WO2000068249B1 - Nouvelles proteines de modulateur de proteine g (gpm), molecules d'acide nucleique, et leurs utilisations - Google Patents

Nouvelles proteines de modulateur de proteine g (gpm), molecules d'acide nucleique, et leurs utilisations

Info

Publication number
WO2000068249B1
WO2000068249B1 PCT/US2000/012502 US0012502W WO0068249B1 WO 2000068249 B1 WO2000068249 B1 WO 2000068249B1 US 0012502 W US0012502 W US 0012502W WO 0068249 B1 WO0068249 B1 WO 0068249B1
Authority
WO
WIPO (PCT)
Prior art keywords
gpm
protein
cell
seq
agent
Prior art date
Application number
PCT/US2000/012502
Other languages
English (en)
Other versions
WO2000068249A3 (fr
WO2000068249A2 (fr
Inventor
Stephen M Lanier
Aya Takesono
Mary Cismowski
Emir Duzic
Original Assignee
Musc Found For Res Dev
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Musc Found For Res Dev, Osi Pharm Inc filed Critical Musc Found For Res Dev
Priority to EP00930459A priority Critical patent/EP1179006A4/fr
Priority to AU48276/00A priority patent/AU4827600A/en
Publication of WO2000068249A2 publication Critical patent/WO2000068249A2/fr
Publication of WO2000068249A3 publication Critical patent/WO2000068249A3/fr
Publication of WO2000068249B1 publication Critical patent/WO2000068249B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

L'invention concerne de nouvelles protéines polypeptidiques de modulateur de protéine G (GPM), et des molécules d'acide nucléique, qui stimulent l'activité de la protéine G indépendamment d'un récepteur. En outre, cette invention permet de fournir des protéines de fusion GPM isolées, des peptides antigènes, et des anticorps anti-GPM aux protéines GPM isolées pleine longueur. Elle fournit également des molécules GPM d'acide nucléique, des vecteurs d'expression de recombinaison contenant ladite molécule d'acide nucléique, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits, et des animaux transgéniques non humains dans lesquels le gène GPM a été introduit ou interrompu. Elle concerne enfin un diagnostic, un criblage et des techniques utilisant lesdites compositions.
PCT/US2000/012502 1999-05-07 2000-05-05 Nouvelles proteines de modulateur de proteine g (gpm), molecules d'acide nucleique, et leurs utilisations WO2000068249A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00930459A EP1179006A4 (fr) 1999-05-07 2000-05-05 Nouvelles proteines de modulateur de proteine g (gpm), molecules d'acide nucleique, et leurs utilisations
AU48276/00A AU4827600A (en) 1999-05-07 2000-05-05 Novel g-protein modulator (gpm) proteins and nucleic acid molecules and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30710599A 1999-05-07 1999-05-07
US09/307,105 1999-05-07

Publications (3)

Publication Number Publication Date
WO2000068249A2 WO2000068249A2 (fr) 2000-11-16
WO2000068249A3 WO2000068249A3 (fr) 2001-10-25
WO2000068249B1 true WO2000068249B1 (fr) 2002-01-17

Family

ID=23188261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/012502 WO2000068249A2 (fr) 1999-05-07 2000-05-05 Nouvelles proteines de modulateur de proteine g (gpm), molecules d'acide nucleique, et leurs utilisations

Country Status (3)

Country Link
EP (1) EP1179006A4 (fr)
AU (1) AU4827600A (fr)
WO (1) WO2000068249A2 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001519157A (ja) * 1997-10-07 2001-10-23 ケイダス ファーマスーティカル コーポレイション 改変ｇ蛋白質を発現する酵母細胞及びそれらの利用方法
WO1999058670A1 (fr) * 1998-05-08 1999-11-18 Cadus Pharmaceutical Corporation Molecules d'acides nucleiques et proteines ags, et utilisations correspondantes
AUPQ223999A0 (en) * 1999-08-16 1999-09-09 University Of Sydney, The Intracellular feedback controls in the diagnosis and treatment of human disease

Also Published As

Publication number Publication date
AU4827600A (en) 2000-11-21
EP1179006A2 (fr) 2002-02-13
WO2000068249A3 (fr) 2001-10-25
EP1179006A4 (fr) 2003-03-19
WO2000068249A2 (fr) 2000-11-16

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