WO2000035414A1 - Composition de produit antisolaire - Google Patents

Composition de produit antisolaire

Info

Publication number
WO2000035414A1
WO2000035414A1 PCT/EP1999/008322 EP9908322W WO0035414A1 WO 2000035414 A1 WO2000035414 A1 WO 2000035414A1 EP 9908322 W EP9908322 W EP 9908322W WO 0035414 A1 WO0035414 A1 WO 0035414A1
Authority
WO
WIPO (PCT)
Prior art keywords
sunscreen
composition
skin
stearic acid
dissolved
Prior art date
Application number
PCT/EP1999/008322
Other languages
English (en)
Inventor
Govindarajan Raman
Original Assignee
Unilever Plc
Unilever Nv
Hindustan Lever Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc, Unilever Nv, Hindustan Lever Limited filed Critical Unilever Plc
Priority to JP2000587735A priority Critical patent/JP2002532402A/ja
Priority to AU16509/00A priority patent/AU746501B2/en
Priority to BR9916226-1A priority patent/BR9916226A/pt
Priority to KR1020017007506A priority patent/KR20010089579A/ko
Publication of WO2000035414A1 publication Critical patent/WO2000035414A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • the present invention relates to an improved cosmetic sunscreen composition for topical application to human skin to provide enhanced protection from sunlight and a process for preparing the same .
  • Melanin is the black pigment synthesised by the action of the enzyme tyrosinase on the amino acid tyrosine. The reaction takes place in organelles called melanosomes contained within cells called melanocytes . Melanocytes transfer melanosomes with melanin to neighbouring keratinocytes which harbour these organelles till they are themselves shed from the body from the superficial layers of the skin. The intensity of the skin colour is directly related to the number, the size, melanin content, the rate of formation and transfer of melanosomes to keratinocytes. Melanin is also an important protectant of skin and tissues beneath the skin as it has the capacity to absorb incident ultraviolet light.
  • UV-A having a wavelength of from about 320 to 400 nm which gives a tanning effect without inflammation
  • UV-B having a wavelength of from about 290-320 nm which is responsible for erythema (sunburn) and eventually for tanning
  • UV-C having a wavelength of from about 200-290 nm, normally absorbed by the ozone layer in the earth's atmosphere, but which is potentially very damaging to the skin.
  • Melanogenesis and pigmentation of the skin are closely related responses to irradiation by UV light. The photobiological changes that cause erythema also lead to melanogenesis and increased pigmentation.
  • the skin has to be protected broadly across the UV-A range of from about 320-400 nm. We have found that by careful selection of sunscreens we can protect the skin against the darkening effects of radiation.
  • GB 1 370 236 discloses a skin lightening composition containing niacin and the method by which it effects skin lightening is by retardation of melanin dispersion or distribution into the epidermis.
  • GB 1 533 119 discloses that niacinamide is useful as a skin lightening agent without causing skin flushing reaction due to vasodialation of blood vessels which is often associated with niacin.
  • GB 2230186 discloses that addition of a silicone compound to the composition containing a mixture of sunscreen and niacinamide improves the coverage of the cream on the skin for improved protection against the UV light.
  • compositions containing sunscreens are enhanced when the sunscreen is dissolved in an oil phase. More specifically the applicants have found that the use of the sunscreen dissolved in oil phase has improved sunscreen efficacy than that which may be obtained otherwise by using the sunscreen at substantially higher levels. Thus, the amount of sunscreen required to achieve the same UV protection is reduced by the present invention.
  • the present invention provides a topical cosmetic sunscreen composition
  • a topical cosmetic sunscreen composition comprising from (i) 0.1 to 10% by weight of the composition of an ultra-violet radiation absorbing sunscreen dissolved in an oil; and (ii) a cosmetically acceptable vehicle.
  • the composition is preferably obtained by the process below provided by the present invention.
  • the present invention also provides a process for the preparation of a cosmetic sunscreen composition comprising the steps of :
  • the dissolved sunscreen may be homogenised with the neutralised stearic acid and subsequently blended with the vehicle (and other ingredients) of the composition. It is preferable however for the neutralised stearic acid and vehicle to be blended together and the dissolved sunscreen subsequently to be added to the blend as this has been found to give a composition with an optimal sunscreen effect.
  • the stearic acid is neutralised with an alkali such as potassium hydroxide. It is preferred that prior to step (ii) the stearic acid is melted at a temperature above 70°C.
  • the sunscreen is preferably chosen from 4-tertiary butyl-4' - methoxy dibenzoylindethane, available under the trade name PARSOL 1789 ex Givaudan, 2 -ethyl hexyl methoxy cinnamate, available under the trade name PARSOL MCX ex Givaudan or mixtures of the two sunscreen compounds.
  • the composition comprises 0.1 to 10% by weight of the composition and preferably 0.1 to 5% by weight of the composition of a sunscreen compound.
  • the oil can be mineral oil, vegetable oil or from any other source but is preferably in the liquid state at temperatures greater than 20°C.
  • the oil can be selected from mineral oil, ground nut oil, sunflower oil, safflower oil, til oil or mixtures thereof. But if the preferred process is used where the sunscreens are dissolved in the oil phase and these are subsequently added to the blended neutralised stearic acid and vehicle in the water phase, then the oil need not be one which is in the liquid state at temperatures above 20 °C. Suitable oils in these circumstances include isopropyl myristate .
  • the stearic acid is first melted at 70°C and then neutralised with aqueous potassium hydroxide to which sunscreen dissolved in oil is added after the emulsion has cooled to a temperature of less than 50°C.
  • This emulsion forms the base for all other ingredients. All other ingredients may then be homogenised with the base. In a preferred embodiment, these other ingredients are blended with stearic acid/water phase prior to homogenisation with the sunscreen/oil phase.
  • the composition of the invention may optionally comprise from 0.1 to 10%, preferably 0.5 to 5% by weight of one or more skin whitening agents.
  • the skin whitening agent is preferably chosen from niacin, niacinamide or a precursor thereof that is capable of releasing niacinamide on the skin.
  • Niacinamide is the amide of niacin and is also known as nicotinamide or pyridine-3-carboxylic acid.
  • An example of a compound which is a niacinamide precursor is niacinamide ascorbate.
  • Other suitable skin whitening agents include extracts of placenta, hydroquinone and derivatives (eg.
  • the vehicle which forms part of the cosmetic composition is one or more substances which are mutually compatible with the sunscreen and if present, the skin whitening agent, and does not harm the skin.
  • the vehicle can act as a diluent, dispersant or carrier for the other ingredients of the composition, and is therefore intended to ensure that they can be readily applied to and distributed evenly over the skin at an appropriate concentration.
  • compositions according to the invention can include water, powder absorbents, binders and carriers and liquids such as emollients, propellants, solvents, humectants and thickeners.
  • compositions according to the invention can be prepared for topical application to the skin in the form of conventional product types such as creams, lotions, ointments and aerosol products .
  • Example 2a Cream containing no sunscreen or niacinamide
  • Example 2b Creams prepared by the conventional process described above where in the sunscreens
  • Example 2c Creams prepared as in Example 2b but containing double the level of sunscreens
  • Example 2d Creams prepared according to the invention as described above in which sunscreens (Parsol 1789 at 0.4% and Parsol MCX at 1.2% by weight of the composition) dissolved in mineral oil was added. Niacinamide at 1.0% was added.
  • the frame with tapes was placed on a UV source such that the sticky surface of the tape faces downwards.
  • a UV filter was placed over the source to ensure a UV light of constant intensity in the range of 240-350 nm. was obtained.
  • a thin uniform film of a fluorescent dye CBS-X which has an absorption maximum of 368 nm and emission maximum of 406 and 426 nm, as a 2% solution in 1:1 gycerol :water was taken between two cover slips and placed on the non glue side of the tape. This enabled the emission of a visible light wherever there was UV light coming through the tape which was picked up by the video camera with a macroscopic lens (6X) was used. Thus wherever sunscreen was present UV light would be blocked and the fluorescer would not be excited thus giving a black area.
  • the video camera was connected to a computer with a frame grabber card and using this images were stored.
  • Optimas image analysis software it was possible to quantify the difference in the amount of UV light passing through the tape. The lesser the intensity the better will be the UV blockage and thus better sunscreen efficacy.
  • the actual amount of UV A and UV B transmitted was also measured using specific probes for UV A and UV B.
  • Table 1 shows that the efficacy of sunscreen in the formulation prepared according to the invention will be superior to creams prepared by the conventional process and is comparable to creams having double the amount of sunscreen in a formulation prepared according the conventional process.
  • creams were fielded in a double blind skin lightening clinical trial.
  • 20 volunteers were selected who applied 0.75 g of creams prepared according to the invention as described in example 1 but using 2% isopropyl myristate (instead of mineral oil) as the oil phase (3a) , or creams prepared according to the conventional process (2b) , on one of their forearms twice daily.
  • the other forearm was maintained as unapplied control.
  • the skin tone was visually evaluated on a 10 point scale one day prior to application and after 8 weeks of application.
  • the data presented in Table 3 is a change in the score after 8 weeks of application. A negative score indicates a lighter skin tone as compared to the control .

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

Cette invention se rapporte à une composition de produit cosmétique antisolaire topique, qui comprend: (a) 0,1 à 10 % en poids de la composition d'un agent antisolaire absorbant les rayonnements ultraviolets, dissous dans une huile; et (b) un véhicule acceptable sur le plan cosmétique. Un procédé de préparation de cette composition est également présenté. Cette composition possède une efficacité antisolaire accrue.
PCT/EP1999/008322 1998-12-16 1999-10-21 Composition de produit antisolaire WO2000035414A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000587735A JP2002532402A (ja) 1998-12-16 1999-10-21 日焼け止め剤組成物
AU16509/00A AU746501B2 (en) 1998-12-16 1999-10-21 Sunscreen composition
BR9916226-1A BR9916226A (pt) 1998-12-16 1999-10-21 Processo para preparar uma composição de protetor solar, e, composição cosmética tópica de protetor solar
KR1020017007506A KR20010089579A (ko) 1998-12-16 1999-10-21 선스크린 조성물

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9827703.1 1998-12-16
GBGB9827703.1A GB9827703D0 (en) 1998-12-16 1998-12-16 Sunscreen composition

Publications (1)

Publication Number Publication Date
WO2000035414A1 true WO2000035414A1 (fr) 2000-06-22

Family

ID=10844338

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/008322 WO2000035414A1 (fr) 1998-12-16 1999-10-21 Composition de produit antisolaire

Country Status (9)

Country Link
JP (1) JP2002532402A (fr)
KR (1) KR20010089579A (fr)
CN (1) CN1165281C (fr)
AU (1) AU746501B2 (fr)
BR (1) BR9916226A (fr)
GB (1) GB9827703D0 (fr)
ID (1) ID29804A (fr)
WO (1) WO2000035414A1 (fr)
ZA (1) ZA200104664B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003015739A1 (fr) * 2001-08-14 2003-02-27 Unilever Plc Composition cosmetique dans un conditionnement a deux compartiments

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8173108B2 (en) * 2009-11-04 2012-05-08 Conopco, Inc. Sunscreen composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1370236A (en) * 1972-01-11 1974-10-16 Unilever Ltd Skin composition
EP0013390A2 (fr) * 1978-12-19 1980-07-23 Dragoco, Inc. Composition pour bâton cosmétique
US4840788A (en) * 1986-07-15 1989-06-20 Ici Americas Inc. Nonalcoholic sunscreen gel
EP0396422A1 (fr) * 1989-05-05 1990-11-07 Unilever Plc Composition pour la peau

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1370236A (en) * 1972-01-11 1974-10-16 Unilever Ltd Skin composition
EP0013390A2 (fr) * 1978-12-19 1980-07-23 Dragoco, Inc. Composition pour bâton cosmétique
US4840788A (en) * 1986-07-15 1989-06-20 Ici Americas Inc. Nonalcoholic sunscreen gel
EP0396422A1 (fr) * 1989-05-05 1990-11-07 Unilever Plc Composition pour la peau

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003015739A1 (fr) * 2001-08-14 2003-02-27 Unilever Plc Composition cosmetique dans un conditionnement a deux compartiments
US6939552B2 (en) 2001-08-14 2005-09-06 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Dual compartment packaged cosmetic composition

Also Published As

Publication number Publication date
CN1165281C (zh) 2004-09-08
AU746501B2 (en) 2002-05-02
GB9827703D0 (en) 1999-02-10
JP2002532402A (ja) 2002-10-02
BR9916226A (pt) 2001-10-02
AU1650900A (en) 2000-07-03
KR20010089579A (ko) 2001-10-06
CN1330535A (zh) 2002-01-09
ZA200104664B (en) 2002-06-07
ID29804A (id) 2001-10-11

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