WO2001003650A2 - Agent conservateur destine a des preparations perissables, notamment des preparations cosmetiques et pharmaceutiques - Google Patents

Agent conservateur destine a des preparations perissables, notamment des preparations cosmetiques et pharmaceutiques Download PDF

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Publication number
WO2001003650A2
WO2001003650A2 PCT/DE2000/002231 DE0002231W WO0103650A2 WO 2001003650 A2 WO2001003650 A2 WO 2001003650A2 DE 0002231 W DE0002231 W DE 0002231W WO 0103650 A2 WO0103650 A2 WO 0103650A2
Authority
WO
WIPO (PCT)
Prior art keywords
weight
glass
preparations
bioactive
bioactive glass
Prior art date
Application number
PCT/DE2000/002231
Other languages
German (de)
English (en)
Other versions
WO2001003650A3 (fr
Inventor
Susanne Kessler
Sean Lee
Original Assignee
Schott Glas
Carl-Zeiss-Stiftung Trading As Schott Glas
Carl-Zeiss-Stiftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020017016668A priority Critical patent/KR20020020753A/ko
Priority to US10/030,278 priority patent/US7628997B1/en
Priority to JP2001508934A priority patent/JP2003504317A/ja
Priority to AT00956075T priority patent/ATE500812T1/de
Priority to MXPA01013165A priority patent/MXPA01013165A/es
Priority to CA002374395A priority patent/CA2374395A1/fr
Priority to PL00352469A priority patent/PL352469A1/xx
Application filed by Schott Glas, Carl-Zeiss-Stiftung Trading As Schott Glas, Carl-Zeiss-Stiftung filed Critical Schott Glas
Priority to DE50016076T priority patent/DE50016076D1/de
Priority to AU68184/00A priority patent/AU780131B2/en
Priority to NZ516136A priority patent/NZ516136A/xx
Priority to BR0012330-7A priority patent/BR0012330A/pt
Priority to IL14730500A priority patent/IL147305A0/xx
Priority to EP00956075A priority patent/EP1194113B1/fr
Priority to DE10081907T priority patent/DE10081907D2/de
Priority to SK1874-2001A priority patent/SK18742001A3/sk
Publication of WO2001003650A2 publication Critical patent/WO2001003650A2/fr
Publication of WO2001003650A3 publication Critical patent/WO2001003650A3/fr
Priority to NO20020082A priority patent/NO20020082L/no
Priority to HK02108546.0A priority patent/HK1046868A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A61Q1/06—Lipsticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C3/00—Glass compositions
    • C03C3/04—Glass compositions containing silica
    • C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C3/00—Glass compositions
    • C03C3/04—Glass compositions containing silica
    • C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
    • C03C3/097—Glass compositions containing silica with 40% to 90% silica, by weight containing phosphorus, niobium or tantalum
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C3/00—Glass compositions
    • C03C3/04—Glass compositions containing silica
    • C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
    • C03C3/11—Glass compositions containing silica with 40% to 90% silica, by weight containing halogen or nitrogen
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C4/00—Compositions for glass with special properties
    • C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/524—Preservatives

Definitions

  • the invention relates to preservatives and their use for the preservation of perishable preparations, in particular of cosmetic and pharmaceutical compositions.
  • GMP Good Manufacturing Practice
  • bioactive glass for oral care.
  • toothpastes are known which bring about the remineralization of the teeth.
  • US-A-5, 834, 008 describes the use of bioglass for wound healing.
  • non-healing, ulcerating wounds, especially in diabetics, and stroke patients can be healed by the application of such types of glass.
  • J. Allen, H. Neumann and M. Wilson describe the inhibition of bacterial colonization by Bioglas ® 45S5 with a grain size of 355 - 500 ⁇ m, whereby normal glass beads (window glass) with a comparable grain size of 455 - 600 ⁇ m show no antibacterial effect.
  • bioactive glass differs from conventional lime sodium silicate - glasses in that it binds living tissue.
  • Bioactive glass is available, for example, under the name “Bioglas ® " from USBiomaterials Corp. Alachua, Fl 32615, USA available and designates a glass that shows a special biological reaction in contact with an organism. When it encounters body fluid, it exchanges ions with it. During the ion exchange, sodium and calcium ions are released, which form a layer of silica gel on the glass within a few minutes, which causes the formation of a hydroxy carbonate apatite layer and which is identical to the mineral phase of the bone. The hydroxy carbonate apatite is formed thereon or cells produce collagen, which is embedded in this layer.
  • bioglass causes the formation or release of the anti-inflammatory hormone interleukin 6 (IL 6) and suppresses the inflammatory cytokines TNF- ⁇ , IL-1- ⁇ and IL-10.
  • IL 6 interleukin 6
  • the aim of the invention is now to provide a preservative which, in contrast to the previously known agents, has no negative effects when applied, in particular when applied to the skin.
  • Bioactive glasses have long been known and are summarized, for example, by Larry L. Hench and John K. West in “Biological Applications of Bioactive Glasses”, Life Chemistry Reports 1996, vol. 13, p. 187-241 or in” An Introduction to Bioceramics ", L. Hench and J. Wilson, eds. World Scientific, New Jersey (1993).
  • Bioactive glasses are distinguished In contrast to conventional glasses, they are soluble in an aqueous medium and form a layer of hydroxylapatite on their surface.
  • the most common bioactive glasses are either manufactured as melting glass, which then has a significantly lower proportion of SiO 2 and one than normal window or bottle glasses have a significantly higher proportion of sodium or they are so-called sol-gel glasses which, in contrast to melting glasses, can then contain a high proportion of silicon oxide and a low to no proportion of sodium.
  • Bioactive silicon-containing glass or bioactive glass refers to a material comprising silicon oxide or silicon hydroxide, which material enables the formation and transfer of SiOH groups.
  • Bioactive silicon-containing glass can therefore be, for example, a bioactive glass composed of a mixture of silicon oxide or silicon hydroxide with one or more elements from the group comprising sodium, potassium, calcium, magnesium, boron, titanium, aluminum and anions containing nitrogen, phosphorus and fluorine.
  • it can be, for example, sodium silicates of the water glass type or silica gels and solutions containing SiOH groups, or silicon oxides or silicon hydroxides comprising hydroxyapatite and silica gel which contains calcium and phosphorus.
  • bioactive glasses contained according to the invention are preferably a conventional bioactive glass, which is well known to the person skilled in the art. Such glasses usually contain SiO 2 , a high proportion of Na 2 0 and CaO as well as phosphorus, namely in a high molar ratio of calcium to phosphorus, which mostly, but not necessarily, is about 5.
  • bioactive glasses come into contact with water or a body fluid, then they are characterized by special reactions, namely sodium and calcium ions of the glass are replaced by H + ions from the solution in the form of a cation exchange reaction, resulting in a silanol -Groups having surface arises, on which sodium and calcium hydroxide attach.
  • the increase in the concentration of hydroxy ions now leads to a further reaction with the Si0 2 network on the glass surface, as a result of which further silanol groups are formed which can also lie deeper in the glass.
  • CaO and P 2 0 5 Due to the high alkaline pH in the interspace between the glass, CaO and P 2 0 5 form a mixed hydroxyapatite phase, which crystallizes on the Si0 2 surface and binds in biological materials with mucopolysaccharides, collagens and glycoproteins.
  • the molar ratio of calcium to phosphorus is preferably> 2 and in particular> 3 and is preferably ⁇ 30, in particular ⁇ 20, with ratios of ⁇ 10 being particularly preferred.
  • Preservatives which contain bioactive glass particles which contain SiO 2 / CaO, Na 2 O, P 2 O 5 , CaF 2 , B 2 O 3 , K 2 O, and / or MgO are particularly preferred. If the cleaning agent contains bioactive glass particles from melting glass, then they preferably based on the total weight of glass 40-60% by weight of Si0 2, 10 -. 30% by weight CaO, 10 -. 35% by weight Na 2 0, 2 -.. 8 weight% P 2 0 5, 0 - 25% by weight CaF 2 , 0 - 10% by weight B 2 0 3 , 0 - 8% by weight K 2 0, and or 0 - 5% by weight % MgO.
  • the upper limit of silicon dioxide contained is 60, preferably 55% by weight, an upper limit of 50% by weight being particularly preferred.
  • the sodium oxide content is preferably more than 15% by weight, in particular more than 18% by weight.
  • a sodium oxide content of> 20% by weight is particularly preferred.
  • bioactive glass contained in the preservative according to the invention is a bioactive glass produced by means of the sol-gel process
  • its silicon dioxide content can be significantly higher than in melting glasses and its sodium oxide content can be zero.
  • Bioactive glasses produced using a sol-gel process preferably contain 40 to 90% by weight of SiO 2 , 4 to 45% by weight of CaO, 0 to 10% by weight of Na 2 0, 2 to 16% by weight of P 2 0 5 , 0 to 25% by weight CaF 2 , 0 to 4% by weight B 2 0 3 , 0 to 8% by weight K 2 0 and / or 0 to 5% by weight MgO.
  • the content of phosphorus oxide in both of the types of bioactive glasses described above is preferably at least 2% by weight, in particular at least 4% by weight.
  • the soluble bioactive glass has no toxic metal cations such as Ag + , Cu 2+ , Cu + and / or Zn 2+ etc. or does not release such in toxic concentrations.
  • toxic metal cations such as Ag + , Cu 2+ , Cu + and / or Zn 2+ etc.
  • Bioactive glass itself is a material that has a more or less round shape, such as sand.
  • Such particles can have a size of up to about 0.5-1 mm, but are preferably much smaller.
  • Usual particle sizes are ⁇ 400 ⁇ m and in particular ⁇ 200 ⁇ m, particle sizes ⁇ 100 ⁇ m, preferably 90 90 ⁇ m, and in particular ⁇ 60 ⁇ m or ⁇ 20 ⁇ m have proven to be particularly expedient.
  • a preferred grain size has a diameter dso of ⁇ 10 ⁇ m, preferably ⁇ 5 ⁇ m, in particular ⁇ 2 ⁇ m. The higher the ratio of surface to weight or volume, the higher the biocidal effect of the particles.
  • bioactive glass is used for the preservation of cosmetic preparations.
  • Preferred cosmetic preparations are in particular creams, make-up agents, lipsticks and lotions and ointments. The moisture contained in the preparations further promotes the microbiocidal effect of bioactive glass.
  • the biocidal preservative according to the invention is preferably contained in an amount of up to 25% by weight, in particular up to 10% by weight, based on the solids content of the preparation to be preserved.
  • upper limits of 7% by weight or 5% by weight are preferred, 3% by weight being particularly preferred.
  • Lower limit values are 0.01% by weight, in particular 0.1% by weight, with 0.5% by weight or 1% by weight is particularly preferred as the lower effective amount.
  • bioactive glass can be used to excellently preserve such preparations without the need to add skin-irritating cytotoxic and possibly allergenic chemical preservatives.
  • an additional care effect is achieved through the healing, especially anti-inflammatory effect of bioactive glass.
  • preservative according to the invention may also be desirable to add the preservative according to the invention to preparations which are preserved by means of conventional preservatives in order to achieve synergistic effects.
  • the preservative is preferably used in proton-containing solvents, in particular in aqueous and / or in alcoholic solvents.
  • preservatives in aprotic solvents, provided that the environment there enables the release of the soluble cations of the glass.
  • Preferred aprotic solvents are ketones such as acetone, fats, waxes, oils and corresponding liquid or solid hydrocarbons.
  • the preservative according to the invention is also particularly suitable for the preservation of water-in-oil and oil-in-water emulsions.
  • liquid cosmetic preparations whose alcohol content is insufficient for preservation can be preserved using bioactive glass. It is preferred to use a glass whose refractive index is the same corresponds to the liquid. In this way, the added glass becomes "invisible" to the user. However, it is also possible to consciously make the glass visible in a desired manner in order to achieve cosmetic effects, for example by coloring.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Ceramic Engineering (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Glass Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un agent conservateur qui contient un verre bioactif. L'agent conservateur selon l'invention est utilisé, de préférence, pour la conservation de préparations cosmétiques et pharmaceutiques, notamment des crèmes, lotions, rouge à lèvres, compositions de maquillage et/ou teintures.
PCT/DE2000/002231 1999-07-09 2000-07-07 Agent conservateur destine a des preparations perissables, notamment des preparations cosmetiques et pharmaceutiques WO2001003650A2 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
EP00956075A EP1194113B1 (fr) 1999-07-09 2000-07-07 Utilisation d'un verre bioactif en tant qu'agent conservateur pour préparations cosmétiques et pharmaceutiques
JP2001508934A JP2003504317A (ja) 1999-07-09 2000-07-07 腐敗しやすい製品、特に化粧品及び医薬品配合物のための防腐剤
AT00956075T ATE500812T1 (de) 1999-07-09 2000-07-07 Verwendung von bioaktivem glas zur konservierung von kosmetischen und pharmazeutischen präparaten
MXPA01013165A MXPA01013165A (es) 1999-07-09 2000-07-07 Conservadores para preparados perecederos, en particular para preparados cosmeticos y farmaceuticos.
CA002374395A CA2374395A1 (fr) 1999-07-09 2000-07-07 Agent conservateur destine a des preparations perissables, notamment des preparations cosmetiques et pharmaceutiques
PL00352469A PL352469A1 (en) 1999-07-09 2000-07-07 Preservative for perishable pharmacological and cosmetic preparations
NZ516136A NZ516136A (en) 1999-07-09 2000-07-07 Preservatives for perishable preparations, in particular for cosmetic and pharmaceutical preparations
DE50016076T DE50016076D1 (de) 1999-07-09 2000-07-07 Verwendung von bioaktivem Glas zur Konservierung von kosmetischen und pharmazeutischen Präparaten
AU68184/00A AU780131B2 (en) 1999-07-09 2000-07-07 Preservatives for perishable preparations, in particular for cosmetic and pharmaceutical preparations
KR1020017016668A KR20020020753A (ko) 1999-07-09 2000-07-07 부패성 조제물, 특히 미용 및 제약조제물을 위한 방부제
BR0012330-7A BR0012330A (pt) 1999-07-09 2000-07-07 Preservativo para preparações perecìveis, particularmente para formulações cosméticas e farmacêuticas
IL14730500A IL147305A0 (en) 1999-07-09 2000-07-07 Preservatives containing bioactive glass
US10/030,278 US7628997B1 (en) 1999-07-09 2000-07-07 Preservatives for perishable preparations, in particular for cosmetic and pharmaceutical preparations
DE10081907T DE10081907D2 (de) 1999-07-09 2000-07-07 Konservierungsmittel für verderbliche Präparate, insbesondere für kosmetische und pharmazeutische Zubereitungen
SK1874-2001A SK18742001A3 (sk) 1999-07-09 2000-07-07 Konzervačný prostriedok do prípravkov, ktoré podliehajú skaze, najmä do kozmetických a farmaceutických prípravkov
NO20020082A NO20020082L (no) 1999-07-09 2002-01-08 Preserveringsmiddel for fordervelige preparater, s¶rlig for kosmetiske og farmasöytiske formuleringer
HK02108546.0A HK1046868A1 (zh) 1999-07-09 2002-11-26 用於易腐製劑，特別是化妝和藥物製劑的防腐劑

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19932239.2 1999-07-09
DE19932239 1999-07-09

Publications (2)

Publication Number Publication Date
WO2001003650A2 true WO2001003650A2 (fr) 2001-01-18
WO2001003650A3 WO2001003650A3 (fr) 2001-09-27

Family

ID=7914299

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/002231 WO2001003650A2 (fr) 1999-07-09 2000-07-07 Agent conservateur destine a des preparations perissables, notamment des preparations cosmetiques et pharmaceutiques

Country Status (23)

Country Link
US (1) US7628997B1 (fr)
EP (1) EP1194113B1 (fr)
JP (1) JP2003504317A (fr)
KR (1) KR20020020753A (fr)
CN (1) CN1360491A (fr)
AT (1) ATE500812T1 (fr)
AU (1) AU780131B2 (fr)
BR (1) BR0012330A (fr)
CA (1) CA2374395A1 (fr)
CZ (1) CZ20014627A3 (fr)
DE (2) DE10081907D2 (fr)
ES (1) ES2360594T3 (fr)
HK (1) HK1046868A1 (fr)
HU (1) HUP0201821A2 (fr)
IL (1) IL147305A0 (fr)
MX (1) MXPA01013165A (fr)
NO (1) NO20020082L (fr)
NZ (1) NZ516136A (fr)
PL (1) PL352469A1 (fr)
SK (1) SK18742001A3 (fr)
TR (1) TR200103723T2 (fr)
WO (1) WO2001003650A2 (fr)
ZA (1) ZA200200155B (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1272144A2 (fr) * 2000-03-27 2003-01-08 Schott Glas Nouvelles compositions de produits cosmetiques, d'hygiene personnelle, d'agents de nettoyage et de supplements nutritionnels contenant du verre bioactif, et procedes de fabrication et d'utilisation de ces dernieres
WO2003050052A1 (fr) 2001-12-12 2003-06-19 Schott Glas Vitroceramique anti-inflammatoire, antimicrobienne et absorbant les rayons ultraviolets
WO2003050051A1 (fr) * 2001-12-12 2003-06-19 Schott Glas Vitroceramique alcali-silicate antimicrobienne et son utilisation
WO2003062163A2 (fr) 2002-01-24 2003-07-31 Schott Glas Poudre de verre de silicate antimicrobienne, insoluble dans l'eau et melange de poudres de verre
WO2004076370A1 (fr) * 2003-02-25 2004-09-10 Schott Ag Verre phosphate antimicrobien
EP1498395A1 (fr) * 2003-07-14 2005-01-19 Schott AG Utilisation d'une composition vitreuse pour obtenir un effet antioxydant
DE10345625A1 (de) * 2003-09-29 2005-04-28 Schott Ag Herstellungsverfahren eines Glaspulvers oder Glasproduktes mit antimikrobieller Wirkung
US7597900B2 (en) 2001-03-27 2009-10-06 Schott Ag Tissue abrasives
US7709027B2 (en) 2001-08-22 2010-05-04 Schott Ag Antimicrobial, anti-inflammatory, wound-healing glass powder and use thereof
EP2189426A1 (fr) 2004-05-29 2010-05-26 Schott AG Procédé pour préparer de nanopoudre de verre
DE10293768B4 (de) * 2001-08-22 2011-05-12 Schott Ag Antimikrobielles Glaspulver, dessen Verwendung und Verfahren zu dessen Herstellung
DE102022131545A1 (de) 2022-11-29 2024-05-29 Schott Ag Färbemittel

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141117A1 (de) 2001-08-22 2003-03-13 Schott Glas Antimikrobielles Silicatglas und dessen Verwendung
KR102611278B1 (ko) * 2023-04-04 2023-12-08 (주)저스트패밀리 고양이 화장실 모래에 사용하는 악취 분해 제거, 항균 및 살균 활성을 갖는 고양이 모래 방부제 성형물의 제조방법
KR102611279B1 (ko) * 2023-04-04 2023-12-08 (주)저스트패밀리 고양이 화장실 모래에 혼합하여 사용하는 악취 분해 제거, 항균 및 살균 활성을 갖는 고양이 모래 첨가제의 제조방법

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US4155870A (en) * 1976-04-19 1979-05-22 Minnesota Mining And Manufacturing Company Skin cleaning compositions containing water-insoluble glass bubbles
WO1996024364A2 (fr) * 1995-02-06 1996-08-15 Giltech Limited Composition antimicrobienne comprenant des verres a liberation controlee
US5766611A (en) * 1991-02-22 1998-06-16 Ishizuka Garasu Kabushiki Kaisha Cosmetic products containing a soluble glass

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JPH0395516A (ja) 1989-09-08 1991-04-19 Advance Co Ltd コンタクトレンズ用洗浄保存剤
US5074916A (en) * 1990-05-18 1991-12-24 Geltech, Inc. Alkali-free bioactive sol-gel compositions
GB2245559A (en) * 1990-06-25 1992-01-08 Farmos Oy Bioceramic system for delivery of a bioactive compound.
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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8551508B2 (en) 1999-12-07 2013-10-08 Schott Ag Cosmetic, personal care, cleaning agent, and nutritional supplement compositions and methods of making and using same
US7250174B2 (en) 1999-12-07 2007-07-31 Schott Ag Cosmetic, personal care, cleaning agent, and nutritional supplement compositions and methods of making and using same
EP1272144A2 (fr) * 2000-03-27 2003-01-08 Schott Glas Nouvelles compositions de produits cosmetiques, d'hygiene personnelle, d'agents de nettoyage et de supplements nutritionnels contenant du verre bioactif, et procedes de fabrication et d'utilisation de ces dernieres
EP1272144A4 (fr) * 2000-03-27 2006-04-26 Schott Ag Nouvelles compositions de produits cosmetiques, d'hygiene personnelle, d'agents de nettoyage et de supplements nutritionnels contenant du verre bioactif, et procedes de fabrication et d'utilisation de ces dernieres
US7597900B2 (en) 2001-03-27 2009-10-06 Schott Ag Tissue abrasives
US7709027B2 (en) 2001-08-22 2010-05-04 Schott Ag Antimicrobial, anti-inflammatory, wound-healing glass powder and use thereof
DE10293768B4 (de) * 2001-08-22 2011-05-12 Schott Ag Antimikrobielles Glaspulver, dessen Verwendung und Verfahren zu dessen Herstellung
WO2003050052A1 (fr) 2001-12-12 2003-06-19 Schott Glas Vitroceramique anti-inflammatoire, antimicrobienne et absorbant les rayons ultraviolets
WO2003050051A1 (fr) * 2001-12-12 2003-06-19 Schott Glas Vitroceramique alcali-silicate antimicrobienne et son utilisation
US7141520B2 (en) 2001-12-12 2006-11-28 Schott Ag Antimicrobial alkali-silicate glass ceramic and the use thereof
WO2003062163A2 (fr) 2002-01-24 2003-07-31 Schott Glas Poudre de verre de silicate antimicrobienne, insoluble dans l'eau et melange de poudres de verre
WO2004076370A1 (fr) * 2003-02-25 2004-09-10 Schott Ag Verre phosphate antimicrobien
EP1498395A1 (fr) * 2003-07-14 2005-01-19 Schott AG Utilisation d'une composition vitreuse pour obtenir un effet antioxydant
US9173822B2 (en) 2003-07-14 2015-11-03 Schott Ag Use of glass compositions for achieving an antioxidative effect
DE10345625A1 (de) * 2003-09-29 2005-04-28 Schott Ag Herstellungsverfahren eines Glaspulvers oder Glasproduktes mit antimikrobieller Wirkung
EP2189426A1 (fr) 2004-05-29 2010-05-26 Schott AG Procédé pour préparer de nanopoudre de verre
US7816292B2 (en) 2004-05-29 2010-10-19 Schott Ag Nano glass powder and use thereof, in particular multicomponent glass powder with a mean particle size of less than 1 μm
DE102022131545A1 (de) 2022-11-29 2024-05-29 Schott Ag Färbemittel

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KR20020020753A (ko) 2002-03-15
MXPA01013165A (es) 2002-11-04
AU6818400A (en) 2001-01-30
WO2001003650A3 (fr) 2001-09-27
US7628997B1 (en) 2009-12-08
TR200103723T2 (tr) 2002-06-21
ATE500812T1 (de) 2011-03-15
NO20020082D0 (no) 2002-01-08
EP1194113B1 (fr) 2011-03-09
CA2374395A1 (fr) 2001-01-18
IL147305A0 (en) 2002-08-14
NO20020082L (no) 2002-01-08
DE10081907D2 (de) 2002-08-29
CN1360491A (zh) 2002-07-24
NZ516136A (en) 2004-02-27
JP2003504317A (ja) 2003-02-04
HK1046868A1 (zh) 2003-01-30
AU780131B2 (en) 2005-03-03
CZ20014627A3 (cs) 2002-05-15
HUP0201821A2 (en) 2002-11-28
PL352469A1 (en) 2003-08-25
DE50016076D1 (de) 2011-04-21
SK18742001A3 (sk) 2002-05-09
ZA200200155B (en) 2004-02-11
EP1194113A2 (fr) 2002-04-10
ES2360594T3 (es) 2011-06-07
BR0012330A (pt) 2002-03-19

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