Puri filed Critical Us Gov Health & Human Serv
Publication of WO2007084567A2 publication Critical patent/WO2007084567A2/en
Publication of WO2007084567A3 publication Critical patent/WO2007084567A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • AIDS & HIV (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present disclosure provides isolated nucleic acid primers and probes that can be used to detect hepatitis B (HBV), hepatitis C (HCV), human immunodeficiency virus type 1 (HIV-I), or combinations thereof (for example simultaneously), in a biological sample. In particular examples, the disclosed methods can discriminate 3-10 genomic equivalents (gEq) of HBV, 10-20 gEq of HCV, and 20 gEq of HIV-I. Also provided are arrays that include the viral-specific probes, as well as kits that include the isolated nucleic acid primers, probes, arrays, or combinations thereof. The method and arrays can be used for example, for diagnosis of these viruses in clinics and in high-risk groups, as discriminatory confirmation assay in screening of blood donors, and in research laboratories.
PCT/US2007/001241 2006-01-17 2007-01-17 Detection and discrimination of hepatitis c virus, human immunodeficiency virus type-1 and hepatitis b virus WO2007084567A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75921406P 2006-01-17 2006-01-17
US60/759,214 2006-01-17

Publications (2)

Publication Number Publication Date
WO2007084567A2 WO2007084567A2 (en) 2007-07-26
WO2007084567A3 true WO2007084567A3 (en) 2007-12-13

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PCT/US2007/001241 WO2007084567A2 (en) 2006-01-17 2007-01-17 Detection and discrimination of hepatitis c virus, human immunodeficiency virus type-1 and hepatitis b virus

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WO (1) WO2007084567A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034841B2 (en) 2011-04-21 2015-05-19 Isis Pharmaceuticals, Inc. Modulation of hepatitis B virus (HBV) expression

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101182585B (en) * 2007-12-12 2010-06-09 博奥生物有限公司 Method for identifying HBV gene mutation type, special chip and reagent kit
EP2098599A1 (en) * 2008-03-05 2009-09-09 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Composition comprising an oligonucleotide mixture for the detection of contaminations in cell cultures
WO2012002594A1 (en) * 2010-07-01 2012-01-05 (주)바이오니아 Diagnostic primer for the hepatitis c virus, probe, kit including same, and method for diagnosing the hepatitis c virus using the kit
ES2659747T3 (en) * 2012-10-18 2018-03-19 F. Hoffmann-La Roche Ag Double probe assay for the detection of heterogeneous amplicon populations
US11274998B2 (en) 2012-12-26 2022-03-15 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
CN105861743B (en) * 2016-03-21 2019-08-16 珠海丽珠试剂股份有限公司 A kind of kit and detection method for being used to detect hepatitis C virus nucleic acid of containing the internal standard
TWI625395B (en) * 2016-09-10 2018-06-01 旭基科技股份有限公司 Kit for simultaneously detecting and quantifying four blood-borne viruses by a multiplex taqman probes quantitative pcr assay
CN107287348A (en) * 2017-06-19 2017-10-24 广州和实生物技术有限公司 A kind of blood sieves three polychrome single tube detection kits
CN107653344A (en) * 2017-10-13 2018-02-02 杭州迪安医学检验中心有限公司 A kind of nucleotide sequence and kit for HCV detection

Citations (12)

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Publication number Priority date Publication date Assignee Title
EP0521318A2 (en) * 1991-06-10 1993-01-07 Lucky Ltd. Hepatitis C diagnostics and vaccines
CA2104649A1 (en) * 1992-08-25 1994-02-26 Makoto Seki Antisense compounds complementary to hcv genome
JPH07184695A (en) * 1993-12-27 1995-07-25 Sanwa Kagaku Kenkyusho Co Ltd Method for simply detecting hepatitis c virus
US5593836A (en) * 1993-05-14 1997-01-14 Niemiec; John T. Primers and probes for detecting Pneumocystis carinii
US5780219A (en) * 1989-07-11 1998-07-14 Gen-Probe Incorporated Nucleic acid amplification oligonucleotides and probes to human hepatitis B virus
US6001990A (en) * 1994-05-10 1999-12-14 The General Hospital Corporation Antisense inhibition of hepatitis C virus
WO2000009745A1 (en) * 1998-08-13 2000-02-24 Canadian Blood Services Primer-specific and mispair extension assay for identifying gene variation
WO2000046403A2 (en) * 1999-02-03 2000-08-10 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OFHEALT H AND HUMAN SERVICES Methods and reagents for molecular detection of hiv-1 groups m, n and o
WO2001036442A1 (en) * 1999-11-17 2001-05-25 Jiuping Ji Simultaneous detection of hbv, hcv and hiv in plasma samples using a multiplex capture assay
JP2002233385A (en) * 2001-02-09 2002-08-20 Fujirebio Inc Method for amplifying nucleic acid and primer- immobilized carrier used for the same
US20030206887A1 (en) * 1992-05-14 2003-11-06 David Morrissey RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
WO2003106714A1 (en) * 2002-06-14 2003-12-24 Gen-Probe Incorporated Compositions and methods for detecting hepatitis b virus

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780219A (en) * 1989-07-11 1998-07-14 Gen-Probe Incorporated Nucleic acid amplification oligonucleotides and probes to human hepatitis B virus
EP0521318A2 (en) * 1991-06-10 1993-01-07 Lucky Ltd. Hepatitis C diagnostics and vaccines
US20030206887A1 (en) * 1992-05-14 2003-11-06 David Morrissey RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
CA2104649A1 (en) * 1992-08-25 1994-02-26 Makoto Seki Antisense compounds complementary to hcv genome
US5593836A (en) * 1993-05-14 1997-01-14 Niemiec; John T. Primers and probes for detecting Pneumocystis carinii
JPH07184695A (en) * 1993-12-27 1995-07-25 Sanwa Kagaku Kenkyusho Co Ltd Method for simply detecting hepatitis c virus
US6001990A (en) * 1994-05-10 1999-12-14 The General Hospital Corporation Antisense inhibition of hepatitis C virus
WO2000009745A1 (en) * 1998-08-13 2000-02-24 Canadian Blood Services Primer-specific and mispair extension assay for identifying gene variation
WO2000046403A2 (en) * 1999-02-03 2000-08-10 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OFHEALT H AND HUMAN SERVICES Methods and reagents for molecular detection of hiv-1 groups m, n and o
WO2001036442A1 (en) * 1999-11-17 2001-05-25 Jiuping Ji Simultaneous detection of hbv, hcv and hiv in plasma samples using a multiplex capture assay
JP2002233385A (en) * 2001-02-09 2002-08-20 Fujirebio Inc Method for amplifying nucleic acid and primer- immobilized carrier used for the same
WO2003106714A1 (en) * 2002-06-14 2003-12-24 Gen-Probe Incorporated Compositions and methods for detecting hepatitis b virus

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DINEVA MAGDA ANASTASSOVA ET AL: "Simultaneous visual detection of multiple viral amplicons by dipstick assay.", JOURNAL OF CLINICAL MICROBIOLOGY AUG 2005, vol. 43, no. 8, August 2005 (2005-08-01), pages 4015 - 4021, XP002449306, ISSN: 0095-1137 *
GONZALEZ-VILLASENOR L I ET AL: "MULTIPLEX RT-PCR BASED TEST FOR HTLV-I/II, HIV-1, HCV AND HBV", CLINICAL CHEMISTRY, vol. 41, no. 11, 1995, pages 9, XP001002366, ISSN: 0009-9147 *
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034841B2 (en) 2011-04-21 2015-05-19 Isis Pharmaceuticals, Inc. Modulation of hepatitis B virus (HBV) expression
US9127278B2 (en) 2011-04-21 2015-09-08 Isis Pharmaceuticals, Inc. Modulation of hepatitis B virus (HBV) expression

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